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The map label for this gene is malY [H]

Identifier: 238894526

GI number: 238894526

Start: 2421012

End: 2422184

Strand: Reverse

Name: malY [H]

Synonym: KP1_2519

Alternate gene names: 238894526

Gene position: 2422184-2421012 (Counterclockwise)

Preceding gene: 238894527

Following gene: 238894524

Centisome position: 46.15

GC content: 62.32

Gene sequence:

>1173_bases
ATGTTTGATTTTGCCACCCCTATCGATCGCCACGGCACCTGGTGCACGCAATGGGACTATGTCGCCGACCGGTTTGGCGC
CGCCGATCTGCTGCCGTTCACTATTTCCGATATGGATTTCGCCACCGCGCCCTGTATTCTCGACGCCGTCAGCCAGCGGC
TGGCCCACGGGGTGTTCGGCTACAGCCGCTGGCGCAACGAGGCGTTTCTCGGGGCGATTGCCCACTGGTACGCCAGCCGC
TTTAACAGCGACATCGATCCGCAATCTGTGGTCTACGGACCGTCGGTTATCTATATGGTGGCGGAAACCATCCGCCAGTG
GTCGAAAGAAGGCGACGGCATCGTGGTCCACACCCCTGCCTACGATGCGTTCTATAACACCATCACCGCTAACCGGCGGC
GGATTGCCCCGGTGCCATTGATCCTGAAGGATAATCGGTGGCGCTGCGATATGGAGCGCCTGGAGGCGGCGCTGGCGGAG
CCAAAGAATACCCTGCTGCTGCTGTGCAGCCCGCACAACCCAACGGGGAAAGTCTGGCGTCGCGAGGAGCTGGAGACCAT
GGCGGCCCTGTGTCAAAGACATGGCGTCAGGGTGATTAGCGACGAAATTCATATGGACATGACCTGGAGCGAACACCGCC
ATATCCCGTGGAGCGAGGTCGCTCAGGGACCATGGGCGCTGTTCACCTCCGGTTCGAAGAGCTTCAATATTCCGGCCTTT
ACCGGGGCCTACGGCTTTATCCCCGAAGAGAACGAGCGCGACAGCTACCTGCAGGCGCTAAAGGGTCGCGACGGGCTCTC
TTCCCCTTCCGTGCCGGCGCTGGTCGCCCATATCGCCGCCTACCGCGACGGGGCTCCCTGGCTCGATGCCCTGCGCGACT
ACCTGCAGGCGAATATGCGCTATGTCGCCGACACGCTCAACAACGCCTTCCCCGCGCTCTGCTGGCAGCCGCCGGAGGCC
ACCTACCTGGCATGGATCGACCTGCGCCCGCTCAACGTTGACGATCGCGCGCTACAGCAGGCGCTGATCGCCGAACAGAA
GGTGGCGATTATGCCGGGTTATACCTATGGTCCTGAGGGCAACGGCTTTCTGCGACTCAACGTCGGCTGCCCGCGCGAGA
AGCTGGAACGCGGTGTCGAAGGACTGATTGCCGCCCTGCGCAGCCTCAGCTGA

Upstream 100 bases:

>100_bases
GTCGGTAAAAGATGAGATGGCCACGCTGATGAATACCGTGCAGGCCTGATCCCACTAGTCCCCCTCCGCTACGGAGGGGG
CGCTCGCTAAGGAAGCTCCA

Downstream 100 bases:

>100_bases
TTCGACGCGCAATCTACAGGTCATCGCGCCGGCGAAACGCCAGGTAACCGGCGCCGAGGGTAAAGACAGCGACAATCACC
ACCAGCAGGATAAACCCGTG

Product: bifunctional PLP-dependent beta-cystathionase and repressor of maltose regulon through interaction with MalT

Products: NA

Alternate protein names: Cystathionine beta-lyase MalY; CBL; Beta-cystathionase; Cysteine lyase; Maltose regulon modulator [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MFDFATPIDRHGTWCTQWDYVADRFGAADLLPFTISDMDFATAPCILDAVSQRLAHGVFGYSRWRNEAFLGAIAHWYASR
FNSDIDPQSVVYGPSVIYMVAETIRQWSKEGDGIVVHTPAYDAFYNTITANRRRIAPVPLILKDNRWRCDMERLEAALAE
PKNTLLLLCSPHNPTGKVWRREELETMAALCQRHGVRVISDEIHMDMTWSEHRHIPWSEVAQGPWALFTSGSKSFNIPAF
TGAYGFIPEENERDSYLQALKGRDGLSSPSVPALVAHIAAYRDGAPWLDALRDYLQANMRYVADTLNNAFPALCWQPPEA
TYLAWIDLRPLNVDDRALQQALIAEQKVAIMPGYTYGPEGNGFLRLNVGCPREKLERGVEGLIAALRSLS

Sequences:

>Translated_390_residues
MFDFATPIDRHGTWCTQWDYVADRFGAADLLPFTISDMDFATAPCILDAVSQRLAHGVFGYSRWRNEAFLGAIAHWYASR
FNSDIDPQSVVYGPSVIYMVAETIRQWSKEGDGIVVHTPAYDAFYNTITANRRRIAPVPLILKDNRWRCDMERLEAALAE
PKNTLLLLCSPHNPTGKVWRREELETMAALCQRHGVRVISDEIHMDMTWSEHRHIPWSEVAQGPWALFTSGSKSFNIPAF
TGAYGFIPEENERDSYLQALKGRDGLSSPSVPALVAHIAAYRDGAPWLDALRDYLQANMRYVADTLNNAFPALCWQPPEA
TYLAWIDLRPLNVDDRALQQALIAEQKVAIMPGYTYGPEGNGFLRLNVGCPREKLERGVEGLIAALRSLS
>Mature_390_residues
MFDFATPIDRHGTWCTQWDYVADRFGAADLLPFTISDMDFATAPCILDAVSQRLAHGVFGYSRWRNEAFLGAIAHWYASR
FNSDIDPQSVVYGPSVIYMVAETIRQWSKEGDGIVVHTPAYDAFYNTITANRRRIAPVPLILKDNRWRCDMERLEAALAE
PKNTLLLLCSPHNPTGKVWRREELETMAALCQRHGVRVISDEIHMDMTWSEHRHIPWSEVAQGPWALFTSGSKSFNIPAF
TGAYGFIPEENERDSYLQALKGRDGLSSPSVPALVAHIAAYRDGAPWLDALRDYLQANMRYVADTLNNAFPALCWQPPEA
TYLAWIDLRPLNVDDRALQQALIAEQKVAIMPGYTYGPEGNGFLRLNVGCPREKLERGVEGLIAALRSLS

Specific function: Acts as a beta-cystathionase and as a repressor of the maltose regulon [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=153, Percent_Identity=28.7581699346405, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI169881279, Length=153, Percent_Identity=28.7581699346405, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI56713254, Length=157, Percent_Identity=26.7515923566879, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI56713256, Length=237, Percent_Identity=24.0506329113924, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1787909, Length=389, Percent_Identity=70.1799485861183, Blast_Score=596, Evalue=1e-172,
Organism=Escherichia coli, GI1788722, Length=384, Percent_Identity=26.0416666666667, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788627, Length=296, Percent_Identity=20.9459459459459, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71994472, Length=310, Percent_Identity=23.8709677419355, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71994476, Length=308, Percent_Identity=24.025974025974, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322401, Length=282, Percent_Identity=24.468085106383, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI18859735, Length=364, Percent_Identity=23.9010989010989, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 43937; Mature: 43937

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDFATPIDRHGTWCTQWDYVADRFGAADLLPFTISDMDFATAPCILDAVSQRLAHGVFG
CCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHH
YSRWRNEAFLGAIAHWYASRFNSDIDPQSVVYGPSVIYMVAETIRQWSKEGDGIVVHTPA
HHHHCCHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHCCCCCEEEECCC
YDAFYNTITANRRRIAPVPLILKDNRWRCDMERLEAALAEPKNTLLLLCSPHNPTGKVWR
HHHHHHHHHCCCCCCCCCCEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCHHHH
REELETMAALCQRHGVRVISDEIHMDMTWSEHRHIPWSEVAQGPWALFTSGSKSFNIPAF
HHHHHHHHHHHHHCCCEEEECCEEEEECHHCCCCCCHHHHCCCCEEEEECCCCCCCCCEE
TGAYGFIPEENERDSYLQALKGRDGLSSPSVPALVAHIAAYRDGAPWLDALRDYLQANMR
CCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
YVADTLNNAFPALCWQPPEATYLAWIDLRPLNVDDRALQQALIAEQKVAIMPGYTYGPEG
HHHHHHCCCCCCEECCCCCCCEEEEEEEEECCCCHHHHHHHHHHHCCEEEECCCCCCCCC
NGFLRLNVGCPREKLERGVEGLIAALRSLS
CCEEEEECCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFDFATPIDRHGTWCTQWDYVADRFGAADLLPFTISDMDFATAPCILDAVSQRLAHGVFG
CCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHH
YSRWRNEAFLGAIAHWYASRFNSDIDPQSVVYGPSVIYMVAETIRQWSKEGDGIVVHTPA
HHHHCCHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHCCCCCEEEECCC
YDAFYNTITANRRRIAPVPLILKDNRWRCDMERLEAALAEPKNTLLLLCSPHNPTGKVWR
HHHHHHHHHCCCCCCCCCCEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCHHHH
REELETMAALCQRHGVRVISDEIHMDMTWSEHRHIPWSEVAQGPWALFTSGSKSFNIPAF
HHHHHHHHHHHHHCCCEEEECCEEEEECHHCCCCCCHHHHCCCCEEEEECCCCCCCCCEE
TGAYGFIPEENERDSYLQALKGRDGLSSPSVPALVAHIAAYRDGAPWLDALRDYLQANMR
CCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
YVADTLNNAFPALCWQPPEATYLAWIDLRPLNVDDRALQQALIAEQKVAIMPGYTYGPEG
HHHHHHCCCCCCEECCCCCCCEEEEEEEEECCCCHHHHHHHHHHHCCEEEECCCCCCCCC
NGFLRLNVGCPREKLERGVEGLIAALRSLS
CCEEEEECCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1856179; 9097039; 9278503; 7665481; 10698925 [H]