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The map label for this gene is nagC [H]

Identifier: 238893725

GI number: 238893725

Start: 1591400

End: 1592620

Strand: Reverse

Name: nagC [H]

Synonym: KP1_1647

Alternate gene names: 238893725

Gene position: 1592620-1591400 (Counterclockwise)

Preceding gene: 238893726

Following gene: 238893724

Centisome position: 30.34

GC content: 58.97

Gene sequence:

>1221_bases
ATGACAGCAGGCGGACAAGCTCAAATTGGTAACGTTGACCTCGTAAAACAACTGAACAGCGCGGCCGTGTACCGCCTGAT
TGACCAGCATGGGCCCATCTCGCGCATTCAGATAGCCGAACAAAGCCAGCTTGCCCCTGCCAGCGTGACCAAAATCACGC
GTCAGCTTATTGAGCGCGGCCTGATCAAAGAAGTCGATCAGCAGGCCTCCACCGGTGGCCGCCGCGCTATCTCTATCATC
GCAGAAACTCGCAACTTCAACGCCATCGGCGTGCGGCTTGGCCGCTATGACGCCACTCTGACCCTGTATGATTTAAGCAG
CAAGACCCTGGAAGAGGAGCACTTCCCGCTGCCCGAGCGCACCCAGGAAACGCTGGAACACGCCCTGCTGAATATCATCG
CCACCTTTATCGAAAACTGTCAGCGCAAAATTCGCGAGCTGATCGCTATCTCAGTGATCCTGCCGGGCCTCGTCGACCCG
GAAAGCGGCGTGATCCGCTATATGCCGCACATTGCGGTGGAAAACTGGGGCCTGGTCGGGGCGCTGGAGAAACGCTTCAA
CGTTACCTGCTTTGTTGGCCACGATATCCGCAGCCTGGCGCTGGCCGAGCACTATTTTGGCGCAAGCCAGGATTGCGAAG
ACTCCATTCTGGTGCGCGTGCACCGCGGTACCGGGGCGGGGATTATCTCCAACGGGCGCATTTTTATCGGCCGCAACGGC
AACGTCGGCGAAATTGGCCATATTCAGGTCGACCCGCTGGGCGAACGCTGCCACTGCGGCAACTTCGGCTGTCTGGAGAC
CGTCGCGGCCAATGCCGCCATTGAACAGCGGGTTCGCCACCTGCTGGAGCAGGGCTACCAGAGCCGTCTGACGCCGGATG
ACTGCACGATCAAAACTATCTGCAAAGCGGCCAACAAGGGCGATGCCCTGGCCTGCGAGGTGATTGAGTACGTGGGGCGC
CACCTCGGGAAAACGATCGCCATCGCCATTAACCTGTTCAACCCACAAAAAATCGTCGTCGCCGGCGAAATAGTGGAAGC
TGAAAAGGTCCTTCTTCCGGCCATCGAAGGCTGCATTAACGCCCAGGCGCTTAAGGCGTTTCGTAAGAACCTGCCGGTGG
TGCGCTCCACCCTCGATCACCGCTCTGCAATCGGCGCCTTCGCGCTGGTCAAACGCGCCATGCTCAATGGCACGCTGCTG
CAGCGTTTGCTTGAGAGCTAA

Upstream 100 bases:

>100_bases
CGCCGGGCATGGTCGCTAACCTGACCGCCTTTACACGCGATTATAAAATCACCAAGACCATCGTTAATGGTAACGAGGTC
GTCACTGAGTAAGTAAAAGT

Downstream 100 bases:

>100_bases
TCGCCCCTTTTCTGATAGCGCGTCACCTTGATACGGACGGGCCTCGCCCGTCAGAGGTGTGAAACCTCATCGATGACGCG
TATAGTTTCGTCTTTGTTAA

Product: transcriptional repressor of genes for catabolic enzyme

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MTAGGQAQIGNVDLVKQLNSAAVYRLIDQHGPISRIQIAEQSQLAPASVTKITRQLIERGLIKEVDQQASTGGRRAISII
AETRNFNAIGVRLGRYDATLTLYDLSSKTLEEEHFPLPERTQETLEHALLNIIATFIENCQRKIRELIAISVILPGLVDP
ESGVIRYMPHIAVENWGLVGALEKRFNVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNG
NVGEIGHIQVDPLGERCHCGNFGCLETVAANAAIEQRVRHLLEQGYQSRLTPDDCTIKTICKAANKGDALACEVIEYVGR
HLGKTIAIAINLFNPQKIVVAGEIVEAEKVLLPAIEGCINAQALKAFRKNLPVVRSTLDHRSAIGAFALVKRAMLNGTLL
QRLLES

Sequences:

>Translated_406_residues
MTAGGQAQIGNVDLVKQLNSAAVYRLIDQHGPISRIQIAEQSQLAPASVTKITRQLIERGLIKEVDQQASTGGRRAISII
AETRNFNAIGVRLGRYDATLTLYDLSSKTLEEEHFPLPERTQETLEHALLNIIATFIENCQRKIRELIAISVILPGLVDP
ESGVIRYMPHIAVENWGLVGALEKRFNVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNG
NVGEIGHIQVDPLGERCHCGNFGCLETVAANAAIEQRVRHLLEQGYQSRLTPDDCTIKTICKAANKGDALACEVIEYVGR
HLGKTIAIAINLFNPQKIVVAGEIVEAEKVLLPAIEGCINAQALKAFRKNLPVVRSTLDHRSAIGAFALVKRAMLNGTLL
QRLLES
>Mature_405_residues
TAGGQAQIGNVDLVKQLNSAAVYRLIDQHGPISRIQIAEQSQLAPASVTKITRQLIERGLIKEVDQQASTGGRRAISIIA
ETRNFNAIGVRLGRYDATLTLYDLSSKTLEEEHFPLPERTQETLEHALLNIIATFIENCQRKIRELIAISVILPGLVDPE
SGVIRYMPHIAVENWGLVGALEKRFNVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGN
VGEIGHIQVDPLGERCHCGNFGCLETVAANAAIEQRVRHLLEQGYQSRLTPDDCTIKTICKAANKGDALACEVIEYVGRH
LGKTIAIAINLFNPQKIVVAGEIVEAEKVLLPAIEGCINAQALKAFRKNLPVVRSTLDHRSAIGAFALVKRAMLNGTLLQ
RLLES

Specific function: Acts as a repressor of the nagEBACD operon and acts both as an activator and a repressor for the transcription of the glmSU operon [H]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Escherichia coli, GI1786891, Length=406, Percent_Identity=88.9162561576355, Blast_Score=738, Evalue=0.0,
Organism=Escherichia coli, GI1787878, Length=400, Percent_Identity=39.75, Blast_Score=301, Evalue=4e-83,
Organism=Escherichia coli, GI87082127, Length=344, Percent_Identity=25, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87081733, Length=272, Percent_Identity=23.1617647058824, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790522, Length=319, Percent_Identity=25.0783699059561, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI87082230, Length=264, Percent_Identity=27.6515151515151, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000835
- InterPro:   IPR000600
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01047 MarR; PF00480 ROK [H]

EC number: NA

Molecular weight: Translated: 44352; Mature: 44221

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAGGQAQIGNVDLVKQLNSAAVYRLIDQHGPISRIQIAEQSQLAPASVTKITRQLIERG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHEEECHHCCCCHHHHHHHHHHHHHHH
LIKEVDQQASTGGRRAISIIAETRNFNAIGVRLGRYDATLTLYDLSSKTLEEEHFPLPER
HHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEEECEEEEEEEEECCCHHHHHHCCCCCHH
TQETLEHALLNIIATFIENCQRKIRELIAISVILPGLVDPESGVIRYMPHIAVENWGLVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCHHHHCCCCHHH
ALEKRFNVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNG
HHHHCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEECCEEEEECCC
NVGEIGHIQVDPLGERCHCGNFGCLETVAANAAIEQRVRHLLEQGYQSRLTPDDCTIKTI
CCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
CKAANKGDALACEVIEYVGRHLGKTIAIAINLFNPQKIVVAGEIVEAEKVLLPAIEGCIN
HHHCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHCC
AQALKAFRKNLPVVRSTLDHRSAIGAFALVKRAMLNGTLLQRLLES
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TAGGQAQIGNVDLVKQLNSAAVYRLIDQHGPISRIQIAEQSQLAPASVTKITRQLIERG
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHEEECHHCCCCHHHHHHHHHHHHHHH
LIKEVDQQASTGGRRAISIIAETRNFNAIGVRLGRYDATLTLYDLSSKTLEEEHFPLPER
HHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEEECEEEEEEEEECCCHHHHHHCCCCCHH
TQETLEHALLNIIATFIENCQRKIRELIAISVILPGLVDPESGVIRYMPHIAVENWGLVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCHHHHCCCCHHH
ALEKRFNVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNG
HHHHCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEECCEEEEECCC
NVGEIGHIQVDPLGERCHCGNFGCLETVAANAAIEQRVRHLLEQGYQSRLTPDDCTIKTI
CCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
CKAANKGDALACEVIEYVGRHLGKTIAIAINLFNPQKIVVAGEIVEAEKVLLPAIEGCIN
HHHCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHCC
AQALKAFRKNLPVVRSTLDHRSAIGAFALVKRAMLNGTLLQRLLES
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]