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The map label for this gene is hutH [H]

Identifier: 238893816

GI number: 238893816

Start: 1687226

End: 1688752

Strand: Direct

Name: hutH [H]

Synonym: KP1_1746

Alternate gene names: 238893816

Gene position: 1687226-1688752 (Clockwise)

Preceding gene: 238893815

Following gene: 238893817

Centisome position: 32.15

GC content: 64.51

Gene sequence:

>1527_bases
ATGAAATCTTTAACTTTGATCCCGGGTCAACTCAGCCTGTCGCAGCTCCGCGACGTTTACAGCCACCCGGTAAATATTAC
CCTCGACAGCGGCGCGTTTGCCGCCATTGACGAGAGCGTGGCCTGCGTTAACGCCATCCTTGCCGAAGGGCGTACCGCCT
ACGGCATCAACACCGGTTTTGGCCTGCTGGCGCAAACCCGTATCTCGACGGAAGATCTGGAGAACCTGCAGCGTTCGCTG
GTGCTGTCCCATGCGGCGGGCGTTGGCGAGCCGCTGGACGATGATCTGGCGCGGCTGATTATGGTGCTGAAGATTAACAG
CCTGTCCCGCGGTTTCTCCGGGATCCGCCTGAGCGTGATCCAGGCGCTGATTGGCCTGGTGAATGCCGGCGTGACGCCGT
GGATCCCGGCCAAAGGCTCCGTCGGCGCTTCCGGCGACCTCGCGCCGCTGGCGCATATGTCGCTGACCCTGCTCGGAGAA
GGTAAAGCGCGGGTACGCGGCGGCGACTGGCTGCCGGCCACCGAAGCGCTGCGTCAGGTGGGGCTGGAGCCGATTACCCT
GGCGGCGAAAGAGGGGCTGGCGCTACTCAACGGCACCCAGGCCTCGACCGCTTTTGCCCTGCGCGGTCTGTTCGAAGCCG
AGGATCTGTTCGCCTCCGCGGTCGTCTGCGGGGCGTTAACCACCGAAGCGGCGCTGGGCTCACGTCGTCCGTTTGATGCG
CGCATCCATGAAGTGCGCGGCCAGCGCGGGCAGATTGATGCGGCGGCGCTGTATCGCCACCTGCTGACCGACGATAGCGC
GATCTCGCAGTCGCACCATAACTGCAGCAAGGTGCAGGACCCGTACTCCCTGCGCTGCCAGCCGCAGGTGATGGGCGCCT
GCCTGACGCAGATCCGCCAGGCGGCTGAGGTGCTGCTGGCTGAAGCCAACGCGGTCTCCGATAACCCGCTGGTCTTTGCC
GCCGAAAATGACGTCATCTCCGGCGGTAACTTCCATGCCGAACCGGTGGCGATGGCCGCGGATAATATCGCGCTGGCGAT
CGCCGAAATCGGCTCGCTCTCCGAGCGCCGCATCGCGCTGATGATGGACAGCCATATGTCGCAGCTGCCGCCGTTCCTCG
TCAAAAATGGCGGCGTCAACTCCGGGTTTATGATTGCCCAGGTCACGGCGGCGGCCTTAGCCAGTGAAAACAAAGCGCTG
TCGCACCCGCATAGCGTTGACAGCCTGCCAACCTCTGCCAACCAGGAAGACCACGTCTCGATGGCGCCGGCGGCCGGTCG
CCGCCTGTGGGCGATGGCCGAGAACACCCGCGGGGTGCTGGCCGTTGAGTGGCTGGCGGCGGCGCAGGGGCTGGATATGC
GCGAAGGACTGACCACCAGTCCGCTGCTGGAAGAGGCGCGTCACTTGCTGCGCGAACGCGTGCCGCACTATACGCAGGAT
CGCTACTTCGCCCCGGATATCGATAACGCCATTGCGCTTCTGGCGGCCCGTCACCTGACGCGTCTGCTGCCTGCCGTACT
GCATTAA

Upstream 100 bases:

>100_bases
TGATGCGTCATGCCGACGCGGGGTATGAGATTGCCATTGAATGCGCAGCAGAACAGGGTCTGAATCTTCCGATGGTGGCG
GCAACGCAGGGGAACGCTAA

Downstream 100 bases:

>100_bases
TCACCGTTGTTCTCTGTACCCGCGTCGGGGGAAGTCATTCCCCCGACCGCCCTACACCGCATATTTGTCGTCATATAAAA
AAATCAGGACACCTGTATAT

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MKSLTLIPGQLSLSQLRDVYSHPVNITLDSGAFAAIDESVACVNAILAEGRTAYGINTGFGLLAQTRISTEDLENLQRSL
VLSHAAGVGEPLDDDLARLIMVLKINSLSRGFSGIRLSVIQALIGLVNAGVTPWIPAKGSVGASGDLAPLAHMSLTLLGE
GKARVRGGDWLPATEALRQVGLEPITLAAKEGLALLNGTQASTAFALRGLFEAEDLFASAVVCGALTTEAALGSRRPFDA
RIHEVRGQRGQIDAAALYRHLLTDDSAISQSHHNCSKVQDPYSLRCQPQVMGACLTQIRQAAEVLLAEANAVSDNPLVFA
AENDVISGGNFHAEPVAMAADNIALAIAEIGSLSERRIALMMDSHMSQLPPFLVKNGGVNSGFMIAQVTAAALASENKAL
SHPHSVDSLPTSANQEDHVSMAPAAGRRLWAMAENTRGVLAVEWLAAAQGLDMREGLTTSPLLEEARHLLRERVPHYTQD
RYFAPDIDNAIALLAARHLTRLLPAVLH

Sequences:

>Translated_508_residues
MKSLTLIPGQLSLSQLRDVYSHPVNITLDSGAFAAIDESVACVNAILAEGRTAYGINTGFGLLAQTRISTEDLENLQRSL
VLSHAAGVGEPLDDDLARLIMVLKINSLSRGFSGIRLSVIQALIGLVNAGVTPWIPAKGSVGASGDLAPLAHMSLTLLGE
GKARVRGGDWLPATEALRQVGLEPITLAAKEGLALLNGTQASTAFALRGLFEAEDLFASAVVCGALTTEAALGSRRPFDA
RIHEVRGQRGQIDAAALYRHLLTDDSAISQSHHNCSKVQDPYSLRCQPQVMGACLTQIRQAAEVLLAEANAVSDNPLVFA
AENDVISGGNFHAEPVAMAADNIALAIAEIGSLSERRIALMMDSHMSQLPPFLVKNGGVNSGFMIAQVTAAALASENKAL
SHPHSVDSLPTSANQEDHVSMAPAAGRRLWAMAENTRGVLAVEWLAAAQGLDMREGLTTSPLLEEARHLLRERVPHYTQD
RYFAPDIDNAIALLAARHLTRLLPAVLH
>Mature_508_residues
MKSLTLIPGQLSLSQLRDVYSHPVNITLDSGAFAAIDESVACVNAILAEGRTAYGINTGFGLLAQTRISTEDLENLQRSL
VLSHAAGVGEPLDDDLARLIMVLKINSLSRGFSGIRLSVIQALIGLVNAGVTPWIPAKGSVGASGDLAPLAHMSLTLLGE
GKARVRGGDWLPATEALRQVGLEPITLAAKEGLALLNGTQASTAFALRGLFEAEDLFASAVVCGALTTEAALGSRRPFDA
RIHEVRGQRGQIDAAALYRHLLTDDSAISQSHHNCSKVQDPYSLRCQPQVMGACLTQIRQAAEVLLAEANAVSDNPLVFA
AENDVISGGNFHAEPVAMAADNIALAIAEIGSLSERRIALMMDSHMSQLPPFLVKNGGVNSGFMIAQVTAAALASENKAL
SHPHSVDSLPTSANQEDHVSMAPAAGRRLWAMAENTRGVLAVEWLAAAQGLDMREGLTTSPLLEEARHLLRERVPHYTQD
RYFAPDIDNAIALLAARHLTRLLPAVLH

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=496, Percent_Identity=43.9516129032258, Blast_Score=402, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17567831, Length=468, Percent_Identity=44.2307692307692, Blast_Score=374, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 53904; Mature: 53904

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLTLIPGQLSLSQLRDVYSHPVNITLDSGAFAAIDESVACVNAILAEGRTAYGINTGF
CCCCEECCCCCCHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCEEEECCCCC
GLLAQTRISTEDLENLQRSLVLSHAAGVGEPLDDDLARLIMVLKINSLSRGFSGIRLSVI
HHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHH
QALIGLVNAGVTPWIPAKGSVGASGDLAPLAHMSLTLLGEGKARVRGGDWLPATEALRQV
HHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHCEEEEEECCCEEECCCCCCCHHHHHHHC
GLEPITLAAKEGLALLNGTQASTAFALRGLFEAEDLFASAVVCGALTTEAALGSRRPFDA
CCCCEEEEHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
RIHEVRGQRGQIDAAALYRHLLTDDSAISQSHHNCSKVQDPYSLRCQPQVMGACLTQIRQ
HHHHHCCCCCCCHHHHHHHHHHCCCHHHHHCCCCHHHCCCCCCCCCCHHHHHHHHHHHHH
AAEVLLAEANAVSDNPLVFAAENDVISGGNFHAEPVAMAADNIALAIAEIGSLSERRIAL
HHHHHHHHCCCCCCCCEEEEECCCEECCCCCCCCCHHEECCCHHHHHHHHCCCCHHHHHH
MMDSHMSQLPPFLVKNGGVNSGFMIAQVTAAALASENKALSHPHSVDSLPTSANQEDHVS
HHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEE
MAPAAGRRLWAMAENTRGVLAVEWLAAAQGLDMREGLTTSPLLEEARHLLRERVPHYTQD
ECCCCCCEEEEEECCCCCEEEEHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHHCCCCCCC
RYFAPDIDNAIALLAARHLTRLLPAVLH
CCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKSLTLIPGQLSLSQLRDVYSHPVNITLDSGAFAAIDESVACVNAILAEGRTAYGINTGF
CCCCEECCCCCCHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCEEEECCCCC
GLLAQTRISTEDLENLQRSLVLSHAAGVGEPLDDDLARLIMVLKINSLSRGFSGIRLSVI
HHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHH
QALIGLVNAGVTPWIPAKGSVGASGDLAPLAHMSLTLLGEGKARVRGGDWLPATEALRQV
HHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHCEEEEEECCCEEECCCCCCCHHHHHHHC
GLEPITLAAKEGLALLNGTQASTAFALRGLFEAEDLFASAVVCGALTTEAALGSRRPFDA
CCCCEEEEHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
RIHEVRGQRGQIDAAALYRHLLTDDSAISQSHHNCSKVQDPYSLRCQPQVMGACLTQIRQ
HHHHHCCCCCCCHHHHHHHHHHCCCHHHHHCCCCHHHCCCCCCCCCCHHHHHHHHHHHHH
AAEVLLAEANAVSDNPLVFAAENDVISGGNFHAEPVAMAADNIALAIAEIGSLSERRIAL
HHHHHHHHCCCCCCCCEEEEECCCEECCCCCCCCCHHEECCCHHHHHHHHCCCCHHHHHH
MMDSHMSQLPPFLVKNGGVNSGFMIAQVTAAALASENKALSHPHSVDSLPTSANQEDHVS
HHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEE
MAPAAGRRLWAMAENTRGVLAVEWLAAAQGLDMREGLTTSPLLEEARHLLRERVPHYTQD
ECCCCCCEEEEEECCCCCEEEEHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHHCCCCCCC
RYFAPDIDNAIALLAARHLTRLLPAVLH
CCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA