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The map label for this gene is dcuR [H]

Identifier: 238894569

GI number: 238894569

Start: 2468207

End: 2468926

Strand: Reverse

Name: dcuR [H]

Synonym: KP1_2567

Alternate gene names: 238894569

Gene position: 2468926-2468207 (Counterclockwise)

Preceding gene: 238894570

Following gene: 238894565

Centisome position: 47.04

GC content: 58.06

Gene sequence:

>720_bases
GTGATAAATGTTTTAATTGTTGACGATGATGCCATGGTGGCCGAACTGAATCGCCTGTACGTGGCAAGGGTTCCCGGCTT
TCGTTGCAGCGGGAGCGCTTCGACGCTCAGTCAGGCCCAGGAGATGATTAACGATCCGCAGCAGGAGATCGATCTGGTGC
TGCTGGATGTCTACATGCAGCAGGACAGCGGGCTCGATCTCCTGCCGACCATCCGCGAGTCGGGTCGCGCCATCGACGTT
ATCATGATTACCTCGGCGGCGGATGCCGCCACGGTACAGACCGCGATGCATTACGGGGTGGTCGATTACCTGATCAAACC
CTTCCAGTTTCCGCGCTTTGAAGAGGCGCTCACCACCTGGCGGGAGAAGCGCAAGCTAATAACCGGCCAGCCCTATTACG
AACAGGCCGATGTCGACCGCCTGCTGCACGGCGGCGCGCCGGAGGCCAGCGACGCGCGCAAGCTGCCTAAAGGATTAACC
GCGCAAACGCTGCGCACACTCTGCCAGTGGATTGACGCCCATCCGGATGTCGAATTCTCTACCGATGAGCTGGCGGCGGC
GGTGAATATCTCCCGCGTTTCCTGCCGCAAATATCTGATTTGGCTGGCGCAGATCAATATTCTCTATACCACTATCCACT
ACGGCGCTACCGGGCGGCCGGTCTATCGCTACCGTCTGGTCGCCGAACAGTACAGTTTGCTTAAGCAGTACAGTCAATAA

Upstream 100 bases:

>100_bases
AGTTGCGCGAGCTCGGCGGCACCCTCGCCGTCGAATCGGAACCCGGCGTATTTACCCAATTTTTTGTTCATCTCCCCTGG
GATAGTAAAAGGAAACCTGC

Downstream 100 bases:

>100_bases
CCCGATAGCCGCTGTCCAGCGGCGCAAAACGCAGCCGCTGCGGCGATGAGAGAATAATGTCGCGATTTTTGGTAACGAAA
ATCGCGTCGATATCCTGCCG

Product: DNA-binding transcriptional activator DcuR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MINVLIVDDDAMVAELNRLYVARVPGFRCSGSASTLSQAQEMINDPQQEIDLVLLDVYMQQDSGLDLLPTIRESGRAIDV
IMITSAADAATVQTAMHYGVVDYLIKPFQFPRFEEALTTWREKRKLITGQPYYEQADVDRLLHGGAPEASDARKLPKGLT
AQTLRTLCQWIDAHPDVEFSTDELAAAVNISRVSCRKYLIWLAQINILYTTIHYGATGRPVYRYRLVAEQYSLLKQYSQ

Sequences:

>Translated_239_residues
MINVLIVDDDAMVAELNRLYVARVPGFRCSGSASTLSQAQEMINDPQQEIDLVLLDVYMQQDSGLDLLPTIRESGRAIDV
IMITSAADAATVQTAMHYGVVDYLIKPFQFPRFEEALTTWREKRKLITGQPYYEQADVDRLLHGGAPEASDARKLPKGLT
AQTLRTLCQWIDAHPDVEFSTDELAAAVNISRVSCRKYLIWLAQINILYTTIHYGATGRPVYRYRLVAEQYSLLKQYSQ
>Mature_239_residues
MINVLIVDDDAMVAELNRLYVARVPGFRCSGSASTLSQAQEMINDPQQEIDLVLLDVYMQQDSGLDLLPTIRESGRAIDV
IMITSAADAATVQTAMHYGVVDYLIKPFQFPRFEEALTTWREKRKLITGQPYYEQADVDRLLHGGAPEASDARKLPKGLT
AQTLRTLCQWIDAHPDVEFSTDELAAAVNISRVSCRKYLIWLAQINILYTTIHYGATGRPVYRYRLVAEQYSLLKQYSQ

Specific function: Member of the two-component regulatory system dcuR/dcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD; nuoAN; dcuB; dcuC; sdhCDAB; etc.). Weakly regulates the aerobic C4-di

COG id: COG4565

COG function: function code KT; Response regulator of citrate/malate metabolism

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790566, Length=239, Percent_Identity=66.9456066945607, Blast_Score=347, Evalue=4e-97,
Organism=Escherichia coli, GI1786838, Length=219, Percent_Identity=31.0502283105023, Blast_Score=114, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR012287
- InterPro:   IPR001789 [H]

Pfam domain/function: PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 26993; Mature: 26993

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINVLIVDDDAMVAELNRLYVARVPGFRCSGSASTLSQAQEMINDPQQEIDLVLLDVYMQ
CEEEEEECCCHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHEEEHHH
QDSGLDLLPTIRESGRAIDVIMITSAADAATVQTAMHYGVVDYLIKPFQFPRFEEALTTW
CCCCCCCCHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
REKRKLITGQPYYEQADVDRLLHGGAPEASDARKLPKGLTAQTLRTLCQWIDAHPDVEFS
HHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCC
TDELAAAVNISRVSCRKYLIWLAQINILYTTIHYGATGRPVYRYRLVAEQYSLLKQYSQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MINVLIVDDDAMVAELNRLYVARVPGFRCSGSASTLSQAQEMINDPQQEIDLVLLDVYMQ
CEEEEEECCCHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHEEEHHH
QDSGLDLLPTIRESGRAIDVIMITSAADAATVQTAMHYGVVDYLIKPFQFPRFEEALTTW
CCCCCCCCHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
REKRKLITGQPYYEQADVDRLLHGGAPEASDARKLPKGLTAQTLRTLCQWIDAHPDVEFS
HHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCC
TDELAAAVNISRVSCRKYLIWLAQINILYTTIHYGATGRPVYRYRLVAEQYSLLKQYSQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]