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The map label for this gene is hutU [H]

Identifier: 238893815

GI number: 238893815

Start: 1685541

End: 1687229

Strand: Direct

Name: hutU [H]

Synonym: KP1_1745

Alternate gene names: 238893815

Gene position: 1685541-1687229 (Clockwise)

Preceding gene: 238893814

Following gene: 238893816

Centisome position: 32.11

GC content: 62.46

Gene sequence:

>1689_bases
ATGTCGCAAAGCAAATATCGCCAGCTGGACGTCCGTGCGCCAAGAGGCACGACGCTGACCGCGAAGAGCTGGCTGACCGA
AGCCCCGCTGCGTATGTTAATGAATAACCTTGATCCCGATGTCGCCGAAAACCCGCACGAGCTGGTGGTCTATGGCGGTA
TTGGTCGCGCAGCGCGCAACTGGGAATGCTATGACGCTATCGTGAAGGCGCTGAAGAACCTGGAAAGCGATGAAACCCTG
CTGGTGCAGTCCGGGAAGCCGGTGGGCGTATTCAAAACCCATGAAAACTCACCGCGCGTGCTGATCGCCAACTCCAACCT
GGTACCGCACTGGGCCACCTGGGAACACTTTAACGAGCTGGATGCCAAAGGGCTGGCGATGTACGGCCAGATGACCGCCG
GCAGCTGGATCTACATCGGCAGCCAGGGCATCGTGCAGGGTACCTACGAAACCTTCGTCGAAGCCGGTCGCCAGCACTAC
CAGGGCAGCCTGAAAGGCCGCTGGGTATTAACCGCCGGTCTGGGCGGCATGGGCGGCGCGCAGCCGCTGGCCGCGACGCT
GGCCGGCGCCTGCTCGCTGAACATCGAATGTCAGCAGAGCCGCATCGATTTCCGTCTGCGTACCCGCTACGTGGATGAGC
AAGCCACCTCGCTGGATGACGCCCTGGCGCGCATCAAAAAATACACCGCCGAAGGGCGGGCCATCTCTATCGCGCTGTGC
GGCAACGCCGCGGAGATCGTACCGGAGCTGGTGAAGCGCGGCGTGCGCCCGGATATGGTCACCGACCAGACCAGCGCCCA
CGACCCGCTGCATGGCTATCTGCCGAAAGGCTGGAGCTGGGAAGAGTATCAGCAGAAAGCCGAATCCGACCCGCAGGGCA
CTATTCTGGCGGCGAAACGCTCGATGGCCGATCACGTGCAGGCGATGCTGGCCTTCCATGAGATGGGGGTCCCAACCTTC
GACTACGGCAACAACATCCGCCAGATGGCGCAGGAAGTGGGCGTCAGCAACGCCTTCGATTTCCCGGGCTTCGTGCCGGC
CTATATCCGCCCGCTGTTCTGCCGCGGTATCGGCCCGTTCCGCTGGGTAGCGCTGTCCGGCGATCCGCAGGATATCTACA
AAACCGACGCGAAAGTGAAAGAGATCATCAAAGATGATCAGCACCTGCACCACTGGCTGGATATGGCGCGCGAGCGCATC
AGCTTCCAGGGACTGCCGGCGCGTATCTGCTGGGTCGGTCTGGAGTGGCGGCAAAAGCTCGGTCTGGCGTTTAACGAAAT
GGTGCGCAGCGGCGAAGTCTCCGCGCCGATCGTCATTGGCCGGGATCACCTTGACTCCGGCTCCGTCGCCAGCCCGAACC
GCGAAACCGAAGCGATGCGCGATGGTTCTGATGCGGTCTCCGACTGGCCGCTGCTCAACGCCCTGCTCAATACCGCCAGC
GGCGCGACCTGGGTGTCGCTGCACCACGGCGGCGGGGTAGGCATGGGCTTCTCGCAACACTCCGGGATGGTTATCGTCTG
TGATGGTACCGATGAAGCGGCGGCGCGTATCGCCCGCGTCCTGCACAACGACCCGGCCACCGGCGTGATGCGTCATGCCG
ACGCGGGGTATGAGATTGCCATTGAATGCGCAGCAGAACAGGGTCTGAATCTTCCGATGGTGGCGGCAACGCAGGGGAAC
GCTAAATGA

Upstream 100 bases:

>100_bases
ACAAAATTGTATCATTTCTGTTAAATCCTGGCTTGCGCATGCTTGTATAGACAAGTATATGTATCTACGTAAACAACGTT
CATTGTCAGGAGAAACCCCG

Downstream 100 bases:

>100_bases
AATCTTTAACTTTGATCCCGGGTCAACTCAGCCTGTCGCAGCTCCGCGACGTTTACAGCCACCCGGTAAATATTACCCTC
GACAGCGGCGCGTTTGCCGC

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 562; Mature: 561

Protein sequence:

>562_residues
MSQSKYRQLDVRAPRGTTLTAKSWLTEAPLRMLMNNLDPDVAENPHELVVYGGIGRAARNWECYDAIVKALKNLESDETL
LVQSGKPVGVFKTHENSPRVLIANSNLVPHWATWEHFNELDAKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRQHY
QGSLKGRWVLTAGLGGMGGAQPLAATLAGACSLNIECQQSRIDFRLRTRYVDEQATSLDDALARIKKYTAEGRAISIALC
GNAAEIVPELVKRGVRPDMVTDQTSAHDPLHGYLPKGWSWEEYQQKAESDPQGTILAAKRSMADHVQAMLAFHEMGVPTF
DYGNNIRQMAQEVGVSNAFDFPGFVPAYIRPLFCRGIGPFRWVALSGDPQDIYKTDAKVKEIIKDDQHLHHWLDMARERI
SFQGLPARICWVGLEWRQKLGLAFNEMVRSGEVSAPIVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNTAS
GATWVSLHHGGGVGMGFSQHSGMVIVCDGTDEAAARIARVLHNDPATGVMRHADAGYEIAIECAAEQGLNLPMVAATQGN
AK

Sequences:

>Translated_562_residues
MSQSKYRQLDVRAPRGTTLTAKSWLTEAPLRMLMNNLDPDVAENPHELVVYGGIGRAARNWECYDAIVKALKNLESDETL
LVQSGKPVGVFKTHENSPRVLIANSNLVPHWATWEHFNELDAKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRQHY
QGSLKGRWVLTAGLGGMGGAQPLAATLAGACSLNIECQQSRIDFRLRTRYVDEQATSLDDALARIKKYTAEGRAISIALC
GNAAEIVPELVKRGVRPDMVTDQTSAHDPLHGYLPKGWSWEEYQQKAESDPQGTILAAKRSMADHVQAMLAFHEMGVPTF
DYGNNIRQMAQEVGVSNAFDFPGFVPAYIRPLFCRGIGPFRWVALSGDPQDIYKTDAKVKEIIKDDQHLHHWLDMARERI
SFQGLPARICWVGLEWRQKLGLAFNEMVRSGEVSAPIVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNTAS
GATWVSLHHGGGVGMGFSQHSGMVIVCDGTDEAAARIARVLHNDPATGVMRHADAGYEIAIECAAEQGLNLPMVAATQGN
AK
>Mature_561_residues
SQSKYRQLDVRAPRGTTLTAKSWLTEAPLRMLMNNLDPDVAENPHELVVYGGIGRAARNWECYDAIVKALKNLESDETLL
VQSGKPVGVFKTHENSPRVLIANSNLVPHWATWEHFNELDAKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRQHYQ
GSLKGRWVLTAGLGGMGGAQPLAATLAGACSLNIECQQSRIDFRLRTRYVDEQATSLDDALARIKKYTAEGRAISIALCG
NAAEIVPELVKRGVRPDMVTDQTSAHDPLHGYLPKGWSWEEYQQKAESDPQGTILAAKRSMADHVQAMLAFHEMGVPTFD
YGNNIRQMAQEVGVSNAFDFPGFVPAYIRPLFCRGIGPFRWVALSGDPQDIYKTDAKVKEIIKDDQHLHHWLDMARERIS
FQGLPARICWVGLEWRQKLGLAFNEMVRSGEVSAPIVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNTASG
ATWVSLHHGGGVGMGFSQHSGMVIVCDGTDEAAARIARVLHNDPATGVMRHADAGYEIAIECAAEQGLNLPMVAATQGNA
K

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=564, Percent_Identity=34.7517730496454, Blast_Score=301, Evalue=9e-82,
Organism=Homo sapiens, GI260306182, Length=220, Percent_Identity=37.7272727272727, Blast_Score=154, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71997891, Length=566, Percent_Identity=35.6890459363958, Blast_Score=324, Evalue=6e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 61534; Mature: 61403

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSKYRQLDVRAPRGTTLTAKSWLTEAPLRMLMNNLDPDVAENPHELVVYGGIGRAARN
CCCCCCCEEEEECCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCC
WECYDAIVKALKNLESDETLLVQSGKPVGVFKTHENSPRVLIANSNLVPHWATWEHFNEL
CHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCHHHHHHC
DAKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRQHYQGSLKGRWVLTAGLGGMGGA
CCCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCC
QPLAATLAGACSLNIECQQSRIDFRLRTRYVDEQATSLDDALARIKKYTAEGRAISIALC
HHHHHHHHHHHEECEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
GNAAEIVPELVKRGVRPDMVTDQTSAHDPLHGYLPKGWSWEEYQQKAESDPQGTILAAKR
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEHHH
SMADHVQAMLAFHEMGVPTFDYGNNIRQMAQEVGVSNAFDFPGFVPAYIRPLFCRGIGPF
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCE
RWVALSGDPQDIYKTDAKVKEIIKDDQHLHHWLDMARERISFQGLPARICWVGLEWRQKL
EEEEECCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHH
GLAFNEMVRSGEVSAPIVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNTAS
CHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCC
GATWVSLHHGGGVGMGFSQHSGMVIVCDGTDEAAARIARVLHNDPATGVMRHADAGYEIA
CCEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHCCCCCEEE
IECAAEQGLNLPMVAATQGNAK
EEEEHHCCCCCCEEEECCCCCC
>Mature Secondary Structure 
SQSKYRQLDVRAPRGTTLTAKSWLTEAPLRMLMNNLDPDVAENPHELVVYGGIGRAARN
CCCCCCEEEEECCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCC
WECYDAIVKALKNLESDETLLVQSGKPVGVFKTHENSPRVLIANSNLVPHWATWEHFNEL
CHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCHHHHHHC
DAKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRQHYQGSLKGRWVLTAGLGGMGGA
CCCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCC
QPLAATLAGACSLNIECQQSRIDFRLRTRYVDEQATSLDDALARIKKYTAEGRAISIALC
HHHHHHHHHHHEECEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
GNAAEIVPELVKRGVRPDMVTDQTSAHDPLHGYLPKGWSWEEYQQKAESDPQGTILAAKR
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEHHH
SMADHVQAMLAFHEMGVPTFDYGNNIRQMAQEVGVSNAFDFPGFVPAYIRPLFCRGIGPF
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCE
RWVALSGDPQDIYKTDAKVKEIIKDDQHLHHWLDMARERISFQGLPARICWVGLEWRQKL
EEEEECCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHH
GLAFNEMVRSGEVSAPIVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNTAS
CHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCC
GATWVSLHHGGGVGMGFSQHSGMVIVCDGTDEAAARIARVLHNDPATGVMRHADAGYEIA
CCEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHCCCCCEEE
IECAAEQGLNLPMVAATQGNAK
EEEEHHCCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA