| Definition | Klebsiella pneumoniae NTUH-K2044 chromosome, complete genome. |
|---|---|
| Accession | NC_012731 |
| Length | 5,248,520 |
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The map label for this gene is kduD [H]
Identifier: 238894296
GI number: 238894296
Start: 2185770
End: 2186531
Strand: Reverse
Name: kduD [H]
Synonym: KP1_2274
Alternate gene names: 238894296
Gene position: 2186531-2185770 (Counterclockwise)
Preceding gene: 238894297
Following gene: 238894295
Centisome position: 41.66
GC content: 61.55
Gene sequence:
>762_bases ATGGTACTGAACGCCTTCGACCTGACGGGTAAGGTCGCCATCGTGACCGGTTGCGATACCGGCCTGGGACAGGGAATGAC GCTGGGCCTGGCGCAGGCCGGGTGCGATATCGTCGGCATCAACCGTAAAATTCCCCATGATACGGCCGCCCAGATGCTGG CGCTGGGCCGCCGCTTTCACGCCATTCAGGCGGATCTCAGCCAAGAGAATGATATGAGCGGTCTGGTCGACCAGGCGGTG GCGGCGATGGGCCGGGTCGATATTCTGGTCAACAACGCCGGAATTATCCGCCGCCATGATGCCCTGACCTTCACGGAAAG CGACTGGGACGCGGTGATCGACCTGAATCTCAAAGCGGTTTTCTTTCTCAGCCAGGCGGTCGCCAGGCAGTTCATTCGCC AGGGGGAAGGCGGGAAAATCATTAACATCGCCTCGATGCTCTCGTTTCAGGGCGGGATCCGCGTCCCCTCCTACACCGCC TCGAAAAGCGGCGTGCTGGGTTTGACCCGTCTGCTGGCCAACGAATGGGCGGGCCAGGGTATCAACGTCAACGCCATAGC GCCCGGGTATATGGCCACCAATAACACCCAGGCGCTGCGCGAAGATGAAGAGCGTAACCAGGCGATCCTCGAGCGCATTC CCGCTGGTCGCTGGGGAGCGCCGAAAGACCTGCAGGGGCCGGTGGTGTTTCTCGCCTCATCAGCGGCCGACTATATTAAC GGCTATACGCTGGCCGTCGATGGCGGATGGTTGGCGCGCTGA
Upstream 100 bases:
>100_bases AAAACATTGTTTCATTTTAATTGTAATTTTGTTTTCCTCCCTCTATGCTGGTCACAGGTGGCGTCATCGTACGCCAGTAG ATCAGCTGACAGAGGTGAAT
Downstream 100 bases:
>100_bases GAGTTTGTGACAAAGAGTTACACCGTCACCTCTTCCGTACACTGTATAAAAACCCTATACTGTATGAATCGACAGTTTAG GGTGTGTTATCATGACGGCG
Product: putative 2-deoxy-D-gluconate 3-dehydrogenase
Products: NA
Alternate protein names: 2-keto-3-deoxygluconate 5-dehydrogenase; 2-keto-3-deoxygluconate oxidoreductase; KDG oxidoreductase [H]
Number of amino acids: Translated: 253; Mature: 253
Protein sequence:
>253_residues MVLNAFDLTGKVAIVTGCDTGLGQGMTLGLAQAGCDIVGINRKIPHDTAAQMLALGRRFHAIQADLSQENDMSGLVDQAV AAMGRVDILVNNAGIIRRHDALTFTESDWDAVIDLNLKAVFFLSQAVARQFIRQGEGGKIINIASMLSFQGGIRVPSYTA SKSGVLGLTRLLANEWAGQGINVNAIAPGYMATNNTQALREDEERNQAILERIPAGRWGAPKDLQGPVVFLASSAADYIN GYTLAVDGGWLAR
Sequences:
>Translated_253_residues MVLNAFDLTGKVAIVTGCDTGLGQGMTLGLAQAGCDIVGINRKIPHDTAAQMLALGRRFHAIQADLSQENDMSGLVDQAV AAMGRVDILVNNAGIIRRHDALTFTESDWDAVIDLNLKAVFFLSQAVARQFIRQGEGGKIINIASMLSFQGGIRVPSYTA SKSGVLGLTRLLANEWAGQGINVNAIAPGYMATNNTQALREDEERNQAILERIPAGRWGAPKDLQGPVVFLASSAADYIN GYTLAVDGGWLAR >Mature_253_residues MVLNAFDLTGKVAIVTGCDTGLGQGMTLGLAQAGCDIVGINRKIPHDTAAQMLALGRRFHAIQADLSQENDMSGLVDQAV AAMGRVDILVNNAGIIRRHDALTFTESDWDAVIDLNLKAVFFLSQAVARQFIRQGEGGKIINIASMLSFQGGIRVPSYTA SKSGVLGLTRLLANEWAGQGINVNAIAPGYMATNNTQALREDEERNQAILERIPAGRWGAPKDLQGPVVFLASSAADYIN GYTLAVDGGWLAR
Specific function: Catalyzes the reduction of 2,5-diketo-3-deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2-keto-3- deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH [H]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI15277342, Length=254, Percent_Identity=34.251968503937, Blast_Score=134, Evalue=7e-32, Organism=Homo sapiens, GI32483357, Length=249, Percent_Identity=33.7349397590361, Blast_Score=126, Evalue=2e-29, Organism=Homo sapiens, GI19923817, Length=254, Percent_Identity=32.6771653543307, Blast_Score=124, Evalue=7e-29, Organism=Homo sapiens, GI40254992, Length=242, Percent_Identity=34.7107438016529, Blast_Score=117, Evalue=9e-27, Organism=Homo sapiens, GI7705925, Length=245, Percent_Identity=31.0204081632653, Blast_Score=114, Evalue=8e-26, Organism=Homo sapiens, GI10190704, Length=253, Percent_Identity=32.8063241106719, Blast_Score=106, Evalue=2e-23, Organism=Homo sapiens, GI66933014, Length=251, Percent_Identity=29.4820717131474, Blast_Score=103, Evalue=1e-22, Organism=Homo sapiens, GI126723750, Length=252, Percent_Identity=31.7460317460317, Blast_Score=102, Evalue=2e-22, Organism=Homo sapiens, GI5031737, Length=245, Percent_Identity=31.8367346938775, Blast_Score=100, Evalue=2e-21, Organism=Homo sapiens, GI4503301, Length=251, Percent_Identity=31.8725099601594, Blast_Score=94, Evalue=9e-20, Organism=Homo sapiens, GI31542939, Length=211, Percent_Identity=29.8578199052133, Blast_Score=86, Evalue=2e-17, Organism=Homo sapiens, GI59889578, Length=197, Percent_Identity=31.9796954314721, Blast_Score=85, Evalue=8e-17, Organism=Homo sapiens, GI4758504, Length=254, Percent_Identity=30.7086614173228, Blast_Score=83, Evalue=2e-16, Organism=Homo sapiens, GI4504505, Length=258, Percent_Identity=27.1317829457364, Blast_Score=82, Evalue=6e-16, Organism=Homo sapiens, GI33667109, Length=197, Percent_Identity=31.4720812182741, Blast_Score=78, Evalue=6e-15, Organism=Homo sapiens, GI126723191, Length=182, Percent_Identity=31.8681318681319, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI142976729, Length=195, Percent_Identity=25.6410256410256, Blast_Score=75, Evalue=4e-14, Organism=Homo sapiens, GI210032110, Length=196, Percent_Identity=25.5102040816327, Blast_Score=74, Evalue=2e-13, Organism=Homo sapiens, GI109715829, Length=240, Percent_Identity=29.1666666666667, Blast_Score=72, Evalue=4e-13, Organism=Homo sapiens, GI224922801, Length=170, Percent_Identity=30, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI83715985, Length=187, Percent_Identity=31.5508021390374, Blast_Score=70, Evalue=3e-12, Organism=Homo sapiens, GI209862901, Length=221, Percent_Identity=28.9592760180996, Blast_Score=69, Evalue=3e-12, Organism=Homo sapiens, GI19923983, Length=221, Percent_Identity=28.9592760180996, Blast_Score=69, Evalue=3e-12, Organism=Homo sapiens, GI40807363, Length=193, Percent_Identity=27.4611398963731, Blast_Score=65, Evalue=7e-11, Organism=Escherichia coli, GI1789208, Length=253, Percent_Identity=72.7272727272727, Blast_Score=386, Evalue=1e-109, Organism=Escherichia coli, GI87082160, Length=257, Percent_Identity=42.8015564202335, Blast_Score=197, Evalue=6e-52, Organism=Escherichia coli, GI1790717, Length=254, Percent_Identity=41.3385826771654, Blast_Score=173, Evalue=1e-44, Organism=Escherichia coli, GI1787335, Length=247, Percent_Identity=35.6275303643725, Blast_Score=152, Evalue=3e-38, Organism=Escherichia coli, GI1788459, Length=249, Percent_Identity=34.9397590361446, Blast_Score=137, Evalue=6e-34, Organism=Escherichia coli, GI87082100, Length=254, Percent_Identity=32.2834645669291, Blast_Score=121, Evalue=5e-29, Organism=Escherichia coli, GI1787905, Length=244, Percent_Identity=34.4262295081967, Blast_Score=116, Evalue=1e-27, Organism=Escherichia coli, GI1786812, Length=251, Percent_Identity=28.2868525896414, Blast_Score=98, Evalue=5e-22, Organism=Escherichia coli, GI1789378, Length=247, Percent_Identity=27.5303643724696, Blast_Score=91, Evalue=5e-20, Organism=Escherichia coli, GI2367175, Length=252, Percent_Identity=30.952380952381, Blast_Score=84, Evalue=1e-17, Organism=Escherichia coli, GI1789057, Length=257, Percent_Identity=28.0155642023346, Blast_Score=79, Evalue=4e-16, Organism=Escherichia coli, GI2367365, Length=251, Percent_Identity=29.4820717131474, Blast_Score=75, Evalue=3e-15, Organism=Escherichia coli, GI1788891, Length=206, Percent_Identity=30.5825242718447, Blast_Score=65, Evalue=4e-12, Organism=Caenorhabditis elegans, GI17560676, Length=249, Percent_Identity=32.5301204819277, Blast_Score=126, Evalue=9e-30, Organism=Caenorhabditis elegans, GI17555706, Length=245, Percent_Identity=32.2448979591837, Blast_Score=125, Evalue=2e-29, Organism=Caenorhabditis elegans, GI25147288, Length=245, Percent_Identity=32.2448979591837, Blast_Score=125, Evalue=2e-29, Organism=Caenorhabditis elegans, GI17561402, Length=260, Percent_Identity=33.0769230769231, Blast_Score=115, Evalue=2e-26, Organism=Caenorhabditis elegans, GI115534694, Length=253, Percent_Identity=29.2490118577075, Blast_Score=108, Evalue=2e-24, Organism=Caenorhabditis elegans, GI71994600, Length=253, Percent_Identity=31.6205533596838, Blast_Score=107, Evalue=9e-24, Organism=Caenorhabditis elegans, GI71994604, Length=247, Percent_Identity=31.1740890688259, Blast_Score=103, Evalue=9e-23, Organism=Caenorhabditis elegans, GI17559104, Length=257, Percent_Identity=31.1284046692607, Blast_Score=102, Evalue=1e-22, Organism=Caenorhabditis elegans, GI17560150, Length=259, Percent_Identity=28.1853281853282, Blast_Score=98, Evalue=4e-21, Organism=Caenorhabditis elegans, GI17531453, Length=260, Percent_Identity=30.3846153846154, Blast_Score=94, Evalue=6e-20, Organism=Caenorhabditis elegans, GI17562906, Length=260, Percent_Identity=29.2307692307692, Blast_Score=93, Evalue=1e-19, Organism=Caenorhabditis elegans, GI17562990, Length=263, Percent_Identity=27.7566539923954, Blast_Score=93, Evalue=1e-19, Organism=Caenorhabditis elegans, GI17560332, Length=261, Percent_Identity=28.3524904214559, Blast_Score=92, Evalue=4e-19, Organism=Caenorhabditis elegans, GI17551412, Length=264, Percent_Identity=26.8939393939394, Blast_Score=91, Evalue=4e-19, Organism=Caenorhabditis elegans, GI17562910, Length=265, Percent_Identity=28.6792452830189, Blast_Score=91, Evalue=8e-19, Organism=Caenorhabditis elegans, GI17544670, Length=266, Percent_Identity=27.0676691729323, Blast_Score=90, Evalue=9e-19, Organism=Caenorhabditis elegans, GI17562908, Length=260, Percent_Identity=28.4615384615385, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI72000259, Length=258, Percent_Identity=28.2945736434109, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17568967, Length=194, Percent_Identity=32.9896907216495, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17538182, Length=251, Percent_Identity=31.4741035856574, Blast_Score=87, Evalue=8e-18, Organism=Caenorhabditis elegans, GI17536651, Length=250, Percent_Identity=26.8, Blast_Score=87, Evalue=9e-18, Organism=Caenorhabditis elegans, GI17538480, Length=261, Percent_Identity=26.0536398467433, Blast_Score=87, Evalue=9e-18, Organism=Caenorhabditis elegans, GI17562904, Length=261, Percent_Identity=27.2030651340996, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17563726, Length=259, Percent_Identity=27.4131274131274, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17536025, Length=249, Percent_Identity=26.9076305220884, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17565030, Length=261, Percent_Identity=29.1187739463602, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17561272, Length=192, Percent_Identity=27.6041666666667, Blast_Score=84, Evalue=8e-17, Organism=Caenorhabditis elegans, GI193204405, Length=263, Percent_Identity=28.8973384030418, Blast_Score=84, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17564282, Length=197, Percent_Identity=27.4111675126904, Blast_Score=83, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17560220, Length=260, Percent_Identity=27.3076923076923, Blast_Score=80, Evalue=9e-16, Organism=Caenorhabditis elegans, GI193203115, Length=191, Percent_Identity=28.7958115183246, Blast_Score=78, Evalue=5e-15, Organism=Caenorhabditis elegans, GI17538486, Length=261, Percent_Identity=27.2030651340996, Blast_Score=77, Evalue=6e-15, Organism=Caenorhabditis elegans, GI193203117, Length=190, Percent_Identity=28.4210526315789, Blast_Score=77, Evalue=8e-15, Organism=Caenorhabditis elegans, GI17508651, Length=256, Percent_Identity=27.734375, Blast_Score=69, Evalue=2e-12, Organism=Saccharomyces cerevisiae, GI6322861, Length=188, Percent_Identity=34.0425531914894, Blast_Score=91, Evalue=2e-19, Organism=Saccharomyces cerevisiae, GI6324126, Length=250, Percent_Identity=27.2, Blast_Score=83, Evalue=5e-17, Organism=Drosophila melanogaster, GI21355319, Length=249, Percent_Identity=33.3333333333333, Blast_Score=139, Evalue=2e-33, Organism=Drosophila melanogaster, GI24639444, Length=247, Percent_Identity=32.7935222672065, Blast_Score=133, Evalue=1e-31, Organism=Drosophila melanogaster, GI23397609, Length=251, Percent_Identity=31.4741035856574, Blast_Score=124, Evalue=6e-29, Organism=Drosophila melanogaster, GI21357041, Length=249, Percent_Identity=33.7349397590361, Blast_Score=120, Evalue=7e-28, Organism=Drosophila melanogaster, GI28571526, Length=249, Percent_Identity=31.7269076305221, Blast_Score=113, Evalue=1e-25, Organism=Drosophila melanogaster, GI24644339, Length=251, Percent_Identity=29.8804780876494, Blast_Score=108, Evalue=5e-24, Organism=Drosophila melanogaster, GI24643142, Length=247, Percent_Identity=31.1740890688259, Blast_Score=105, Evalue=2e-23, Organism=Drosophila melanogaster, GI18859837, Length=252, Percent_Identity=31.3492063492063, Blast_Score=89, Evalue=3e-18, Organism=Drosophila melanogaster, GI24644337, Length=204, Percent_Identity=29.4117647058824, Blast_Score=88, Evalue=5e-18, Organism=Drosophila melanogaster, GI24649181, Length=197, Percent_Identity=31.4720812182741, Blast_Score=85, Evalue=4e-17, Organism=Drosophila melanogaster, GI17737361, Length=253, Percent_Identity=28.8537549407115, Blast_Score=81, Evalue=7e-16, Organism=Drosophila melanogaster, GI21358495, Length=197, Percent_Identity=29.4416243654822, Blast_Score=79, Evalue=2e-15, Organism=Drosophila melanogaster, GI21357673, Length=198, Percent_Identity=26.2626262626263, Blast_Score=72, Evalue=4e-13, Organism=Drosophila melanogaster, GI21355631, Length=179, Percent_Identity=27.9329608938547, Blast_Score=71, Evalue=5e-13, Organism=Drosophila