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The map label for this gene is tyrB [H]

Identifier: 238894451

GI number: 238894451

Start: 2343089

End: 2344288

Strand: Reverse

Name: tyrB [H]

Synonym: KP1_2440

Alternate gene names: 238894451

Gene position: 2344288-2343089 (Counterclockwise)

Preceding gene: 238894452

Following gene: 238894447

Centisome position: 44.67

GC content: 64.42

Gene sequence:

>1200_bases
GTGTTCCAGAACGTTGACGCCTACGCGGGCGATCCTATCCTGTCCCTGATGGAAGCCTTTCAACAGGATCCCCGGGCAGA
CAAAGTTAACCTCAGCATCGGGCTGTACTATAACGAGCAGGCCATCATTCCTCAGCTGGAGGCGGTCCGTCAGGCCGCTG
ACCGGCTGCAGAGCCAGTTGCAAAAGGCCAGCCTCTATCTGCCGATGGAGGGACTGGCGCCCTATCGCCGCGCCGTCCAG
ACCCTGCTGTTTGGCGAACATCATCCGGCGTTGCGTGCCGGACGCATCGCCACCATCCAGACGCTGGGCGGCTCCGGCGC
GCTGAAGGTGGGCGCAGATTTCCTCAAGCGCTACTTCCCCGACTCCGCGGTCTGGGTCAGCGATCCGACCTGGGAGAACC
ATGTGGCCATCTTTGCCGGGGCGGGCTTCGAGGTGCATACCTATCCCTGGTTCGACAGGGCCACCCGCGGGGTCAATTTC
CCCGCCATGCTTGCCGCCCTCCAGCAGCTCCCGCCGCGCAGCATCGTGCTGCTCCATCCTTGCTGCCATAATCCGACGGG
GGCCGATCTCACCCCCGAGCAGTGGGATCGGGTGATTGAGGTGGTGATCGTCCGGGAGCTGATCCCGTTCCTCGATATTG
CCTACCAGGGCTTTGGCCGCGGGCTGGATGAAGATGCCTATGCCATTCGCGCCATCGCCAGCGCCGGGCTGACGGCGCTG
GTCAGCAACTCGTTCTCGAAGATTTTTTCGCTGTACGGCGAGCGCGTCGGCGGCCTGTCGGTGGTCTGTGACAACGCCGA
TGCCGCCGGGCGCGTGCTGGGCCAGTTGAAAGCCACCGTGCGCCGCAACTACTCCAGCCCGCCGGGGTTTGGCGCCCAGG
TGGTGTCGCAGGTGCTCAACGATCCCGAGCTGAATGCCCTGTGGCAGGAAGAAGTGGAGGCCATGCGCACCCGCATCAGC
GCCATGCGCGTCGCGCTGGTGAAGGCCCTGCAGGCAGCCCTGCCGGCGGGGGATTTTTCCTATCTGCTGACCCAGCGCGG
CATGTTCAGTTACACCGGCTTTAGCGCCGATCAGGTAGACGTTCTGCGTCAAGAGCATGGCATCTATCTGATCGCCAGCG
GTCGGGTCTGCGTGGCCGGGCTCAACCACGGCAATATTGCGCGGGTAGCCAGCGCCTTCGCCGCGGTCTGCGCACGCTAG

Upstream 100 bases:

>100_bases
GCGCCGTGATTTTGAATTCGATTATCGCCATGAACCACCGCCCCGGACGCTATGCGGTGTAATGGCTTCACCTTTAACGG
TCATTTCAGGAGTAACCACT

Downstream 100 bases:

>100_bases
TCGGGTCAACCCCGGCGCGGTAGAGCGATTAATCGCGACGCAGCCGGCGAGCCAGGCGGGTCCCCAGCGTCTGAATAAGC
TGGACAATAACAATCAGCAC

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: ARAT; AROAT [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MFQNVDAYAGDPILSLMEAFQQDPRADKVNLSIGLYYNEQAIIPQLEAVRQAADRLQSQLQKASLYLPMEGLAPYRRAVQ
TLLFGEHHPALRAGRIATIQTLGGSGALKVGADFLKRYFPDSAVWVSDPTWENHVAIFAGAGFEVHTYPWFDRATRGVNF
PAMLAALQQLPPRSIVLLHPCCHNPTGADLTPEQWDRVIEVVIVRELIPFLDIAYQGFGRGLDEDAYAIRAIASAGLTAL
VSNSFSKIFSLYGERVGGLSVVCDNADAAGRVLGQLKATVRRNYSSPPGFGAQVVSQVLNDPELNALWQEEVEAMRTRIS
AMRVALVKALQAALPAGDFSYLLTQRGMFSYTGFSADQVDVLRQEHGIYLIASGRVCVAGLNHGNIARVASAFAAVCAR

Sequences:

>Translated_399_residues
MFQNVDAYAGDPILSLMEAFQQDPRADKVNLSIGLYYNEQAIIPQLEAVRQAADRLQSQLQKASLYLPMEGLAPYRRAVQ
TLLFGEHHPALRAGRIATIQTLGGSGALKVGADFLKRYFPDSAVWVSDPTWENHVAIFAGAGFEVHTYPWFDRATRGVNF
PAMLAALQQLPPRSIVLLHPCCHNPTGADLTPEQWDRVIEVVIVRELIPFLDIAYQGFGRGLDEDAYAIRAIASAGLTAL
VSNSFSKIFSLYGERVGGLSVVCDNADAAGRVLGQLKATVRRNYSSPPGFGAQVVSQVLNDPELNALWQEEVEAMRTRIS
AMRVALVKALQAALPAGDFSYLLTQRGMFSYTGFSADQVDVLRQEHGIYLIASGRVCVAGLNHGNIARVASAFAAVCAR
>Mature_399_residues
MFQNVDAYAGDPILSLMEAFQQDPRADKVNLSIGLYYNEQAIIPQLEAVRQAADRLQSQLQKASLYLPMEGLAPYRRAVQ
TLLFGEHHPALRAGRIATIQTLGGSGALKVGADFLKRYFPDSAVWVSDPTWENHVAIFAGAGFEVHTYPWFDRATRGVNF
PAMLAALQQLPPRSIVLLHPCCHNPTGADLTPEQWDRVIEVVIVRELIPFLDIAYQGFGRGLDEDAYAIRAIASAGLTAL
VSNSFSKIFSLYGERVGGLSVVCDNADAAGRVLGQLKATVRRNYSSPPGFGAQVVSQVLNDPELNALWQEEVEAMRTRIS
AMRVALVKALQAALPAGDFSYLLTQRGMFSYTGFSADQVDVLRQEHGIYLIASGRVCVAGLNHGNIARVASAFAAVCAR

Specific function: Biosynthesis of Phe, Tyr, Asp and Leu. [C]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=389, Percent_Identity=40.3598971722365, Blast_Score=307, Evalue=1e-83,
Organism=Homo sapiens, GI4504067, Length=394, Percent_Identity=40.3553299492386, Blast_Score=304, Evalue=1e-82,
Organism=Homo sapiens, GI117414139, Length=384, Percent_Identity=28.125, Blast_Score=165, Evalue=7e-41,
Organism=Escherichia coli, GI1790488, Length=396, Percent_Identity=76.010101010101, Blast_Score=619, Evalue=1e-179,
Organism=Escherichia coli, GI1787159, Length=396, Percent_Identity=41.6666666666667, Blast_Score=336, Evalue=2e-93,
Organism=Caenorhabditis elegans, GI71981858, Length=398, Percent_Identity=37.9396984924623, Blast_Score=315, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI25147133, Length=392, Percent_Identity=39.030612244898, Blast_Score=291, Evalue=4e-79,
Organism=Caenorhabditis elegans, GI17569539, Length=393, Percent_Identity=38.4223918575064, Blast_Score=275, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI17569537, Length=390, Percent_Identity=31.025641025641, Blast_Score=187, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI17550384, Length=263, Percent_Identity=35.361216730038, Blast_Score=181, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI25147136, Length=216, Percent_Identity=34.2592592592593, Blast_Score=145, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6323055, Length=404, Percent_Identity=36.3861386138614, Blast_Score=285, Evalue=9e-78,
Organism=Saccharomyces cerevisiae, GI6322743, Length=425, Percent_Identity=33.6470588235294, Blast_Score=232, Evalue=7e-62,
Organism=Drosophila melanogaster, GI19922362, Length=385, Percent_Identity=41.038961038961, Blast_Score=307, Evalue=1e-83,
Organism=Drosophila melanogaster, GI24654046, Length=385, Percent_Identity=41.038961038961, Blast_Score=306, Evalue=1e-83,
Organism=Drosophila melanogaster, GI24580972, Length=398, Percent_Identity=36.4321608040201, Blast_Score=274, Evalue=8e-74,
Organism=Drosophila melanogaster, GI24580970, Length=398, Percent_Identity=36.4321608040201, Blast_Score=274, Evalue=1e-73,
Organism=Drosophila melanogaster, GI19920542, Length=389, Percent_Identity=36.7609254498715, Blast_Score=273, Evalue=1e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.57 [H]

Molecular weight: Translated: 43496; Mature: 43496

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQNVDAYAGDPILSLMEAFQQDPRADKVNLSIGLYYNEQAIIPQLEAVRQAADRLQSQL
CCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
QKASLYLPMEGLAPYRRAVQTLLFGEHHPALRAGRIATIQTLGGSGALKVGADFLKRYFP
HHHHCCCCHHCCHHHHHHHHHHHHCCCCCCHHCCCEEEEEECCCCCCHHHHHHHHHHHCC
DSAVWVSDPTWENHVAIFAGAGFEVHTYPWFDRATRGVNFPAMLAALQQLPPRSIVLLHP
CCEEEECCCCCCCCEEEEEECCEEEECCCCHHHHHCCCCHHHHHHHHHHCCCCCEEEEEC
CCHNPTGADLTPEQWDRVIEVVIVRELIPFLDIAYQGFGRGLDEDAYAIRAIASAGLTAL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
VSNSFSKIFSLYGERVGGLSVVCDNADAAGRVLGQLKATVRRNYSSPPGFGAQVVSQVLN
HHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHC
DPELNALWQEEVEAMRTRISAMRVALVKALQAALPAGDFSYLLTQRGMFSYTGFSADQVD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEECCCCCHHHH
VLRQEHGIYLIASGRVCVAGLNHGNIARVASAFAAVCAR
HHHHHCCEEEEECCCEEEEECCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MFQNVDAYAGDPILSLMEAFQQDPRADKVNLSIGLYYNEQAIIPQLEAVRQAADRLQSQL
CCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
QKASLYLPMEGLAPYRRAVQTLLFGEHHPALRAGRIATIQTLGGSGALKVGADFLKRYFP
HHHHCCCCHHCCHHHHHHHHHHHHCCCCCCHHCCCEEEEEECCCCCCHHHHHHHHHHHCC
DSAVWVSDPTWENHVAIFAGAGFEVHTYPWFDRATRGVNFPAMLAALQQLPPRSIVLLHP
CCEEEECCCCCCCCEEEEEECCEEEECCCCHHHHHCCCCHHHHHHHHHHCCCCCEEEEEC
CCHNPTGADLTPEQWDRVIEVVIVRELIPFLDIAYQGFGRGLDEDAYAIRAIASAGLTAL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
VSNSFSKIFSLYGERVGGLSVVCDNADAAGRVLGQLKATVRRNYSSPPGFGAQVVSQVLN
HHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHC
DPELNALWQEEVEAMRTRISAMRVALVKALQAALPAGDFSYLLTQRGMFSYTGFSADQVD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEECCCCCHHHH
VLRQEHGIYLIASGRVCVAGLNHGNIARVASAFAAVCAR
HHHHHCCEEEEECCCEEEEECCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521591; 3907634; 8265357; 9278503; 3308851; 10417420 [H]