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The map label for this gene is gpo [H]

Identifier: 238894244

GI number: 238894244

Start: 2132957

End: 2133469

Strand: Reverse

Name: gpo [H]

Synonym: KP1_2213

Alternate gene names: 238894244

Gene position: 2133469-2132957 (Counterclockwise)

Preceding gene: 238894246

Following gene: 238894242

Centisome position: 40.65

GC content: 57.89

Gene sequence:

>513_bases
TTGAACTGTTTCTACTCTCAGGAGCCTGCTATGACCCCTTTTTATCAATTGACGGCTACCCGCCTGCGCGGCCAGCCCCT
CTCCATGGCTGACTATGCTGGCAAGGTGGTTCTGGTGGTGAATACGGCCAGCCATTGTGGCTTCACACCGCAATACGCTG
GCCTGGAAGCGCTCTACAAAAAGTACGCGGCTCAGGGGCTGGTAGTGCTTGGTTTCCCGTGCAACCAGTTTGGTAAGCAG
GAACCCGGCGGTGCGGATGAAATCGAGCAGACTTGTCACGTTAACTACGGCGTGAGCTTCCCGATGTTTGAGAAAGTGGA
CGTCAACGGCCCCGCCGCACACCCGCTGTTTCGTTATCTGAAACAAGCGTTGCCCGGCGTGCTCGGCGGACGGATCAAGT
GGAATTTCACCAAGTTCCTCATCGGTCGCGACGGCACACCCCTCACGCGTTTTGCGCCGTTCACGACGCCGGAGAAAATG
GAAGCCTCCATTGTCGCGGCCCTCACGCGCTGA

Upstream 100 bases:

>100_bases
CTATGACATCTGGCGTTTTTTTAACACTCCAGGTACAAATCCCTAACCCTGTGTATCATAACTGCCTAATCTGCTTCAAA
CATTCGCGCGATCGTCAGCG

Downstream 100 bases:

>100_bases
GTGTTCCCATCATGCCACGTTCACCCAGCGGCGGCTGGCTGCCCATACAAGGTAGACGTCGCTCTCGCGCAGCCAGCAAC
CGCCTGCTGCTGGCCAAACT

Product: putative glutathione peroxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MNCFYSQEPAMTPFYQLTATRLRGQPLSMADYAGKVVLVVNTASHCGFTPQYAGLEALYKKYAAQGLVVLGFPCNQFGKQ
EPGGADEIEQTCHVNYGVSFPMFEKVDVNGPAAHPLFRYLKQALPGVLGGRIKWNFTKFLIGRDGTPLTRFAPFTTPEKM
EASIVAALTR

Sequences:

>Translated_170_residues
MNCFYSQEPAMTPFYQLTATRLRGQPLSMADYAGKVVLVVNTASHCGFTPQYAGLEALYKKYAAQGLVVLGFPCNQFGKQ
EPGGADEIEQTCHVNYGVSFPMFEKVDVNGPAAHPLFRYLKQALPGVLGGRIKWNFTKFLIGRDGTPLTRFAPFTTPEKM
EASIVAALTR
>Mature_170_residues
MNCFYSQEPAMTPFYQLTATRLRGQPLSMADYAGKVVLVVNTASHCGFTPQYAGLEALYKKYAAQGLVVLGFPCNQFGKQ
EPGGADEIEQTCHVNYGVSFPMFEKVDVNGPAAHPLFRYLKQALPGVLGGRIKWNFTKFLIGRDGTPLTRFAPFTTPEKM
EASIVAALTR

Specific function: Not Essential For B12 Transport; However, It Is An Auxiliary Component Of The Transport System. [C]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI15618997, Length=158, Percent_Identity=42.4050632911392, Blast_Score=128, Evalue=3e-30,
Organism=Homo sapiens, GI90903240, Length=173, Percent_Identity=39.8843930635838, Blast_Score=126, Evalue=8e-30,
Organism=Homo sapiens, GI75709200, Length=154, Percent_Identity=42.2077922077922, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI4557629, Length=191, Percent_Identity=37.696335078534, Blast_Score=115, Evalue=1e-26,
Organism=Homo sapiens, GI192455698, Length=163, Percent_Identity=37.4233128834356, Blast_Score=113, Evalue=8e-26,
Organism=Homo sapiens, GI6006001, Length=177, Percent_Identity=39.5480225988701, Blast_Score=112, Evalue=1e-25,
Organism=Homo sapiens, GI90903238, Length=129, Percent_Identity=44.9612403100775, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI41406084, Length=172, Percent_Identity=37.2093023255814, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI33186887, Length=166, Percent_Identity=39.1566265060241, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI32967607, Length=164, Percent_Identity=35.3658536585366, Blast_Score=91, Evalue=4e-19,
Organism=Escherichia coli, GI1788003, Length=171, Percent_Identity=43.2748538011696, Blast_Score=144, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17506887, Length=159, Percent_Identity=43.3962264150943, Blast_Score=144, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17535473, Length=159, Percent_Identity=42.7672955974843, Blast_Score=137, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI193210707, Length=161, Percent_Identity=39.7515527950311, Blast_Score=117, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71993584, Length=156, Percent_Identity=37.1794871794872, Blast_Score=115, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17550320, Length=154, Percent_Identity=36.3636363636364, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI193209493, Length=162, Percent_Identity=32.7160493827161, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71999642, Length=67, Percent_Identity=44.7761194029851, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71993573, Length=93, Percent_Identity=39.7849462365591, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319721, Length=160, Percent_Identity=49.375, Blast_Score=177, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6322228, Length=161, Percent_Identity=49.0683229813665, Blast_Score=175, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6322826, Length=161, Percent_Identity=42.2360248447205, Blast_Score=143, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24656777, Length=158, Percent_Identity=46.8354430379747, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24656772, Length=154, Percent_Identity=47.4025974025974, Blast_Score=141, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24656767, Length=155, Percent_Identity=47.0967741935484, Blast_Score=141, Evalue=2e-34,
Organism=Drosophila melanogaster, GI85726443, Length=160, Percent_Identity=38.125, Blast_Score=100, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: =1.11.1.9 [H]

Molecular weight: Translated: 18706; Mature: 18706

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1 ; PS00763 GLUTATHIONE_PEROXID_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNCFYSQEPAMTPFYQLTATRLRGQPLSMADYAGKVVLVVNTASHCGFTPQYAGLEALYK
CCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHCCEEEEEEECHHHCCCCCCHHHHHHHHH
KYAAQGLVVLGFPCNQFGKQEPGGADEIEQTCHVNYGVSFPMFEKVDVNGPAAHPLFRYL
HHHHCCEEEEECCCHHHCCCCCCCHHHHHHHHCCCCCCCCCCEEEECCCCCCCCHHHHHH
KQALPGVLGGRIKWNFTKFLIGRDGTPLTRFAPFTTPEKMEASIVAALTR
HHHCCHHHCCCEEEEEEEEEEECCCCCCCEECCCCCCHHHHHHHHHEECC
>Mature Secondary Structure
MNCFYSQEPAMTPFYQLTATRLRGQPLSMADYAGKVVLVVNTASHCGFTPQYAGLEALYK
CCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHCCEEEEEEECHHHCCCCCCHHHHHHHHH
KYAAQGLVVLGFPCNQFGKQEPGGADEIEQTCHVNYGVSFPMFEKVDVNGPAAHPLFRYL
HHHHCCEEEEECCCHHHCCCCCCCHHHHHHHHCCCCCCCCCCEEEECCCCCCCCHHHHHH
KQALPGVLGGRIKWNFTKFLIGRDGTPLTRFAPFTTPEKMEASIVAALTR
HHHCCHHHCCCEEEEEEEEEEECCCCCCCEECCCCCCHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]