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The map label for this gene is pyrD [H]

Identifier: 238894001

GI number: 238894001

Start: 1897403

End: 1898440

Strand: Direct

Name: pyrD [H]

Synonym: KP1_1946

Alternate gene names: 238894001

Gene position: 1897403-1898440 (Clockwise)

Preceding gene: 238893995

Following gene: 238894002

Centisome position: 36.15

GC content: 52.02

Gene sequence:

>1038_bases
TTGCACACCGGGAATCCAGGAGAGTTCATGTACTACCCCTTCGTTCGTAAAGCCCTTTTTCAGCTCGATCCTGAGCGCGC
TCATGAAGTTACCTTTCAACAATTACGCCGTGTCACCGGGACGCCGCTGGAAATGCTGGTTCGCCAGAAGGTACCGGCCA
GGCCTGTCACCTGCATGGGGCTAACCTTTAAAAACCCGCTGGGTCTGGCGGCCGGGCTGGATAAAAATGGGGAATGCATT
GACGCGCTGGGCGCGATGGGGTTTGGTTCGATTGAGATCGGCACCGTGACGCCGCGTCCGCAGCCGGGCAACGATAAGCC
AAGGATCTTCCGTCTGGTTGATGCCGAGGGATTGATCAACCGCATGGGCTTTAATAACCATGGCGTCGATAACCTGGTTG
AGAACGTGAAAAAGGCGCATTTTGACGGCGTGCTGGGTATCAATATCGGCAAAAATAAAGATACGCCGGTTGAGCACGGG
AAAGATGATTACCTGATTTGTATGGAAAAAGTCTATCCGTACGCCGGGTATATCGCCATTAATATCTCCTCGCCGAATAC
CCCAGGGCTGCGCACGCTGCAATACGGCGAAGCGCTGGATGATTTACTCTCCGGTATTAAAAATAAGCAGCTCGAGCTGC
AGCAGAAGCATCAAAAATATGTCCCGGTCGCCGTAAAGATCGCGCCGGATCTTTTACCTGAGGAATTGATCCAGGTTGCC
GATAGCCTCGTGCGTCATAATATTGATGGCGTGATTGCAACCAATACCACCCTCGATCGTTCCCTGGTTCAGGGAATGAA
ACATTGCGATGAGACCGGCGGGCTTAGCGGTCGTCCATTACAATTAAAAAGCACTGAAATTATCCGTATGCTCTCCGCTG
AGCTGAATGGCCGTTTGCCTATCATCGGCGTGGGCGGCATTGATTCGGTGATTGCCGCGCGGGAAAAGATTGCCGCCGGG
GCATCGCTGGTGCAGATCTATTCTGGATTTATTTTTAAAGGTCCGCCGCTGATTAAAGAAATTGTTACCCACATCTAA

Upstream 100 bases:

>100_bases
TAATGGCGCGCGGGGTAGGTAATCGTTTGCGCTGATGGGGGATTTTTTGTCGCAGGTCAATTCCCTTTCCGCAACAGATC
GCACATAATACGCCCCCGGT

Downstream 100 bases:

>100_bases
TCTTTTCCTCCTCTGAATCCCACCCAGGGCTTTATTTCCGGCCCTGGTTGTTTTATATTCCCTCACTGTTGCTTATTTAA
ACATTTTAGACTTTTCTTAA

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MHTGNPGEFMYYPFVRKALFQLDPERAHEVTFQQLRRVTGTPLEMLVRQKVPARPVTCMGLTFKNPLGLAAGLDKNGECI
DALGAMGFGSIEIGTVTPRPQPGNDKPRIFRLVDAEGLINRMGFNNHGVDNLVENVKKAHFDGVLGINIGKNKDTPVEHG
KDDYLICMEKVYPYAGYIAINISSPNTPGLRTLQYGEALDDLLSGIKNKQLELQQKHQKYVPVAVKIAPDLLPEELIQVA
DSLVRHNIDGVIATNTTLDRSLVQGMKHCDETGGLSGRPLQLKSTEIIRMLSAELNGRLPIIGVGGIDSVIAAREKIAAG
ASLVQIYSGFIFKGPPLIKEIVTHI

Sequences:

>Translated_345_residues
MHTGNPGEFMYYPFVRKALFQLDPERAHEVTFQQLRRVTGTPLEMLVRQKVPARPVTCMGLTFKNPLGLAAGLDKNGECI
DALGAMGFGSIEIGTVTPRPQPGNDKPRIFRLVDAEGLINRMGFNNHGVDNLVENVKKAHFDGVLGINIGKNKDTPVEHG
KDDYLICMEKVYPYAGYIAINISSPNTPGLRTLQYGEALDDLLSGIKNKQLELQQKHQKYVPVAVKIAPDLLPEELIQVA
DSLVRHNIDGVIATNTTLDRSLVQGMKHCDETGGLSGRPLQLKSTEIIRMLSAELNGRLPIIGVGGIDSVIAAREKIAAG
ASLVQIYSGFIFKGPPLIKEIVTHI
>Mature_345_residues
MHTGNPGEFMYYPFVRKALFQLDPERAHEVTFQQLRRVTGTPLEMLVRQKVPARPVTCMGLTFKNPLGLAAGLDKNGECI
DALGAMGFGSIEIGTVTPRPQPGNDKPRIFRLVDAEGLINRMGFNNHGVDNLVENVKKAHFDGVLGINIGKNKDTPVEHG
KDDYLICMEKVYPYAGYIAINISSPNTPGLRTLQYGEALDDLLSGIKNKQLELQQKHQKYVPVAVKIAPDLLPEELIQVA
DSLVRHNIDGVIATNTTLDRSLVQGMKHCDETGGLSGRPLQLKSTEIIRMLSAELNGRLPIIGVGGIDSVIAAREKIAAG
ASLVQIYSGFIFKGPPLIKEIVTHI

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=333, Percent_Identity=44.7447447447448, Blast_Score=239, Evalue=2e-63,
Organism=Escherichia coli, GI1787177, Length=336, Percent_Identity=91.9642857142857, Blast_Score=633, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17509475, Length=303, Percent_Identity=45.8745874587459, Blast_Score=242, Evalue=2e-64,
Organism=Drosophila melanogaster, GI281361352, Length=293, Percent_Identity=43.0034129692833, Blast_Score=237, Evalue=9e-63,
Organism=Drosophila melanogaster, GI17137316, Length=293, Percent_Identity=43.0034129692833, Blast_Score=237, Evalue=9e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 37720; Mature: 37720

Theoretical pI: Translated: 8.00; Mature: 8.00

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTGNPGEFMYYPFVRKALFQLDPERAHEVTFQQLRRVTGTPLEMLVRQKVPARPVTCMG
CCCCCCCCEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEE
LTFKNPLGLAAGLDKNGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRIFRLVDAEGLIN
EEECCCCCCCCCCCCCCCHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEEECHHHHHH
RMGFNNHGVDNLVENVKKAHFDGVLGINIGKNKDTPVEHGKDDYLICMEKVYPYAGYIAI
HCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEEEHHHHCCCCCEEEE
NISSPNTPGLRTLQYGEALDDLLSGIKNKQLELQQKHQKYVPVAVKIAPDLLPEELIQVA
EECCCCCCCCEEHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHH
DSLVRHNIDGVIATNTTLDRSLVQGMKHCDETGGLSGRPLQLKSTEIIRMLSAELNGRLP
HHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHCCCCC
IIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI
EEECCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MHTGNPGEFMYYPFVRKALFQLDPERAHEVTFQQLRRVTGTPLEMLVRQKVPARPVTCMG
CCCCCCCCEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEE
LTFKNPLGLAAGLDKNGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRIFRLVDAEGLIN
EEECCCCCCCCCCCCCCCHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEEECHHHHHH
RMGFNNHGVDNLVENVKKAHFDGVLGINIGKNKDTPVEHGKDDYLICMEKVYPYAGYIAI
HCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEEEHHHHCCCCCEEEE
NISSPNTPGLRTLQYGEALDDLLSGIKNKQLELQQKHQKYVPVAVKIAPDLLPEELIQVA
EECCCCCCCCEEHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHH
DSLVRHNIDGVIATNTTLDRSLVQGMKHCDETGGLSGRPLQLKSTEIIRMLSAELNGRLP
HHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHCCCCC
IIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI
EEECCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA