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The map label for this gene is glcR [H]

Identifier: 238894750

GI number: 238894750

Start: 2632929

End: 2633702

Strand: Direct

Name: glcR [H]

Synonym: KP1_2757

Alternate gene names: 238894750

Gene position: 2632929-2633702 (Clockwise)

Preceding gene: 238894749

Following gene: 238894754

Centisome position: 50.17

GC content: 52.97

Gene sequence:

>774_bases
ATGTTTGCAGAAGAAAGACAGGAGAAGTTACTCGGTATTCTCAGGGAAAAACGCAAAGTTGCTGTTTCTGAGATGTGTGA
CGTCTTTAATGTATCTGGCGCTACCATTCGTGCCGATCTCCGCCAGCTGGAAGAGGAGGGGTTGCTGACCCGAACGCATG
GCGGAGCCGTTCTTCGTACCCGAGCGAGCTTCGAACAAGCATCGGACGCCCGCGAAATTGTCAATCTCAGCGCGAAAGAA
CGGATCGGCCAGCGCGCGGCGGCGCTGGTTGAGGATGGCGATATAATCGTGCTGGATACCGGTACCACGACGCTACATAT
CGCGCGCAATATTCGTGACAGACAGAACGTCACGGTGGTTACCAATGATTACCAAATCGCCCGGGAGCTTGAGGCCAGTC
CCTCGATTCAAACGATTCTGCTCGGGGGGATCGTTAAGAAGGGATACCACTGCGTGGTGGCAATTAACGGACGTTCCATT
CTCGACACGCTAAACGTCGATAAAGCATTTATGGGCACCAATTCGCTGTCGCTGAAACACGGCGCCTGCGTGGCCGATAT
CATGCTGGCAGAAACGAAACGAGGCATGGTGGAACACGCCAGTCAGGTGATTATTGTCTGCGACTACAGCAAGCTGAATA
ACACCTCGCTTGCCCAATTTACCGCCGCAGATCGAATTGACACGGTGGTGGTGGATCGTCTGCCTGATGATGTTCAGGCG
TATCGTAATGCCGGCATTCAGGTGATTTCTCTGGATGAAGAGAATCTTCTCTAG

Upstream 100 bases:

>100_bases
TACGACAGGCTGGATGCGCTCAGCGTAGGACCCGACTGATACGCAAAGGTAAGCCAGCGCCGCTGCGCGCGTAACGAGCT
GTAAAAAAGAGAGAGGCAGA

Downstream 100 bases:

>100_bases
CGCGGAGTTCAGGCGGTATCAAATATCAGGTGGGCCGTAAAACCCCGCCCAGATGGACGGGGATGTAAGGCGCGTTTTAC
CGAGTCACGTGAAGAGGAGC

Product: putative DeoR family regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MFAEERQEKLLGILREKRKVAVSEMCDVFNVSGATIRADLRQLEEEGLLTRTHGGAVLRTRASFEQASDAREIVNLSAKE
RIGQRAAALVEDGDIIVLDTGTTTLHIARNIRDRQNVTVVTNDYQIARELEASPSIQTILLGGIVKKGYHCVVAINGRSI
LDTLNVDKAFMGTNSLSLKHGACVADIMLAETKRGMVEHASQVIIVCDYSKLNNTSLAQFTAADRIDTVVVDRLPDDVQA
YRNAGIQVISLDEENLL

Sequences:

>Translated_257_residues
MFAEERQEKLLGILREKRKVAVSEMCDVFNVSGATIRADLRQLEEEGLLTRTHGGAVLRTRASFEQASDAREIVNLSAKE
RIGQRAAALVEDGDIIVLDTGTTTLHIARNIRDRQNVTVVTNDYQIARELEASPSIQTILLGGIVKKGYHCVVAINGRSI
LDTLNVDKAFMGTNSLSLKHGACVADIMLAETKRGMVEHASQVIIVCDYSKLNNTSLAQFTAADRIDTVVVDRLPDDVQA
YRNAGIQVISLDEENLL
>Mature_257_residues
MFAEERQEKLLGILREKRKVAVSEMCDVFNVSGATIRADLRQLEEEGLLTRTHGGAVLRTRASFEQASDAREIVNLSAKE
RIGQRAAALVEDGDIIVLDTGTTTLHIARNIRDRQNVTVVTNDYQIARELEASPSIQTILLGGIVKKGYHCVVAINGRSI
LDTLNVDKAFMGTNSLSLKHGACVADIMLAETKRGMVEHASQVIIVCDYSKLNNTSLAQFTAADRIDTVVVDRLPDDVQA
YRNAGIQVISLDEENLL

Specific function: Plays a role in carbon catabolite repression (CCR). Specifically required for transcriptional repression of the levanase operon by glucose but not by other sugars [H]

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789519, Length=253, Percent_Identity=30.8300395256917, Blast_Score=130, Evalue=7e-32,
Organism=Escherichia coli, GI1789059, Length=261, Percent_Identity=32.5670498084291, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI226510968, Length=237, Percent_Identity=31.6455696202532, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1790753, Length=257, Percent_Identity=26.8482490272374, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI87082344, Length=230, Percent_Identity=24.7826086956522, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788069, Length=244, Percent_Identity=28.2786885245902, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1789829, Length=235, Percent_Identity=25.531914893617, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787540, Length=228, Percent_Identity=28.0701754385965, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1789170, Length=230, Percent_Identity=26.9565217391304, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787063, Length=249, Percent_Identity=27.710843373494, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790635, Length=253, Percent_Identity=22.5296442687747, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 28219; Mature: 28219

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00894 HTH_DEOR_1 ; PS51000 HTH_DEOR_2 ; PS00141 ASP_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFAEERQEKLLGILREKRKVAVSEMCDVFNVSGATIRADLRQLEEEGLLTRTHGGAVLRT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEECCCEEEEE
RASFEQASDAREIVNLSAKERIGQRAAALVEDGDIIVLDTGTTTLHIARNIRDRQNVTVV
HHHHHHHHHHHHHHCCHHHHHHHHHHHHEECCCCEEEEECCCCEEEEECCCCCCCCEEEE
TNDYQIARELEASPSIQTILLGGIVKKGYHCVVAINGRSILDTLNVDKAFMGTNSLSLKH
ECCHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEECCCCEEHHCCCCHHHCCCCCCCCCC
GACVADIMLAETKRGMVEHASQVIIVCDYSKLNNTSLAQFTAADRIDTVVVDRLPDDVQA
CCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHEEEECCCCHHHHH
YRNAGIQVISLDEENLL
HHHCCEEEEEECCCCCC
>Mature Secondary Structure
MFAEERQEKLLGILREKRKVAVSEMCDVFNVSGATIRADLRQLEEEGLLTRTHGGAVLRT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEECCCEEEEE
RASFEQASDAREIVNLSAKERIGQRAAALVEDGDIIVLDTGTTTLHIARNIRDRQNVTVV
HHHHHHHHHHHHHHCCHHHHHHHHHHHHEECCCCEEEEECCCCEEEEECCCCCCCCEEEE
TNDYQIARELEASPSIQTILLGGIVKKGYHCVVAINGRSILDTLNVDKAFMGTNSLSLKH
ECCHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEECCCCEEHHCCCCHHHCCCCCCCCCC
GACVADIMLAETKRGMVEHASQVIIVCDYSKLNNTSLAQFTAADRIDTVVVDRLPDDVQA
CCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHEEEECCCCHHHHH
YRNAGIQVISLDEENLL
HHHCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]