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The map label for this gene is yadQ [H]

Identifier: 238893153

GI number: 238893153

Start: 988517

End: 989935

Strand: Direct

Name: yadQ [H]

Synonym: KP1_1007

Alternate gene names: 238893153

Gene position: 988517-989935 (Clockwise)

Preceding gene: 238893151

Following gene: 238893154

Centisome position: 18.83

GC content: 60.68

Gene sequence:

>1419_bases
ATGAAAGCAGAAACTCCCTCTTTTGAAGCACATCAGTTTGTGCGGGTGCGTCGCGGCGATGCGGTGCGCCGTCTGATTCA
ACGCGATAAAACGCCGCTGGCGGTGCTGTTTATGGCGGCAGTGGTCGGCACGCTGGCGGGGCTGGTGGGCGTCGCCTTTG
AAAAGAGCGTGAACTGGGTGCAGAACCAGCGGATCGGCGCGCTGGCGCAGGTGGCGGACCACTGGTATCTGGTCTGGCCG
CTGGCGTTTATCCTGTCGGCGCTGCTGGCGATGGTCGGCTATTTTCTGGTGCGTCGCTTTGCGCCGGAGGCCGGCGGCTC
CGGGATTCCGGAAATTGAGGGCGCGCTGGAGGAGCTGCGGCCGGTGCGCTGGTGGCGCGTGCTGCCGGTGAAATTCGTTG
GCGGCATGGGGACCCTTGGCGCCGGGATGGTGCTGGGTCGTGAAGGACCGATGGTACAGCTTGGCGGCAACATTGGGCGC
ATGGTGCTGGACGTTTTCCGCATGCGCAGTCCGGAAGCGCGGCATACGTTGTTGGCGACCGGTGCGGCGTCGGGGCTTTC
GGCGGCCTTTAATGCGCCGCTGGCCGGTATTCTGTTTATCATCGAAGAGATGCGCCCGCAGTTCCGCTACAACCTGATCT
CCATTAAAGCGGTGTTTACCGGCGTGATCATGTCGAGCATTGTGTTTCGCATTTTCAACGGCGAAGCGGCGATCATTGAG
GTGGGTAAACTAAGCAACGCCCCGGTAAATACCCTATGGCTGTATCTGGTGCTGGGCATGCTGTTTGGCTGCTTTGGCCC
GCTGTTTAATTTTCTGGTGCTGCGCACTCAGGATCTGTTCCAGCGCATCCACGGCGGCAACATCAAAAAATGGGTGTTGA
TTGGCGGATTAATCGGCGGGCTCTGCGGTCTGCTGGGGCTGATGCAGCCCTCCGCGGTGGGCGGTGGCTTTAACTTGATC
CCTATCGCCGCTGCCGGTAACTTCTCCGTCGGACTGCTGCTGTTTATCTTTATTGCCCGCGTGGTGACCACGCTGATCTG
CTTCTCTTCCGGCGCGCCAGGGGGCATTTTCGCGCCTATGTTGGCGCTCGGCACGCTGCTGGGCACGGCGTTCGGCATGG
CGGCTATTCCGCTGTTTCCGGCCTACCATCTCGATGCCGGCACCTTCGCGATTGCCGGTATGGGGGCGCTGCTCGCCGCC
TCGGTGCGTGCGCCGCTGACCGGGATCGTGCTGGTGCTTGAGATGACCGATAACTATCAGCTCATTTTGCCAATGATTAT
TACCTGCCTTGGCGCAACACTACTGGCGCAATTCCTCGGCGGTAAGCCTTTGTATTCGACCATTCTGCAGCGTACTCTGG
CGAAGCAGGAAGCCGAGCAGGCGGCAAAAGCGCAGCAGGCTCCCCGGGAGAATACTTGA

Upstream 100 bases:

>100_bases
TGAAACAATGTGCCGCAAGGGCATTTTTTTGACGACGCAGCGCGCCGGGACGGCTAAAATGCCGCTCTCTTCATTTGTAT
TACCAATAATTGATAACGGC

Downstream 100 bases:

>100_bases
ACGATTTACCAGGGTATTAGATAATGGCTCAAAAGGTCCGGTTATTCTTTAACCGGCCGGAAGTATCAATGGGAGCAGAA
AATGAGTGATGACGTAGCGT

Product: chloride channel protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MKAETPSFEAHQFVRVRRGDAVRRLIQRDKTPLAVLFMAAVVGTLAGLVGVAFEKSVNWVQNQRIGALAQVADHWYLVWP
LAFILSALLAMVGYFLVRRFAPEAGGSGIPEIEGALEELRPVRWWRVLPVKFVGGMGTLGAGMVLGREGPMVQLGGNIGR
MVLDVFRMRSPEARHTLLATGAASGLSAAFNAPLAGILFIIEEMRPQFRYNLISIKAVFTGVIMSSIVFRIFNGEAAIIE
VGKLSNAPVNTLWLYLVLGMLFGCFGPLFNFLVLRTQDLFQRIHGGNIKKWVLIGGLIGGLCGLLGLMQPSAVGGGFNLI
PIAAAGNFSVGLLLFIFIARVVTTLICFSSGAPGGIFAPMLALGTLLGTAFGMAAIPLFPAYHLDAGTFAIAGMGALLAA
SVRAPLTGIVLVLEMTDNYQLILPMIITCLGATLLAQFLGGKPLYSTILQRTLAKQEAEQAAKAQQAPRENT

Sequences:

>Translated_472_residues
MKAETPSFEAHQFVRVRRGDAVRRLIQRDKTPLAVLFMAAVVGTLAGLVGVAFEKSVNWVQNQRIGALAQVADHWYLVWP
LAFILSALLAMVGYFLVRRFAPEAGGSGIPEIEGALEELRPVRWWRVLPVKFVGGMGTLGAGMVLGREGPMVQLGGNIGR
MVLDVFRMRSPEARHTLLATGAASGLSAAFNAPLAGILFIIEEMRPQFRYNLISIKAVFTGVIMSSIVFRIFNGEAAIIE
VGKLSNAPVNTLWLYLVLGMLFGCFGPLFNFLVLRTQDLFQRIHGGNIKKWVLIGGLIGGLCGLLGLMQPSAVGGGFNLI
PIAAAGNFSVGLLLFIFIARVVTTLICFSSGAPGGIFAPMLALGTLLGTAFGMAAIPLFPAYHLDAGTFAIAGMGALLAA
SVRAPLTGIVLVLEMTDNYQLILPMIITCLGATLLAQFLGGKPLYSTILQRTLAKQEAEQAAKAQQAPRENT
>Mature_472_residues
MKAETPSFEAHQFVRVRRGDAVRRLIQRDKTPLAVLFMAAVVGTLAGLVGVAFEKSVNWVQNQRIGALAQVADHWYLVWP
LAFILSALLAMVGYFLVRRFAPEAGGSGIPEIEGALEELRPVRWWRVLPVKFVGGMGTLGAGMVLGREGPMVQLGGNIGR
MVLDVFRMRSPEARHTLLATGAASGLSAAFNAPLAGILFIIEEMRPQFRYNLISIKAVFTGVIMSSIVFRIFNGEAAIIE
VGKLSNAPVNTLWLYLVLGMLFGCFGPLFNFLVLRTQDLFQRIHGGNIKKWVLIGGLIGGLCGLLGLMQPSAVGGGFNLI
PIAAAGNFSVGLLLFIFIARVVTTLICFSSGAPGGIFAPMLALGTLLGTAFGMAAIPLFPAYHLDAGTFAIAGMGALLAA
SVRAPLTGIVLVLEMTDNYQLILPMIITCLGATLLAQFLGGKPLYSTILQRTLAKQEAEQAAKAQQAPRENT

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557473, Length=478, Percent_Identity=26.3598326359833, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI189217923, Length=478, Percent_Identity=26.3598326359833, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI189217921, Length=478, Percent_Identity=26.3598326359833, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI153252026, Length=484, Percent_Identity=24.7933884297521, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI55770838, Length=461, Percent_Identity=23.8611713665944, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI55770840, Length=461, Percent_Identity=23.8611713665944, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI1786350, Length=473, Percent_Identity=76.1099365750529, Blast_Score=664, Evalue=0.0,
Organism=Escherichia coli, GI87081943, Length=323, Percent_Identity=29.1021671826625, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17532615, Length=409, Percent_Identity=25.4278728606357, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71985148, Length=459, Percent_Identity=24.8366013071895, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71985141, Length=459, Percent_Identity=24.8366013071895, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71980828, Length=478, Percent_Identity=22.8033472803347, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71980824, Length=478, Percent_Identity=22.8033472803347, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17559050, Length=473, Percent_Identity=26.8498942917548, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71980820, Length=483, Percent_Identity=22.9813664596273, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322500, Length=482, Percent_Identity=22.8215767634855, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24665008, Length=437, Percent_Identity=26.0869565217391, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI45551566, Length=350, Percent_Identity=27.7142857142857, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 50482; Mature: 50482

Theoretical pI: Translated: 10.30; Mature: 10.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAETPSFEAHQFVRVRRGDAVRRLIQRDKTPLAVLFMAAVVGTLAGLVGVAFEKSVNWV
CCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QNQRIGALAQVADHWYLVWPLAFILSALLAMVGYFLVRRFAPEAGGSGIPEIEGALEELR
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHC
PVRWWRVLPVKFVGGMGTLGAGMVLGREGPMVQLGGNIGRMVLDVFRMRSPEARHTLLAT
HHHHHHEEHHHHHCCCCCCCCCEEECCCCCEEEECCCHHHHHHHHHHHCCCCHHHHHHHH
GAASGLSAAFNAPLAGILFIIEEMRPQFRYNLISIKAVFTGVIMSSIVFRIFNGEAAIIE
CCCHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
VGKLSNAPVNTLWLYLVLGMLFGCFGPLFNFLVLRTQDLFQRIHGGNIKKWVLIGGLIGG
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LCGLLGLMQPSAVGGGFNLIPIAAAGNFSVGLLLFIFIARVVTTLICFSSGAPGGIFAPM
HHHHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LALGTLLGTAFGMAAIPLFPAYHLDAGTFAIAGMGALLAASVRAPLTGIVLVLEMTDNYQ
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCE
LILPMIITCLGATLLAQFLGGKPLYSTILQRTLAKQEAEQAAKAQQAPRENT
EHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKAETPSFEAHQFVRVRRGDAVRRLIQRDKTPLAVLFMAAVVGTLAGLVGVAFEKSVNWV
CCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QNQRIGALAQVADHWYLVWPLAFILSALLAMVGYFLVRRFAPEAGGSGIPEIEGALEELR
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHC
PVRWWRVLPVKFVGGMGTLGAGMVLGREGPMVQLGGNIGRMVLDVFRMRSPEARHTLLAT
HHHHHHEEHHHHHCCCCCCCCCEEECCCCCEEEECCCHHHHHHHHHHHCCCCHHHHHHHH
GAASGLSAAFNAPLAGILFIIEEMRPQFRYNLISIKAVFTGVIMSSIVFRIFNGEAAIIE
CCCHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
VGKLSNAPVNTLWLYLVLGMLFGCFGPLFNFLVLRTQDLFQRIHGGNIKKWVLIGGLIGG
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LCGLLGLMQPSAVGGGFNLIPIAAAGNFSVGLLLFIFIARVVTTLICFSSGAPGGIFAPM
HHHHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LALGTLLGTAFGMAAIPLFPAYHLDAGTFAIAGMGALLAASVRAPLTGIVLVLEMTDNYQ
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCE
LILPMIITCLGATLLAQFLGGKPLYSTILQRTLAKQEAEQAAKAQQAPRENT
EHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA