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The map label for this gene is pyrG [H]

Identifier: 238894227

GI number: 238894227

Start: 2120489

End: 2121256

Strand: Direct

Name: pyrG [H]

Synonym: KP1_2195

Alternate gene names: 238894227

Gene position: 2120489-2121256 (Clockwise)

Preceding gene: 238894224

Following gene: 238894230

Centisome position: 40.4

GC content: 63.54

Gene sequence:

>768_bases
TTGTGTTCCACAGGCGGGATCGCTATTCTGACGTGCCTTGTGCTGTCCGTCTCGTCCAGACATAAGGAACCTGCTATGAA
AACTCCTTTACGCCTCGCCCTTGTCGGCGATTATCACCCCGATATTGTTGCCCATCAGGCCATTCCCCTGGCGATAGACG
ATGCCGCCGCCGTGCTGGAGCAGCCGGTGAAATATGACTGGCTCGTCACCCCGTCGATCGCCTCCGGCGAGGCGCTGGCG
GAGTACGATGCCATCTGGGTCGTTCCCGGCAGCCCGTATCGTCACCCGGAAGGCGTGTTTACCGCGATCCGCTATGCCCG
GGAAAACAGCATTCCTTTCCTCGGCACCTGCGGCGGCTTTCAGCACGCGGTGATTGAATACGCCCGCAACGTGCTCGGCT
GGCAGGACGCCGGACATGCGGAAACCGACAGCGAAGGGCGGATGGTGATCGCTCCCCTCAGCTGCTCGCTGGTGGAGACC
TCTGCCGTCGTCGAGCTGCGGGCGAATACGCTGATTGCCCGCGCCTATGGCCGGGAGAGCATTGAAGAGGGCTACCACTG
CCGGTACGGCGTGAGCAGCGCGTTTGCGGCGGAGCTGGAGCAGGGCGATCTGCGCGTCACCGGCTGGGATGAAGAGGGTG
AGATCCGCGCCGTCGAGCTGGTGACGCACCCGTTTTTTGTCGCCACCTTGTTCCAGCATGAGCGTCACGCGCTGGACGGG
CGTCCCGCGCCGCTGGTGCAGGCGTTTCTCCGCGCCGCGGCACAATAA

Upstream 100 bases:

>100_bases
GCAGGCGCTGACCAAAAGCTTATTTTTCATTCTCTCTCCCCTACGCGCTTTTTCCAGTATACCTCACCCGTCGGCCACGG
CGGTGGGGTGAAAATAAGGA

Downstream 100 bases:

>100_bases
TTCCACCGGCAGCGGGCGCTGCCGGTCATCTTCAGGGGTGAATTTCCCGGTCACGTCCGGCGAGCGCGCCGCAGAACGCC
ATCACCAGCGAAATCAGCGC

Product: hypothetical protein

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MCSTGGIAILTCLVLSVSSRHKEPAMKTPLRLALVGDYHPDIVAHQAIPLAIDDAAAVLEQPVKYDWLVTPSIASGEALA
EYDAIWVVPGSPYRHPEGVFTAIRYARENSIPFLGTCGGFQHAVIEYARNVLGWQDAGHAETDSEGRMVIAPLSCSLVET
SAVVELRANTLIARAYGRESIEEGYHCRYGVSSAFAAELEQGDLRVTGWDEEGEIRAVELVTHPFFVATLFQHERHALDG
RPAPLVQAFLRAAAQ

Sequences:

>Translated_255_residues
MCSTGGIAILTCLVLSVSSRHKEPAMKTPLRLALVGDYHPDIVAHQAIPLAIDDAAAVLEQPVKYDWLVTPSIASGEALA
EYDAIWVVPGSPYRHPEGVFTAIRYARENSIPFLGTCGGFQHAVIEYARNVLGWQDAGHAETDSEGRMVIAPLSCSLVET
SAVVELRANTLIARAYGRESIEEGYHCRYGVSSAFAAELEQGDLRVTGWDEEGEIRAVELVTHPFFVATLFQHERHALDG
RPAPLVQAFLRAAAQ
>Mature_255_residues
MCSTGGIAILTCLVLSVSSRHKEPAMKTPLRLALVGDYHPDIVAHQAIPLAIDDAAAVLEQPVKYDWLVTPSIASGEALA
EYDAIWVVPGSPYRHPEGVFTAIRYARENSIPFLGTCGGFQHAVIEYARNVLGWQDAGHAETDSEGRMVIAPLSCSLVET
SAVVELRANTLIARAYGRESIEEGYHCRYGVSSAFAAELEQGDLRVTGWDEEGEIRAVELVTHPFFVATLFQHERHALDG
RPAPLVQAFLRAAAQ

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=249, Percent_Identity=29.3172690763052, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI28559085, Length=212, Percent_Identity=31.6037735849057, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI28559083, Length=212, Percent_Identity=31.6037735849057, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI221316689, Length=212, Percent_Identity=31.6037735849057, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1789142, Length=200, Percent_Identity=30.5, Blast_Score=92, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI25148299, Length=188, Percent_Identity=28.1914893617021, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319432, Length=241, Percent_Identity=26.9709543568465, Blast_Score=79, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6322563, Length=238, Percent_Identity=24.7899159663866, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24664469, Length=180, Percent_Identity=32.2222222222222, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21357815, Length=180, Percent_Identity=32.2222222222222, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 27737; Mature: 27737

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCSTGGIAILTCLVLSVSSRHKEPAMKTPLRLALVGDYHPDIVAHQAIPLAIDDAAAVLE
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHCCCCEEECHHHHHHH
QPVKYDWLVTPSIASGEALAEYDAIWVVPGSPYRHPEGVFTAIRYARENSIPFLGTCGGF
CCCCEEEEECCCCCCCCHHHHCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEECCCCH
QHAVIEYARNVLGWQDAGHAETDSEGRMVIAPLSCSLVETSAVVELRANTLIARAYGRES
HHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCEEEHHHHHEEEHHHHHHHHHHCHHH
IEEGYHCRYGVSSAFAAELEQGDLRVTGWDEEGEIRAVELVTHPFFVATLFQHERHALDG
HHCCCCEECCCCHHHHHHHCCCCEEEECCCCCCCEEEEEEEHHHHHHHHHHHHHHHHCCC
RPAPLVQAFLRAAAQ
CCHHHHHHHHHHHCC
>Mature Secondary Structure
MCSTGGIAILTCLVLSVSSRHKEPAMKTPLRLALVGDYHPDIVAHQAIPLAIDDAAAVLE
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHCCCCEEECHHHHHHH
QPVKYDWLVTPSIASGEALAEYDAIWVVPGSPYRHPEGVFTAIRYARENSIPFLGTCGGF
CCCCEEEEECCCCCCCCHHHHCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEECCCCH
QHAVIEYARNVLGWQDAGHAETDSEGRMVIAPLSCSLVETSAVVELRANTLIARAYGRES
HHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCEEEHHHHHEEEHHHHHHHHHHCHHH
IEEGYHCRYGVSSAFAAELEQGDLRVTGWDEEGEIRAVELVTHPFFVATLFQHERHALDG
HHCCCCEECCCCHHHHHHHCCCCEEEECCCCCCCEEEEEEEHHHHHHHHHHHHHHHHCCC
RPAPLVQAFLRAAAQ
CCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA