| Definition | Klebsiella pneumoniae NTUH-K2044 chromosome, complete genome. |
|---|---|
| Accession | NC_012731 |
| Length | 5,248,520 |
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The map label for this gene is sdh [H]
Identifier: 238893603
GI number: 238893603
Start: 1456938
End: 1457795
Strand: Reverse
Name: sdh [H]
Synonym: KP1_1516
Alternate gene names: 238893603
Gene position: 1457795-1456938 (Counterclockwise)
Preceding gene: 238893605
Following gene: 238893598
Centisome position: 27.78
GC content: 62.82
Gene sequence:
>858_bases GTGACACGGTGTCACATCCCTGCCCGTCGTCTGGCCCTGTGCCTTGTCGTCCGGCGTTTTTATAGTGAAGGGACAACCGC ACAGGAGAATGAGATGGCAACGAGCAACGTAGTGTTTATCACCGGGGCGACCTCGGGTTTTGGCGAAGCGGCAGCGCAGG TGTTTGCCGACGCGGGCTGGTCGCTGGTGCTGAGCGGGCGCCGCTATCCGCGACTGAAGGCCTTGCAGGACAGACTCGCC GCCAGGGTGCCGGTGCATATTATTGAGCTTGACGTTCGTGACAGCGAGGCGGTGGCTGCCGCCGTGGCGTCGCTGCCCGC CGATTTCGCCGATATCACCACCCTGATCAACAACGCCGGGCTGGCGCTGTCGCCGCTGCCGGCGCAGGAGGTGGCGCTGG AGGACTGGAAAACGATGATCGACACCAACGTCACCGGTCTGGTGACAGTCACTCACGCCCTGCTGCCGACGCTGATCCGC CATGGCGCCGGGGCGAGTATTATCAATATCGGCTCGATCGCCGGGCAGTGGCCCTATCCCGGCAGCCATGTGTATGGCGC CAGCAAGGCGTTTGTGAAGCAGTTCAGCTATAACCTGCGCTGCGATCTGCTTGGCACCGGCGTGCGGGTCACCGATCTGG CGCCGGGGATTGCCGAGACCGAATTCACCCTGGTGCGTACCAAAGGCGACCAGGCGGCATCGGATAAGCTCTATCGCGGC ACCACGCCGCTGAGCGCGCACGATATCGCCGAGCAGATGTTTTATATCGCCACGTTGCCGGCGCATATGAACATTAACCG GGTGGAGGTGATGCCGGTGCGTCAGGCGTGGCAGCCGTTCGCTATCGACCGGGATTAA
Upstream 100 bases:
>100_bases TTGCCAGCTTCATACCCTGCCCTCTCTCATGTCGTAGTGGTTGGCTTCATCATTGGCCTTGGCCGCGCAAATCGGATAGA GCCAGTGCGCGCATAACGAT
Downstream 100 bases:
>100_bases GCGAAACCCGACACATCCCCTGTCGGCGATACCGGCAGGTGATGCAGGCCGGACTAACGGCTGCTTTGCAGAAACTGCCT GACGCGTTCGGAGTCAGGCT
Product: putative oxidoreductase
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 285; Mature: 284
Protein sequence:
>285_residues MTRCHIPARRLALCLVVRRFYSEGTTAQENEMATSNVVFITGATSGFGEAAAQVFADAGWSLVLSGRRYPRLKALQDRLA ARVPVHIIELDVRDSEAVAAAVASLPADFADITTLINNAGLALSPLPAQEVALEDWKTMIDTNVTGLVTVTHALLPTLIR HGAGASIINIGSIAGQWPYPGSHVYGASKAFVKQFSYNLRCDLLGTGVRVTDLAPGIAETEFTLVRTKGDQAASDKLYRG TTPLSAHDIAEQMFYIATLPAHMNINRVEVMPVRQAWQPFAIDRD
Sequences:
>Translated_285_residues MTRCHIPARRLALCLVVRRFYSEGTTAQENEMATSNVVFITGATSGFGEAAAQVFADAGWSLVLSGRRYPRLKALQDRLA ARVPVHIIELDVRDSEAVAAAVASLPADFADITTLINNAGLALSPLPAQEVALEDWKTMIDTNVTGLVTVTHALLPTLIR HGAGASIINIGSIAGQWPYPGSHVYGASKAFVKQFSYNLRCDLLGTGVRVTDLAPGIAETEFTLVRTKGDQAASDKLYRG TTPLSAHDIAEQMFYIATLPAHMNINRVEVMPVRQAWQPFAIDRD >Mature_284_residues TRCHIPARRLALCLVVRRFYSEGTTAQENEMATSNVVFITGATSGFGEAAAQVFADAGWSLVLSGRRYPRLKALQDRLAA RVPVHIIELDVRDSEAVAAAVASLPADFADITTLINNAGLALSPLPAQEVALEDWKTMIDTNVTGLVTVTHALLPTLIRH GAGASIINIGSIAGQWPYPGSHVYGASKAFVKQFSYNLRCDLLGTGVRVTDLAPGIAETEFTLVRTKGDQAASDKLYRGT TPLSAHDIAEQMFYIATLPAHMNINRVEVMPVRQAWQPFAIDRD
Specific function: Catalyzes the oxidation of the hydroxyl group of serine to form 2-aminomalonate semialdehyde which is spontaneously converted into 2-aminoacetaldehyde and CO(2). Also acts on D- serine, L-glycerate, D-glycerate and 2-methyl-DL-serine. Does not act on O-me
COG id: COG4221
COG function: function code R; Short-chain alcohol dehydrogenase of unknown specificity
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI20149619, Length=195, Percent_Identity=35.3846153846154, Blast_Score=97, Evalue=1e-20, Organism=Homo sapiens, GI109715829, Length=247, Percent_Identity=27.5303643724696, Blast_Score=93, Evalue=3e-19, Organism=Homo sapiens, GI7706318, Length=263, Percent_Identity=28.8973384030418, Blast_Score=88, Evalue=1e-17, Organism=Homo sapiens, GI157739938, Length=245, Percent_Identity=28.5714285714286, Blast_Score=85, Evalue=7e-17, Organism=Homo sapiens, GI40548397, Length=194, Percent_Identity=31.9587628865979, Blast_Score=83, Evalue=3e-16, Organism=Homo sapiens, GI214010158, Length=194, Percent_Identity=31.9587628865979, Blast_Score=83, Evalue=3e-16, Organism=Homo sapiens, GI214010156, Length=194, Percent_Identity=31.9587628865979, Blast_Score=83, Evalue=3e-16, Organism=Homo sapiens, GI22758144, Length=194, Percent_Identity=31.9587628865979, Blast_Score=83, Evalue=3e-16, Organism=Homo sapiens, GI19923817, Length=204, Percent_Identity=27.9411764705882, Blast_Score=81, Evalue=9e-16, Organism=Homo sapiens, GI150247226, Length=188, Percent_Identity=32.9787234042553, Blast_Score=81, Evalue=1e-15, Organism=Homo sapiens, GI22507405, Length=189, Percent_Identity=30.6878306878307, Blast_Score=75, Evalue=6e-14, Organism=Homo sapiens, GI119392083, Length=211, Percent_Identity=27.4881516587678, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI10190704, Length=235, Percent_Identity=29.7872340425532, Blast_Score=72, Evalue=4e-13, Organism=Homo sapiens, GI223718074, Length=198, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=8e-13, Organism=Homo sapiens, GI4504503, Length=217, Percent_Identity=27.1889400921659, Blast_Score=71, Evalue=1e-12, Organism=Homo sapiens, GI40254992, Length=189, Percent_Identity=29.6296296296296, Blast_Score=71, Evalue=1e-12, Organism=Homo sapiens, GI44680136, Length=263, Percent_Identity=27.3764258555133, Blast_Score=70, Evalue=3e-12, Organism=Homo sapiens, GI44680133, Length=263, Percent_Identity=27.3764258555133, Blast_Score=70, Evalue=3e-12, Organism=Homo sapiens, GI17738292, Length=263, Percent_Identity=27.3764258555133, Blast_Score=70, Evalue=3e-12, Organism=Homo sapiens, GI19743808, Length=239, Percent_Identity=29.2887029288703, Blast_Score=70, Evalue=3e-12, Organism=Homo sapiens, GI7705855, Length=192, Percent_Identity=28.125, Blast_Score=69, Evalue=3e-12, Organism=Homo sapiens, GI226371731, Length=188, Percent_Identity=27.6595744680851, Blast_Score=67, Evalue=2e-11, Organism=Escherichia coli, GI1787820, Length=249, Percent_Identity=49.3975903614458, Blast_Score=251, Evalue=5e-68, Organism=Escherichia coli, GI1787335, Length=189, Percent_Identity=29.1005291005291, Blast_Score=83, Evalue=2e-17, Organism=Escherichia coli, GI87082100, Length=190, Percent_Identity=32.1052631578947, Blast_Score=77, Evalue=2e-15, Organism=Escherichia coli, GI1786812, Length=244, Percent_Identity=25.8196721311475, Blast_Score=74, Evalue=1e-14, Organism=Escherichia coli, GI2367175, Length=193, Percent_Identity=25.3886010362694, Blast_Score=72, Evalue=3e-14, Organism=Escherichia coli, GI1788459, Length=184, Percent_Identity=24.4565217391304, Blast_Score=64, Evalue=8e-12, Organism=Escherichia coli, GI1786701, Length=216, Percent_Identity=29.1666666666667, Blast_Score=62, Evalue=5e-11, Organism=Escherichia coli, GI87082160, Length=192, Percent_Identity=28.125, Blast_Score=61, Evalue=7e-11, Organism=Caenorhabditis elegans, GI71994604, Length=232, Percent_Identity=29.7413793103448, Blast_Score=100, Evalue=1e-21, Organism=Caenorhabditis elegans, GI71994600, Length=233, Percent_Identity=27.8969957081545, Blast_Score=91, Evalue=9e-19, Organism=Caenorhabditis elegans, GI17562990, Length=207, Percent_Identity=31.4009661835749, Blast_Score=84, Evalue=8e-17, Organism=Caenorhabditis elegans, GI17560150, Length=207, Percent_Identity=30.4347826086957, Blast_Score=81, Evalue=5e-16, Organism=Caenorhabditis elegans, GI17562908, Length=199, Percent_Identity=31.1557788944724, Blast_Score=79, Evalue=3e-15, Organism=Caenorhabditis elegans, GI17562904, Length=214, Percent_Identity=27.1028037383178, Blast_Score=78, Evalue=4e-15, Organism=Caenorhabditis elegans, GI17562910, Length=205, Percent_Identity=28.780487804878, Blast_Score=78, Evalue=6e-15, Organism=Caenorhabditis elegans, GI17538486, Length=198, Percent_Identity=30.3030303030303, Blast_Score=77, Evalue=8e-15, Organism=Caenorhabditis elegans, GI17565030, Length=221, Percent_Identity=29.8642533936652, Blast_Score=77, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17559104, Length=195, Percent_Identity=29.2307692307692, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI193204405, Length=198, Percent_Identity=30.3030303030303, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI17560332, Length=213, Percent_Identity=27.2300469483568, Blast_Score=74, Evalue=6e-14, Organism=Caenorhabditis elegans, GI17560220, Length=199, Percent_Identity=30.6532663316583, Blast_Score=74, Evalue=8e-14, Organism=Caenorhabditis elegans, GI17538480, Length=213, Percent_Identity=25.8215962441315, Blast_Score=74, Evalue=1e-13, Organism=Caenorhabditis elegans, GI17562906, Length=199, Percent_Identity=29.1457286432161, Blast_Score=73, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17563726, Length=235, Percent_Identity=28.0851063829787, Blast_Score=71, Evalue=5e-13, Organism=Caenorhabditis elegans, GI17531453, Length=193, Percent_Identity=30.5699481865285, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17551412, Length=202, Percent_Identity=26.7326732673267, Blast_Score=68, Evalue=6e-12, Organism=Caenorhabditis elegans, GI72000259, Length=191, Percent_Identity=27.7486910994764, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17538182, Length=194, Percent_Identity=28.8659793814433, Blast_Score=66, Evalue=2e-11, Organism=Saccharomyces cerevisiae, GI6323882, Length=252, Percent_Identity=37.3015873015873, Blast_Score=174, Evalue=1e-44, Organism=Saccharomyces cerevisiae, GI6319635, Length=242, Percent_Identity=26.8595041322314, Blast_Score=79, Evalue=1e-15, Organism=Saccharomyces cerevisiae, GI6322227, Length=210, Percent_Identity=25.7142857142857, Blast_Score=65, Evalue=9e-12, Organism=Drosophila melanogaster, GI116007236, Length=255, Percent_Identity=28.2352941176471, Blast_Score=103, Evalue=2e-22, Organism=Drosophila melanogaster, GI23397609, Length=193, Percent_Identity=35.2331606217617, Blast_Score=102, Evalue=4e-22, Organism=Drosophila melanogaster, GI21358495, Length=250, Percent_Identity=30, Blast_Score=100, Evalue=1e-21, Organism=Drosophila melanogaster, GI21357041, Length=188, Percent_Identity=31.3829787234043, Blast_Score=93, Evalue=2e-19, Organism=Drosophila melanogaster, GI28571526, Length=189, Percent_Identity=32.8042328042328, Blast_Score=91, Evalue=8e-19, Organism=Drosophila melanogaster, GI24643142, Length=215, Percent_Identity=33.4883720930233, Blast_Score=89, Evalue=2e-18, Organism=Drosophila melanogaster, GI24641232, Length=250, Percent_Identity=27.2, Blast_Score=80, Evalue=2e-15, Organism=Drosophila melanogaster, GI116007234, Length=256, Percent_Identity=28.515625, Blast_Score=79, Evalue=4e-15, Organism=Drosophila melanogaster, GI24644339, Length=189, Percent_Identity=28.5714285714286, Blast_Score=78, Evalue=5e-15, Organism=Drosophila melanogaster, GI28571387, Length=249, Percent_Identity=27.710843373494, Blast_Score=77, Evalue=2e-14, Organism=Drosophila melanogaster, GI116007238, Length=186, Percent_Identity=30.1075268817204, Blast_Score=77, Evalue=2e-14, Organism=Drosophila melanogaster, GI24640442, Length=222, Percent_Identity=27.4774774774775, Blast_Score=75, Evalue=3e-14, Organism=Drosophila melanogaster, GI24648944, Length=251, Percent_Identity=26.2948207171315, Blast_Score=75, Evalue=5e-14, Organism=Drosophila melanogaster, GI281364494, Length=254, Percent_Identity=24.0157480314961, Blast_Score=74, Evalue=1e-13, Organism=Drosophila melanogaster, GI161076933, Length=207, Percent_Identity=27.0531400966184, Blast_Score=73, Evalue=2e-13, Organism=Drosophila melanogaster, GI24584748, Length=207, Percent_Identity=27.0531400966184, Blast_Score=73, Evalue=3e-13, Organism=Drosophila melanogaster, GI24580925, Length=246, Percent_Identity=26.8292682926829, Blast_Score=69, Evalue=3e-12, Organism=Drosophila melanogaster, GI28574402, Length=205, Percent_Identity=27.8048780487805, Blast_Score=69, Evalue=4e-12, Organism=Drosophila melanogaster, GI24584744, Length=186, Percent_Identity=29.0322580645161, Blast_Score=69, Evalue=4e-12, Organism=Drosophila melanogaster, GI24663911, Length=253, Percent_Identity=22.1343873517787, Blast_Score=66, Evalue=3e-11, Organism=Drosophila melanogaster, GI24641388, Length=253, Percent_Identity=26.8774703557312, Blast_Score=65, Evalue=6e-11, Organism=Drosophila melanogaster, GI21355319, Length=218, Percent_Identity=25.6880733944954, Blast_Score=64, Evalue=9e-11,
Paralogues:
None
Copy number: 1300 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.276 [H]
Molecular weight: Translated: 30831; Mature: 30699
Theoretical pI: Translated: 6.88; Mature: 6.88
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.1 %Cys (Translated Protein) 2.1 %Met (Translated Protein) 3.2 %Cys+Met (Translated Protein) 1.1 %Cys (Mature Protein) 1.8 %Met (Mature Protein) 2.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTRCHIPARRLALCLVVRRFYSEGTTAQENEMATSNVVFITGATSGFGEAAAQVFADAGW CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCC SLVLSGRRYPRLKALQDRLAARVPVHIIELDVRDSEAVAAAVASLPADFADITTLINNAG EEEECCCCCCHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHCCC LALSPLPAQEVALEDWKTMIDTNVTGLVTVTHALLPTLIRHGAGASIINIGSIAGQWPYP CEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCC GSHVYGASKAFVKQFSYNLRCDLLGTGVRVTDLAPGIAETEFTLVRTKGDQAASDKLYRG CCCCCCCHHHHHHHHCCCEEEEEEECCEEEEECCCCCCCCEEEEEEECCCCHHCCCEECC TTPLSAHDIAEQMFYIATLPAHMNINRVEVMPVRQAWQPFAIDRD CCCCCHHHHHHHHHHEEECCCCCCCCEEEEEEHHHCCCCCCCCCC >Mature Secondary Structure TRCHIPARRLALCLVVRRFYSEGTTAQENEMATSNVVFITGATSGFGEAAAQVFADAGW CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCC SLVLSGRRYPRLKALQDRLAARVPVHIIELDVRDSEAVAAAVASLPADFADITTLINNAG EEEECCCCCCHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHCCC LALSPLPAQEVALEDWKTMIDTNVTGLVTVTHALLPTLIRHGAGASIINIGSIAGQWPYP CEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCC GSHVYGASKAFVKQFSYNLRCDLLGTGVRVTDLAPGIAETEFTLVRTKGDQAASDKLYRG CCCCCCCHHHHHHHHCCCEEEEEEECCEEEEECCCCCCCCEEEEEEECCCCHHCCCEECC TTPLSAHDIAEQMFYIATLPAHMNINRVEVMPVRQAWQPFAIDRD CCCCCHHHHHHHHHHEEECCCCCCCCEEEEEEHHHCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 11743193; 11743194 [H]