melanogaster, GI24663911, Length=200, Percent_Identity=27.5, Blast_Score=71, Evalue=7e-13, Organism=Drosophila melanogaster, GI161076933, Length=191, Percent_Identity=28.2722513089005, Blast_Score=69, Evalue=3e-12, Organism=Drosophila melanogaster, GI24584748, Length=191, Percent_Identity=28.2722513089005, Blast_Score=69, Evalue=3e-12, Organism=Drosophila melanogaster, GI24640492, Length=215, Percent_Identity=25.1162790697674, Blast_Score=69, Evalue=4e-12, Organism=Drosophila melanogaster, GI24648693, Length=207, Percent_Identity=29.951690821256, Blast_Score=68, Evalue=6e-12, Organism=Drosophila melanogaster, GI21355889, Length=207, Percent_Identity=29.951690821256, Blast_Score=68, Evalue=6e-12, Organism=Drosophila melanogaster, GI28571387, Length=195, Percent_Identity=26.1538461538462, Blast_Score=68, Evalue=7e-12, Organism=Drosophila melanogaster, GI24641388, Length=202, Percent_Identity=28.2178217821782, Blast_Score=68, Evalue=7e-12, Organism=Drosophila melanogaster, GI17647419, Length=227, Percent_Identity=22.4669603524229, Blast_Score=67, Evalue=1e-11, Organism=Drosophila melanogaster, GI24665243, Length=218, Percent_Identity=26.605504587156, Blast_Score=66, Evalue=2e-11, Organism=Drosophila melanogaster, GI221331218, Length=218, Percent_Identity=26.605504587156, Blast_Score=66, Evalue=2e-11, Organism=Drosophila melanogaster, GI24665247, Length=223, Percent_Identity=26.0089686098655, Blast_Score=65, Evalue=4e-11, Organism=Drosophila melanogaster, GI221331216, Length=223, Percent_Identity=26.0089686098655, Blast_Score=65, Evalue=4e-11, Organism=Drosophila melanogaster, GI281364892, Length=213, Percent_Identity=26.7605633802817, Blast_Score=64, Evalue=8e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR011286 - InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.127 [H]
Molecular weight: Translated: 26939; Mature: 26939
Theoretical pI: Translated: 5.72; Mature: 5.72
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 2.8 %Met (Translated Protein) 3.6 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 2.8 %Met (Mature Protein) 3.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MVLNAFDLTGKVAIVTGCDTGLGQGMTLGLAQAGCDIVGINRKIPHDTAAQMLALGRRFH CEEEEEECCCCEEEEEECCCCCCCCCEEEHHHCCCCEEECCCCCCCHHHHHHHHHHHHHH AIQADLSQENDMSGLVDQAVAAMGRVDILVNNAGIIRRHDALTFTESDWDAVIDLNLKAV HHHHHCCCCCCHHHHHHHHHHHHCCEEEEECCCCEEEECCCEEEECCCCCEEEECCHHHH FFLSQAVARQFIRQGEGGKIINIASMLSFQGGIRVPSYTASKSGVLGLTRLLANEWAGQG HHHHHHHHHHHHHCCCCCCEEEHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC INVNAIAPGYMATNNTQALREDEERNQAILERIPAGRWGAPKDLQGPVVFLASSAADYIN EEEEEECCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCHHHHHC GYTLAVDGGWLAR CEEEEECCCCCCC >Mature Secondary Structure MVLNAFDLTGKVAIVTGCDTGLGQGMTLGLAQAGCDIVGINRKIPHDTAAQMLALGRRFH CEEEEEECCCCEEEEEECCCCCCCCCEEEHHHCCCCEEECCCCCCCHHHHHHHHHHHHHH AIQADLSQENDMSGLVDQAVAAMGRVDILVNNAGIIRRHDALTFTESDWDAVIDLNLKAV HHHHHCCCCCCHHHHHHHHHHHHCCEEEEECCCCEEEECCCEEEECCCCCEEEECCHHHH FFLSQAVARQFIRQGEGGKIINIASMLSFQGGIRVPSYTASKSGVLGLTRLLANEWAGQG HHHHHHHHHHHHHCCCCCCEEEHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC INVNAIAPGYMATNNTQALREDEERNQAILERIPAGRWGAPKDLQGPVVFLASSAADYIN EEEEEECCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCHHHHHC GYTLAVDGGWLAR CEEEEECCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 1766386 [H]