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The map label for this gene is moeA [H]

Identifier: 238893886

GI number: 238893886

Start: 1760875

End: 1762110

Strand: Reverse

Name: moeA [H]

Synonym: KP1_1819

Alternate gene names: 238893886

Gene position: 1762110-1760875 (Counterclockwise)

Preceding gene: 238893892

Following gene: 238893885

Centisome position: 33.57

GC content: 63.83

Gene sequence:

>1236_bases
ATGGATTTTACCGCCGGACTGATGCCGCTCGACACAGCCCTCGCCCAGATGCTCGATCGTATTACGCCGCTGAACGCGAC
GGAAACTGTACCGCTGTTGCAGGCCTTCTCGCGTGTGACCGCCCATGACATCGTCTCTCCGCTGGATGTGCCCGGCTTTG
ATAACGCGGCGATGGATGGCTATGCCGTCCGGCTGAACGACCTTCGCGACGGCGCGGCGCTGCCGGTCGCTGGTAAGGCC
TTCGCCGGCCAGCCGTTCAACGACGCCTGGCCGTCGGGCACCTGTATCCGCATCATGACCGGCGCGCCGGTGCCGGAAGG
CTGCGATGCGGTGGTGATGCAGGAAGAGACTGAACAGACCGAGGCCGGCGTGCGCTTTATCGCGCCGGTAAAAGCCGGGC
AGCATATTCGCCGCCGCGGAGAAGATATTGCCCACGGCGCGGTGGTCTTCCCGGCGGGGATACCCCTGACGGTGGCCGAG
CTGCCGGTGCTGGCCTCGCTGGGCATTGCCGAGGTCGAGGTGGTGCGCAAGGTACGCGTCGCGGTCTTCTCAACCGGCGA
TGAGCTGCAGCTGCCGGGTCAACCGCTCGGCGACGGCCAGATTTACGATACCAACCGCCTGGCAGTGCACCTGATGCTGC
AGCAGTTGGGCTACGAGGTCATTAACCTCGGCATTATTCCTGACGACCCGGCGAAGCTGCGCGACGCCTTTATCGCCGCC
GACCAGCAGGCCGATGTGGTCATTAGCTCAGGCGGCGTCTCGGTGGGTGAAGCCGATTACACCAAAACTATCCTCGAAGA
GCTGGGGGAGATCGGATTCTGGAAGCTGGCGATTAAGCCGGGGAAACCCTTCGCCTTCGGCAAGCTCAGCAGCAGCTGGT
TCTGCGGCCTGCCGGGTAACCCGGTGTCTGCCACCGTCACCTTCTGTCAGCTGGTGCAACCCCTGCTGGCGAAACTCTCG
GGCAAGCACGGCCCGCTTCAGGCGCCCCGCCTGCGGGTCCGCGCCGCCACGCGCCTGAAAAAGTCGCCTGGCCGCCTCGA
TTTTCAGCGCGGTATTCTGCAGCGTAACCCGGACGGCGAACTGGTGGTGAACACCACCGGCCATCAGGGCTCGCACATTT
TCAGCTCCTTCAGCCTCGGCAACTGCTTTATCGTGCTGGAGCGTGAGCGCGGCCATGTTGAAGCAGGTGAATGGGTCGAG
GTCGAACCCTTCAGTCACCTGTTTGGGGGGCTGTAA

Upstream 100 bases:

>100_bases
GCGGCGGGCGATGTAAAGCCTCGTACCCAGGTGGCATACAGCCCGCGCCGCTTTTCTGCCATAATAGGCGTTTTCGCTGT
TTTGCCCGCAGGAGTGACCC

Downstream 100 bases:

>100_bases
TGACCGTTGAGCTGAGCGATGAAGAGATGCTGCGCTATAACCGGCAGATCGTCTTGCGCGGTTTTGATTTTGACGGCCAG
GAGCGGTTAAAAGCCGCTCG

Product: molybdopterin biosynthesis protein MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MDFTAGLMPLDTALAQMLDRITPLNATETVPLLQAFSRVTAHDIVSPLDVPGFDNAAMDGYAVRLNDLRDGAALPVAGKA
FAGQPFNDAWPSGTCIRIMTGAPVPEGCDAVVMQEETEQTEAGVRFIAPVKAGQHIRRRGEDIAHGAVVFPAGIPLTVAE
LPVLASLGIAEVEVVRKVRVAVFSTGDELQLPGQPLGDGQIYDTNRLAVHLMLQQLGYEVINLGIIPDDPAKLRDAFIAA
DQQADVVISSGGVSVGEADYTKTILEELGEIGFWKLAIKPGKPFAFGKLSSSWFCGLPGNPVSATVTFCQLVQPLLAKLS
GKHGPLQAPRLRVRAATRLKKSPGRLDFQRGILQRNPDGELVVNTTGHQGSHIFSSFSLGNCFIVLERERGHVEAGEWVE
VEPFSHLFGGL

Sequences:

>Translated_411_residues
MDFTAGLMPLDTALAQMLDRITPLNATETVPLLQAFSRVTAHDIVSPLDVPGFDNAAMDGYAVRLNDLRDGAALPVAGKA
FAGQPFNDAWPSGTCIRIMTGAPVPEGCDAVVMQEETEQTEAGVRFIAPVKAGQHIRRRGEDIAHGAVVFPAGIPLTVAE
LPVLASLGIAEVEVVRKVRVAVFSTGDELQLPGQPLGDGQIYDTNRLAVHLMLQQLGYEVINLGIIPDDPAKLRDAFIAA
DQQADVVISSGGVSVGEADYTKTILEELGEIGFWKLAIKPGKPFAFGKLSSSWFCGLPGNPVSATVTFCQLVQPLLAKLS
GKHGPLQAPRLRVRAATRLKKSPGRLDFQRGILQRNPDGELVVNTTGHQGSHIFSSFSLGNCFIVLERERGHVEAGEWVE
VEPFSHLFGGL
>Mature_411_residues
MDFTAGLMPLDTALAQMLDRITPLNATETVPLLQAFSRVTAHDIVSPLDVPGFDNAAMDGYAVRLNDLRDGAALPVAGKA
FAGQPFNDAWPSGTCIRIMTGAPVPEGCDAVVMQEETEQTEAGVRFIAPVKAGQHIRRRGEDIAHGAVVFPAGIPLTVAE
LPVLASLGIAEVEVVRKVRVAVFSTGDELQLPGQPLGDGQIYDTNRLAVHLMLQQLGYEVINLGIIPDDPAKLRDAFIAA
DQQADVVISSGGVSVGEADYTKTILEELGEIGFWKLAIKPGKPFAFGKLSSSWFCGLPGNPVSATVTFCQLVQPLLAKLS
GKHGPLQAPRLRVRAATRLKKSPGRLDFQRGILQRNPDGELVVNTTGHQGSHIFSSFSLGNCFIVLERERGHVEAGEWVE
VEPFSHLFGGL

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=414, Percent_Identity=36.4734299516908, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI10880983, Length=414, Percent_Identity=36.4734299516908, Blast_Score=194, Evalue=2e-49,
Organism=Escherichia coli, GI1787049, Length=411, Percent_Identity=80.0486618004866, Blast_Score=651, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147659, Length=358, Percent_Identity=32.4022346368715, Blast_Score=151, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17562606, Length=221, Percent_Identity=28.5067873303167, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI17136978, Length=274, Percent_Identity=32.8467153284672, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24638841, Length=274, Percent_Identity=32.8467153284672, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44010; Mature: 44010

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFTAGLMPLDTALAQMLDRITPLNATETVPLLQAFSRVTAHDIVSPLDVPGFDNAAMDG
CCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
YAVRLNDLRDGAALPVAGKAFAGQPFNDAWPSGTCIRIMTGAPVPEGCDAVVMQEETEQT
EEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECHHHHH
EAGVRFIAPVKAGQHIRRRGEDIAHGAVVFPAGIPLTVAELPVLASLGIAEVEVVRKVRV
HCCEEEEEECCCCHHHHHCCCHHHCCEEEECCCCCEEHHHHHHHHHCCHHHHHHHHHHHH
AVFSTGDELQLPGQPLGDGQIYDTNRLAVHLMLQQLGYEVINLGIIPDDPAKLRDAFIAA
EEEECCCCEECCCCCCCCCEEEECCHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHCC
DQQADVVISSGGVSVGEADYTKTILEELGEIGFWKLAIKPGKPFAFGKLSSSWFCGLPGN
CCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCCEEECCCCC
PVSATVTFCQLVQPLLAKLSGKHGPLQAPRLRVRAATRLKKSPGRLDFQRGILQRNPDGE
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCC
LVVNTTGHQGSHIFSSFSLGNCFIVLERERGHVEAGEWVEVEPFSHLFGGL
EEEEECCCCCCHHHEEECCCCEEEEEECCCCCCCCCCEEEECCHHHHHCCC
>Mature Secondary Structure
MDFTAGLMPLDTALAQMLDRITPLNATETVPLLQAFSRVTAHDIVSPLDVPGFDNAAMDG
CCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
YAVRLNDLRDGAALPVAGKAFAGQPFNDAWPSGTCIRIMTGAPVPEGCDAVVMQEETEQT
EEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECHHHHH
EAGVRFIAPVKAGQHIRRRGEDIAHGAVVFPAGIPLTVAELPVLASLGIAEVEVVRKVRV
HCCEEEEEECCCCHHHHHCCCHHHCCEEEECCCCCEEHHHHHHHHHCCHHHHHHHHHHHH
AVFSTGDELQLPGQPLGDGQIYDTNRLAVHLMLQQLGYEVINLGIIPDDPAKLRDAFIAA
EEEECCCCEECCCCCCCCCEEEECCHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHCC
DQQADVVISSGGVSVGEADYTKTILEELGEIGFWKLAIKPGKPFAFGKLSSSWFCGLPGN
CCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCCEEECCCCC
PVSATVTFCQLVQPLLAKLSGKHGPLQAPRLRVRAATRLKKSPGRLDFQRGILQRNPDGE
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCC
LVVNTTGHQGSHIFSSFSLGNCFIVLERERGHVEAGEWVEVEPFSHLFGGL
EEEEECCCCCCHHHEEECCCCEEEEEECCCCCCCCCCEEEECCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]