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The map label for this gene is paaZ [H]

Identifier: 238894479

GI number: 238894479

Start: 2374666

End: 2376711

Strand: Reverse

Name: paaZ [H]

Synonym: KP1_2470

Alternate gene names: 238894479

Gene position: 2376711-2374666 (Counterclockwise)

Preceding gene: 238894495

Following gene: 238894478

Centisome position: 45.28

GC content: 61.83

Gene sequence:

>2046_bases
ATGCAGCAGTTAGCCAGCTACTTATCCGGCGCCTGGCAGACCGGCCGGGGCCGCGCCCGTACTATCCATCACGCCATCAC
CGGCGCGGCGCTTTGGGAGGTGACCAGTGAAGGCCTGGATATGGCGCAGGCGCGCCGCTTCGCGATTGAGCGCGGTGGTA
AAGCCCTGCAGGCGATGACCTTTATTGAACGCAGCGCGATGCTGAAAGCGGTGGCGAAACACCTGCTGGAGCAGAAAGAC
CAGTTCTACGCCATCTCCGCGCAAACCGGCGCCACTCGCGCCGACAGTTGGGTGGATATTGAAGGCGGTATCGGTACCCT
TTTCACCTATGCCGGGCTCGGTAGTCGAGAATTACCGGACGATATCCTGTGGCCGGAAGACGAGCTCATCCCGCTCTCCA
AACAGGGCGGTTTTGCCGCGCGTCATGTGCTAACCTCGAAATCAGGCGTCGCCGTCCATATCAACGCCTTCAACTTCCCC
TGCTGGGGAATGCTGGAAAAACTGGCGCCCACGTGGCTTGCCGGTATGCCGGCGATCATTAAACCGGCCACCGCTACCGC
CCAGCTCACCCAGGCAATGGTGAAAGCGATTGTCGACAGCGGCCTGGTGCCGGAGGGCGCCATCAGCCTGATTTGCGGCG
GCGCGGGCGATCTGCTCGACCACCTCGATAGCCAGGACGTGGTGACCTTTACCGGGTCAGCCGCCACCGGCCAGCAGCTA
CGGGCGCACCCTAACCTGGTAGCCAAATCCATTCCCTTTACCATGGAAGCAGATTCACTCAACTGCTGCGTGTTAGGCGA
AGACGTCACTCCGGAGCAACCGGAATTCGCGCTGTTTATTCGGGAAGTGGTCCGCGAGATGACAGCGAAAGCCGGGCAAA
AATGTACCGCTATCCGCAGAATCATTGTGCCACTGGCTCAGATTAATGCGGTTAGCGATGCACTGATCTCCCGCCTGCAT
AAAGTAACCATCGGTGACCCTGCGCAGGAGGGCGTTAAGATGGGGGCCCTGGTTAATAGCGAACAGCGTCAGGACGTACA
GGAGAGCGTCAATAAGCTGATAGCCGCTGGCTGCGAAGTACTGCTCGGTGGAGAGGCGGATCTCAGCGCGGCCGGCGCAT
TTTTCCCGCCGACCCTGTTGTACTGCTCACAGCCGGATGAAACGCCGGTGGTTCACGCCATTGAAGCTTTTGGTCCGGTG
GCGACGCTGATGCCGTATCGCGACCGCCAGCATGCGCTGACGCTGGCGCGCGCCGGCGGCGGCAGTCTGGCGGGGACGCT
GGTCACCGCCAGCGGCGAGCTGGCGCGCGAGTTTATCCTCGGCGCCGCCCGCGCCCATGGCCGTATTCAGATACTGAACG
AGGCGTCCTCGGTCGAGTCAACCGGCCACGGTTCGCCGCTGCCGCAGCTGGTGCACGGCGGTCCCGGCCGCGCTGGCGGC
GGAGAAGAGCTTGGCGGGCTGCGTTCGGTGAAACACTATATGCAGCGTACCGCGGTCCAGGGCAGCCCAACGATGCTGGC
GACCATCGGCCAGCAGTGGGTGCGCGGCGCCCAGGTGAGCGAAGACCGCATTCACCCGTTCCGCAAATATTTCGAAGAGA
TTCAGCCTGGCGACAGCTTATTAACCCCGCGCCGAACCCTGACCGAAGCGGATATCGTTAACTTCGCCTGCCTGAGCGGC
GATCATTTCTACGCGCACATGGACAAAATCGCCGCCGCCGAGTCGATTTTTGGCGAGCGGGTGGTCCACGGCTATTTCCT
GATCTCCGCCGCGGCCGGGCTGTTCGTCGATGCCGGCGTCGGGCCGGTTATCGCCAACTATGGGATGGAAAACCTGCGCT
TTATTGAGCCGGTCAAACCGGGCGACACCATTCAGGTTCGCCTGACCTGTAAGCGGAAAACGGTCAAACGTCAGCGCAGC
GCCGATGAGAAAGCCACCGGCGTGGTGGAATGGGCGGTGGAGATTTTCAATCAGCACCAGCAGGCGGTGGCGCTGTATTC
CATTCTGACCCTGGTGGCGCGTCAACAGGGAGATTTCCCGGCGTGA

