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The map label for this gene is betA [H]

Identifier: 238893614

GI number: 238893614

Start: 1467410

End: 1469119

Strand: Reverse

Name: betA [H]

Synonym: KP1_1528

Alternate gene names: 238893614

Gene position: 1469119-1467410 (Counterclockwise)

Preceding gene: 238893615

Following gene: 238893612

Centisome position: 27.99

GC content: 62.51

Gene sequence:

>1710_bases
TTGAGATGGGTAAATTCCAGTCCATATTTTAACCGGGAGGTTTTTTTGCAATTTGACTACATCATTATTGGTGCCGGCTC
CGCCGGCAACGTTCTGGCAACACGACTGACTGAAGATCCAAACACCACCGTCCTGCTGCTGGAAGCCGGCGGCCCTGACT
ACCGGTTCGATTTCCGCACCCAGATGCCCGCCGCGCTGGCTTATCCGCTGCAGGGCAAGCGCTACAACTGGGCCTACGAG
ACCGAACCTGAGCCGTACATGAACAATCGCCGCATGGAGTGCGGACGCGGCAAAGGGCTCGGCGGATCCTCGCTGATCAA
CGGCATGTGCTACATTCGCGGTAACGCGATGGATCTGGATAACTGGGCCAAAGAGCCGGGTCTGGAACACTGGAGCTATC
TCGACTGCCTGCCCTACTACCGGAAAGCGGAAACCCGCGATATCGGGCCTAACGACTACCACGGCGGCGATGGCCCGGTG
AGCGTGACGACGCCGAAGCCGGGCAATAATCCGCTCTTCGAGGCGATGGTTGAAGCCGGGGTGCAGGCGGGCTATCCGCG
TACCGACGATCTCAACGGCTACCAGCAGGAAGGCTTTGGCCCGATGGACCGCACCGTGACGCCGCAGGGCCGTCGCGCCA
GCACCGCCCGCGGCTATCTCGACCAGGCGCGCGGTCGCCCGAACCTGACCATCCGCACCCATGCGCTGACCGATCACATT
ATTTTTGCCGGCAAGCGCGCGGTGGGCGTCGAGTGGCTGGAGGGAGAGAGCACGATCCCGTCAAAAGCGACGGCCAACAA
AGAGGTGCTGCTGTGCGCCGGGGCGATTGCCTCGCCGCAGATCCTGCAGCGCTCCGGCGTGGGTAACCCGGAGCTGCTCA
GGCAGTTCGATATCCCGGTGGTGCACGATCTCCCCGGCGTGGGTGAGAACCTGCAGGACCATCTGGAGATGTATCTGCAG
TACGAGTGCAAAGAGCCGGTATCGCTCTACCCGGCGCTACAGTGGTGGAACCAGCCGAAGATCGGCGCCGAGTGGCTGTT
CGGCGGCACCGGCATCGGCGCCAGCAACCAGTTCGAAGCGGGCGGTTTTATCCGCAGCCGCGCAGAATTCGCCTGGCCGA
ACATTCAGTACCACTTCCTGCCGGTGGCGATTAACTACAATGGCTCCAACGCGGTGAAAGAGCACGGCTTCCAGTGCCAC
GTCGGCTCAATGCGTTCGCCCAGCCGCGGCCACGTGCGCCTGAAGTCGCGCGACCCGCACGCCCATCCGGCGATCCTGTT
TAACTATATGTCCCATGAGCAGGACTGGCAGGAGTTCCGCGACGCCATCCGCATTACCCGGGAGATCATGAACCAGCCGG
CGCTGGATAAGTATCGCGGCCGCGAAATCAGTCCGGGAATAGAATGCCAGAGCGATGCCGAACTGGATGAGTTTGTGCGC
AACCACGCCGAGACCGCGTTCCACCCGTGCGGGACCTGTAAGATGGGTTACGACGAGATGGCGGTGGTCGATGGCGAGGG
CCGCGTCCACGGTCTGGAAGGATTGCGGGTGGTCGACGCCTCGATCATGCCGCAGATCATCACCGGCAACCTCAACGCCA
CCACCATTATGATCGGCGAGAAGATGGCCGACGCCATTCGCGGCCGCCAGCCGCTGCCGCGCAGCACCGCGACGTATTAT
GTCGCTGGCGACGCGCCGGTTCGCCGCTAA

Upstream 100 bases:

>100_bases
CCGGCGGAAATGCCGGTTGGCGGCTACAAACACTCCGGCATTGGCCGCGAGAACGGCGTGATGACGCTGCAGAGTTACAC
CCAGGTGAAGTCCATCCAGG

Downstream 100 bases:

>100_bases
CAGGTCAATGCCGGGCGGCGACTACGCCTTGCCCGGCCTACCCTGAGGCGATGTAACGTAGCCCCGGTAAGCGCAGCGCG
ACCGGGGTGCCGTTCCGGGT

Product: choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 569; Mature: 569

Protein sequence:

>569_residues
MRWVNSSPYFNREVFLQFDYIIIGAGSAGNVLATRLTEDPNTTVLLLEAGGPDYRFDFRTQMPAALAYPLQGKRYNWAYE
TEPEPYMNNRRMECGRGKGLGGSSLINGMCYIRGNAMDLDNWAKEPGLEHWSYLDCLPYYRKAETRDIGPNDYHGGDGPV
SVTTPKPGNNPLFEAMVEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPQGRRASTARGYLDQARGRPNLTIRTHALTDHI
IFAGKRAVGVEWLEGESTIPSKATANKEVLLCAGAIASPQILQRSGVGNPELLRQFDIPVVHDLPGVGENLQDHLEMYLQ
YECKEPVSLYPALQWWNQPKIGAEWLFGGTGIGASNQFEAGGFIRSRAEFAWPNIQYHFLPVAINYNGSNAVKEHGFQCH
VGSMRSPSRGHVRLKSRDPHAHPAILFNYMSHEQDWQEFRDAIRITREIMNQPALDKYRGREISPGIECQSDAELDEFVR
NHAETAFHPCGTCKMGYDEMAVVDGEGRVHGLEGLRVVDASIMPQIITGNLNATTIMIGEKMADAIRGRQPLPRSTATYY
VAGDAPVRR

Sequences:

>Translated_569_residues
MRWVNSSPYFNREVFLQFDYIIIGAGSAGNVLATRLTEDPNTTVLLLEAGGPDYRFDFRTQMPAALAYPLQGKRYNWAYE
TEPEPYMNNRRMECGRGKGLGGSSLINGMCYIRGNAMDLDNWAKEPGLEHWSYLDCLPYYRKAETRDIGPNDYHGGDGPV
SVTTPKPGNNPLFEAMVEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPQGRRASTARGYLDQARGRPNLTIRTHALTDHI
IFAGKRAVGVEWLEGESTIPSKATANKEVLLCAGAIASPQILQRSGVGNPELLRQFDIPVVHDLPGVGENLQDHLEMYLQ
YECKEPVSLYPALQWWNQPKIGAEWLFGGTGIGASNQFEAGGFIRSRAEFAWPNIQYHFLPVAINYNGSNAVKEHGFQCH
VGSMRSPSRGHVRLKSRDPHAHPAILFNYMSHEQDWQEFRDAIRITREIMNQPALDKYRGREISPGIECQSDAELDEFVR
NHAETAFHPCGTCKMGYDEMAVVDGEGRVHGLEGLRVVDASIMPQIITGNLNATTIMIGEKMADAIRGRQPLPRSTATYY
VAGDAPVRR
>Mature_569_residues
MRWVNSSPYFNREVFLQFDYIIIGAGSAGNVLATRLTEDPNTTVLLLEAGGPDYRFDFRTQMPAALAYPLQGKRYNWAYE
TEPEPYMNNRRMECGRGKGLGGSSLINGMCYIRGNAMDLDNWAKEPGLEHWSYLDCLPYYRKAETRDIGPNDYHGGDGPV
SVTTPKPGNNPLFEAMVEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPQGRRASTARGYLDQARGRPNLTIRTHALTDHI
IFAGKRAVGVEWLEGESTIPSKATANKEVLLCAGAIASPQILQRSGVGNPELLRQFDIPVVHDLPGVGENLQDHLEMYLQ
YECKEPVSLYPALQWWNQPKIGAEWLFGGTGIGASNQFEAGGFIRSRAEFAWPNIQYHFLPVAINYNGSNAVKEHGFQCH
VGSMRSPSRGHVRLKSRDPHAHPAILFNYMSHEQDWQEFRDAIRITREIMNQPALDKYRGREISPGIECQSDAELDEFVR
NHAETAFHPCGTCKMGYDEMAVVDGEGRVHGLEGLRVVDASIMPQIITGNLNATTIMIGEKMADAIRGRQPLPRSTATYY
VAGDAPVRR

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=558, Percent_Identity=47.8494623655914, Blast_Score=497, Evalue=1e-141,
Organism=Escherichia coli, GI1786503, Length=553, Percent_Identity=91.6817359855335, Blast_Score=1078, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17532301, Length=562, Percent_Identity=46.085409252669, Blast_Score=481, Evalue=1e-136,
Organism=Drosophila melanogaster, GI24642048, Length=608, Percent_Identity=35.3618421052632, Blast_Score=305, Evalue=8e-83,
Organism=Drosophila melanogaster, GI24642059, Length=575, Percent_Identity=35.6521739130435, Blast_Score=300, Evalue=2e-81,
Organism=Drosophila melanogaster, GI45549471, Length=574, Percent_Identity=35.0174216027875, Blast_Score=292, Evalue=4e-79,
Organism=Drosophila melanogaster, GI45551458, Length=574, Percent_Identity=35.0174216027875, Blast_Score=292, Evalue=4e-79,
Organism=Drosophila melanogaster, GI24642042, Length=585, Percent_Identity=35.3846153846154, Blast_Score=286, Evalue=4e-77,
Organism=Drosophila melanogaster, GI17137792, Length=569, Percent_Identity=35.3251318101933, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24642055, Length=583, Percent_Identity=34.6483704974271, Blast_Score=266, Evalue=3e-71,
Organism=Drosophila melanogaster, GI24642051, Length=574, Percent_Identity=33.6236933797909, Blast_Score=250, Evalue=2e-66,
Organism=Drosophila melanogaster, GI18859995, Length=573, Percent_Identity=34.5549738219895, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24650267, Length=578, Percent_Identity=33.0449826989619, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24642039, Length=573, Percent_Identity=35.0785340314136, Blast_Score=246, Evalue=4e-65,
Organism=Drosophila melanogaster, GI24642035, Length=577, Percent_Identity=33.4488734835355, Blast_Score=231, Evalue=8e-61,
Organism=Drosophila melanogaster, GI24642037, Length=590, Percent_Identity=32.3728813559322, Blast_Score=223, Evalue=4e-58,
Organism=Drosophila melanogaster, GI18859993, Length=575, Percent_Identity=34.0869565217391, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24645930, Length=587, Percent_Identity=28.4497444633731, Blast_Score=162, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24642057, Length=584, Percent_Identity=29.2808219178082, Blast_Score=132, Evalue=9e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 63447; Mature: 63447

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRWVNSSPYFNREVFLQFDYIIIGAGSAGNVLATRLTEDPNTTVLLLEAGGPDYRFDFRT
CCCCCCCCCCCCEEEEEEEEEEEECCCCCCEEEEEECCCCCCEEEEEECCCCCEEEEECC
QMPAALAYPLQGKRYNWAYETEPEPYMNNRRMECGRGKGLGGSSLINGMCYIRGNAMDLD
CCCCCEECCCCCCEECCEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCCCCCH
NWAKEPGLEHWSYLDCLPYYRKAETRDIGPNDYHGGDGPVSVTTPKPGNNPLFEAMVEAG
HHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHH
VQAGYPRTDDLNGYQQEGFGPMDRTVTPQGRRASTARGYLDQARGRPNLTIRTHALTDHI
HHCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEEECEE
IFAGKRAVGVEWLEGESTIPSKATANKEVLLCAGAIASPQILQRSGVGNPELLRQFDIPV
EEECCCEECEEEECCCCCCCCCCCCCCEEEEEECCCCCHHHHHHCCCCCHHHHHHCCCCC
VHDLPGVGENLQDHLEMYLQYECKEPVSLYPALQWWNQPKIGAEWLFGGTGIGASNQFEA
EECCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCC
GGFIRSRAEFAWPNIQYHFLPVAINYNGSNAVKEHGFQCHVGSMRSPSRGHVRLKSRDPH
CCEECCCCHHCCCCCEEEEEEEEEEECCCCHHHHCCCEEEECCCCCCCCCEEEEECCCCC
AHPAILFNYMSHEQDWQEFRDAIRITREIMNQPALDKYRGREISPGIECQSDAELDEFVR
CCHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCHHHHHH
NHAETAFHPCGTCKMGYDEMAVVDGEGRVHGLEGLRVVDASIMPQIITGNLNATTIMIGE
HHHHHHCCCCCCCCCCCCCEEEECCCCCEECCCCEEEECHHHCCEEEECCCCEEEEEECH
KMADAIRGRQPLPRSTATYYVAGDAPVRR
HHHHHHHCCCCCCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MRWVNSSPYFNREVFLQFDYIIIGAGSAGNVLATRLTEDPNTTVLLLEAGGPDYRFDFRT
CCCCCCCCCCCCEEEEEEEEEEEECCCCCCEEEEEECCCCCCEEEEEECCCCCEEEEECC
QMPAALAYPLQGKRYNWAYETEPEPYMNNRRMECGRGKGLGGSSLINGMCYIRGNAMDLD
CCCCCEECCCCCCEECCEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCCCCCH
NWAKEPGLEHWSYLDCLPYYRKAETRDIGPNDYHGGDGPVSVTTPKPGNNPLFEAMVEAG
HHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHH
VQAGYPRTDDLNGYQQEGFGPMDRTVTPQGRRASTARGYLDQARGRPNLTIRTHALTDHI
HHCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEEECEE
IFAGKRAVGVEWLEGESTIPSKATANKEVLLCAGAIASPQILQRSGVGNPELLRQFDIPV
EEECCCEECEEEECCCCCCCCCCCCCCEEEEEECCCCCHHHHHHCCCCCHHHHHHCCCCC
VHDLPGVGENLQDHLEMYLQYECKEPVSLYPALQWWNQPKIGAEWLFGGTGIGASNQFEA
EECCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCC
GGFIRSRAEFAWPNIQYHFLPVAINYNGSNAVKEHGFQCHVGSMRSPSRGHVRLKSRDPH
CCEECCCCHHCCCCCEEEEEEEEEEECCCCHHHHCCCEEEECCCCCCCCCEEEEECCCCC
AHPAILFNYMSHEQDWQEFRDAIRITREIMNQPALDKYRGREISPGIECQSDAELDEFVR
CCHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCHHHHHH
NHAETAFHPCGTCKMGYDEMAVVDGEGRVHGLEGLRVVDASIMPQIITGNLNATTIMIGE
HHHHHHCCCCCCCCCCCCCEEEECCCCCEECCCCEEEECHHHCCEEEECCCCEEEEEECH
KMADAIRGRQPLPRSTATYYVAGDAPVRR
HHHHHHHCCCCCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA