Click here to switch to the map view.

The map label for this gene is manY [H]

Identifier: 238893575

GI number: 238893575

Start: 1427215

End: 1427958

Strand: Reverse

Name: manY [H]

Synonym: KP1_1483

Alternate gene names: 238893575

Gene position: 1427958-1427215 (Counterclockwise)

Preceding gene: 238893576

Following gene: 238893574

Centisome position: 27.21

GC content: 56.32

Gene sequence:

>744_bases
ATGTTGCTCACCGCAACGTTACTCGGACTGATCGCTGCCCTGGGGATACTTGATGGCCGCCTGCTTGGGGTATCAATGAT
CGATCGACCGCTGGTGATGTGCGCCCTCACCGGTCTGGTCTGCGGTAATTTACATGAGGGGATTCTGATTGGCGCTACGC
TGGAGCTTATTTTCCTCGGCAACGTCGCCATCGGCGCCGCGCACCCGCCAGATATCGTGACCGGCTCCGTATTGGCCACC
GCGTTTTCGATCATGTCCGGTCGTGGTCCAGAGGCTGCGCTCACCATCGCCATCCCTGTCTCAATGCTGGCGCAGACGCT
GGGAATCCTGGTGCGCGTGGTGAACGCCCGCTTTGGTCATCTGGCGGACCGCTATGCGGCACAGGGTAATACCCGAATGG
TCGGCCTGATGCACCTCGCCGGTCCGACGCTACTCTATTTTTTAAACGGATTTCTACCGGTATTTTTTGCCATTCTGCTT
GGTTCTTCGGCGGTAAGCTGGTTCCTGGAGGCCATTCCGCCGGTGATAACCAATGGATTGATCGTCGCCAGTAAGATCCT
GCCAGCGCTCGGCTTCGCCCTGCTGATCAGCATGATGCTCAGCAGCAAACTGATGCCGTACCTCGGTCTGGGATTTCTGA
TAGCGGCATATACCAAACTGGATATCATCGCCATCGCGCTGTTCGCTGTGGTGTTGGCATTTATCATCAGCCAGTTCCTT
AATCTTAAGCAGCAGGAGAGCTAA

Upstream 100 bases:

>100_bases
GCAGAGCGCTAAAAGAAAAAGGTATTCGGCTGGAGATGCGTCAGGTACCCGCCCACTCGGCTGAACTCCTTAACGACCAA
CTTTAACTTCGGAGGTCACT

Downstream 100 bases:

>100_bases
TCATGAGCGAAATGACGCAAACTGTGACTGGCGCTACCCAGCCGCAAAGCGATGATGCAAGCCGCATCACCGCCCGCGAT
TTACGCAGCGTGTTCTGGCG

Product: putative inner membrane protein

Products: protein histidine; sugar phosphate; D-glucosamine-6-phosphate [Cytoplasm]; pyruvate; glucose-6-phosphate [Cytoplasm]; N-acetyl-D-glucosamine-6-phosphate [Cytoplasm]; mannose-6-phosphate [Cytoplasm]; fructose-6-phosphate [Cytoplasm] [C]

Alternate protein names: EII-P-Man; EIIC-Man; PTS system mannose-specific EIIC component [H]

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MLLTATLLGLIAALGILDGRLLGVSMIDRPLVMCALTGLVCGNLHEGILIGATLELIFLGNVAIGAAHPPDIVTGSVLAT
AFSIMSGRGPEAALTIAIPVSMLAQTLGILVRVVNARFGHLADRYAAQGNTRMVGLMHLAGPTLLYFLNGFLPVFFAILL
GSSAVSWFLEAIPPVITNGLIVASKILPALGFALLISMMLSSKLMPYLGLGFLIAAYTKLDIIAIALFAVVLAFIISQFL
NLKQQES

Sequences:

>Translated_247_residues
MLLTATLLGLIAALGILDGRLLGVSMIDRPLVMCALTGLVCGNLHEGILIGATLELIFLGNVAIGAAHPPDIVTGSVLAT
AFSIMSGRGPEAALTIAIPVSMLAQTLGILVRVVNARFGHLADRYAAQGNTRMVGLMHLAGPTLLYFLNGFLPVFFAILL
GSSAVSWFLEAIPPVITNGLIVASKILPALGFALLISMMLSSKLMPYLGLGFLIAAYTKLDIIAIALFAVVLAFIISQFL
NLKQQES
>Mature_247_residues
MLLTATLLGLIAALGILDGRLLGVSMIDRPLVMCALTGLVCGNLHEGILIGATLELIFLGNVAIGAAHPPDIVTGSVLAT
AFSIMSGRGPEAALTIAIPVSMLAQTLGILVRVVNARFGHLADRYAAQGNTRMVGLMHLAGPTLLYFLNGFLPVFFAILL
GSSAVSWFLEAIPPVITNGLIVASKILPALGFALLISMMLSSKLMPYLGLGFLIAAYTKLDIIAIALFAVVLAFIISQFL
NLKQQES

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system i

COG id: COG3715

COG function: function code G; Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-4 domain [H]

Homologues:

Organism=Escherichia coli, GI1788121, Length=220, Percent_Identity=36.3636363636364, Blast_Score=120, Evalue=8e-29,
Organism=Escherichia coli, GI1789528, Length=221, Percent_Identity=27.6018099547511, Blast_Score=97, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004700
- InterPro:   IPR018404 [H]

Pfam domain/function: PF03609 EII-Sor [H]

EC number: NA

Molecular weight: Translated: 25897; Mature: 25897

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: PS51106 PTS_EIIC_TYPE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLTATLLGLIAALGILDGRLLGVSMIDRPLVMCALTGLVCGNLHEGILIGATLELIFLG
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHCC
NVAIGAAHPPDIVTGSVLATAFSIMSGRGPEAALTIAIPVSMLAQTLGILVRVVNARFGH
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
LADRYAAQGNTRMVGLMHLAGPTLLYFLNGFLPVFFAILLGSSAVSWFLEAIPPVITNGL
HHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCH
IVASKILPALGFALLISMMLSSKLMPYLGLGFLIAAYTKLDIIAIALFAVVLAFIISQFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLKQQES
HHHCCCC
>Mature Secondary Structure
MLLTATLLGLIAALGILDGRLLGVSMIDRPLVMCALTGLVCGNLHEGILIGATLELIFLG
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHCC
NVAIGAAHPPDIVTGSVLATAFSIMSGRGPEAALTIAIPVSMLAQTLGILVRVVNARFGH
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
LADRYAAQGNTRMVGLMHLAGPTLLYFLNGFLPVFFAILLGSSAVSWFLEAIPPVITNGL
HHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCH
IVASKILPALGFALLISMMLSSKLMPYLGLGFLIAAYTKLDIIAIALFAVVLAFIISQFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLKQQES
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: protein N p -phosphohistidine; sugar; phosphoenolpyruvate; glucosamine [Periplasm]; phosphoenolpyruvate; beta-D-glucose [Periplasm]; N-acetyl-D-glucosamine [Periplasm]; mannose [Periplasm]; fructose [Periplasm] [C]

Specific reaction: protein N p -phosphohistidine + sugar = protein histidine + sugar phosphate phosphoenolpyruvate + glucosamine [Periplasm] = D-glucosamine-6-phosphate [Cytoplasm] + pyruvate phosphoenolpyruvate + beta-D-glucose [Periplasm] = glucose-6-phosphate [Cytoplasm]

General reaction: Transferring phosphorus-containing groups; Phosphotransferases with an alcohol group as acceptor [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]