Upstream 100 bases:

>100_bases
CGATCACAATGTTAATAATTTATTAAATACGGGCTTGCATTTTATGATTCATAAAAGAACTATTTATAGATATCACACGT
AACACATTTGGAGATTTGCG

Downstream 100 bases:

>100_bases
TAGCGAAAAATAGATCGCTGGCGCTCTGTTGGCCGACCCTTTAGCCATTGATACAGCAATCGGTTTGCAACGGTTTCGCC
CCGGGAAGTCCTTTATGTTA

Product: bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase

Products: NA

Alternate protein names: Phenylacetic acid degradation protein paaZ [H]

Number of amino acids: Translated: 681; Mature: 681

Protein sequence:

>681_residues
MQQLASYLSGAWQTGRGRARTIHHAITGAALWEVTSEGLDMAQARRFAIERGGKALQAMTFIERSAMLKAVAKHLLEQKD
QFYAISAQTGATRADSWVDIEGGIGTLFTYAGLGSRELPDDILWPEDELIPLSKQGGFAARHVLTSKSGVAVHINAFNFP
CWGMLEKLAPTWLAGMPAIIKPATATAQLTQAMVKAIVDSGLVPEGAISLICGGAGDLLDHLDSQDVVTFTGSAATGQQL
RAHPNLVAKSIPFTMEADSLNCCVLGEDVTPEQPEFALFIREVVREMTAKAGQKCTAIRRIIVPLAQINAVSDALISRLH
KVTIGDPAQEGVKMGALVNSEQRQDVQESVNKLIAAGCEVLLGGEADLSAAGAFFPPTLLYCSQPDETPVVHAIEAFGPV
ATLMPYRDRQHALTLARAGGGSLAGTLVTASGELAREFILGAARAHGRIQILNEASSVESTGHGSPLPQLVHGGPGRAGG
GEELGGLRSVKHYMQRTAVQGSPTMLATIGQQWVRGAQVSEDRIHPFRKYFEEIQPGDSLLTPRRTLTEADIVNFACLSG
DHFYAHMDKIAAAESIFGERVVHGYFLISAAAGLFVDAGVGPVIANYGMENLRFIEPVKPGDTIQVRLTCKRKTVKRQRS
ADEKATGVVEWAVEIFNQHQQAVALYSILTLVARQQGDFPA

Sequences:

>Translated_681_residues
MQQLASYLSGAWQTGRGRARTIHHAITGAALWEVTSEGLDMAQARRFAIERGGKALQAMTFIERSAMLKAVAKHLLEQKD
QFYAISAQTGATRADSWVDIEGGIGTLFTYAGLGSRELPDDILWPEDELIPLSKQGGFAARHVLTSKSGVAVHINAFNFP
CWGMLEKLAPTWLAGMPAIIKPATATAQLTQAMVKAIVDSGLVPEGAISLICGGAGDLLDHLDSQDVVTFTGSAATGQQL
RAHPNLVAKSIPFTMEADSLNCCVLGEDVTPEQPEFALFIREVVREMTAKAGQKCTAIRRIIVPLAQINAVSDALISRLH
KVTIGDPAQEGVKMGALVNSEQRQDVQESVNKLIAAGCEVLLGGEADLSAAGAFFPPTLLYCSQPDETPVVHAIEAFGPV
ATLMPYRDRQHALTLARAGGGSLAGTLVTASGELAREFILGAARAHGRIQILNEASSVESTGHGSPLPQLVHGGPGRAGG
GEELGGLRSVKHYMQRTAVQGSPTMLATIGQQWVRGAQVSEDRIHPFRKYFEEIQPGDSLLTPRRTLTEADIVNFACLSG
DHFYAHMDKIAAAESIFGERVVHGYFLISAAAGLFVDAGVGPVIANYGMENLRFIEPVKPGDTIQVRLTCKRKTVKRQRS
ADEKATGVVEWAVEIFNQHQQAVALYSILTLVARQQGDFPA
>Mature_681_residues
MQQLASYLSGAWQTGRGRARTIHHAITGAALWEVTSEGLDMAQARRFAIERGGKALQAMTFIERSAMLKAVAKHLLEQKD
QFYAISAQTGATRADSWVDIEGGIGTLFTYAGLGSRELPDDILWPEDELIPLSKQGGFAARHVLTSKSGVAVHINAFNFP
CWGMLEKLAPTWLAGMPAIIKPATATAQLTQAMVKAIVDSGLVPEGAISLICGGAGDLLDHLDSQDVVTFTGSAATGQQL
RAHPNLVAKSIPFTMEADSLNCCVLGEDVTPEQPEFALFIREVVREMTAKAGQKCTAIRRIIVPLAQINAVSDALISRLH
KVTIGDPAQEGVKMGALVNSEQRQDVQESVNKLIAAGCEVLLGGEADLSAAGAFFPPTLLYCSQPDETPVVHAIEAFGPV
ATLMPYRDRQHALTLARAGGGSLAGTLVTASGELAREFILGAARAHGRIQILNEASSVESTGHGSPLPQLVHGGPGRAGG
GEELGGLRSVKHYMQRTAVQGSPTMLATIGQQWVRGAQVSEDRIHPFRKYFEEIQPGDSLLTPRRTLTEADIVNFACLSG
DHFYAHMDKIAAAESIFGERVVHGYFLISAAAGLFVDAGVGPVIANYGMENLRFIEPVKPGDTIQVRLTCKRKTVKRQRS
ADEKATGVVEWAVEIFNQHQQAVALYSILTLVARQQGDFPA

