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The map label for this gene is mtnE [H]

Identifier: 238894447

GI number: 238894447

Start: 2339175

End: 2340350

Strand: Reverse

Name: mtnE [H]

Synonym: KP1_2435

Alternate gene names: 238894447

Gene position: 2340350-2339175 (Counterclockwise)

Preceding gene: 238894451

Following gene: 238894445

Centisome position: 44.59

GC content: 62.16

Gene sequence:

>1176_bases
ATGCCTGATTTTACTGCTTCGCCGCTGGTGGACGCCCTGGAAGAGAATCTGTTCAGCCTGCTGGAAAAACTGGCCGCGGA
GGTCAACACCGAAGCGCTGCCGCTGATCGATCTTTCCAGCGGCAGTCCGGATCAACCCACCCCGCCGGAAGTGATCGACT
CGCTGCAGAGCGCTATTCATCGTCGTGAAAACCATGGCTACCCGTCGTTCTGGGGCAAACCACAGGTCCGCGAGGCGATC
GCCCGGTTCTATCGCCGGCAGTATGATGTGGAACTCGATCCGCACAGCGAAGTCGCCGTGTTTCAGGGGTCGCATATCGG
TATAGGCGGCATCCCGCGGGCGCTGCTCAGCCCCGGGCAATACCTCATCTCCACCGATCCCTGCTATCCGATTTACCGCT
CGGCGGCGCTGCAGTCCCAGGCGGCGTTTTATGGCCTGCCTCTCAGGGCGGAGAACCATTTCCTGCCGGATTTTAACGAT
CTTCCCCGGGAAGTCGCTGACAAGGCCGGGCTGGTGGTGCTTAACTATCCGCATAATCCAACCGGCGCCCTCGCCACGCC
GGCGCTGTTCGCCAGCGCGCTGCAGTTTGCTCGTCGTCACCAGGTGCCGATCCTCCATGATTTTGCCTATGCGGCCATCG
GCAGCGCGGCCAGCGATGCGCCGCTGAGCCTCTTCTCCCAGCCCGACGCGAAAGCATGGGGAGTGGAAACCTATACTTTT
TCCAAGACCTTTAATATGGCCGGCTGGCGCTTCGGCTTCGCGGTCGGCAACGCCTCGATTATCCGGGCGTTTAAAAAGCT
GCACACCCATAGCTACAGTACGGTGTTTGGCGCGATTCAGGATGCGGCGATCGCCGCGCTCAACCTGCCGGCCGAACGGA
TTACGCAGCTGACGGCGGTCTATCATCAACGTCGGGAGTGGGTTCTGCGTCGACTAGCCGCGCTGCGCTGGCCGGCGCGT
GACGCACAAGGCACTTTCTTCCTCTGGCTCGGCGTGCCGCCCGGCTACCGTTCGCAGGAGTTTGCCCGCCTGCTGCTGCA
GGAAGCGCATATTCTGGTGGCGCCGGGCACGGGTTTTGGCGCAGGGGGAGAAGGATTTATTCGCATCAGCCTGACCGCAG
GGGACGAGGCGCTGAGCAACGCGCTGGACCGTCTTGCCCGGCTGGCGCTGTTTTAG

Upstream 100 bases:

>100_bases
TATCTTAAAAACAAGAATCTTTTGCGTATATTGTTATTTAGCCAGCCGCTATAAATCCCTTAAAGATGGTTAATTATTCG
TGATTTAAACCGGGAATGTT

Downstream 100 bases:

>100_bases
TCCGCCGCCGGGAGAAGCAAAAACGCAACCCTGGCCGTCGGGGATTACCCGGCTGACGAGTCCATCACCGACAGCACGAT
TTTGCCCTCAAGATGCCCCT

Product: putative aminotransferase

Products: NA

Alternate protein names: DAP-AT; DAP-aminotransferase; LL-DAP-aminotransferase [H]

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MPDFTASPLVDALEENLFSLLEKLAAEVNTEALPLIDLSSGSPDQPTPPEVIDSLQSAIHRRENHGYPSFWGKPQVREAI
ARFYRRQYDVELDPHSEVAVFQGSHIGIGGIPRALLSPGQYLISTDPCYPIYRSAALQSQAAFYGLPLRAENHFLPDFND
LPREVADKAGLVVLNYPHNPTGALATPALFASALQFARRHQVPILHDFAYAAIGSAASDAPLSLFSQPDAKAWGVETYTF
SKTFNMAGWRFGFAVGNASIIRAFKKLHTHSYSTVFGAIQDAAIAALNLPAERITQLTAVYHQRREWVLRRLAALRWPAR
DAQGTFFLWLGVPPGYRSQEFARLLLQEAHILVAPGTGFGAGGEGFIRISLTAGDEALSNALDRLARLALF

Sequences:

>Translated_391_residues
MPDFTASPLVDALEENLFSLLEKLAAEVNTEALPLIDLSSGSPDQPTPPEVIDSLQSAIHRRENHGYPSFWGKPQVREAI
ARFYRRQYDVELDPHSEVAVFQGSHIGIGGIPRALLSPGQYLISTDPCYPIYRSAALQSQAAFYGLPLRAENHFLPDFND
LPREVADKAGLVVLNYPHNPTGALATPALFASALQFARRHQVPILHDFAYAAIGSAASDAPLSLFSQPDAKAWGVETYTF
SKTFNMAGWRFGFAVGNASIIRAFKKLHTHSYSTVFGAIQDAAIAALNLPAERITQLTAVYHQRREWVLRRLAALRWPAR
DAQGTFFLWLGVPPGYRSQEFARLLLQEAHILVAPGTGFGAGGEGFIRISLTAGDEALSNALDRLARLALF
>Mature_390_residues
PDFTASPLVDALEENLFSLLEKLAAEVNTEALPLIDLSSGSPDQPTPPEVIDSLQSAIHRRENHGYPSFWGKPQVREAIA
RFYRRQYDVELDPHSEVAVFQGSHIGIGGIPRALLSPGQYLISTDPCYPIYRSAALQSQAAFYGLPLRAENHFLPDFNDL
PREVADKAGLVVLNYPHNPTGALATPALFASALQFARRHQVPILHDFAYAAIGSAASDAPLSLFSQPDAKAWGVETYTFS
KTFNMAGWRFGFAVGNASIIRAFKKLHTHSYSTVFGAIQDAAIAALNLPAERITQLTAVYHQRREWVLRRLAALRWPARD
AQGTFFLWLGVPPGYRSQEFARLLLQEAHILVAPGTGFGAGGEGFIRISLTAGDEALSNALDRLARLALF

Specific function: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=413, Percent_Identity=19.3704600484261, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI56713254, Length=413, Percent_Identity=19.3704600484261, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI95147551, Length=338, Percent_Identity=21.5976331360947, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI169881279, Length=338, Percent_Identity=21.5976331360947, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1788722, Length=377, Percent_Identity=33.42175066313, Blast_Score=224, Evalue=6e-60,
Organism=Escherichia coli, GI1786816, Length=357, Percent_Identity=27.1708683473389, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788627, Length=292, Percent_Identity=28.4246575342466, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71994472, Length=406, Percent_Identity=23.6453201970443, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71994476, Length=406, Percent_Identity=23.6453201970443, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17567369, Length=283, Percent_Identity=21.9081272084806, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322401, Length=388, Percent_Identity=22.1649484536082, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28573069, Length=387, Percent_Identity=20.1550387596899, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24646114, Length=387, Percent_Identity=20.1550387596899, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28573067, Length=387, Percent_Identity=20.1550387596899, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28573065, Length=387, Percent_Identity=20.1550387596899, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR019881
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.83 [H]

Molecular weight: Translated: 42907; Mature: 42776

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00398 RECOMBINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDFTASPLVDALEENLFSLLEKLAAEVNTEALPLIDLSSGSPDQPTPPEVIDSLQSAIH
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHH
RRENHGYPSFWGKPQVREAIARFYRRQYDVELDPHSEVAVFQGSHIGIGGIPRALLSPGQ
HHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHCCCC
YLISTDPCYPIYRSAALQSQAAFYGLPLRAENHFLPDFNDLPREVADKAGLVVLNYPHNP
EEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCC
TGALATPALFASALQFARRHQVPILHDFAYAAIGSAASDAPLSLFSQPDAKAWGVETYTF
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCEEEEE
SKTFNMAGWRFGFAVGNASIIRAFKKLHTHSYSTVFGAIQDAAIAALNLPAERITQLTAV
CCCCCCCCEEEEHEECCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
YHQRREWVLRRLAALRWPARDAQGTFFLWLGVPPGYRSQEFARLLLQEAHILVAPGTGFG
HHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEECCCCCC
AGGEGFIRISLTAGDEALSNALDRLARLALF
CCCCCEEEEEEECCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PDFTASPLVDALEENLFSLLEKLAAEVNTEALPLIDLSSGSPDQPTPPEVIDSLQSAIH
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHH
RRENHGYPSFWGKPQVREAIARFYRRQYDVELDPHSEVAVFQGSHIGIGGIPRALLSPGQ
HHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHCCCC
YLISTDPCYPIYRSAALQSQAAFYGLPLRAENHFLPDFNDLPREVADKAGLVVLNYPHNP
EEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCC
TGALATPALFASALQFARRHQVPILHDFAYAAIGSAASDAPLSLFSQPDAKAWGVETYTF
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCEEEEE
SKTFNMAGWRFGFAVGNASIIRAFKKLHTHSYSTVFGAIQDAAIAALNLPAERITQLTAV
CCCCCCCCEEEEHEECCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
YHQRREWVLRRLAALRWPARDAQGTFFLWLGVPPGYRSQEFARLLLQEAHILVAPGTGFG
HHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEECCCCCC
AGGEGFIRISLTAGDEALSNALDRLARLALF
CCCCCEEEEEEECCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]