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The map label for this gene is dacC [H]

Identifier: 238893899

GI number: 238893899

Start: 1776667

End: 1777953

Strand: Direct

Name: dacC [H]

Synonym: KP1_1832

Alternate gene names: 238893899

Gene position: 1776667-1777953 (Clockwise)

Preceding gene: 238893895

Following gene: 238893902

Centisome position: 33.85

GC content: 56.41

Gene sequence:

>1287_bases
TTGTACGCTTTACTCACCGGTTGCTGCGGCGCGGTCAGAGTGGCGCGGCATATTTTGTTTGGAAAGGATACTTGGGTGGC
TCTTATGATGCATGACGCTTTTTCCCTTCGCGGCCTCGCGGCAGGTTGCGCGCTGTTATTTCTTGTCGCACCTGCGGTGC
AGGCTGCGGAACAACTCCCCGACGCCCCTTCAATTAACGCTCGCGCCTGGATCCTGATGGACTATGCCAGCGGGAAGGTG
CTCAGCGAAGGCAATGCCGATGAAAAACTCGACCCGGCCAGTCTGACGAAGATCATGACCAGCTACGTGGTAGGGCAGGC
AATAAAAGCGGGAAAAATCAAACTGACCGATATGGTGACCGTTGGGCGCGATGCCTGGGCGACCGGCAACCCGGCGCTGC
GCGGCTCATCGGTGATGTTCCTCAAGCCTGGCATGCAGGTTTCCGTAGAAGATCTGAATAAAGGGGTCATCATTCAGTCC
GGTAACGACGCCAGCATTGCGATTGCTGACTACGTAGCGGGCAGCCAGGACGCTTTCGTTAGCCTGATGAACGGCTACGC
CAAAAAAATGGGGCTGACCAACACCACCTTTATGACCGTCCACGGCCTTGACGCGCCGGGGCAGTTCAGCACCGCCCGCG
ATATGGCGCTGCTGACCAAAGCGATGATCCACGACGTACCGGAAGAGTACGCGGTACATAAAGAGAAAGAGTTCACTTTC
AATAAAATTCGCCAGCCGAACCGCAACCGCCTGCTGTGGAGCAGCAACCTCAACGCCGATGGCGTGAAAACCGGGACCAC
CGCCGGGGCCGGCTATAACCTCGTCTCCTCGGCCACTCAGGGTGATATGCGTTTGATCGCCGTGGTGCTGGGGACCAAAA
CCGACCGCATTCGCTTTAACGAGTCAGAAAAACTGCTGACCTGGGGCTTCCGCTTCTTTGAAACCGTGACGCCGATTAAA
CCAGATGCCACCTTCGTTACCCAGCGCGTGTGGTTTGGCGATAGCAATGAAGCGAAACTGGGGGCTGGCGAGGCGGGCTC
TATCACTTTGCCGAAGGGCCAGCTGAAAAACCTGAAAGCCAGCTATACCTTAAATCAGCCGCAGCTTACCGCGCCGCTGG
AGAAGGGGCAGGTGGTCGGGACTATCGACTTTAAGCTAAATGATAAAACCATTGAACAGCGTCCGCTGATTGTCATGGAG
TCGGTAAAAGAGGGCGGCTTCTTCAGCCGGATGATCGACTTCGTGCTGATGAAACTGCACGGCTGGTTTGGCAGCTGGTT
CTCCTGA

Upstream 100 bases:

>100_bases
AGGCGATTACGATCAAAAAAATTGTTCTGATTAAAGCACAGCGGCATGTTATTGCGTAAACTTTAAAAACTTTACCAACT
CGCTGTTTCTTTAAGGTCAT

Downstream 100 bases:

>100_bases
TGCCTGCCCGCGCCCTGCGGGGCGCGGGCAGCGACGCTTCAATACAGTAGGGAAATCTGCTGCGCCTTCGCCAGCGCGAC
CAGCTCATCATCCGGGCAGA

Product: D-alanyl-D-alanine carboxypeptidase fraction C

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 6; PBP-6 [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MYALLTGCCGAVRVARHILFGKDTWVALMMHDAFSLRGLAAGCALLFLVAPAVQAAEQLPDAPSINARAWILMDYASGKV
LSEGNADEKLDPASLTKIMTSYVVGQAIKAGKIKLTDMVTVGRDAWATGNPALRGSSVMFLKPGMQVSVEDLNKGVIIQS
GNDASIAIADYVAGSQDAFVSLMNGYAKKMGLTNTTFMTVHGLDAPGQFSTARDMALLTKAMIHDVPEEYAVHKEKEFTF
NKIRQPNRNRLLWSSNLNADGVKTGTTAGAGYNLVSSATQGDMRLIAVVLGTKTDRIRFNESEKLLTWGFRFFETVTPIK
PDATFVTQRVWFGDSNEAKLGAGEAGSITLPKGQLKNLKASYTLNQPQLTAPLEKGQVVGTIDFKLNDKTIEQRPLIVME
SVKEGGFFSRMIDFVLMKLHGWFGSWFS

Sequences:

>Translated_428_residues
MYALLTGCCGAVRVARHILFGKDTWVALMMHDAFSLRGLAAGCALLFLVAPAVQAAEQLPDAPSINARAWILMDYASGKV
LSEGNADEKLDPASLTKIMTSYVVGQAIKAGKIKLTDMVTVGRDAWATGNPALRGSSVMFLKPGMQVSVEDLNKGVIIQS
GNDASIAIADYVAGSQDAFVSLMNGYAKKMGLTNTTFMTVHGLDAPGQFSTARDMALLTKAMIHDVPEEYAVHKEKEFTF
NKIRQPNRNRLLWSSNLNADGVKTGTTAGAGYNLVSSATQGDMRLIAVVLGTKTDRIRFNESEKLLTWGFRFFETVTPIK
PDATFVTQRVWFGDSNEAKLGAGEAGSITLPKGQLKNLKASYTLNQPQLTAPLEKGQVVGTIDFKLNDKTIEQRPLIVME
SVKEGGFFSRMIDFVLMKLHGWFGSWFS
>Mature_428_residues
MYALLTGCCGAVRVARHILFGKDTWVALMMHDAFSLRGLAAGCALLFLVAPAVQAAEQLPDAPSINARAWILMDYASGKV
LSEGNADEKLDPASLTKIMTSYVVGQAIKAGKIKLTDMVTVGRDAWATGNPALRGSSVMFLKPGMQVSVEDLNKGVIIQS
GNDASIAIADYVAGSQDAFVSLMNGYAKKMGLTNTTFMTVHGLDAPGQFSTARDMALLTKAMIHDVPEEYAVHKEKEFTF
NKIRQPNRNRLLWSSNLNADGVKTGTTAGAGYNLVSSATQGDMRLIAVVLGTKTDRIRFNESEKLLTWGFRFFETVTPIK
PDATFVTQRVWFGDSNEAKLGAGEAGSITLPKGQLKNLKASYTLNQPQLTAPLEKGQVVGTIDFKLNDKTIEQRPLIVME
SVKEGGFFSRMIDFVLMKLHGWFGSWFS

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=N-terminal lies in the periplasmic space [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=393, Percent_Identity=86.2595419847328, Blast_Score=710, Evalue=0.0,
Organism=Escherichia coli, GI1786851, Length=366, Percent_Identity=62.0218579234973, Blast_Score=489, Evalue=1e-139,
Organism=Escherichia coli, GI87082022, Length=385, Percent_Identity=47.7922077922078, Blast_Score=371, Evalue=1e-104,
Organism=Escherichia coli, GI87082054, Length=251, Percent_Identity=26.2948207171315, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 46538; Mature: 46538

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYALLTGCCGAVRVARHILFGKDTWVALMMHDAFSLRGLAAGCALLFLVAPAVQAAEQLP
CCEEHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DAPSINARAWILMDYASGKVLSEGNADEKLDPASLTKIMTSYVVGQAIKAGKIKLTDMVT
CCCCCCCEEEEEEEECCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEE
VGRDAWATGNPALRGSSVMFLKPGMQVSVEDLNKGVIIQSGNDASIAIADYVAGSQDAFV
ECCCCCCCCCCCCCCCEEEEECCCCEEEHHHCCCCEEEECCCCCEEEEEEECCCCHHHHH
SLMNGYAKKMGLTNTTFMTVHGLDAPGQFSTARDMALLTKAMIHDVPEEYAVHKEKEFTF
HHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCH
NKIRQPNRNRLLWSSNLNADGVKTGTTAGAGYNLVSSATQGDMRLIAVVLGTKTDRIRFN
HHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHCCCCCCEEEEEEEECCCCCEEEEC
ESEKLLTWGFRFFETVTPIKPDATFVTQRVWFGDSNEAKLGAGEAGSITLPKGQLKNLKA
CCCCEEHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCEECCCCCCEEECCCHHHHCCEE
SYTLNQPQLTAPLEKGQVVGTIDFKLNDKTIEQRPLIVMESVKEGGFFSRMIDFVLMKLH
EEEECCCCEECCCCCCCEEEEEEEEECCCCCCCCCEEEEEHHHCCCHHHHHHHHHHHHHH
GWFGSWFS
HHHHCCCC
>Mature Secondary Structure
MYALLTGCCGAVRVARHILFGKDTWVALMMHDAFSLRGLAAGCALLFLVAPAVQAAEQLP
CCEEHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DAPSINARAWILMDYASGKVLSEGNADEKLDPASLTKIMTSYVVGQAIKAGKIKLTDMVT
CCCCCCCEEEEEEEECCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEE
VGRDAWATGNPALRGSSVMFLKPGMQVSVEDLNKGVIIQSGNDASIAIADYVAGSQDAFV
ECCCCCCCCCCCCCCCEEEEECCCCEEEHHHCCCCEEEECCCCCEEEEEEECCCCHHHHH
SLMNGYAKKMGLTNTTFMTVHGLDAPGQFSTARDMALLTKAMIHDVPEEYAVHKEKEFTF
HHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCH
NKIRQPNRNRLLWSSNLNADGVKTGTTAGAGYNLVSSATQGDMRLIAVVLGTKTDRIRFN
HHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHCCCCCCEEEEEEEECCCCCEEEEC
ESEKLLTWGFRFFETVTPIKPDATFVTQRVWFGDSNEAKLGAGEAGSITLPKGQLKNLKA
CCCCEEHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCEECCCCCCEEECCCHHHHCCEE
SYTLNQPQLTAPLEKGQVVGTIDFKLNDKTIEQRPLIVMESVKEGGFFSRMIDFVLMKLH
EEEECCCCEECCCCCCCEEEEEEEEECCCCCCCCCEEEEEHHHCCCHHHHHHHHHHHHHH
GWFGSWFS
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3279397; 8905232; 9278503; 7042389 [H]