Specific function: Phenylacetic acid aerobic catabolism. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldehyde dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115387104, Length=448, Percent_Identity=24.7767857142857, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI25777724, Length=499, Percent_Identity=24.0480961923848, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI12007648, Length=292, Percent_Identity=24.3150684931507, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI153266822, Length=395, Percent_Identity=23.5443037974684, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI21361176, Length=503, Percent_Identity=23.6580516898608, Blast_Score=77, Evalue=8e-14,
Organism=Homo sapiens, GI4507229, Length=357, Percent_Identity=25.4901960784314, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI25777728, Length=402, Percent_Identity=24.1293532338308, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI25777730, Length=452, Percent_Identity=24.5575221238938, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI25777721, Length=371, Percent_Identity=25.0673854447439, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI25777732, Length=466, Percent_Identity=24.4635193133047, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI310128103, Length=355, Percent_Identity=23.943661971831, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI188035924, Length=355, Percent_Identity=23.943661971831, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1787653, Length=679, Percent_Identity=86.8924889543446, Blast_Score=1196, Evalue=0.0,
Organism=Escherichia coli, GI1789015, Length=482, Percent_Identity=25.3112033195021, Blast_Score=102, Evalue=9e-23,
Organism=Escherichia coli, GI1787684, Length=446, Percent_Identity=24.6636771300448, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1786504, Length=509, Percent_Identity=26.7190569744597, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI87081926, Length=343, Percent_Identity=26.2390670553936, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1788042, Length=463, Percent_Identity=25.9179265658747, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI87082295, Length=354, Percent_Identity=25.4237288135593, Blast_Score=86, Evalue=9e-18,
Organism=Escherichia coli, GI1787715, Length=359, Percent_Identity=27.2980501392758, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1787250, Length=361, Percent_Identity=22.1606648199446, Blast_Score=63, Evalue=5e-11,
Organism=Escherichia coli, GI87081896, Length=366, Percent_Identity=24.0437158469945, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI25143874, Length=460, Percent_Identity=25.2173913043478, Blast_Score=110, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI25143876, Length=460, Percent_Identity=25.2173913043478, Blast_Score=110, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI115534176, Length=363, Percent_Identity=26.9972451790634, Blast_Score=85, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17551164, Length=389, Percent_Identity=21.8508997429306, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71995606, Length=424, Percent_Identity=24.5283018867925, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17562198, Length=401, Percent_Identity=24.1895261845387, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71995613, Length=368, Percent_Identity=24.1847826086957, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17534119, Length=291, Percent_Identity=25.4295532646048, Blast_Score=67, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324950, Length=355, Percent_Identity=23.0985915492958, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320917, Length=355, Percent_Identity=22.8169014084507, Blast_Score=70, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6325196, Length=290, Percent_Identity=24.1379310344828, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319478, Length=424, Percent_Identity=21.9339622641509, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI20129399, Length=511, Percent_Identity=25.2446183953033, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI281362580, Length=446, Percent_Identity=25.1121076233184, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI62472918, Length=446, Percent_Identity=25.1121076233184, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI62472926, Length=446, Percent_Identity=25.1121076233184, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI62472936, Length=446, Percent_Identity=25.1121076233184, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21356737, Length=446, Percent_Identity=25.1121076233184, Blast_Score=86, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR002539
- InterPro:   IPR011966 [H]

Pfam domain/function: PF00171 Aldedh; PF01575 MaoC_dehydratas [H]

EC number: NA

Molecular weight: Translated: 72948; Mature: 72948

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQLASYLSGAWQTGRGRARTIHHAITGAALWEVTSEGLDMAQARRFAIERGGKALQAMT
CHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
FIERSAMLKAVAKHLLEQKDQFYAISAQTGATRADSWVDIEGGIGTLFTYAGLGSRELPD
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEECCCHHHHHHHCCCCCCCCCC
DILWPEDELIPLSKQGGFAARHVLTSKSGVAVHINAFNFPCWGMLEKLAPTWLAGMPAII
CCCCCCCCEEECCCCCCHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCHHHHCCCCHHH
KPATATAQLTQAMVKAIVDSGLVPEGAISLICGGAGDLLDHLDSQDVVTFTGSAATGQQL
CCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHCCCCCEEEEECCCCCCHHH
RAHPNLVAKSIPFTMEADSLNCCVLGEDVTPEQPEFALFIREVVREMTAKAGQKCTAIRR
HCCCCHHHHCCCCEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHH
IIVPLAQINAVSDALISRLHKVTIGDPAQEGVKMGALVNSEQRQDVQESVNKLIAAGCEV
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCE
LLGGEADLSAAGAFFPPTLLYCSQPDETPVVHAIEAFGPVATLMPYRDRQHALTLARAGG
EECCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCHHHHCCCCCCHHHEEEEECCC
GSLAGTLVTASGELAREFILGAARAHGRIQILNEASSVESTGHGSPLPQLVHGGPGRAGG
CCEEEEEEECCHHHHHHHHHHHHCCCCEEEEECCHHCCCCCCCCCCCHHHHCCCCCCCCC
GEELGGLRSVKHYMQRTAVQGSPTMLATIGQQWVRGAQVSEDRIHPFRKYFEEIQPGDSL
CHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCC
LTPRRTLTEADIVNFACLSGDHFYAHMDKIAAAESIFGERVVHGYFLISAAAGLFVDAGV
CCCCHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC
GPVIANYGMENLRFIEPVKPGDTIQVRLTCKRKTVKRQRSADEKATGVVEWAVEIFNQHQ
CHHHHHCCCCCCEEECCCCCCCEEEEEEEECHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
QAVALYSILTLVARQQGDFPA
HHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQQLASYLSGAWQTGRGRARTIHHAITGAALWEVTSEGLDMAQARRFAIERGGKALQAMT
CHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
FIERSAMLKAVAKHLLEQKDQFYAISAQTGATRADSWVDIEGGIGTLFTYAGLGSRELPD
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEECCCHHHHHHHCCCCCCCCCC
DILWPEDELIPLSKQGGFAARHVLTSKSGVAVHINAFNFPCWGMLEKLAPTWLAGMPAII
CCCCCCCCEEECCCCCCHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCHHHHCCCCHHH
KPATATAQLTQAMVKAIVDSGLVPEGAISLICGGAGDLLDHLDSQDVVTFTGSAATGQQL
CCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHCCCCCEEEEECCCCCCHHH
RAHPNLVAKSIPFTMEADSLNCCVLGEDVTPEQPEFALFIREVVREMTAKAGQKCTAIRR
HCCCCHHHHCCCCEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHH
IIVPLAQINAVSDALISRLHKVTIGDPAQEGVKMGALVNSEQRQDVQESVNKLIAAGCEV
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCE
LLGGEADLSAAGAFFPPTLLYCSQPDETPVVHAIEAFGPVATLMPYRDRQHALTLARAGG
EECCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCHHHHCCCCCCHHHEEEEECCC
GSLAGTLVTASGELAREFILGAARAHGRIQILNEASSVESTGHGSPLPQLVHGGPGRAGG
CCEEEEEEECCHHHHHHHHHHHHCCCCEEEEECCHHCCCCCCCCCCCHHHHCCCCCCCCC
GEELGGLRSVKHYMQRTAVQGSPTMLATIGQQWVRGAQVSEDRIHPFRKYFEEIQPGDSL
CHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCC
LTPRRTLTEADIVNFACLSGDHFYAHMDKIAAAESIFGERVVHGYFLISAAAGLFVDAGV
CCCCHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC
GPVIANYGMENLRFIEPVKPGDTIQVRLTCKRKTVKRQRSADEKATGVVEWAVEIFNQHQ
CHHHHHCCCCCCEEECCCCCCCEEEEEEEECHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
QAVALYSILTLVARQQGDFPA
HHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]