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The map label for this gene is gloB [H]

Identifier: 238893205

GI number: 238893205

Start: 1047840

End: 1048595

Strand: Reverse

Name: gloB [H]

Synonym: KP1_1071

Alternate gene names: 238893205

Gene position: 1048595-1047840 (Counterclockwise)

Preceding gene: 238893207

Following gene: 238893204

Centisome position: 19.98

GC content: 43.78

Gene sequence:

>756_bases
ATGAATCTTATCAGTATTCCCGCGTTTCAGGACAACTACATCTGGGTTCTCAGTGAGAATAACGGCCGCTGCATCATCGT
AGATCCAGGCGAAGCCGCGCCGGTTCTGGCAGCCATCGAGGAAAACCAGTGGCAGCCCGAGGCTATTTTATTGACCCATC
ATCATCAGGATCACGTCGGCGGCGTAAAACAATTACGTGAAAAATTCCCTTCTATAGTGGTTTACGGGCCGGCGGAAACC
CAGGATAAAGGCGTCACTCAGGTGGTAGGCGATGGCGATCGGCTGTCAATTCTCGGGCACGATTTTTCCATTTTCTCTAC
GCCAGGTCACACATTAGGACATATCTGTTACTACAGCGAACCTTATCTGTTCTGTGGCGATACGATGTTTTCCGGCGGCT
GCGGAAGGCTGTTCGAAGGTACAGCAGAGCAGATGTATCAATCATTTATGAAAATTAATGCCCTTCCTGAAGAAACCCTC
ATATGTTGCGCACATGAATATACGTTAGCGAATATGAAGTTTGCATTGAGTATCCTGCCAGATGATAGGGACATAAACGA
TTACTATCATAAAGTTAATGAGTTACGTGCAAAAAAACAAAAAACACTACCCGTAACTCTGAAAAATGAGCGGCGTATAA
ATTTATTTTTACGCGTAAATGATATTGATTTAATTGACAAAATTAACAAAGAAACAAATTTGCAACACTCTGTGGCGCGA
TTTGCATGGTTAAGGTCAAAGAAAGATGACTTCTGA

Upstream 100 bases:

>100_bases
TCGCCCCACGGCATACTGGACCAATGCTCAGGCGCTGTCACTGTGTGAGGTATCCTTGCCGGCTTCATTGCCACCTTCCG
CTACGCTTTAGAGGTAATTT

Downstream 100 bases:

>100_bases
TATTTAATTCTTGTCATCGGCCAACTTCGCCGTTATCCTTGGTCGTCTTTTAAGCAACTATTGACACACACATGAAGGCA
CGAGCGATATTACTCGCCTC

Product: hydroxyacylglutathione hydrolase

Products: NA

Alternate protein names: Glyoxalase II; Glx II [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MNLISIPAFQDNYIWVLSENNGRCIIVDPGEAAPVLAAIEENQWQPEAILLTHHHQDHVGGVKQLREKFPSIVVYGPAET
QDKGVTQVVGDGDRLSILGHDFSIFSTPGHTLGHICYYSEPYLFCGDTMFSGGCGRLFEGTAEQMYQSFMKINALPEETL
ICCAHEYTLANMKFALSILPDDRDINDYYHKVNELRAKKQKTLPVTLKNERRINLFLRVNDIDLIDKINKETNLQHSVAR
FAWLRSKKDDF

Sequences:

>Translated_251_residues
MNLISIPAFQDNYIWVLSENNGRCIIVDPGEAAPVLAAIEENQWQPEAILLTHHHQDHVGGVKQLREKFPSIVVYGPAET
QDKGVTQVVGDGDRLSILGHDFSIFSTPGHTLGHICYYSEPYLFCGDTMFSGGCGRLFEGTAEQMYQSFMKINALPEETL
ICCAHEYTLANMKFALSILPDDRDINDYYHKVNELRAKKQKTLPVTLKNERRINLFLRVNDIDLIDKINKETNLQHSVAR
FAWLRSKKDDF
>Mature_251_residues
MNLISIPAFQDNYIWVLSENNGRCIIVDPGEAAPVLAAIEENQWQPEAILLTHHHQDHVGGVKQLREKFPSIVVYGPAET
QDKGVTQVVGDGDRLSILGHDFSIFSTPGHTLGHICYYSEPYLFCGDTMFSGGCGRLFEGTAEQMYQSFMKINALPEETL
ICCAHEYTLANMKFALSILPDDRDINDYYHKVNELRAKKQKTLPVTLKNERRINLFLRVNDIDLIDKINKETNLQHSVAR
FAWLRSKKDDF

Specific function: Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid [H]

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family [H]

Homologues:

Organism=Homo sapiens, GI94538320, Length=260, Percent_Identity=30.7692307692308, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI94538322, Length=260, Percent_Identity=30.7692307692308, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI14150041, Length=229, Percent_Identity=33.1877729257642, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI21703352, Length=237, Percent_Identity=33.3333333333333, Blast_Score=128, Evalue=5e-30,
Organism=Homo sapiens, GI116642887, Length=237, Percent_Identity=33.3333333333333, Blast_Score=128, Evalue=5e-30,
Organism=Homo sapiens, GI46361987, Length=221, Percent_Identity=33.0316742081448, Blast_Score=116, Evalue=2e-26,
Organism=Escherichia coli, GI1786406, Length=251, Percent_Identity=74.9003984063745, Blast_Score=390, Evalue=1e-110,
Organism=Escherichia coli, GI1787158, Length=157, Percent_Identity=28.0254777070064, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17536925, Length=214, Percent_Identity=35.981308411215, Blast_Score=127, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6320478, Length=237, Percent_Identity=32.9113924050633, Blast_Score=102, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6324614, Length=233, Percent_Identity=30.9012875536481, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21356335, Length=261, Percent_Identity=36.3984674329502, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24667711, Length=261, Percent_Identity=36.3984674329502, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24667703, Length=261, Percent_Identity=36.3984674329502, Blast_Score=165, Evalue=2e-41,
Organism=Drosophila melanogaster, GI221330176, Length=166, Percent_Identity=29.5180722891566, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR017782 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.2.6 [H]

Molecular weight: Translated: 28559; Mature: 28559

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLISIPAFQDNYIWVLSENNGRCIIVDPGEAAPVLAAIEENQWQPEAILLTHHHQDHVG
CCEEECCCCCCCEEEEEECCCCEEEEECCCCCCCEEEEECCCCCCCCEEEEEECCCHHHH
GVKQLREKFPSIVVYGPAETQDKGVTQVVGDGDRLSILGHDFSIFSTPGHTLGHICYYSE
HHHHHHHHCCCEEEECCCCCCCCCCEEEECCCCEEEEEECCEEEEECCCCHHEEEEEECC
PYLFCGDTMFSGGCGRLFEGTAEQMYQSFMKINALPEETLICCAHEYTLANMKFALSILP
CEEEECCCEECCCCCHHHCCHHHHHHHHHHHHCCCCCHHEEEEECCEEEECEEEEEEECC
DDRDINDYYHKVNELRAKKQKTLPVTLKNERRINLFLRVNDIDLIDKINKETNLQHSVAR
CCCCHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEEEECCCHHHHHCCCCCCHHHHHHH
FAWLRSKKDDF
HHHHHCCCCCC
>Mature Secondary Structure
MNLISIPAFQDNYIWVLSENNGRCIIVDPGEAAPVLAAIEENQWQPEAILLTHHHQDHVG
CCEEECCCCCCCEEEEEECCCCEEEEECCCCCCCEEEEECCCCCCCCEEEEEECCCHHHH
GVKQLREKFPSIVVYGPAETQDKGVTQVVGDGDRLSILGHDFSIFSTPGHTLGHICYYSE
HHHHHHHHCCCEEEECCCCCCCCCCEEEECCCCEEEEEECCEEEEECCCCHHEEEEEECC
PYLFCGDTMFSGGCGRLFEGTAEQMYQSFMKINALPEETLICCAHEYTLANMKFALSILP
CEEEECCCEECCCCCHHHCCHHHHHHHHHHHHCCCCCHHEEEEECCEEEECEEEEEEECC
DDRDINDYYHKVNELRAKKQKTLPVTLKNERRINLFLRVNDIDLIDKINKETNLQHSVAR
CCCCHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEEEECCCHHHHHCCCCCCHHHHHHH
FAWLRSKKDDF
HHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA