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The map label for this gene is xanP [H]

Identifier: 238894704

GI number: 238894704

Start: 2588381

End: 2589790

Strand: Direct

Name: xanP [H]

Synonym: KP1_2710

Alternate gene names: 238894704

Gene position: 2588381-2589790 (Clockwise)

Preceding gene: 238894702

Following gene: 238894705

Centisome position: 49.32

GC content: 61.21

Gene sequence:

>1410_bases
ATGCACTTCTCTTTGCTACGGGATATCACTATGTCTGACGAACATCACAGTGGCCTGCTTTACGGCCTTGAACAGCGGAT
CCCACCGCTTCCGGCCTTTTTCAGCGCTCTCCAGCATGTGCTGGCGGGCCTGGTGGGGATCATCACGCCGCCGCTGATCA
TCGGCGCTACCCTCGGGCTTGGCGACTGGCTGCCGTATCTCATCAGTATGTCGCTGCTGGCCTCGGGCATTGGCACTTTT
CTGCAGTCCAATCGGGTATGGGGCATCGGCGCCGGGATGATCTGCATGCAGGGCACCAGTTTTGCCTTCCTCGGCGTGAC
GGTGGCCGGAGGGATGTGGGTAAAAGCGCAGGGCGGCGGGCCGCAGGATATGATGGCGATGCTGTTTGGCGTTAACTTTG
TCGCCGCTCTGGTGCCGGTGATTGTCAGCCGCTTTATCGAACCGCTGAAGAAAATCTTTACTCCCATCATTACCGGCAGC
GTGATTGCGCTGATCGGCATCAGCCTGATCAAGGTCAGCGTCATCAACTGGTGCGGTGGGGAAAAGGCAGAGGATTTCGC
CAGCATGAGCAACATCGCGCTCGGGGCGGGCACCCTCGGGGTTATCGTCCTGCTGAGCTGCGCCAAAAACCGCTGGCTGC
GGCTCTCCTCGGTGGTGGTGGGCATTGCCGTGGGCTGCATCGCAGCGGGGCTGAGCGGTCAGTTCCATCTCCACAGCCTG
GGCGACACTCTGTTTCGCCTGCCGACGCTGTTTCCGTTCGGCTTTCAGTTTAACAGCGCGATATTTCTGCCGGTCGCCCT
GGTGTCGCTGGTCTGTATTCTGGAGGCGGTGGGCGATCTGACGGCCAACTCGCTGATTTCACAACAGTCTGTTGACGATC
GCGCTTTCCGTAACCGGCTGAAGGGCGGTATCCTGGCGGATGGCGTCAGCTGTATGGTGGCGGCCATGCTCTGTGCTTTT
CCGAACACCACCTTCGCGCAGAACAACGGCGTGATCCAGATGACCGGGGTGGCCAGCCGCTATGTCGGACGCTACATTGG
CGTGATTCTGATCCTGCTCGGGCTGTTCCCCCCGGTGGGCGAACTGCTGCGGCAGATCCCGGCGCCGGTGCTGGGGGGCG
CCACGATGGTGATGTTTGGCTGCGTGGTGGCGGCCGGGATCCGGATTATTACCCAGACCCCGCTGAGCCGTCGCGATGTG
CTGATCGTGGGGCTGGCGTTTGGCGCGGGTCTTGGCGTGGAGTCGGTGCCGGCGTTTCTCAGCCATTTTCCGCCGATGGT
CGGCGATCTGTTCGGTTCGGCGGCCACCAGCGGTGGGCTGGTAGCGATAGCGCTGAACCTTATTCTGCCGCAGGAGCAGG
CGGCGACGAAATCGTTAAGGAGTCAGGATGATCGCGCTGAGTCAGTTTAA

Upstream 100 bases:

>100_bases
GGTGATGCATCACGAGCGTAATATAAGTTGATGATTTTTAAGTGATAATAAATTTATTGGTGCCCTTTTGTCGTCTCTGG
CCTGCTTTGTGCACTAGCCC

Downstream 100 bases:

>100_bases
CAGCCTGAGCAAAGATGAGGCGGCGGGGCTGCTGGCCCCTTGCGTGGCGATCCCGGCCTGGGGCGAGACGCTGGTGAGCT
TGCGACCTTTCGCCAGCCGC

Product: putative guanine/xanthin permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MHFSLLRDITMSDEHHSGLLYGLEQRIPPLPAFFSALQHVLAGLVGIITPPLIIGATLGLGDWLPYLISMSLLASGIGTF
LQSNRVWGIGAGMICMQGTSFAFLGVTVAGGMWVKAQGGGPQDMMAMLFGVNFVAALVPVIVSRFIEPLKKIFTPIITGS
VIALIGISLIKVSVINWCGGEKAEDFASMSNIALGAGTLGVIVLLSCAKNRWLRLSSVVVGIAVGCIAAGLSGQFHLHSL
GDTLFRLPTLFPFGFQFNSAIFLPVALVSLVCILEAVGDLTANSLISQQSVDDRAFRNRLKGGILADGVSCMVAAMLCAF
PNTTFAQNNGVIQMTGVASRYVGRYIGVILILLGLFPPVGELLRQIPAPVLGGATMVMFGCVVAAGIRIITQTPLSRRDV
LIVGLAFGAGLGVESVPAFLSHFPPMVGDLFGSAATSGGLVAIALNLILPQEQAATKSLRSQDDRAESV

Sequences:

>Translated_469_residues
MHFSLLRDITMSDEHHSGLLYGLEQRIPPLPAFFSALQHVLAGLVGIITPPLIIGATLGLGDWLPYLISMSLLASGIGTF
LQSNRVWGIGAGMICMQGTSFAFLGVTVAGGMWVKAQGGGPQDMMAMLFGVNFVAALVPVIVSRFIEPLKKIFTPIITGS
VIALIGISLIKVSVINWCGGEKAEDFASMSNIALGAGTLGVIVLLSCAKNRWLRLSSVVVGIAVGCIAAGLSGQFHLHSL
GDTLFRLPTLFPFGFQFNSAIFLPVALVSLVCILEAVGDLTANSLISQQSVDDRAFRNRLKGGILADGVSCMVAAMLCAF
PNTTFAQNNGVIQMTGVASRYVGRYIGVILILLGLFPPVGELLRQIPAPVLGGATMVMFGCVVAAGIRIITQTPLSRRDV
LIVGLAFGAGLGVESVPAFLSHFPPMVGDLFGSAATSGGLVAIALNLILPQEQAATKSLRSQDDRAESV
>Mature_469_residues
MHFSLLRDITMSDEHHSGLLYGLEQRIPPLPAFFSALQHVLAGLVGIITPPLIIGATLGLGDWLPYLISMSLLASGIGTF
LQSNRVWGIGAGMICMQGTSFAFLGVTVAGGMWVKAQGGGPQDMMAMLFGVNFVAALVPVIVSRFIEPLKKIFTPIITGS
VIALIGISLIKVSVINWCGGEKAEDFASMSNIALGAGTLGVIVLLSCAKNRWLRLSSVVVGIAVGCIAAGLSGQFHLHSL
GDTLFRLPTLFPFGFQFNSAIFLPVALVSLVCILEAVGDLTANSLISQQSVDDRAFRNRLKGGILADGVSCMVAAMLCAF
PNTTFAQNNGVIQMTGVASRYVGRYIGVILILLGLFPPVGELLRQIPAPVLGGATMVMFGCVVAAGIRIITQTPLSRRDV
LIVGLAFGAGLGVESVPAFLSHFPPMVGDLFGSAATSGGLVAIALNLILPQEQAATKSLRSQDDRAESV

Specific function: Specific, proton motive force-dependent high-affinity transporter for xanthine [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790087, Length=451, Percent_Identity=41.2416851441242, Blast_Score=320, Evalue=1e-88,
Organism=Escherichia coli, GI87082178, Length=448, Percent_Identity=43.0803571428571, Blast_Score=308, Evalue=6e-85,
Organism=Escherichia coli, GI87082181, Length=446, Percent_Identity=29.8206278026906, Blast_Score=148, Evalue=7e-37,
Organism=Escherichia coli, GI87081818, Length=415, Percent_Identity=26.5060240963855, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788843, Length=396, Percent_Identity=28.2828282828283, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17558856, Length=450, Percent_Identity=26.6666666666667, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17541904, Length=516, Percent_Identity=23.6434108527132, Blast_Score=75, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI71993493, Length=219, Percent_Identity=27.3972602739726, Blast_Score=66, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17542260, Length=237, Percent_Identity=26.5822784810127, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 49150; Mature: 49150

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHCCHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHCCCHHCCCC
>Mature Secondary Structure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HHCCHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]