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The map label for this gene is ycdC [H]

Identifier: 238894078

GI number: 238894078

Start: 1974162

End: 1974800

Strand: Direct

Name: ycdC [H]

Synonym: KP1_2028

Alternate gene names: 238894078

Gene position: 1974162-1974800 (Clockwise)

Preceding gene: 238894070

Following gene: 238894081

Centisome position: 37.61

GC content: 59.47

Gene sequence:

>639_bases
ATGGCACAGGGCGCGGTGAAGAAAAGCGGCAAACGTTCACAAGCGGTCAGCGCCAAAAAGGAGGCCATCCTGGCCGCCGC
GCTGGAGGCATTTTCGCAATTTGGTATTCACGGTACGCGGCTGGAGCAGGTGGCTGAGCGCGCCGGGGTATCGAAAACCA
ATCTGCTCTATTACTACCCTTCGAAAGAGGCGCTGTATGTGGCAGTCCTGCAGCAGATCCTCGCCATCTGGCTGGCGCCG
CTGAAGGCCTTTCGTGAGGATATCAGCCCGCTGGTGGCGATCCGCGAATATATTCGCCTGAAGCTGGAGGTGTCCCGCGA
TCACCCCCAGGCCTCGAAGCTCTTCTGCCTCGAGATGCTGCAGGGGGCGCCGCTGCTGATGGGCGAACTGACCGGGGATC
TGAAAGCGCTGGTCGACGAAAAATCGGCGATAGTCTCCGGCTGGATCGACCGCGGCAAGCTGGCGCCGGTCGATCCACAG
CATTTAATCTTTATGATCTGGGCTACCACCCAGCATTACGCCGACTTCGCCACCCAGGTGGAGGCGGTCACCGGCGCCAC
GCTGCAGGATGCGGCCTTTTTTGAACAAACGGTCGATAATGTCCAGCGGATGATTATCGAAGGCATTCGCGTCCGTTAA

Upstream 100 bases:

>100_bases
GTGCACGAAAAAACGGCAGTCATGCGCAATCAGGGTGCATGGGGTCGTGCCGGCGCAGGGCTTTTGCTATGCTGGTGGCA
TCAACTGAAGGAGAGGATGT

Downstream 100 bases:

>100_bases
TTGGCGGGCGGCAGCGGGCAGCTTTGATCGCCATCCTCGCACTGTAGCAGCGAGGCGAGGAAAGACTCCCGCTCCACGCT
CTTATCGGTCATGCACTGGC

Product: hypothetical transcriptional regulator

Products: NA

Alternate protein names: Rut operon repressor [H]

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MAQGAVKKSGKRSQAVSAKKEAILAAALEAFSQFGIHGTRLEQVAERAGVSKTNLLYYYPSKEALYVAVLQQILAIWLAP
LKAFREDISPLVAIREYIRLKLEVSRDHPQASKLFCLEMLQGAPLLMGELTGDLKALVDEKSAIVSGWIDRGKLAPVDPQ
HLIFMIWATTQHYADFATQVEAVTGATLQDAAFFEQTVDNVQRMIIEGIRVR

Sequences:

>Translated_212_residues
MAQGAVKKSGKRSQAVSAKKEAILAAALEAFSQFGIHGTRLEQVAERAGVSKTNLLYYYPSKEALYVAVLQQILAIWLAP
LKAFREDISPLVAIREYIRLKLEVSRDHPQASKLFCLEMLQGAPLLMGELTGDLKALVDEKSAIVSGWIDRGKLAPVDPQ
HLIFMIWATTQHYADFATQVEAVTGATLQDAAFFEQTVDNVQRMIIEGIRVR
>Mature_211_residues
AQGAVKKSGKRSQAVSAKKEAILAAALEAFSQFGIHGTRLEQVAERAGVSKTNLLYYYPSKEALYVAVLQQILAIWLAPL
KAFREDISPLVAIREYIRLKLEVSRDHPQASKLFCLEMLQGAPLLMGELTGDLKALVDEKSAIVSGWIDRGKLAPVDPQH
LIFMIWATTQHYADFATQVEAVTGATLQDAAFFEQTVDNVQRMIIEGIRVR

Specific function: Master transcription regulator which represses the degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for maintenance of metabolic balance between pyrimidines and purines. It also regulates the synthesis of pyrimidine nucleotides and arginin

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787249, Length=212, Percent_Identity=80.6603773584906, Blast_Score=365, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR019915
- InterPro:   IPR001647
- InterPro:   IPR013573 [H]

Pfam domain/function: PF08362 TetR_C_3; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 23471; Mature: 23339

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQGAVKKSGKRSQAVSAKKEAILAAALEAFSQFGIHGTRLEQVAERAGVSKTNLLYYYP
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEC
SKEALYVAVLQQILAIWLAPLKAFREDISPLVAIREYIRLKLEVSRDHPQASKLFCLEML
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHH
QGAPLLMGELTGDLKALVDEKSAIVSGWIDRGKLAPVDPQHLIFMIWATTQHYADFATQV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEEEEEECHHHHHHHHHHH
EAVTGATLQDAAFFEQTVDNVQRMIIEGIRVR
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AQGAVKKSGKRSQAVSAKKEAILAAALEAFSQFGIHGTRLEQVAERAGVSKTNLLYYYP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEC
SKEALYVAVLQQILAIWLAPLKAFREDISPLVAIREYIRLKLEVSRDHPQASKLFCLEML
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHH
QGAPLLMGELTGDLKALVDEKSAIVSGWIDRGKLAPVDPQHLIFMIWATTQHYADFATQV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEEEEEECHHHHHHHHHHH
EAVTGATLQDAAFFEQTVDNVQRMIIEGIRVR
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]