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The map label for this gene is hutC

Identifier: 238893814

GI number: 238893814

Start: 1684673

End: 1685398

Strand: Direct

Name: hutC

Synonym: KP1_1744

Alternate gene names: 238893814

Gene position: 1684673-1685398 (Clockwise)

Preceding gene: 238893813

Following gene: 238893815

Centisome position: 32.1

GC content: 60.74

Gene sequence:

>726_bases
ATGTTTGCACAACAACCTCGTTCCGCGCCCGCGCCTTTCTATGAAAAGGTGAAGCAGGCGATCAGCGAAAAGATCCACAG
CGGCGTCTGGCGACCGCATGACCGTATCCCGTCGGAAGCTGAGCTGGTGGCCCAGTTCGGCTTCAGCCGAATGACCATCA
ATCGCGCGCTGCGCGAGCTGACGGACGAAGGCCTGCTGGTCAGGTTGCAAGGGGTGGGAACCTTTGTCGCCGAGCCGAAA
GGGCAGTCAGCGCTGTTCGAGGTGCGCAGTATTGCCGCAGAAATTGTCGCCCGTCACCATCAGCACCGCTGTGAGGTACT
CCTGCTTGAGGAGACCCGGGCGGATCATATTCAGGCGACGGCGCTCAGCGTCCCGGAAGGCACCCGCATTTTTCACTCGC
TGATGGTGCATTACGAAAACGAGGTGCCGGTGCAAATCGAAGATCGCTGCGTCAATGCCGCAGTGGTCCCGGACTATCTG
CATCAGGACTACACCGCCACCACGCCCCATGATTACCTGTCGCTGATCGCGCCGTTAACTGAAGGTGAACACATTGTTGA
AGCGGTGCAGGCCACGGCGGAAGAGTGCGCGCTGCTGCATATTCACGCCCACGATCCGTGCCTGCTGATCCGTCGCCGCA
CCTGGTCGACAACCCACATCGTCTCCCACGCGCGCCTGCTGTTCCCCGGTAGCCGATATCGTCTGCAGGGGCGCTTTGGC
TCCTGA

Upstream 100 bases:

>100_bases
GCCCGTGTGGCATGGCAAATCGCCCATTGGTGGCGCTAGCGATCCGCGCTATTATTTTCGTTTCGCCGCTCCGCTTATTA
CGCATAAGGAAAGCCAGGCC

Downstream 100 bases:

>100_bases
TCCACGCTGGCGTCAGCAAAACGTGATTGCTGACGCAATATAACAAAATTGTATCATTTCTGTTAAATCCTGGCTTGCGC
ATGCTTGTATAGACAAGTAT

Product: histidine utilization repressor C

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MFAQQPRSAPAPFYEKVKQAISEKIHSGVWRPHDRIPSEAELVAQFGFSRMTINRALRELTDEGLLVRLQGVGTFVAEPK
GQSALFEVRSIAAEIVARHHQHRCEVLLLEETRADHIQATALSVPEGTRIFHSLMVHYENEVPVQIEDRCVNAAVVPDYL
HQDYTATTPHDYLSLIAPLTEGEHIVEAVQATAEECALLHIHAHDPCLLIRRRTWSTTHIVSHARLLFPGSRYRLQGRFG
S

Sequences:

>Translated_241_residues
MFAQQPRSAPAPFYEKVKQAISEKIHSGVWRPHDRIPSEAELVAQFGFSRMTINRALRELTDEGLLVRLQGVGTFVAEPK
GQSALFEVRSIAAEIVARHHQHRCEVLLLEETRADHIQATALSVPEGTRIFHSLMVHYENEVPVQIEDRCVNAAVVPDYL
HQDYTATTPHDYLSLIAPLTEGEHIVEAVQATAEECALLHIHAHDPCLLIRRRTWSTTHIVSHARLLFPGSRYRLQGRFG
S
>Mature_241_residues
MFAQQPRSAPAPFYEKVKQAISEKIHSGVWRPHDRIPSEAELVAQFGFSRMTINRALRELTDEGLLVRLQGVGTFVAEPK
GQSALFEVRSIAAEIVARHHQHRCEVLLLEETRADHIQATALSVPEGTRIFHSLMVHYENEVPVQIEDRCVNAAVVPDYL
HQDYTATTPHDYLSLIAPLTEGEHIVEAVQATAEECALLHIHAHDPCLLIRRRTWSTTHIVSHARLLFPGSRYRLQGRFG
S

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI1786950, Length=201, Percent_Identity=29.3532338308458, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI87082252, Length=147, Percent_Identity=30.6122448979592, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTC_KLEAE (P12380)

Other databases:

- EMBL:   M34604
- EMBL:   M19665
- ProteinModelPortal:   P12380
- SMR:   P12380
- GO:   GO:0005622
- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00035
- SMART:   SM00345
- SMART:   SM00866
- TIGRFAMs:   TIGR02018

Pfam domain/function: PF00392 GntR; PF07702 UTRA

EC number: NA

Molecular weight: Translated: 27215; Mature: 27215

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFAQQPRSAPAPFYEKVKQAISEKIHSGVWRPHDRIPSEAELVAQFGFSRMTINRALREL
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHH
TDEGLLVRLQGVGTFVAEPKGQSALFEVRSIAAEIVARHHQHRCEVLLLEETRADHIQAT
CCCCEEEEEECCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEE
ALSVPEGTRIFHSLMVHYENEVPVQIEDRCVNAAVVPDYLHQDYTATTPHDYLSLIAPLT
EECCCCHHHHHHHHHHHCCCCCCEEECCCCCCCEECHHHHHCCCCCCCHHHHHHHHHCCC
EGEHIVEAVQATAEECALLHIHAHDPCLLIRRRTWSTTHIVSHARLLFPGSRYRLQGRFG
CCHHHHHHHHHHHHHEEEEEEECCCCEEEEEECCCCHHHHHHHHHEECCCCCEEEECCCC
S
C
>Mature Secondary Structure
MFAQQPRSAPAPFYEKVKQAISEKIHSGVWRPHDRIPSEAELVAQFGFSRMTINRALREL
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHH
TDEGLLVRLQGVGTFVAEPKGQSALFEVRSIAAEIVARHHQHRCEVLLLEETRADHIQAT
CCCCEEEEEECCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEE
ALSVPEGTRIFHSLMVHYENEVPVQIEDRCVNAAVVPDYLHQDYTATTPHDYLSLIAPLT
EECCCCHHHHHHHHHHHCCCCCCEEECCCCCCCEECHHHHHCCCCCCCHHHHHHHHHCCC
EGEHIVEAVQATAEECALLHIHAHDPCLLIRRRTWSTTHIVSHARLLFPGSRYRLQGRFG
CCHHHHHHHHHHHHHEEEEEEECCCCEEEEEECCCCHHHHHHHHHEECCCCCEEEECCCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2203754; 2834335