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The map label for this gene is galK [H]

Identifier: 238893786

GI number: 238893786

Start: 1655351

End: 1656499

Strand: Reverse

Name: galK [H]

Synonym: KP1_1715

Alternate gene names: 238893786

Gene position: 1656499-1655351 (Counterclockwise)

Preceding gene: 238893787

Following gene: 238893785

Centisome position: 31.56

GC content: 60.14

Gene sequence:

>1149_bases
ATGAGTCTGAAAGAGAAAACCCAAACCCTGTTCGCTGACGCCTTCGGCTACCCGGCCAGCCATGTCATTCAAGCGCCAGG
CCGCGTCAACCTGATCGGCGAGCATACCGATTACAACGACGGTTTTGTGCTCCCCTGCGCTATTGACTACCAGACGGTGA
TCAGCTGTGCGCCGCGCGACGATCGTACCGTGCGGGTGATTGCCGCCGATTACGACAATCAGACCGATGAGTTCTCTCTC
GACGCGCCGATTATCAGCCACGACACCCAGCAGTGGTCGAACTATGTCCGCGGCGTGGTAAAGCATCTGCAGCAGCGGAA
CAGCCACTTTGGCGGCGCGGATCTGGTGATCAGCGGCAATGTACCGCAGGGTGCGGGGTTAAGCTCCTCAGCCTCGCTGG
AAGTCGCCGTCGGCACCGTGTTCCAACAGCTGTATCATCTGCCGCTGGATGGCGCGCAAATCGCCCTCAACGGCCAGGAG
GCGGAAAACCAGTTCGTCGGCTGCAACTGCGGCATCATGGATCAGCTGATTTCAGCGCTGGGCAAAAAAGACCACGCGCT
GCTGATCGACTGCCGTTCGCTGGGCACCAAAGCCGTCTCGATGCCGAAAGGCGTGGCGGTGGTGATCATCAACAGCAACT
TTAAGCGCACCCTCGTCGGCAGCGAGTACAACACCCGTCGTGAACAGTGCGAAACCGGCGCGCGCTTCTTCCAGCAGCCC
GCCCTGCGCGATGTCACCCTTGAGCAATTTAACGCCGTCGCCCATGAGCTGGATCCGGTCGTCGCGAAGCGCGTACGCCA
CGTGCTGACGGAGAATGCCCGCACTGTGGAAGCCGCCAGCGCCCTCGAAAAAGGCGACCTGAAGCGGATGGGTGAGCTGA
TGGCAGAGTCCCACGCCTCGATGCGTGATGATTTCGAGATCACCGTCCCGCAGATCGACACCCTGGTGGAGATCGTTAAG
GCCGCGATCGGCGATAAGGGCGGCGTGCGCATGACCGGCGGCGGCTTTGGCGGCTGCGTGGTAGCGTTAATCCCGGAAGA
TCTGGTCGATACCGTTCAGCAGGCCGTTGCCAACGAGTATGAAGCGAAAACCGGTATTAAAGAGACATTCTATGTCTGCA
AACCGTCACAGGGGGCCGGGCAATGCTAA

Upstream 100 bases:

>100_bases
AAATGCTGGCCGAAACTCAGCGCGATCTGACCGCCGAGCAAGCTGCCGAACGACTGCGCGCTGTCAGCGACGTCCATTTT
AGTGAATCCGGAGTGTAATG

Downstream 100 bases:

>100_bases
CGCAAAACACCGCGCTGGCCCCGGACGGTCAGCCATGGCAGCAGGTGACCCTGCGCAATAAGTCGGGGATGACCGTCACC
GTGGCGGACTGGGGCGCGAC

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MSLKEKTQTLFADAFGYPASHVIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPRDDRTVRVIAADYDNQTDEFSL
DAPIISHDTQQWSNYVRGVVKHLQQRNSHFGGADLVISGNVPQGAGLSSSASLEVAVGTVFQQLYHLPLDGAQIALNGQE
AENQFVGCNCGIMDQLISALGKKDHALLIDCRSLGTKAVSMPKGVAVVIINSNFKRTLVGSEYNTRREQCETGARFFQQP
ALRDVTLEQFNAVAHELDPVVAKRVRHVLTENARTVEAASALEKGDLKRMGELMAESHASMRDDFEITVPQIDTLVEIVK
AAIGDKGGVRMTGGGFGGCVVALIPEDLVDTVQQAVANEYEAKTGIKETFYVCKPSQGAGQC

Sequences:

>Translated_382_residues
MSLKEKTQTLFADAFGYPASHVIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPRDDRTVRVIAADYDNQTDEFSL
DAPIISHDTQQWSNYVRGVVKHLQQRNSHFGGADLVISGNVPQGAGLSSSASLEVAVGTVFQQLYHLPLDGAQIALNGQE
AENQFVGCNCGIMDQLISALGKKDHALLIDCRSLGTKAVSMPKGVAVVIINSNFKRTLVGSEYNTRREQCETGARFFQQP
ALRDVTLEQFNAVAHELDPVVAKRVRHVLTENARTVEAASALEKGDLKRMGELMAESHASMRDDFEITVPQIDTLVEIVK
AAIGDKGGVRMTGGGFGGCVVALIPEDLVDTVQQAVANEYEAKTGIKETFYVCKPSQGAGQC
>Mature_381_residues
SLKEKTQTLFADAFGYPASHVIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPRDDRTVRVIAADYDNQTDEFSLD
APIISHDTQQWSNYVRGVVKHLQQRNSHFGGADLVISGNVPQGAGLSSSASLEVAVGTVFQQLYHLPLDGAQIALNGQEA
ENQFVGCNCGIMDQLISALGKKDHALLIDCRSLGTKAVSMPKGVAVVIINSNFKRTLVGSEYNTRREQCETGARFFQQPA
LRDVTLEQFNAVAHELDPVVAKRVRHVLTENARTVEAASALEKGDLKRMGELMAESHASMRDDFEITVPQIDTLVEIVKA
AIGDKGGVRMTGGGFGGCVVALIPEDLVDTVQQAVANEYEAKTGIKETFYVCKPSQGAGQC

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=379, Percent_Identity=43.7994722955145, Blast_Score=281, Evalue=6e-76,
Organism=Homo sapiens, GI4503897, Length=440, Percent_Identity=28.1818181818182, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI48527957, Length=440, Percent_Identity=28.1818181818182, Blast_Score=137, Evalue=1e-32,
Organism=Escherichia coli, GI1786972, Length=382, Percent_Identity=91.6230366492147, Blast_Score=741, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71989053, Length=441, Percent_Identity=26.530612244898, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6319494, Length=264, Percent_Identity=28.7878787878788, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320212, Length=241, Percent_Identity=27.3858921161826, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24661292, Length=411, Percent_Identity=26.2773722627737, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21355577, Length=411, Percent_Identity=26.2773722627737, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24661285, Length=411, Percent_Identity=26.2773722627737, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 41329; Mature: 41198

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKEKTQTLFADAFGYPASHVIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPRD
CCCHHHHHHHHHHHCCCCHHHHEECCCCEEEEECCCCCCCCEEEEEEECHHHHHCCCCCC
DRTVRVIAADYDNQTDEFSLDAPIISHDTQQWSNYVRGVVKHLQQRNSHFGGADLVISGN
CCEEEEEEECCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
VPQGAGLSSSASLEVAVGTVFQQLYHLPLDGAQIALNGQEAENQFVGCNCGIMDQLISAL
CCCCCCCCCCCCEEHHHHHHHHHHHHCCCCCCEEEECCCCCCCCEECCCCCHHHHHHHHH
GKKDHALLIDCRSLGTKAVSMPKGVAVVIINSNFKRTLVGSEYNTRREQCETGARFFQQP
CCCCCEEEEEHHHCCCHHCCCCCCEEEEEECCCCCEEECCCCCHHHHHHHHHHHHHHHCC
ALRDVTLEQFNAVAHELDPVVAKRVRHVLTENARTVEAASALEKGDLKRMGELMAESHAS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
MRDDFEITVPQIDTLVEIVKAAIGDKGGVRMTGGGFGGCVVALIPEDLVDTVQQAVANEY
CCCCCEEECCHHHHHHHHHHHHHCCCCCEEECCCCCCCEEEEECCHHHHHHHHHHHHHHH
EAKTGIKETFYVCKPSQGAGQC
HHHCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure 
SLKEKTQTLFADAFGYPASHVIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPRD
CCHHHHHHHHHHHCCCCHHHHEECCCCEEEEECCCCCCCCEEEEEEECHHHHHCCCCCC
DRTVRVIAADYDNQTDEFSLDAPIISHDTQQWSNYVRGVVKHLQQRNSHFGGADLVISGN
CCEEEEEEECCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
VPQGAGLSSSASLEVAVGTVFQQLYHLPLDGAQIALNGQEAENQFVGCNCGIMDQLISAL
CCCCCCCCCCCCEEHHHHHHHHHHHHCCCCCCEEEECCCCCCCCEECCCCCHHHHHHHHH
GKKDHALLIDCRSLGTKAVSMPKGVAVVIINSNFKRTLVGSEYNTRREQCETGARFFQQP
CCCCCEEEEEHHHCCCHHCCCCCCEEEEEECCCCCEEECCCCCHHHHHHHHHHHHHHHCC
ALRDVTLEQFNAVAHELDPVVAKRVRHVLTENARTVEAASALEKGDLKRMGELMAESHAS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
MRDDFEITVPQIDTLVEIVKAAIGDKGGVRMTGGGFGGCVVALIPEDLVDTVQQAVANEY
CCCCCEEECCHHHHHHHHHHHHHCCCCCEEECCCCCCCEEEEECCHHHHHHHHHHHHHHH
EAKTGIKETFYVCKPSQGAGQC
HHHCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA