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The map label for this gene is acoD [H]

Identifier: 238893246

GI number: 238893246

Start: 1088321

End: 1089718

Strand: Reverse

Name: acoD [H]

Synonym: KP1_1116

Alternate gene names: 238893246

Gene position: 1089718-1088321 (Counterclockwise)

Preceding gene: 238893247

Following gene: 238893245

Centisome position: 20.76

GC content: 58.66

Gene sequence:

>1398_bases
ATGCACGATAAATACGATGTGCTGATCATCGGCGGGGGTCCTGGGGGATACGTTGCCGCCATCCGTGCCGGCCAGCTAGG
GCTTCGTACCGTATTAGTGGAAAAACAACATCTGGGCGGCATCTGCCTGAACTGGGGATGCATTCCAACCAAGGCGCTGC
TGCATGGCGCTGAGGTTGCGCACACTATCACCCATGCCAGTCAGCTGGGCATCAGCGTGGGCGAGGTGAACGTCGATCTG
CAGAAACTGGTGCAGTTTAGCCGTACCGTATCGCAACAGCTCACCGCTGGGGTTGCGTACCTGTTGAAGAAAAATGGCGT
GCAGGTCATTGATGGCACCGCGCGGCTGCGCGGCAAGGGGCAAATCACGGTCGAGGATGCCCGAGGGGAGGCGCGCGATT
ACCGGGCCGATCACGTGATCCTGGCAACCGGCGCCCGACCACGCGCATTGCCAGGCATAGCGCCAGATGGCGAACATATC
TGGACCTATTTCGAGGCGCTGCGGCCTAAGCTTTTACCCAAGTCGCTCTTAATCATCGGTTCAGGGGCAATTGGCGTCGA
GTTCGCCAGCCTCTATAACGATCTGGGCTGTAAAGTGACGCTGGTCGAGCTAGCGTCGCAGATTTTGCCAGTGGAAGATG
CCGAGGTGTCTGCAGCAGTGCGTAAGTCATTCGAAAAACGCGATATTCAGATCCATACCCAGACCCTGGTGACGCAAGTA
CAGCTCACCGATACCGGGGTGCGCTGCACACTAAACAACACCGGCGGCGAATATTCTCAGGATGTCGAACGTGTGCTGCT
GGCGGTTGGCGTACAGCCGAATATTGAAGATCTGGGGCTGGAAGCACTGGGCGTCGAGTTAGACCGCGGTTTTATCAAGA
CGGACGCGGCTTGTCGCACTAACGTATTCGGGCTTTATGCCATCGGCGATGTAGCCGGCCCGCCGTGCCTGGCGCACAAG
GCCAGCCACGAAGGCGTGATCTGCGTTGAGACACTGGCCGGTGTCGAAGGCGCCCACCCTCTCGATCGCGACTATGTGCC
TGGTTGCACTTATGCCCGGCCCCAGGTTGCCAGTCTGGGCCTGACGGAATCGACGGCCCTGGCCAGGGGACGGCCCGTCA
GGATCGGTAAGTTCTCTTATCAGAGCAATGGTAAGGCGCTGGCCAGCGGCGAGACAGAGGGTTTTGTGAAGACGATTTTC
GATGCTGAAACCGGCGAGTTGCTGGGCGCGCATATGGTTGGCGCACAGGTCACGGAACAGATCCAGGGCTTTGGCATCGC
CCGTCACCTGGAGGCCACAGACGAAAGTCTCCTGTCGATGATCTTTGCGCATCCGACACTTTCCGAAGCGATGCATGAAT
CAATCCTCGCGGCCTGCGACCAACCGTTGCATCAATAA

Upstream 100 bases:

>100_bases
GATCACCGGGTCATCGATGGCGCGGCAGGTGCGGCTTTTCTCCGGGAACTCAAGCGACTGATTGAAACCCCGACCTTGAT
GTTTATCCAGGAGACGAGCT

Downstream 100 bases:

>100_bases
AAAATAAGGGAGGCGATAGCTGTGCGATACGGAGTAAGTTCCCGTTATCCCTCCCGCACTCCCCGGCAGAAGATCCCCAA
CAACGGTTACGGCAGGATCT

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes [H]

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MHDKYDVLIIGGGPGGYVAAIRAGQLGLRTVLVEKQHLGGICLNWGCIPTKALLHGAEVAHTITHASQLGISVGEVNVDL
QKLVQFSRTVSQQLTAGVAYLLKKNGVQVIDGTARLRGKGQITVEDARGEARDYRADHVILATGARPRALPGIAPDGEHI
WTYFEALRPKLLPKSLLIIGSGAIGVEFASLYNDLGCKVTLVELASQILPVEDAEVSAAVRKSFEKRDIQIHTQTLVTQV
QLTDTGVRCTLNNTGGEYSQDVERVLLAVGVQPNIEDLGLEALGVELDRGFIKTDAACRTNVFGLYAIGDVAGPPCLAHK
ASHEGVICVETLAGVEGAHPLDRDYVPGCTYARPQVASLGLTESTALARGRPVRIGKFSYQSNGKALASGETEGFVKTIF
DAETGELLGAHMVGAQVTEQIQGFGIARHLEATDESLLSMIFAHPTLSEAMHESILAACDQPLHQ

Sequences:

>Translated_465_residues
MHDKYDVLIIGGGPGGYVAAIRAGQLGLRTVLVEKQHLGGICLNWGCIPTKALLHGAEVAHTITHASQLGISVGEVNVDL
QKLVQFSRTVSQQLTAGVAYLLKKNGVQVIDGTARLRGKGQITVEDARGEARDYRADHVILATGARPRALPGIAPDGEHI
WTYFEALRPKLLPKSLLIIGSGAIGVEFASLYNDLGCKVTLVELASQILPVEDAEVSAAVRKSFEKRDIQIHTQTLVTQV
QLTDTGVRCTLNNTGGEYSQDVERVLLAVGVQPNIEDLGLEALGVELDRGFIKTDAACRTNVFGLYAIGDVAGPPCLAHK
ASHEGVICVETLAGVEGAHPLDRDYVPGCTYARPQVASLGLTESTALARGRPVRIGKFSYQSNGKALASGETEGFVKTIF
DAETGELLGAHMVGAQVTEQIQGFGIARHLEATDESLLSMIFAHPTLSEAMHESILAACDQPLHQ
>Mature_465_residues
MHDKYDVLIIGGGPGGYVAAIRAGQLGLRTVLVEKQHLGGICLNWGCIPTKALLHGAEVAHTITHASQLGISVGEVNVDL
QKLVQFSRTVSQQLTAGVAYLLKKNGVQVIDGTARLRGKGQITVEDARGEARDYRADHVILATGARPRALPGIAPDGEHI
WTYFEALRPKLLPKSLLIIGSGAIGVEFASLYNDLGCKVTLVELASQILPVEDAEVSAAVRKSFEKRDIQIHTQTLVTQV
QLTDTGVRCTLNNTGGEYSQDVERVLLAVGVQPNIEDLGLEALGVELDRGFIKTDAACRTNVFGLYAIGDVAGPPCLAHK
ASHEGVICVETLAGVEGAHPLDRDYVPGCTYARPQVASLGLTESTALARGRPVRIGKFSYQSNGKALASGETEGFVKTIF
DAETGELLGAHMVGAQVTEQIQGFGIARHLEATDESLLSMIFAHPTLSEAMHESILAACDQPLHQ

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=462, Percent_Identity=38.3116883116883, Blast_Score=293, Evalue=3e-79,
Organism=Homo sapiens, GI50301238, Length=465, Percent_Identity=28.6021505376344, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI22035672, Length=465, Percent_Identity=28.1720430107527, Blast_Score=109, Evalue=7e-24,
Organism=Homo sapiens, GI33519430, Length=470, Percent_Identity=25.1063829787234, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI33519428, Length=470, Percent_Identity=25.1063829787234, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI33519426, Length=470, Percent_Identity=25.1063829787234, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI148277065, Length=470, Percent_Identity=25.1063829787234, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI148277071, Length=470, Percent_Identity=25.1063829787234, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI291045266, Length=472, Percent_Identity=25.635593220339, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI291045268, Length=466, Percent_Identity=24.4635193133047, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1786307, Length=451, Percent_Identity=37.0288248337029, Blast_Score=288, Evalue=6e-79,
Organism=Escherichia coli, GI87082354, Length=451, Percent_Identity=27.9379157427938, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1789915, Length=438, Percent_Identity=28.5388127853881, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI87081717, Length=465, Percent_Identity=27.5268817204301, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1788892, Length=221, Percent_Identity=29.8642533936652, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI32565766, Length=467, Percent_Identity=35.3319057815846, Blast_Score=267, Evalue=8e-72,
Organism=Caenorhabditis elegans, GI71983429, Length=441, Percent_Identity=25.3968253968254, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI71983419, Length=441, Percent_Identity=25.3968253968254, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17557007, Length=480, Percent_Identity=25, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI71982272, Length=481, Percent_Identity=25.7796257796258, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17559934, Length=185, Percent_Identity=30.2702702702703, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321091, Length=478, Percent_Identity=37.8661087866109, Blast_Score=276, Evalue=5e-75,
Organism=Saccharomyces cerevisiae, GI6325240, Length=472, Percent_Identity=27.5423728813559, Blast_Score=167, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6325166, Length=466, Percent_Identity=27.0386266094421, Blast_Score=164, Evalue=3e-41,
Organism=Drosophila melanogaster, GI21358499, Length=469, Percent_Identity=37.5266524520256, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24640553, Length=464, Percent_Identity=27.3706896551724, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24640549, Length=464, Percent_Identity=27.3706896551724, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24640551, Length=464, Percent_Identity=27.1551724137931, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI17737741, Length=471, Percent_Identity=26.963906581741, Blast_Score=115, Evalue=7e-26,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 49526; Mature: 49526

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDKYDVLIIGGGPGGYVAAIRAGQLGLRTVLVEKQHLGGICLNWGCIPTKALLHGAEVA
CCCCEEEEEEECCCCCEEEEEECCCCCCEEEEEEHHHCCCEEEECCCCCHHHHHHHHHHH
HTITHASQLGISVGEVNVDLQKLVQFSRTVSQQLTAGVAYLLKKNGVQVIDGTARLRGKG
HHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEECCCC
QITVEDARGEARDYRADHVILATGARPRALPGIAPDGEHIWTYFEALRPKLLPKSLLIIG
CEEEECCCCCCHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCHHCCCCEEEEEE
SGAIGVEFASLYNDLGCKVTLVELASQILPVEDAEVSAAVRKSFEKRDIQIHTQTLVTQV
CCCHHHHHHHHHHHCCCEEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEEEEEEEEE
QLTDTGVRCTLNNTGGEYSQDVERVLLAVGVQPNIEDLGLEALGVELDRGFIKTDAACRT
EEECCCEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHCCHHHCCEECCCCEEECCCCHHC
NVFGLYAIGDVAGPPCLAHKASHEGVICVETLAGVEGAHPLDRDYVPGCTYARPQVASLG
CCEEEEEECCCCCCCHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHCC
LTESTALARGRPVRIGKFSYQSNGKALASGETEGFVKTIFDAETGELLGAHMVGAQVTEQ
CCCHHHHHCCCCEEEEEEEECCCCCEEECCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHH
IQGFGIARHLEATDESLLSMIFAHPTLSEAMHESILAACDQPLHQ
HHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MHDKYDVLIIGGGPGGYVAAIRAGQLGLRTVLVEKQHLGGICLNWGCIPTKALLHGAEVA
CCCCEEEEEEECCCCCEEEEEECCCCCCEEEEEEHHHCCCEEEECCCCCHHHHHHHHHHH
HTITHASQLGISVGEVNVDLQKLVQFSRTVSQQLTAGVAYLLKKNGVQVIDGTARLRGKG
HHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEECCCC
QITVEDARGEARDYRADHVILATGARPRALPGIAPDGEHIWTYFEALRPKLLPKSLLIIG
CEEEECCCCCCHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCHHCCCCEEEEEE
SGAIGVEFASLYNDLGCKVTLVELASQILPVEDAEVSAAVRKSFEKRDIQIHTQTLVTQV
CCCHHHHHHHHHHHCCCEEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEEEEEEEEE
QLTDTGVRCTLNNTGGEYSQDVERVLLAVGVQPNIEDLGLEALGVELDRGFIKTDAACRT
EEECCCEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHCCHHHCCEECCCCEEECCCCHHC
NVFGLYAIGDVAGPPCLAHKASHEGVICVETLAGVEGAHPLDRDYVPGCTYARPQVASLG
CCEEEEEECCCCCCCHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHCC
LTESTALARGRPVRIGKFSYQSNGKALASGETEGFVKTIFDAETGELLGAHMVGAQVTEQ
CCCHHHHHCCCCEEEEEEEECCCCCEEECCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHH
IQGFGIARHLEATDESLLSMIFAHPTLSEAMHESILAACDQPLHQ
HHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]