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The map label for this gene is uxaB [H]

Identifier: 238894675

GI number: 238894675

Start: 2564812

End: 2566263

Strand: Direct

Name: uxaB [H]

Synonym: KP1_2680

Alternate gene names: 238894675

Gene position: 2564812-2566263 (Clockwise)

Preceding gene: 238894674

Following gene: 238894676

Centisome position: 48.87

GC content: 58.82

Gene sequence:

>1452_bases
GTGAAAACTTTAAACCGTCGTGATTTCCCCGGCGCGCAGTACCCTGACCGTATCATCCAGTTTGGGGAAGGTAACTTCCT
GCGCGCATTCGTTGACTGGCAGATCGACCTGCTCAACGAGCATACCGACCTGAATGCGGGCATCGTGGTCGTGCGGCCTA
TCGCCACAGATTTTCCGCCTTCGCTGAACACCCAGGATGGCCTGTACACGACTATTATTCGCGGCCTGAACGAGCAGGGC
GAAGCGGTCAGCGATGCGCGTCTTATCCGCTCGGTCAACCGGGAGATCAGCGCTTACGCAGACTTCGACGCTTTTTTACG
CCTGGCGCATAACCCGGAGATGCGGTTTGTCTTCTCCAACACCACCGAGGCGGGCATCAGCTACCATGCCGGGGATCGGT
TTGACGACGCGCCGCCGGTCAGTTATCCGGCGAAACTGACCCGTCTGTTGTTTGAGCGTTATCAGCATTTCGCCGGTGCG
GCCGACAAGGGATGGGTGATTATTCCCTGCGAGCTGATCGATTATAACGGCGAGGCGCTGCAGGCGCTGGTGCTGCGCTA
TGCTAGCGAATGGGAACTGCCGCAGGCATTTATCACCTGGCTGACCTCAGCGAATACCTTCTGTTCGACGCTGGTGGATC
GCATTGTGACCGGCTATCCGCGTGATGAAGTGGAGGCTCTCGAGGCGCAGACCGGCTATAAAGATGCTTTCCTTGATACC
GCTGAGCATTTCTACCTGTTCGTTATCCAGGGACCTGCCTCGCTGGAGGCCGAGCTGCGTCTCGATAAACTGCCGCTGAA
TGTGCGCATTGTGGACGATATCAAGCCGTATAAAGAACGCAAAGTGGCGATCCTTAACGGGGCGCACACCGCGCTGGTGC
CGGTGGCCTTCCAGGCCGGGATCGACACCGTGGGTGAGGCGATGAACGATGCGGAGATTTGCGCGTTTGTCGAAAAAGCG
ATTTATGACGAAATTATTCCGGTGCTGGATCTGCCGCGCGATGAGCTGGTGTCATTCGCCAGCGCCGTGACAGGGCGCTT
CCGTAATCCCTATATTAAACATCAGCTGCTCTCGATTGCGCTCAACGGCATGACCAAGTACCGCACCCGTATTCTGCCGC
AGCTGCTGGCGGGGCAGAAAGCGCATGGCGCGCTGCCGCCGCGTCTGACCTTTGCCCTGGCGGCGCTGATCGCCTTTTAC
CGGGGAGAGCGGGATGGTGAGAGCTATCCAGTACAGGATGACGCCGACTGGATATCGCGCTATCAAACGCTGTGGGCCCG
CCATCGCGATGGCCAGATGAGCACTCGCGAGCTGGTCACCGCCGTGCTCAGCGTGGCGGATCACTGGCAGCAGGATCTGA
GCCAGATCCCGGGATTGGTGGAGCTGGTGACTGCCGACCTTGACGCTATCCTGACCTGCGGTATGCGCGACGCCGTCAAA
CCTCTTTGCTGA

Upstream 100 bases:

>100_bases
AGATTGCTTTGATCAAAACAGGGTTTCACTGGTAGCAAAACCTGATAACTTATTGGACCAATTACTCAGGTTGTATGACT
ACTATTAGAGGGAACCCATT

Downstream 100 bases:

>100_bases
TAGTCCATCTATACACCCGGCTGCGGCCGGGTTGTGCAGGATTTTTATTAGTTACAACATACTATTATACTAACCTGTAA
CAGCCGGTCAGTGGCTCCTC

Product: altronate oxidoreductase

Products: NA

Alternate protein names: Tagaturonate dehydrogenase; Tagaturonate reductase [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MKTLNRRDFPGAQYPDRIIQFGEGNFLRAFVDWQIDLLNEHTDLNAGIVVVRPIATDFPPSLNTQDGLYTTIIRGLNEQG
EAVSDARLIRSVNREISAYADFDAFLRLAHNPEMRFVFSNTTEAGISYHAGDRFDDAPPVSYPAKLTRLLFERYQHFAGA
ADKGWVIIPCELIDYNGEALQALVLRYASEWELPQAFITWLTSANTFCSTLVDRIVTGYPRDEVEALEAQTGYKDAFLDT
AEHFYLFVIQGPASLEAELRLDKLPLNVRIVDDIKPYKERKVAILNGAHTALVPVAFQAGIDTVGEAMNDAEICAFVEKA
IYDEIIPVLDLPRDELVSFASAVTGRFRNPYIKHQLLSIALNGMTKYRTRILPQLLAGQKAHGALPPRLTFALAALIAFY
RGERDGESYPVQDDADWISRYQTLWARHRDGQMSTRELVTAVLSVADHWQQDLSQIPGLVELVTADLDAILTCGMRDAVK
PLC

Sequences:

>Translated_483_residues
MKTLNRRDFPGAQYPDRIIQFGEGNFLRAFVDWQIDLLNEHTDLNAGIVVVRPIATDFPPSLNTQDGLYTTIIRGLNEQG
EAVSDARLIRSVNREISAYADFDAFLRLAHNPEMRFVFSNTTEAGISYHAGDRFDDAPPVSYPAKLTRLLFERYQHFAGA
ADKGWVIIPCELIDYNGEALQALVLRYASEWELPQAFITWLTSANTFCSTLVDRIVTGYPRDEVEALEAQTGYKDAFLDT
AEHFYLFVIQGPASLEAELRLDKLPLNVRIVDDIKPYKERKVAILNGAHTALVPVAFQAGIDTVGEAMNDAEICAFVEKA
IYDEIIPVLDLPRDELVSFASAVTGRFRNPYIKHQLLSIALNGMTKYRTRILPQLLAGQKAHGALPPRLTFALAALIAFY
RGERDGESYPVQDDADWISRYQTLWARHRDGQMSTRELVTAVLSVADHWQQDLSQIPGLVELVTADLDAILTCGMRDAVK
PLC
>Mature_483_residues
MKTLNRRDFPGAQYPDRIIQFGEGNFLRAFVDWQIDLLNEHTDLNAGIVVVRPIATDFPPSLNTQDGLYTTIIRGLNEQG
EAVSDARLIRSVNREISAYADFDAFLRLAHNPEMRFVFSNTTEAGISYHAGDRFDDAPPVSYPAKLTRLLFERYQHFAGA
ADKGWVIIPCELIDYNGEALQALVLRYASEWELPQAFITWLTSANTFCSTLVDRIVTGYPRDEVEALEAQTGYKDAFLDT
AEHFYLFVIQGPASLEAELRLDKLPLNVRIVDDIKPYKERKVAILNGAHTALVPVAFQAGIDTVGEAMNDAEICAFVEKA
IYDEIIPVLDLPRDELVSFASAVTGRFRNPYIKHQLLSIALNGMTKYRTRILPQLLAGQKAHGALPPRLTFALAALIAFY
RGERDGESYPVQDDADWISRYQTLWARHRDGQMSTRELVTAVLSVADHWQQDLSQIPGLVELVTADLDAILTCGMRDAVK
PLC

