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The map label for this gene is sapA [H]

Identifier: 238894353

GI number: 238894353

Start: 2243429

End: 2245072

Strand: Reverse

Name: sapA [H]

Synonym: KP1_2335

Alternate gene names: 238894353

Gene position: 2245072-2243429 (Counterclockwise)

Preceding gene: 238894354

Following gene: 238894352

Centisome position: 42.78

GC content: 61.62

Gene sequence:

>1644_bases
ATGCGCCTGAAATTGTCATCTCTCCTGGCAGCCGTTTCCGTGCTGTGTGGGCAAGCTTTTGCCGCCCCTGCGCTCCCCGA
CCGCGCCGATATCCGCGATAGCGGTTTCGTCTATTGCGTCAGCGGCCAGGTTAATACCTTTAACCCGCAGAAAGTCAGCA
GCGGCCTGATTGTCGATACGCTGGCCGCTCAGATCTACGATCGTCTGCTTGACGTCGATCCCTATACCTACCGGCTGGTC
CCCGAGCTGGCGGAGAGCTGGGAAGTTCTCGATAACGGCGCCACCTACCGCTTTCACCTGCGCCGCCACGTCCCGTTTCA
ACGCACGGCGTGGTTTACCCCGACGCGGGACTTTAATGCCGATGACGTCATTTTTACCTTTGGCCGTATTTTTAACCGCG
ACCATCCGTGGCACAACGTCAACGGCAGCAGCTTCCCCTACTTCGACAGTCTGCAGTTTGCTGACAGCGTGGAGAGCGTC
CGCAAGCTGGATAATCAGACCGTGGAGTTTCGCCTCAAGCGGCCGGACGCCTCGTTCCTCTGGCATCTGGCCACCCACTA
TGCGTCAATTACCTCTGCCGAATATGCCGCCCGCTTAACGCAGGACGACCGCCAGGAGCAACTGGACCGCCAGCCGGTTG
GCACCGGCCCGTTCCAGCTATCCGATTACCGCTCCGGACAATATGTTCGCCTGCAGCGCCACCCCGGCTACTGGCGCGGC
AAACCGTTGATGCCCCAGGTGGTGGTCGACCTTGGCTCCGGCGGCACCGGCCGCCTGTCGAAACTGCTGACCGGAGAATG
CGACGTGCTGGCCTGGCCAGCCGCCAGCCAGTTGACGATCCTGCGTGACGACCCGCGCCTGCGCCTGACGCTGCGCCCGG
GAATGAACATCGCCTGGCTGGCCTTCAACACCGCCAAGCCGCCGCTGGATAACCCTGAGGTGCGCCATGCCCTGGCGCTG
GCGATTAACAACCAGCGCCTGATGCAGTCCATCTACTATGGCACCGCGGAGACAGCGGCGTCCATGCTGCCGCGGGCCTC
GTGGGCCTACGATAATGACGCTAAAATTACCGAATATAATCCGCAGGAGGCCCGCGCCCGCCTGAAAGCCCTGGGGCTGG
AAAACCTGACCCTCAAGCTGTGGGTGCCCACCAGCTCGCAGGCGTGGAATCCCAGCCCGCTGAAAACGGCGGAGCTTATC
CAGGCGGATATGGCGCAGATTGGCGTTAAGGTGATTATTGTGCCGGTAGAGGGACGTTTCCAGGAGGCGCGCCTGATGGA
CATGAGCCACGACCTGACGCTCTCCGGCTGGGCGACGGACAGTAACGATCCGGACAGTTTCTTCCGACCGCTGCTGAGCT
GCGCGGCCATCGCCTCGCAAACCAACTTTGCCCACTGGTGTAACCGGGAGTTTGACGACGTGCTGCAAAAAGCGCTGCTC
TCGCAGCAGCTCTCCTCGCGGATGGACGCTTACAAAGAGGCGCAGCGGATCCTCGCCCGCGAACTGCCGGTCCTGCCGCT
GGCCTCGTCGCTGCGGCTGCAGGCCTACCGCTATGATATGAAAGGCCTGGTGCTCAGCCCTTTCGGTAACGCTTCGTTCG
CTGGCGTATCGAGGGAAAATACCGAAGAGGTGAAAAAGCCATGA

Upstream 100 bases:

>100_bases
CACCCGGTAACCGCATTATCCCTCAGGCTTGTTGAAGGCGGTGGTGAATGTCTATTAATCTTAATAAGATAGAGTTCAGC
TCTATAATCAAACAGAAAAT

Downstream 100 bases:

>100_bases
TTATTTTTACCCTGCGCCGTCTGCTGCTGCTGCTGATCACCCTCTTTTTTCTGACCTTTGTCGGTTTCAGCCTGAGCTAT
TTCACCCCTCATGCCCCACT

Product: ABC-type peptide transport system periplasmic component

Products: ADP; phosphate; peptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 547; Mature: 547

Protein sequence:

>547_residues
MRLKLSSLLAAVSVLCGQAFAAPALPDRADIRDSGFVYCVSGQVNTFNPQKVSSGLIVDTLAAQIYDRLLDVDPYTYRLV
PELAESWEVLDNGATYRFHLRRHVPFQRTAWFTPTRDFNADDVIFTFGRIFNRDHPWHNVNGSSFPYFDSLQFADSVESV
RKLDNQTVEFRLKRPDASFLWHLATHYASITSAEYAARLTQDDRQEQLDRQPVGTGPFQLSDYRSGQYVRLQRHPGYWRG
KPLMPQVVVDLGSGGTGRLSKLLTGECDVLAWPAASQLTILRDDPRLRLTLRPGMNIAWLAFNTAKPPLDNPEVRHALAL
AINNQRLMQSIYYGTAETAASMLPRASWAYDNDAKITEYNPQEARARLKALGLENLTLKLWVPTSSQAWNPSPLKTAELI
QADMAQIGVKVIIVPVEGRFQEARLMDMSHDLTLSGWATDSNDPDSFFRPLLSCAAIASQTNFAHWCNREFDDVLQKALL
SQQLSSRMDAYKEAQRILARELPVLPLASSLRLQAYRYDMKGLVLSPFGNASFAGVSRENTEEVKKP

Sequences:

>Translated_547_residues
MRLKLSSLLAAVSVLCGQAFAAPALPDRADIRDSGFVYCVSGQVNTFNPQKVSSGLIVDTLAAQIYDRLLDVDPYTYRLV
PELAESWEVLDNGATYRFHLRRHVPFQRTAWFTPTRDFNADDVIFTFGRIFNRDHPWHNVNGSSFPYFDSLQFADSVESV
RKLDNQTVEFRLKRPDASFLWHLATHYASITSAEYAARLTQDDRQEQLDRQPVGTGPFQLSDYRSGQYVRLQRHPGYWRG
KPLMPQVVVDLGSGGTGRLSKLLTGECDVLAWPAASQLTILRDDPRLRLTLRPGMNIAWLAFNTAKPPLDNPEVRHALAL
AINNQRLMQSIYYGTAETAASMLPRASWAYDNDAKITEYNPQEARARLKALGLENLTLKLWVPTSSQAWNPSPLKTAELI
QADMAQIGVKVIIVPVEGRFQEARLMDMSHDLTLSGWATDSNDPDSFFRPLLSCAAIASQTNFAHWCNREFDDVLQKALL
SQQLSSRMDAYKEAQRILARELPVLPLASSLRLQAYRYDMKGLVLSPFGNASFAGVSRENTEEVKKP
>Mature_547_residues
MRLKLSSLLAAVSVLCGQAFAAPALPDRADIRDSGFVYCVSGQVNTFNPQKVSSGLIVDTLAAQIYDRLLDVDPYTYRLV
PELAESWEVLDNGATYRFHLRRHVPFQRTAWFTPTRDFNADDVIFTFGRIFNRDHPWHNVNGSSFPYFDSLQFADSVESV
RKLDNQTVEFRLKRPDASFLWHLATHYASITSAEYAARLTQDDRQEQLDRQPVGTGPFQLSDYRSGQYVRLQRHPGYWRG
KPLMPQVVVDLGSGGTGRLSKLLTGECDVLAWPAASQLTILRDDPRLRLTLRPGMNIAWLAFNTAKPPLDNPEVRHALAL
AINNQRLMQSIYYGTAETAASMLPRASWAYDNDAKITEYNPQEARARLKALGLENLTLKLWVPTSSQAWNPSPLKTAELI
QADMAQIGVKVIIVPVEGRFQEARLMDMSHDLTLSGWATDSNDPDSFFRPLLSCAAIASQTNFAHWCNREFDDVLQKALL
SQQLSSRMDAYKEAQRILARELPVLPLASSLRLQAYRYDMKGLVLSPFGNASFAGVSRENTEEVKKP

Specific function: Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides [H]

COG id: COG4166

COG function: function code E; ABC-type oligopeptide transport system, periplasmic component

Gene ontology:

Cell location: Periplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1787551, Length=547, Percent_Identity=84.2778793418647, Blast_Score=948, Evalue=0.0,
Organism=Escherichia coli, GI1789966, Length=512, Percent_Identity=36.9140625, Blast_Score=393, Evalue=1e-110,
Organism=Escherichia coli, GI1787052, Length=555, Percent_Identity=27.027027027027, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI1787762, Length=489, Percent_Identity=23.5173824130879, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1789887, Length=487, Percent_Identity=24.435318275154, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1787495, Length=543, Percent_Identity=22.4677716390424, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI87081878, Length=462, Percent_Identity=22.0779220779221, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 61605; Mature: 61605

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLKLSSLLAAVSVLCGQAFAAPALPDRADIRDSGFVYCVSGQVNTFNPQKVSSGLIVDT
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHCCCHHHHH
LAAQIYDRLLDVDPYTYRLVPELAESWEVLDNGATYRFHLRRHVPFQRTAWFTPTRDFNA
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEECCCCCCCC
DDVIFTFGRIFNRDHPWHNVNGSSFPYFDSLQFADSVESVRKLDNQTVEFRLKRPDASFL
CHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHH
WHLATHYASITSAEYAARLTQDDRQEQLDRQPVGTGPFQLSDYRSGQYVRLQRHPGYWRG
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCEEECCCCCCCEEEEECCCCCCCC
KPLMPQVVVDLGSGGTGRLSKLLTGECDVLAWPAASQLTILRDDPRLRLTLRPGMNIAWL
CCCCHHHHEECCCCCCHHHHHHHCCCCCEEECCCCCCEEEEECCCEEEEEECCCCCEEEE
AFNTAKPPLDNPEVRHALALAINNQRLMQSIYYGTAETAASMLPRASWAYDNDAKITEYN
EEECCCCCCCCHHHHHEEHEEECCHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCEEECCC
PQEARARLKALGLENLTLKLWVPTSSQAWNPSPLKTAELIQADMAQIGVKVIIVPVEGRF
HHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCC
QEARLMDMSHDLTLSGWATDSNDPDSFFRPLLSCAAIASQTNFAHWCNREFDDVLQKALL
CHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHH
SQQLSSRMDAYKEAQRILARELPVLPLASSLRLQAYRYDMKGLVLSPFGNASFAGVSREN
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHEEECCCCEEECCCCCCCCCCCCCCC
TEEVKKP
HHHHCCC
>Mature Secondary Structure
MRLKLSSLLAAVSVLCGQAFAAPALPDRADIRDSGFVYCVSGQVNTFNPQKVSSGLIVDT
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHCCCHHHHH
LAAQIYDRLLDVDPYTYRLVPELAESWEVLDNGATYRFHLRRHVPFQRTAWFTPTRDFNA
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEECCCCCCCC
DDVIFTFGRIFNRDHPWHNVNGSSFPYFDSLQFADSVESVRKLDNQTVEFRLKRPDASFL
CHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHH
WHLATHYASITSAEYAARLTQDDRQEQLDRQPVGTGPFQLSDYRSGQYVRLQRHPGYWRG
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCEEECCCCCCCEEEEECCCCCCCC
KPLMPQVVVDLGSGGTGRLSKLLTGECDVLAWPAASQLTILRDDPRLRLTLRPGMNIAWL
CCCCHHHHEECCCCCCHHHHHHHCCCCCEEECCCCCCEEEEECCCEEEEEECCCCCEEEE
AFNTAKPPLDNPEVRHALALAINNQRLMQSIYYGTAETAASMLPRASWAYDNDAKITEYN
EEECCCCCCCCHHHHHEEHEEECCHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCEEECCC
PQEARARLKALGLENLTLKLWVPTSSQAWNPSPLKTAELIQADMAQIGVKVIIVPVEGRF
HHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCC
QEARLMDMSHDLTLSGWATDSNDPDSFFRPLLSCAAIASQTNFAHWCNREFDDVLQKALL
CHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHH
SQQLSSRMDAYKEAQRILARELPVLPLASSLRLQAYRYDMKGLVLSPFGNASFAGVSREN
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHEEECCCCEEECCCCCCCCCCCCCCC
TEEVKKP
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; peptides [Periplasm]; H2O [C]

Specific reaction: ATP + peptides [Periplasm] + H2O = ADP + phosphate + peptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8223423; 11677609 [H]