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The map label for this gene is lrp [H]

Identifier: 238894453

GI number: 238894453

Start: 2345193

End: 2345672

Strand: Reverse

Name: lrp [H]

Synonym: KP1_2443

Alternate gene names: 238894453

Gene position: 2345672-2345193 (Counterclockwise)

Preceding gene: 238894456

Following gene: 238894452

Centisome position: 44.69

GC content: 58.54

Gene sequence:

>480_bases
ATGTACAACATCGACGACTATGATCTGAAAATACTTACCCTGCTGCAGGCCAATGGCCGTTTAACCAATCAGGAGCTGAG
CGAGCTTATCGGCCTGTCCGCTTCCCAGTGTTCGCGCCGCCGTATCGCCCTTGAACAGGCACAGCTTATCCTCGGCTACC
ATGCGCGTCTGGCGCCGGATGCAGCCGGGCAGGAGATGCTTGGCCTGATTGAGGTGCGTCTGCTGAATCACACCCCGCAA
TGCGTGGAGAGCTTTCATCAGATGCTCAGTGAAGTGGACGCCATTCTGGACGCCTGGAAAACCACCGGCGACGCCGATTA
TCTGCTGCGGGTAACGGTCCCGGACCTGCCCGGTCTGAGCCATTTGATCAGCCATATTCTGGCGCAAAACAAAGGGGTGG
CCCATCTGAAAACCGCCGTCGTGCTCAACCGCCTTAAAGAGAACGGCCAGCTGATGCCGGGCACGACCCCGCTGCGCTGA

Upstream 100 bases:

>100_bases
CCGTTTTGGTGCATCCGGTTTGCCGCCGTCCGCTCAGGCTTCACGCCAGGCAAAAAACTGTTAGGCTGGTAGCCACTTTT
ACGTTCCGCTAGTGGCCACT

Downstream 100 bases:

>100_bases
ACCGGGGCACAGTGCCCTGCGCTGGTGCAGACGCGGGGCCAGACAATGCGCGACAAGCGGCAAATTCGCACAATTCACGC
ATTCGGAAACCATAAAACGC

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MYNIDDYDLKILTLLQANGRLTNQELSELIGLSASQCSRRRIALEQAQLILGYHARLAPDAAGQEMLGLIEVRLLNHTPQ
CVESFHQMLSEVDAILDAWKTTGDADYLLRVTVPDLPGLSHLISHILAQNKGVAHLKTAVVLNRLKENGQLMPGTTPLR

Sequences:

>Translated_159_residues
MYNIDDYDLKILTLLQANGRLTNQELSELIGLSASQCSRRRIALEQAQLILGYHARLAPDAAGQEMLGLIEVRLLNHTPQ
CVESFHQMLSEVDAILDAWKTTGDADYLLRVTVPDLPGLSHLISHILAQNKGVAHLKTAVVLNRLKENGQLMPGTTPLR
>Mature_159_residues
MYNIDDYDLKILTLLQANGRLTNQELSELIGLSASQCSRRRIALEQAQLILGYHARLAPDAAGQEMLGLIEVRLLNHTPQ
CVESFHQMLSEVDAILDAWKTTGDADYLLRVTVPDLPGLSHLISHILAQNKGVAHLKTAVVLNRLKENGQLMPGTTPLR

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=153, Percent_Identity=33.3333333333333, Blast_Score=90, Evalue=8e-20,
Organism=Escherichia coli, GI87081742, Length=148, Percent_Identity=25, Blast_Score=71, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 17602; Mature: 17602

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYNIDDYDLKILTLLQANGRLTNQELSELIGLSASQCSRRRIALEQAQLILGYHARLAPD
CCCCCCCCHHHHEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
AAGQEMLGLIEVRLLNHTPQCVESFHQMLSEVDAILDAWKTTGDADYLLRVTVPDLPGLS
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHH
HLISHILAQNKGVAHLKTAVVLNRLKENGQLMPGTTPLR
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MYNIDDYDLKILTLLQANGRLTNQELSELIGLSASQCSRRRIALEQAQLILGYHARLAPD
CCCCCCCCHHHHEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
AAGQEMLGLIEVRLLNHTPQCVESFHQMLSEVDAILDAWKTTGDADYLLRVTVPDLPGLS
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHH
HLISHILAQNKGVAHLKTAVVLNRLKENGQLMPGTTPLR
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]