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The map label for this gene is fhuB [H]

Identifier: 238893151

GI number: 238893151

Start: 984937

End: 986919

Strand: Direct

Name: fhuB [H]

Synonym: KP1_1005

Alternate gene names: 238893151

Gene position: 984937-986919 (Clockwise)

Preceding gene: 238893150

Following gene: 238893153

Centisome position: 18.77

GC content: 65.91

Gene sequence:

>1983_bases
ATGAATACGCGTCTCTCGCCGTTAGCTATTATCCTGCTGGCCGGGCTGCTGGGCGTCGCCTTCGCGCTGAGCATCGTCAA
CCTCAATGTCGCCTTGCCCTATGCGCAGTGGCGGCAGGCGCTGTGGCAGCCGGATGTCGATGATATAGCCCAAATGCTGT
TTCATTACAGTTTGTTACCGAGACTGGCTGTTGCGCTGCTGGTGGGCGCCGGGCTGGGACTGGTTGGCGTCCTGTTCCAG
CAGGTGCTGCGTAATCCGCTGGCGGAACCGACCACCCTTGGCGTCGCCACCGGCGCGCAGCTGGGGATAACGGTCACCAC
GTTATGGGCTATTCCCGGCGTGCTGGCGTCGCAATTCGCCGCGCTGGCCGGGGCCTGTCTGGTGGGCGCGCTGGTGTTTG
GCGTCTCGTGGGGTAAGCGCCTGTCGCCGGTAACGCTGATCCTGGCGGGGCTGGTGGTCAGCCTTTACTGTGGCGCGCTG
AACCAGCTGATGGTGATTTTCCATCACGACCAGCTGCAAAGCATGTTCCTGTGGAGCACCGGGACGCTGACGCAGACCGA
CTGGAGCGTAGCGCAGCGCCTGTGGCCGCAGCTGCTTGGCGGGGCAATACTCACCTTGCTGCTGCTGCGGCCGCTGACCC
TGATGGGGCTCGATGACGGGGTGGCGCGTAACCTCGGGCTGGCGCTGTCCCTGGCGCGCCTCGGCGCCCTGACGCTGGCG
ATTGTCATCAGCGCGCTGCTGGTGAACGCGGTAGGGATTATCGGCTTTATCGGCCTGTTCGCGCCGCTGCTGGCGAAAAT
GCTTGGCGCCCGTCGGCTGCTGGCGCGGCTGCTGCTGGCGGCGCTGATCGGCGCGCTGCTCCTGTGGCTTTCCGATCAGG
TGATCCTCTGGCTGAGCCGGGTATGGCGGGAAGTCTCCACCGGCTCGGTCACCGCCCTGATTGGCGCGCCGCTGCTGCTG
TGGCTGCTGCCGCGGTTGCGTAGCATCAGCGCCCCGGTGATGAACGGCGGCGATAATGTGCAGCCTGAGCGCTATCATGT
GCAATGGTTTGTTCTCGCAGGCGTCGCGTTGCTGCTGCTGGCGGTGAGCGTGGCGCTGGCCTTTGGTCGCGATGCCCACG
GCTGGCTGTGGGCCCACGGCGATCTGCTGGAGCAACTCCTGCCCTGGCGCTGGCCGCGGGTGCTGTCGGCCCTGTTCGCC
GGGGTCATGCTGGCGGTCGCCGGCTGTATTATCCAGCGCCTGACCGGCAACCCGATGGCCAGCCCGGAAGTGCTGGGCAT
CAGCTCCGGCGCGGCTTTTGGCGTGGTGCTGATGCTGTTCTTCGTGCCTGGCGACGCCTTTGGCTGGCTGCTGCCGGCCG
GCAGCCTTGGCGCGGCGGCCACCTTGCTGATCATTATGCTCGCCGCCGGGCGCGGCGGCTTCTCGCCGCATCGGATGCTG
CTGGCGGGGATGGCGCTGAGCACCGCCTTCACTATGCTGCTGATGATGCTGCAGGCCAGCGGCGATCCGCGTATGGCGCA
GATCCTGACGTGGATCTCGGGGTCGACATATAGCGCGACGCCGGAGAGGGTTGTGCGTAGCGGCGCGGTAATGCTGGCGC
TGCTGGCGCTGGCGCCGCTCTGTCGTCGCTGGTTAACCATCCTGCCGCTGGGCGGGGAGGCGGCGCGAGCGGTGGGCATG
GCGCTGACGTCATCGCGGATTGTTCTGCTGCTGCTGGCGGCCTGCCTGACGGCGGCGGCGACGCTGACCATCGGCCCGCT
GAGCTTTGTCGGGCTGATGGCGCCGCATATCGCGCGGATGATGGGCTTCCGGCGAACCCTACCGCATATGGTGATTTCAG
GGCTGACTGGCGGGCTGCTGCTGGTCTTCGCCGACTGGTGCGGACGGATGATGATGTTCCCGTATCAGATCCCGGCGGGG
CTACTGTCGACCTTTATCGGCGCGCCTTACTTTATTTATTTGCTGAGAAAGCAGAGTCGCTAA

Upstream 100 bases:

>100_bases
CGGGCCGCTTCCAGCGCGTTCCGGCGGTTTGGTTCTACGGCGCGACGCTGTCAGCGATGCATTTTGCCCGCGTGCTGGCT
GATGCCCAGGGGAGTCCGGC

Downstream 100 bases:

>100_bases
CGGTCCTGGATGGCTTCAACATCCCCGGTGGCGCTATCGCTTACCGGGGCTACAGCGCTGTGCGATTTGGTAGCCCGGAT
AAGGCGCAATGCGCCTCCTC

Product: iron-hydroxamate transporter permease subunit

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Ferrichrome uptake protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 660; Mature: 660

Protein sequence:

>660_residues
MNTRLSPLAIILLAGLLGVAFALSIVNLNVALPYAQWRQALWQPDVDDIAQMLFHYSLLPRLAVALLVGAGLGLVGVLFQ
QVLRNPLAEPTTLGVATGAQLGITVTTLWAIPGVLASQFAALAGACLVGALVFGVSWGKRLSPVTLILAGLVVSLYCGAL
NQLMVIFHHDQLQSMFLWSTGTLTQTDWSVAQRLWPQLLGGAILTLLLLRPLTLMGLDDGVARNLGLALSLARLGALTLA
IVISALLVNAVGIIGFIGLFAPLLAKMLGARRLLARLLLAALIGALLLWLSDQVILWLSRVWREVSTGSVTALIGAPLLL
WLLPRLRSISAPVMNGGDNVQPERYHVQWFVLAGVALLLLAVSVALAFGRDAHGWLWAHGDLLEQLLPWRWPRVLSALFA
GVMLAVAGCIIQRLTGNPMASPEVLGISSGAAFGVVLMLFFVPGDAFGWLLPAGSLGAAATLLIIMLAAGRGGFSPHRML
LAGMALSTAFTMLLMMLQASGDPRMAQILTWISGSTYSATPERVVRSGAVMLALLALAPLCRRWLTILPLGGEAARAVGM
ALTSSRIVLLLLAACLTAAATLTIGPLSFVGLMAPHIARMMGFRRTLPHMVISGLTGGLLLVFADWCGRMMMFPYQIPAG
LLSTFIGAPYFIYLLRKQSR

Sequences:

>Translated_660_residues
MNTRLSPLAIILLAGLLGVAFALSIVNLNVALPYAQWRQALWQPDVDDIAQMLFHYSLLPRLAVALLVGAGLGLVGVLFQ
QVLRNPLAEPTTLGVATGAQLGITVTTLWAIPGVLASQFAALAGACLVGALVFGVSWGKRLSPVTLILAGLVVSLYCGAL
NQLMVIFHHDQLQSMFLWSTGTLTQTDWSVAQRLWPQLLGGAILTLLLLRPLTLMGLDDGVARNLGLALSLARLGALTLA
IVISALLVNAVGIIGFIGLFAPLLAKMLGARRLLARLLLAALIGALLLWLSDQVILWLSRVWREVSTGSVTALIGAPLLL
WLLPRLRSISAPVMNGGDNVQPERYHVQWFVLAGVALLLLAVSVALAFGRDAHGWLWAHGDLLEQLLPWRWPRVLSALFA
GVMLAVAGCIIQRLTGNPMASPEVLGISSGAAFGVVLMLFFVPGDAFGWLLPAGSLGAAATLLIIMLAAGRGGFSPHRML
LAGMALSTAFTMLLMMLQASGDPRMAQILTWISGSTYSATPERVVRSGAVMLALLALAPLCRRWLTILPLGGEAARAVGM
ALTSSRIVLLLLAACLTAAATLTIGPLSFVGLMAPHIARMMGFRRTLPHMVISGLTGGLLLVFADWCGRMMMFPYQIPAG
LLSTFIGAPYFIYLLRKQSR
>Mature_660_residues
MNTRLSPLAIILLAGLLGVAFALSIVNLNVALPYAQWRQALWQPDVDDIAQMLFHYSLLPRLAVALLVGAGLGLVGVLFQ
QVLRNPLAEPTTLGVATGAQLGITVTTLWAIPGVLASQFAALAGACLVGALVFGVSWGKRLSPVTLILAGLVVSLYCGAL
NQLMVIFHHDQLQSMFLWSTGTLTQTDWSVAQRLWPQLLGGAILTLLLLRPLTLMGLDDGVARNLGLALSLARLGALTLA
IVISALLVNAVGIIGFIGLFAPLLAKMLGARRLLARLLLAALIGALLLWLSDQVILWLSRVWREVSTGSVTALIGAPLLL
WLLPRLRSISAPVMNGGDNVQPERYHVQWFVLAGVALLLLAVSVALAFGRDAHGWLWAHGDLLEQLLPWRWPRVLSALFA
GVMLAVAGCIIQRLTGNPMASPEVLGISSGAAFGVVLMLFFVPGDAFGWLLPAGSLGAAATLLIIMLAAGRGGFSPHRML
LAGMALSTAFTMLLMMLQASGDPRMAQILTWISGSTYSATPERVVRSGAVMLALLALAPLCRRWLTILPLGGEAARAVGM
ALTSSRIVLLLLAACLTAAATLTIGPLSFVGLMAPHIARMMGFRRTLPHMVISGLTGGLLLVFADWCGRMMMFPYQIPAG
LLSTFIGAPYFIYLLRKQSR

Specific function: Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786347, Length=642, Percent_Identity=85.0467289719626, Blast_Score=962, Evalue=0.0,
Organism=Escherichia coli, GI1790740, Length=277, Percent_Identity=36.8231046931408, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI1790741, Length=281, Percent_Identity=35.2313167259786, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1786804, Length=278, Percent_Identity=34.5323741007194, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1786805, Length=287, Percent_Identity=33.4494773519164, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1788004, Length=277, Percent_Identity=31.4079422382672, Blast_Score=89, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522
- InterPro:   IPR006311 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 70220; Mature: 70220

Theoretical pI: Translated: 11.16; Mature: 11.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTRLSPLAIILLAGLLGVAFALSIVNLNVALPYAQWRQALWQPDVDDIAQMLFHYSLLP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHCCCCHHHHHHHHHHHHHHH
RLAVALLVGAGLGLVGVLFQQVLRNPLAEPTTLGVATGAQLGITVTTLWAIPGVLASQFA
HHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
ALAGACLVGALVFGVSWGKRLSPVTLILAGLVVSLYCGALNQLMVIFHHDQLQSMFLWST
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GTLTQTDWSVAQRLWPQLLGGAILTLLLLRPLTLMGLDDGVARNLGLALSLARLGALTLA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
IVISALLVNAVGIIGFIGLFAPLLAKMLGARRLLARLLLAALIGALLLWLSDQVILWLSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VWREVSTGSVTALIGAPLLLWLLPRLRSISAPVMNGGDNVQPERYHVQWFVLAGVALLLL
HHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
AVSVALAFGRDAHGWLWAHGDLLEQLLPWRWPRVLSALFAGVMLAVAGCIIQRLTGNPMA
HHHHHHHHCCCCCCEEEECHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
SPEVLGISSGAAFGVVLMLFFVPGDAFGWLLPAGSLGAAATLLIIMLAAGRGGFSPHRML
CCCEEECCCCHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHH
LAGMALSTAFTMLLMMLQASGDPRMAQILTWISGSTYSATPERVVRSGAVMLALLALAPL
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
CRRWLTILPLGGEAARAVGMALTSSRIVLLLLAACLTAAATLTIGPLSFVGLMAPHIARM
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGFRRTLPHMVISGLTGGLLLVFADWCGRMMMFPYQIPAGLLSTFIGAPYFIYLLRKQSR
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHCCHHHHHHHHHCCC
>Mature Secondary Structure
MNTRLSPLAIILLAGLLGVAFALSIVNLNVALPYAQWRQALWQPDVDDIAQMLFHYSLLP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHCCCCHHHHHHHHHHHHHHH
RLAVALLVGAGLGLVGVLFQQVLRNPLAEPTTLGVATGAQLGITVTTLWAIPGVLASQFA
HHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
ALAGACLVGALVFGVSWGKRLSPVTLILAGLVVSLYCGALNQLMVIFHHDQLQSMFLWST
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GTLTQTDWSVAQRLWPQLLGGAILTLLLLRPLTLMGLDDGVARNLGLALSLARLGALTLA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
IVISALLVNAVGIIGFIGLFAPLLAKMLGARRLLARLLLAALIGALLLWLSDQVILWLSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VWREVSTGSVTALIGAPLLLWLLPRLRSISAPVMNGGDNVQPERYHVQWFVLAGVALLLL
HHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
AVSVALAFGRDAHGWLWAHGDLLEQLLPWRWPRVLSALFAGVMLAVAGCIIQRLTGNPMA
HHHHHHHHCCCCCCEEEECHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
SPEVLGISSGAAFGVVLMLFFVPGDAFGWLLPAGSLGAAATLLIIMLAAGRGGFSPHRML
CCCEEECCCCHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHH
LAGMALSTAFTMLLMMLQASGDPRMAQILTWISGSTYSATPERVVRSGAVMLALLALAPL
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
CRRWLTILPLGGEAARAVGMALTSSRIVLLLLAACLTAAATLTIGPLSFVGLMAPHIARM
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGFRRTLPHMVISGLTGGLLLVFADWCGRMMMFPYQIPAGLLSTFIGAPYFIYLLRKQSR
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677609; 10103258 [H]