Click here to switch to the map view.

The map label for this gene is rnb [H]

Identifier: 238894344

GI number: 238894344

Start: 2233222

End: 2235156

Strand: Reverse

Name: rnb [H]

Synonym: KP1_2325

Alternate gene names: 238894344

Gene position: 2235156-2233222 (Counterclockwise)

Preceding gene: 238894345

Following gene: 238894343

Centisome position: 42.59

GC content: 59.84

Gene sequence:

>1935_bases
ATGTTTCAGGATAACCCGCTGCTAGCGCAGCTTAAACAGCAACTGCATTCCCAGACGCCGCGCGCGGAAGGGGTCGTTAA
GGGCACGGAAAAGGGCTTTGGCTTCCTCGAAGTGGACGCTCAGAAGAGCTACTTCATTCCGCCGCCGCAGATGAAAAAAG
TGATGCATGGCGACCGTATCGTCGCGGTGATCCATTCTGAAAAAGAACGCGAAAGCGCCGAGCCGGAATCGCTGGTTGAG
CCCTTCCTGACTCGTTTTGTCGGTAAAGTCCAGAAGAAAGACGATCGCCTCGCTATCGTTCCTGACCATCCGCTGCTGAA
AGACGCCATTCCCTGCCGCGCCGCCCGCGGCGTTGAGCACGATTTTAAACAGGGTGACTGGGCCGTCGCCGAGATGCGCC
GTCATCCATTAAAAGGCGACCGCGGATTTTACGCGGAGTTGACCCAGTTCATCACTTTTAGCGACGACCACTTCGTCCCA
TGGTGGGTAACCCTGGCGCGCCATAATCTTGAGAAAGAGGCACCGGACGGCGTCGCCACCGAGATGCTCGACGAGGGGCT
GACGCGCCGCGACCTAACCGCCCTCGACTTCGTCACCATTGACAGCGCCAGCACCGAAGATATGGACGATGCGTTGTATG
CCGAGTCCACTGCTGATGGCAAACTGCTGCTGACGGTCGCCATTGCCGACCCGACCGCCTGGATTGCCGAAGGCAGCAAG
CTGGATAACGCCGCAAAAGTGCGCGCCTTTACCAACTATCTGCCGGGCTTCAACATTCCAATGCTGCCGCGCGAGCTGTC
GGACGACCTCTGCTCCCTGCGTGCTAACGAAGTGCGCCCGGTGCTGGCCTGCCGGATGACTCTGGCGGCCGATGGCACCA
TCGAAGACAATATCGAGTTCTTTGCCGCCACCATCGAATCGAAAGCCAAGCTGGCCTATGACGACGTCTCTGACTGGCTG
GAAGGCCGCGGCAGCTGGCAGCCGGACAGCGAGGCGATCGCGCAGCAAATTACGCTGCTGAAGGACGTGTGCCAGCGTCG
TAGCGAATGGCGTCAGACCCATGCGCTGGTGTTCAAAGACCGTCCGGACTACCGTTTCGTTCTCGGCGAAAAAGGCGAAG
TGCTGGATATCGTCGCGGAACCGCGTCGCATTGCCAACCGCATTGTCGAAGAGTCGATGATCGCCGCCAACATCTGTGCC
GCCCGCGTTCTGCGCGACAAGCTCGGCTTCGGCGTTTATAACGTTCATACCGGTTTCGACCCGGCGAACACCGAGCAGTT
GGCCGCCCTGCTGAAAACCCATGATGTGCACGTCGACCCGACGGAAGTGCTCACCCTGGAAGGGTTCTGCAAGCTGCGCC
GGGAACTGGACGCTCAGCCGACCGGTTTCCTCGACAGCCGCATTCGCCGCTTCCAGTCGTTTGCGGAAATCAGCACCGAG
CCGGGCCCGCACTTTGGTCTTGGGCTTGAAGCCTATGCCACCTGGACCTCGCCGATCCGTAAGTATGGCGACATGATCAA
CCACCGTCTGCTGAAAGCCATCATTAAAGGCGAGACCATTGCGCGTCCCCAGGATGAAGCCACCGTGCAGATGGCGGAGC
GCCGTCGTCTCAACCGGATGGCCGAGCGCGACGTCGCCGACTGGCTGTACGCCCGTTTCCTCAACGATAAAGCCGGGACC
GATACCCGCTTCGCGGCGGAGATCATCGACGTCAGCCGCGGCGGGATGCGCGTGCGTCTGGTGGACAATGGCGCGGTCGC
CTTTATTCCGGCCCCGTTCCTCCACGCCGTGCGCGACGAACTGGTGTGCAGTCAGGAGAACGGTACCGTGCAGATCAAAG
GTGAAGTAGTCTATAAAGTGACTGACGTTATCGATGTCACTATCGCTGAAGTTCGCATGGAAACCCGCAGCATTATTGCG
CGTCCGGCGGTCTGA

Upstream 100 bases:

>100_bases
CGTGCGTCAGCAGACGTAAATTGCTGAAACAGCGCTTGCTGCGGCAGGCATATTCGCGTAAAAATGTCAGCCGCTCTTTT
AGCCACGAAAATACCTAATT

Downstream 100 bases:

>100_bases
CGCCCCTTCACAGCGGTTCCTGCGGGAACCGCTGCTTCTTTCCTCTCTATCAAGCCATTTCCGTCGCACCGATTAAGGTT
GTGCGTTTTTTTCGCTTCTC

Product: exoribonuclease II

Products: NA

Alternate protein names: Exoribonuclease II; RNase II; Ribonuclease II [H]

Number of amino acids: Translated: 644; Mature: 644

Protein sequence:

>644_residues
MFQDNPLLAQLKQQLHSQTPRAEGVVKGTEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRIVAVIHSEKERESAEPESLVE
PFLTRFVGKVQKKDDRLAIVPDHPLLKDAIPCRAARGVEHDFKQGDWAVAEMRRHPLKGDRGFYAELTQFITFSDDHFVP
WWVTLARHNLEKEAPDGVATEMLDEGLTRRDLTALDFVTIDSASTEDMDDALYAESTADGKLLLTVAIADPTAWIAEGSK
LDNAAKVRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPVLACRMTLAADGTIEDNIEFFAATIESKAKLAYDDVSDWL
EGRGSWQPDSEAIAQQITLLKDVCQRRSEWRQTHALVFKDRPDYRFVLGEKGEVLDIVAEPRRIANRIVEESMIAANICA
ARVLRDKLGFGVYNVHTGFDPANTEQLAALLKTHDVHVDPTEVLTLEGFCKLRRELDAQPTGFLDSRIRRFQSFAEISTE
PGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAIIKGETIARPQDEATVQMAERRRLNRMAERDVADWLYARFLNDKAGT
DTRFAAEIIDVSRGGMRVRLVDNGAVAFIPAPFLHAVRDELVCSQENGTVQIKGEVVYKVTDVIDVTIAEVRMETRSIIA
RPAV

Sequences:

>Translated_644_residues
MFQDNPLLAQLKQQLHSQTPRAEGVVKGTEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRIVAVIHSEKERESAEPESLVE
PFLTRFVGKVQKKDDRLAIVPDHPLLKDAIPCRAARGVEHDFKQGDWAVAEMRRHPLKGDRGFYAELTQFITFSDDHFVP
WWVTLARHNLEKEAPDGVATEMLDEGLTRRDLTALDFVTIDSASTEDMDDALYAESTADGKLLLTVAIADPTAWIAEGSK
LDNAAKVRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPVLACRMTLAADGTIEDNIEFFAATIESKAKLAYDDVSDWL
EGRGSWQPDSEAIAQQITLLKDVCQRRSEWRQTHALVFKDRPDYRFVLGEKGEVLDIVAEPRRIANRIVEESMIAANICA
ARVLRDKLGFGVYNVHTGFDPANTEQLAALLKTHDVHVDPTEVLTLEGFCKLRRELDAQPTGFLDSRIRRFQSFAEISTE
PGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAIIKGETIARPQDEATVQMAERRRLNRMAERDVADWLYARFLNDKAGT
DTRFAAEIIDVSRGGMRVRLVDNGAVAFIPAPFLHAVRDELVCSQENGTVQIKGEVVYKVTDVIDVTIAEVRMETRSIIA
RPAV
>Mature_644_residues
MFQDNPLLAQLKQQLHSQTPRAEGVVKGTEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRIVAVIHSEKERESAEPESLVE
PFLTRFVGKVQKKDDRLAIVPDHPLLKDAIPCRAARGVEHDFKQGDWAVAEMRRHPLKGDRGFYAELTQFITFSDDHFVP
WWVTLARHNLEKEAPDGVATEMLDEGLTRRDLTALDFVTIDSASTEDMDDALYAESTADGKLLLTVAIADPTAWIAEGSK
LDNAAKVRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPVLACRMTLAADGTIEDNIEFFAATIESKAKLAYDDVSDWL
EGRGSWQPDSEAIAQQITLLKDVCQRRSEWRQTHALVFKDRPDYRFVLGEKGEVLDIVAEPRRIANRIVEESMIAANICA
ARVLRDKLGFGVYNVHTGFDPANTEQLAALLKTHDVHVDPTEVLTLEGFCKLRRELDAQPTGFLDSRIRRFQSFAEISTE
PGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAIIKGETIARPQDEATVQMAERRRLNRMAERDVADWLYARFLNDKAGT
DTRFAAEIIDVSRGGMRVRLVDNGAVAFIPAPFLHAVRDELVCSQENGTVQIKGEVVYKVTDVIDVTIAEVRMETRSIIA
RPAV

Specific function: Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction [H]

COG id: COG4776

COG function: function code K; Exoribonuclease II

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=338, Percent_Identity=26.9230769230769, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI190014625, Length=338, Percent_Identity=26.9230769230769, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI134288890, Length=357, Percent_Identity=28.0112044817927, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI219521928, Length=456, Percent_Identity=25, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI19115966, Length=456, Percent_Identity=25, Blast_Score=92, Evalue=2e-18,
Organism=Escherichia coli, GI1787542, Length=642, Percent_Identity=90.3426791277259, Blast_Score=1199, Evalue=0.0,
Organism=Escherichia coli, GI87082383, Length=652, Percent_Identity=26.5337423312883, Blast_Score=174, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17553506, Length=403, Percent_Identity=25.3101736972705, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI212645896, Length=467, Percent_Identity=26.7665952890792, Blast_Score=108, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6324552, Length=423, Percent_Identity=24.113475177305, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24654592, Length=453, Percent_Identity=26.9315673289183, Blast_Score=116, Evalue=5e-26,
Organism=Drosophila melanogaster, GI19922976, Length=433, Percent_Identity=27.4826789838337, Blast_Score=116, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24654597, Length=433, Percent_Identity=27.4826789838337, Blast_Score=116, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24649634, Length=357, Percent_Identity=28.0112044817927, Blast_Score=109, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011804 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: =3.1.13.1 [H]

Molecular weight: Translated: 72352; Mature: 72352

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQDNPLLAQLKQQLHSQTPRAEGVVKGTEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRI
CCCCCHHHHHHHHHHHHCCCCCCCCEECCCCCCEEEEECCCCCCCCCCHHHHHHHCCCEE
VAVIHSEKERESAEPESLVEPFLTRFVGKVQKKDDRLAIVPDHPLLKDAIPCRAARGVEH
EEEEECCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHCCCHHHHCCCCC
DFKQGDWAVAEMRRHPLKGDRGFYAELTQFITFSDDHFVPWWVTLARHNLEKEAPDGVAT
HHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCHHHH
EMLDEGLTRRDLTALDFVTIDSASTEDMDDALYAESTADGKLLLTVAIADPTAWIAEGSK
HHHHCCCCCCCCCEEEEEEECCCCCCCCHHHHHHCCCCCCEEEEEEEECCCCHHHHCCCC
LDNAAKVRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPVLACRMTLAADGTIEDNIEF
CCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHH
FAATIESKAKLAYDDVSDWLEGRGSWQPDSEAIAQQITLLKDVCQRRSEWRQTHALVFKD
HHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEC
RPDYRFVLGEKGEVLDIVAEPRRIANRIVEESMIAANICAARVLRDKLGFGVYNVHTGFD
CCCEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
PANTEQLAALLKTHDVHVDPTEVLTLEGFCKLRRELDAQPTGFLDSRIRRFQSFAEISTE
CCCHHHHHHHHHHCCCCCCHHHHEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCC
PGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAIIKGETIARPQDEATVQMAERRRLNRM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
AERDVADWLYARFLNDKAGTDTRFAAEIIDVSRGGMRVRLVDNGAVAFIPAPFLHAVRDE
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCEEEECHHHHHHHHHH
LVCSQENGTVQIKGEVVYKVTDVIDVTIAEVRMETRSIIARPAV
HHEECCCCEEEEECEEEEEEHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFQDNPLLAQLKQQLHSQTPRAEGVVKGTEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRI
CCCCCHHHHHHHHHHHHCCCCCCCCEECCCCCCEEEEECCCCCCCCCCHHHHHHHCCCEE
VAVIHSEKERESAEPESLVEPFLTRFVGKVQKKDDRLAIVPDHPLLKDAIPCRAARGVEH
EEEEECCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHCCCHHHHCCCCC
DFKQGDWAVAEMRRHPLKGDRGFYAELTQFITFSDDHFVPWWVTLARHNLEKEAPDGVAT
HHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCHHHH
EMLDEGLTRRDLTALDFVTIDSASTEDMDDALYAESTADGKLLLTVAIADPTAWIAEGSK
HHHHCCCCCCCCCEEEEEEECCCCCCCCHHHHHHCCCCCCEEEEEEEECCCCHHHHCCCC
LDNAAKVRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPVLACRMTLAADGTIEDNIEF
CCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHH
FAATIESKAKLAYDDVSDWLEGRGSWQPDSEAIAQQITLLKDVCQRRSEWRQTHALVFKD
HHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEC
RPDYRFVLGEKGEVLDIVAEPRRIANRIVEESMIAANICAARVLRDKLGFGVYNVHTGFD
CCCEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
PANTEQLAALLKTHDVHVDPTEVLTLEGFCKLRRELDAQPTGFLDSRIRRFQSFAEISTE
CCCHHHHHHHHHHCCCCCCHHHHEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCC
PGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAIIKGETIARPQDEATVQMAERRRLNRM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
AERDVADWLYARFLNDKAGTDTRFAAEIIDVSRGGMRVRLVDNGAVAFIPAPFLHAVRDE
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCEEEECHHHHHHHHHH
LVCSQENGTVQIKGEVVYKVTDVIDVTIAEVRMETRSIIARPAV
HHEECCCCEEEEECEEEEEEHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA