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The map label for this gene is serA [H]

Identifier: 238894661

GI number: 238894661

Start: 2551033

End: 2551983

Strand: Reverse

Name: serA [H]

Synonym: KP1_2666

Alternate gene names: 238894661

Gene position: 2551983-2551033 (Counterclockwise)

Preceding gene: 238894662

Following gene: 238894660

Centisome position: 48.62

GC content: 49.11

Gene sequence:

>951_bases
ATGAAAGTAATTTGCACCTCGCCCTCATTCGCCAAATACGACGATGCGCCCATTTCGGCACTGAAAGAGGCCGATCTTGA
ACTGGTCATGTTGCCTGCCGATGCCTCTATAGAGATGCTGGCTCAGCATCTGCCTGATGCCATAGCGATGATTGTCGCCT
TCACCGACATCAATGAATCGCTGCTGGCAAAGGCCCCGAGGTTAAAAATTGTCTGCAAACACGGCGTTGGTGTGGATAAC
ATCGATCTTAACGCTACACGTCAGCGCAAAATTTTTGTCACTAACGTTCCTGATGCCAACAAGCATGCGGTGGCCGATTT
TGCTTTTGGCTTAATTCTCAATACTGCCCGCCAGATTTGTCAGGCAATCAGTGAAACGAAAGCAGGCAACTGGCCTCGTA
TTTTTGCCACTGATGTGTATGGCAAAACCCTGGGGATCGTCGGTTTAGGCCATATCGGTAAGGAAGTGGCGCGACGTGCG
CGCGGATTCAATATGCGAGTGCTCGCCACCGACGCCTGGCCAGACAGAGAATTTGCACAACAACACCAGATTGAATATGT
CTCACTGGATACCCTGACGGCGCAAAGTGATTTTATTAGCCTGCATACCCCTTTAACCCCGGAAACTGAAAATATGTTTA
ATGCCGCCCGGCTACAGCAGATGAAATCAGGGGCATTCCTGATCAATGTTTCCAGAGGCGGTATTGTTGATGAACAAGCG
TTGTATGAAGCACTAAAATCAGGACACCTCGCCGGAGCCGCAGCTGACGTTTTTCTCGAGGAACCTTGCGCTACGCACCC
TTTATTTACCCTGGCGAATTTTGCGCCAACATCTCATATTGCTGGATATACGGATGGCGCAATTAGCAATATTAGCGCGC
GCTGCGTCAACAATATTATTACCTGCGTCTGTCGTGGTGAACGACCTGAAAACATTATGAATTCGCTGTAA

Upstream 100 bases:

>100_bases
ACCTACCTTCACTAATTTACGTATCCGCCCCGGCCATCACTGGCTGGGGCAAGGTCTTGTATTTGCGACGCTCATTGTCG
CCAGTAAACAGGAAACGGTT

Downstream 100 bases:

>100_bases
ATAACGAGGTGGGAAGCATGCCATTCCCACCAATATAACGAACATCTACTTAGAGCCGAATATATGAACACGACAGCTAA
CACTACTCGTATTCGCTGGT

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MKVICTSPSFAKYDDAPISALKEADLELVMLPADASIEMLAQHLPDAIAMIVAFTDINESLLAKAPRLKIVCKHGVGVDN
IDLNATRQRKIFVTNVPDANKHAVADFAFGLILNTARQICQAISETKAGNWPRIFATDVYGKTLGIVGLGHIGKEVARRA
RGFNMRVLATDAWPDREFAQQHQIEYVSLDTLTAQSDFISLHTPLTPETENMFNAARLQQMKSGAFLINVSRGGIVDEQA
LYEALKSGHLAGAAADVFLEEPCATHPLFTLANFAPTSHIAGYTDGAISNISARCVNNIITCVCRGERPENIMNSL

Sequences:

>Translated_316_residues
MKVICTSPSFAKYDDAPISALKEADLELVMLPADASIEMLAQHLPDAIAMIVAFTDINESLLAKAPRLKIVCKHGVGVDN
IDLNATRQRKIFVTNVPDANKHAVADFAFGLILNTARQICQAISETKAGNWPRIFATDVYGKTLGIVGLGHIGKEVARRA
RGFNMRVLATDAWPDREFAQQHQIEYVSLDTLTAQSDFISLHTPLTPETENMFNAARLQQMKSGAFLINVSRGGIVDEQA
LYEALKSGHLAGAAADVFLEEPCATHPLFTLANFAPTSHIAGYTDGAISNISARCVNNIITCVCRGERPENIMNSL
>Mature_316_residues
MKVICTSPSFAKYDDAPISALKEADLELVMLPADASIEMLAQHLPDAIAMIVAFTDINESLLAKAPRLKIVCKHGVGVDN
IDLNATRQRKIFVTNVPDANKHAVADFAFGLILNTARQICQAISETKAGNWPRIFATDVYGKTLGIVGLGHIGKEVARRA
RGFNMRVLATDAWPDREFAQQHQIEYVSLDTLTAQSDFISLHTPLTPETENMFNAARLQQMKSGAFLINVSRGGIVDEQA
LYEALKSGHLAGAAADVFLEEPCATHPLFTLANFAPTSHIAGYTDGAISNISARCVNNIITCVCRGERPENIMNSL

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=282, Percent_Identity=37.9432624113475, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI6912396, Length=297, Percent_Identity=36.026936026936, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI145580578, Length=297, Percent_Identity=32.6599326599327, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI4557499, Length=297, Percent_Identity=32.6599326599327, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI61743967, Length=298, Percent_Identity=33.8926174496644, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI4557497, Length=298, Percent_Identity=33.8926174496644, Blast_Score=131, Evalue=6e-31,
Organism=Homo sapiens, GI145580575, Length=278, Percent_Identity=33.4532374100719, Blast_Score=128, Evalue=6e-30,
Organism=Escherichia coli, GI87082289, Length=286, Percent_Identity=37.0629370629371, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1787645, Length=206, Percent_Identity=38.8349514563107, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1789279, Length=253, Percent_Identity=35.9683794466403, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1788660, Length=247, Percent_Identity=31.1740890688259, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI87081824, Length=253, Percent_Identity=26.8774703557312, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=287, Percent_Identity=39.0243902439024, Blast_Score=191, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI25147481, Length=297, Percent_Identity=30.6397306397306, Blast_Score=122, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6322116, Length=277, Percent_Identity=35.7400722021661, Blast_Score=151, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6320925, Length=290, Percent_Identity=33.448275862069, Blast_Score=149, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6324055, Length=244, Percent_Identity=30.7377049180328, Blast_Score=135, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6324964, Length=285, Percent_Identity=30.1754385964912, Blast_Score=111, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6324980, Length=200, Percent_Identity=29.5, Blast_Score=78, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321253, Length=278, Percent_Identity=28.0575539568345, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI19921140, Length=271, Percent_Identity=36.5313653136531, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI45551003, Length=250, Percent_Identity=32.4, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI45552429, Length=250, Percent_Identity=32.4, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24585514, Length=250, Percent_Identity=32.4, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI28574282, Length=250, Percent_Identity=32.4, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI28574284, Length=250, Percent_Identity=32.4, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI28574286, Length=268, Percent_Identity=33.2089552238806, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24646446, Length=272, Percent_Identity=33.4558823529412, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24646448, Length=272, Percent_Identity=33.4558823529412, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24646452, Length=272, Percent_Identity=33.4558823529412, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24646450, Length=272, Percent_Identity=33.4558823529412, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI62472511, Length=272, Percent_Identity=33.4558823529412, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI28571528, Length=259, Percent_Identity=35.1351351351351, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24585516, Length=276, Percent_Identity=26.8115942028986, Blast_Score=112, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 34336; Mature: 34336

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVICTSPSFAKYDDAPISALKEADLELVMLPADASIEMLAQHLPDAIAMIVAFTDINES
CEEEECCCCCCCCCCCHHHHHHHCCCEEEEECCCCCHHHHHHHCCHHHHHHHHHHCCCHH
LLAKAPRLKIVCKHGVGVDNIDLNATRQRKIFVTNVPDANKHAVADFAFGLILNTARQIC
HHCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
QAISETKAGNWPRIFATDVYGKTLGIVGLGHIGKEVARRARGFNMRVLATDAWPDREFAQ
HHHHHHCCCCCCEEEEECCCCCCEEEEECHHHHHHHHHHHCCCCEEEEEECCCCCHHHHH
QHQIEYVSLDTLTAQSDFISLHTPLTPETENMFNAARLQQMKSGAFLINVSRGGIVDEQA
HHCEEEEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHH
LYEALKSGHLAGAAADVFLEEPCATHPLFTLANFAPTSHIAGYTDGAISNISARCVNNII
HHHHHHCCCCCCHHHHHHHCCCCCCCCHHHHHCCCCCHHCCCCCCCHHHHHHHHHHHHHH
TCVCRGERPENIMNSL
HEEECCCCCHHHHHCC
>Mature Secondary Structure
MKVICTSPSFAKYDDAPISALKEADLELVMLPADASIEMLAQHLPDAIAMIVAFTDINES
CEEEECCCCCCCCCCCHHHHHHHCCCEEEEECCCCCHHHHHHHCCHHHHHHHHHHCCCHH
LLAKAPRLKIVCKHGVGVDNIDLNATRQRKIFVTNVPDANKHAVADFAFGLILNTARQIC
HHCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
QAISETKAGNWPRIFATDVYGKTLGIVGLGHIGKEVARRARGFNMRVLATDAWPDREFAQ
HHHHHHCCCCCCEEEEECCCCCCEEEEECHHHHHHHHHHHCCCCEEEEEECCCCCHHHHH
QHQIEYVSLDTLTAQSDFISLHTPLTPETENMFNAARLQQMKSGAFLINVSRGGIVDEQA
HHCEEEEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHH
LYEALKSGHLAGAAADVFLEEPCATHPLFTLANFAPTSHIAGYTDGAISNISARCVNNII
HHHHHHCCCCCCHHHHHHHCCCCCCCCHHHHHCCCCCHHCCCCCCCHHHHHHHHHHHHHH
TCVCRGERPENIMNSL
HEEECCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]