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxaB subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994885, Length=483, Percent_Identity=84.0579710144928, Blast_Score=854, Evalue=0.0,
Organism=Escherichia coli, GI1787823, Length=368, Percent_Identity=26.0869565217391, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1788497, Length=489, Percent_Identity=24.3353783231084, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1790779, Length=482, Percent_Identity=24.0663900414938, Blast_Score=99, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6324401, Length=430, Percent_Identity=23.7209302325581, Blast_Score=103, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6320765, Length=430, Percent_Identity=23.7209302325581, Blast_Score=103, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR013118
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.58 [H]

Molecular weight: Translated: 54170; Mature: 54170

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLNRRDFPGAQYPDRIIQFGEGNFLRAFVDWQIDLLNEHTDLNAGIVVVRPIATDFPP
CCCCCCCCCCCCCCCHHHHCCCCCCEEEEEEEEEHEECCCCCCCCCCEEEEEECCCCCCC
SLNTQDGLYTTIIRGLNEQGEAVSDARLIRSVNREISAYADFDAFLRLAHNPEMRFVFSN
CCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCEEEEECC
TTEAGISYHAGDRFDDAPPVSYPAKLTRLLFERYQHFAGAADKGWVIIPCELIDYNGEAL
CCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCHHHH
QALVLRYASEWELPQAFITWLTSANTFCSTLVDRIVTGYPRDEVEALEAQTGYKDAFLDT
HHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHC
AEHFYLFVIQGPASLEAELRLDKLPLNVRIVDDIKPYKERKVAILNGAHTALVPVAFQAG
CCCEEEEEEECCCCCCHHEEEECCCCEEEEECCCCCHHHCEEEEEECCCHHHHHHHHHHC
IDTVGEAMNDAEICAFVEKAIYDEIIPVLDLPRDELVSFASAVTGRFRNPYIKHQLLSIA
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LNGMTKYRTRILPQLLAGQKAHGALPPRLTFALAALIAFYRGERDGESYPVQDDADWISR
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
YQTLWARHRDGQMSTRELVTAVLSVADHWQQDLSQIPGLVELVTADLDAILTCGMRDAVK
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHC
PLC
CCC
>Mature Secondary Structure
MKTLNRRDFPGAQYPDRIIQFGEGNFLRAFVDWQIDLLNEHTDLNAGIVVVRPIATDFPP
CCCCCCCCCCCCCCCHHHHCCCCCCEEEEEEEEEHEECCCCCCCCCCEEEEEECCCCCCC
SLNTQDGLYTTIIRGLNEQGEAVSDARLIRSVNREISAYADFDAFLRLAHNPEMRFVFSN
CCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCEEEEECC
TTEAGISYHAGDRFDDAPPVSYPAKLTRLLFERYQHFAGAADKGWVIIPCELIDYNGEAL
CCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCHHHH
QALVLRYASEWELPQAFITWLTSANTFCSTLVDRIVTGYPRDEVEALEAQTGYKDAFLDT
HHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHC
AEHFYLFVIQGPASLEAELRLDKLPLNVRIVDDIKPYKERKVAILNGAHTALVPVAFQAG
CCCEEEEEEECCCCCCHHEEEECCCCEEEEECCCCCHHHCEEEEEECCCHHHHHHHHHHC
IDTVGEAMNDAEICAFVEKAIYDEIIPVLDLPRDELVSFASAVTGRFRNPYIKHQLLSIA
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LNGMTKYRTRILPQLLAGQKAHGALPPRLTFALAALIAFYRGERDGESYPVQDDADWISR
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
YQTLWARHRDGQMSTRELVTAVLSVADHWQQDLSQIPGLVELVTADLDAILTCGMRDAVK
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHC
PLC
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA