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The map label for this gene is galM [H]

Identifier: 238893785

GI number: 238893785

Start: 1654314

End: 1655357

Strand: Reverse

Name: galM [H]

Synonym: KP1_1714

Alternate gene names: 238893785

Gene position: 1655357-1654314 (Counterclockwise)

Preceding gene: 238893786

Following gene: 238893784

Centisome position: 31.54

GC content: 63.31

Gene sequence:

>1044_bases
ATGCTAACGCAAAACACCGCGCTGGCCCCGGACGGTCAGCCATGGCAGCAGGTGACCCTGCGCAATAAGTCGGGGATGAC
CGTCACCGTGGCGGACTGGGGCGCGACGCTGCTCAGCGCCGAGGTGCCGCTGGCCGATGGCAGCCTGCGCCGACCGCTGC
TGGGCTGCGCAAAGCTGGAAGACTATGCTCGCCAGGCCGCATTTCTTGGCGCCTCGGTAGGCCGCTACGCCAACCGTATC
GGCCACAGCCGCTTCCCGCTTGACGGCCAGGTCGTCAACGTCACGCCGTCAAACGACGCGGGCCACCAGCTCCACGGCGG
CCCGGAAGGGTTTGATAAGCGCCGCTGGCGCATTGTCCGCGCCGACGAGCAGGAAGTGCTGTTCGCCCTGACCTCGCCCG
ATGGCGATCAAGGCTTTCCGGGCACCCTGCAGGCCACCGCGCACTATCGTCTGAGCGACGATAACCGCATCGCGATTACC
TATCGCGCCACCGTGGACCAACCCTGCCCGGTGAATATGACCAATCACGTCTATTTCAACCTCGACGGTGAGCAGGGCGA
TGTGCGCCAGCATCAGCTCCAGATCCTCGCCCAGAGGTATCTGCCGGTGGAAAGCGACGGTATCCCGGGTGGCGAACTGA
AAGATGTTGCTAACACCAGCTTTGATTTCCGCCAGCCGAAAACCATCGCCGCCGACTTCCTCGCGGATGCCGATCAGCAA
AAGGTGAAGGGATACGATCATGCCTTCCTGCTGGATGCCAAAGGCGACGCCAGCCAGCCTGCGGCACAGGTCTGGTCGCA
GGATGGCAAGCTGCAGATGACGGTCTATACCTCCGCTCCGGCGCTGCAGTTTTACTCCGGCAACTATCTCGGCGGCACCC
CGTCGCAGACGACGGAGCCCTACGCCGACTGGCAGGGACTGGCGCTGGAGAGCGAATTCCTGCCGGATTCGCCGAACCAT
CCGCAATGGCCGCAGCCGGACTGTGTATTACGTCCGGGCCAGGAGTACGTCAGCCTGACGGAATATCAGTTTATCGCCCG
ATAA

Upstream 100 bases:

>100_bases
TGGTCGATACCGTTCAGCAGGCCGTTGCCAACGAGTATGAAGCGAAAACCGGTATTAAAGAGACATTCTATGTCTGCAAA
CCGTCACAGGGGGCCGGGCA

Downstream 100 bases:

>100_bases
TCGCCAGCGCCCTCCATCAGGGGGCGCTGCTTTTCGTCCCCGCCCTCCTCTCTGCCGCCTCTTTTTTCAGCAACCTGCTC
TATTTTCCGTCACCAAAGGA

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MLTQNTALAPDGQPWQQVTLRNKSGMTVTVADWGATLLSAEVPLADGSLRRPLLGCAKLEDYARQAAFLGASVGRYANRI
GHSRFPLDGQVVNVTPSNDAGHQLHGGPEGFDKRRWRIVRADEQEVLFALTSPDGDQGFPGTLQATAHYRLSDDNRIAIT
YRATVDQPCPVNMTNHVYFNLDGEQGDVRQHQLQILAQRYLPVESDGIPGGELKDVANTSFDFRQPKTIAADFLADADQQ
KVKGYDHAFLLDAKGDASQPAAQVWSQDGKLQMTVYTSAPALQFYSGNYLGGTPSQTTEPYADWQGLALESEFLPDSPNH
PQWPQPDCVLRPGQEYVSLTEYQFIAR

Sequences:

>Translated_347_residues
MLTQNTALAPDGQPWQQVTLRNKSGMTVTVADWGATLLSAEVPLADGSLRRPLLGCAKLEDYARQAAFLGASVGRYANRI
GHSRFPLDGQVVNVTPSNDAGHQLHGGPEGFDKRRWRIVRADEQEVLFALTSPDGDQGFPGTLQATAHYRLSDDNRIAIT
YRATVDQPCPVNMTNHVYFNLDGEQGDVRQHQLQILAQRYLPVESDGIPGGELKDVANTSFDFRQPKTIAADFLADADQQ
KVKGYDHAFLLDAKGDASQPAAQVWSQDGKLQMTVYTSAPALQFYSGNYLGGTPSQTTEPYADWQGLALESEFLPDSPNH
PQWPQPDCVLRPGQEYVSLTEYQFIAR
>Mature_347_residues
MLTQNTALAPDGQPWQQVTLRNKSGMTVTVADWGATLLSAEVPLADGSLRRPLLGCAKLEDYARQAAFLGASVGRYANRI
GHSRFPLDGQVVNVTPSNDAGHQLHGGPEGFDKRRWRIVRADEQEVLFALTSPDGDQGFPGTLQATAHYRLSDDNRIAIT
YRATVDQPCPVNMTNHVYFNLDGEQGDVRQHQLQILAQRYLPVESDGIPGGELKDVANTSFDFRQPKTIAADFLADADQQ
KVKGYDHAFLLDAKGDASQPAAQVWSQDGKLQMTVYTSAPALQFYSGNYLGGTPSQTTEPYADWQGLALESEFLPDSPNH
PQWPQPDCVLRPGQEYVSLTEYQFIAR

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=321, Percent_Identity=36.1370716510903, Blast_Score=196, Evalue=4e-50,
Organism=Escherichia coli, GI1786971, Length=347, Percent_Identity=72.6224783861671, Blast_Score=530, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI17557428, Length=329, Percent_Identity=31.9148936170213, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI115533334, Length=329, Percent_Identity=31.9148936170213, Blast_Score=187, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6319493, Length=347, Percent_Identity=25.6484149855908, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6324399, Length=353, Percent_Identity=25.2124645892351, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6322004, Length=362, Percent_Identity=27.0718232044199, Blast_Score=103, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24659048, Length=348, Percent_Identity=33.0459770114943, Blast_Score=188, Evalue=4e-48,
Organism=Drosophila melanogaster, GI24668278, Length=340, Percent_Identity=31.7647058823529, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24583720, Length=338, Percent_Identity=30.4733727810651, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24641876, Length=346, Percent_Identity=30.9248554913295, Blast_Score=171, Evalue=5e-43,
Organism=Drosophila melanogaster, GI24668282, Length=343, Percent_Identity=32.0699708454811, Blast_Score=160, Evalue=9e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR013458
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 38222; Mature: 38222

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTQNTALAPDGQPWQQVTLRNKSGMTVTVADWGATLLSAEVPLADGSLRRPLLGCAKLE
CCCCCCCCCCCCCCHHEEEEECCCCCEEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHH
DYARQAAFLGASVGRYANRIGHSRFPLDGQVVNVTPSNDAGHQLHGGPEGFDKRRWRIVR
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEE
ADEQEVLFALTSPDGDQGFPGTLQATAHYRLSDDNRIAITYRATVDQPCPVNMTNHVYFN
CCCCEEEEEEECCCCCCCCCCEEEEEEEEEECCCCEEEEEEEECCCCCCCCCCCCEEEEE
LDGEQGDVRQHQLQILAQRYLPVESDGIPGGELKDVANTSFDFRQPKTIAADFLADADQQ
ECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHCCCCHH
KVKGYDHAFLLDAKGDASQPAAQVWSQDGKLQMTVYTSAPALQFYSGNYLGGTPSQTTEP
HHCCCCEEEEEECCCCCCCHHHHHHCCCCCEEEEEEECCCEEEEECCCCCCCCCCCCCCC
YADWQGLALESEFLPDSPNHPQWPQPDCVLRPGQEYVSLTEYQFIAR
CCCCCCEEEECCCCCCCCCCCCCCCCCCEECCCHHHHHHHHEEEECC
>Mature Secondary Structure
MLTQNTALAPDGQPWQQVTLRNKSGMTVTVADWGATLLSAEVPLADGSLRRPLLGCAKLE
CCCCCCCCCCCCCCHHEEEEECCCCCEEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHH
DYARQAAFLGASVGRYANRIGHSRFPLDGQVVNVTPSNDAGHQLHGGPEGFDKRRWRIVR
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEE
ADEQEVLFALTSPDGDQGFPGTLQATAHYRLSDDNRIAITYRATVDQPCPVNMTNHVYFN
CCCCEEEEEEECCCCCCCCCCEEEEEEEEEECCCCEEEEEEEECCCCCCCCCCCCEEEEE
LDGEQGDVRQHQLQILAQRYLPVESDGIPGGELKDVANTSFDFRQPKTIAADFLADADQQ
ECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHCCCCHH
KVKGYDHAFLLDAKGDASQPAAQVWSQDGKLQMTVYTSAPALQFYSGNYLGGTPSQTTEP
HHCCCCEEEEEECCCCCCCHHHHHHCCCCCEEEEEEECCCEEEEECCCCCCCCCCCCCCC
YADWQGLALESEFLPDSPNHPQWPQPDCVLRPGQEYVSLTEYQFIAR
CCCCCCEEEECCCCCCCCCCCCCCCCCCEECCCHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7966338; 8905232; 9278503 [H]