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The map label for this gene is murC [H]

Identifier: 238893071

GI number: 238893071

Start: 897919

End: 899394

Strand: Direct

Name: murC [H]

Synonym: KP1_0913

Alternate gene names: 238893071

Gene position: 897919-899394 (Clockwise)

Preceding gene: 238893070

Following gene: 238893072

Centisome position: 17.11

GC content: 60.77

Gene sequence:

>1476_bases
ATGAATACACAAGATTTGGCAAAACTGCGTTCCATAGTGCCCGAGATGCGTCGCGTTCGGCACATTCACTTTGTCGGCAT
CGGCGGTGCCGGTATGGGCGGTATTGCCGAAGTGTTGGCTAACGAAGGTTACCAGATCAGCGGCTCCGACCTGGCGCCGA
ATCCGGTGACCCAGCAGCTGTCGCAGCTTGGCGCCACCATTTATTTCAACCATCGCCCGGAAAACGTGCGTGATGCCAGC
GTGGTTGTCGTTTCCAGCGCGATTTCGGCAGATAACCCGGAAATCGTTGCCGCGCATGAGGCGCGTATCCCGGTGATCCG
TCGTGCCGAAATGCTGGCGGAACTTATGCGCTTTCGCCACGGGATCGCCATTGCCGGGACCCACGGCAAAACCACCACCA
CCGCGATGGTATCCAGCATTTACGCCGAGGCCGGGCTGGACCCGACCTTCGTCAACGGCGGACTGGTAAAAGCGGCGGGC
GTACATGCCCGTCTTGGCCATAGCCGTTACCTGATCGCGGAAGCGGATGAGAGCGACGCGTCGTTTCTGCATCTGCAGCC
GATGGTGGCCATTGTCACCAACATCGAAGCCGATCACATGGATACCTACCATGGCGACTTTGAGAATCTGAAGCAGACCT
TTATCAACTTCCTGCACAACCTGCCGTTCTACGGACGCGCGGTGATGTGCGTGGACGATCCGGTGATCCGGGAACTGCTG
CCGCGCGTTGGCCGGCAGATCACCACCTACGGTTTTAGCGACGACGCCGACGTGCGCGTCGAGGACTATCGTCAGGTTGG
GGCGCAGGGGCATTTCCGCCTGGTGCGCCAGGATAAAGCGATCCTGCAGGTGACGCTCAATGCCCCGGGACGCCATAACG
CGCTGAACGCGGCGGCGGCCGTCGCCGTGGCGACGGAAGAGGGGATTGACGATCGGGCTATTCTGCGCGCACTGGAGAGC
TTCCAGGGAACTGGACGCCGCTTTGATTTTCTTGGCGAGTTTCCGCTGGCCGAAGTCAACGGCAAACCGGGCAGCGCGAT
GCTGATCGATGATTACGGTCACCACCCGACGGAAGTGGACGCCACCATTAAAGCAGCGCGCGCCGGCTGGCCGGATAAAA
ACCTGGTGATGGTATTCCAGCCGCACCGTTATACCCGTACCCGCGATCTGTATGATGATTTTGCCAACGTGCTGACCCAG
GTGGATGCCCTGCTGATGCTGGACGTCTATCCGGCGGGCGAAGCGCCGATCCCGGGCGCCGACAGCCGCTCGCTGTGCCG
CACCATTCGCGGTCGCGGGAAAGTGGATCCGATCCTGGTGCCCGATTCGGCCCAGGCCGCGGAGATGCTGGCGTCAGTCC
TGACCGGCAACGATTTAGTACTGGTGCAGGGCGCCGGTAACATCGGTAAAATCGCCCGCCACCTGGCTGAAATCAAACTG
ATCCCGCAAAAAACGGAGGAGGAGCGCCATGGCTGA

Upstream 100 bases:

>100_bases
ACGCTACCGAGCGGGTAGCAGAAGAGGTCAGCGCCGTAGCTTTGGCGCGCTAATTGCGGTGATTTTCACCGCCCGAATAC
AGAAGTTGATGGCGTAAAGA

Downstream 100 bases:

>100_bases
TAAAATCGCGGTGCTTTTCGGTGGAACCTCCGCTGAACGTGAAGTGTCGCTGAATTCAGGCGCGGCGGTGCTGGCCGGGC
TGCGTGAAGGCGGGGTGGAC

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MNTQDLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLSQLGATIYFNHRPENVRDAS
VVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAG
VHARLGHSRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYHGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELL
PRVGRQITTYGFSDDADVRVEDYRQVGAQGHFRLVRQDKAILQVTLNAPGRHNALNAAAAVAVATEEGIDDRAILRALES
FQGTGRRFDFLGEFPLAEVNGKPGSAMLIDDYGHHPTEVDATIKAARAGWPDKNLVMVFQPHRYTRTRDLYDDFANVLTQ
VDALLMLDVYPAGEAPIPGADSRSLCRTIRGRGKVDPILVPDSAQAAEMLASVLTGNDLVLVQGAGNIGKIARHLAEIKL
IPQKTEEERHG

Sequences:

>Translated_491_residues
MNTQDLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLSQLGATIYFNHRPENVRDAS
VVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAG
VHARLGHSRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYHGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELL
PRVGRQITTYGFSDDADVRVEDYRQVGAQGHFRLVRQDKAILQVTLNAPGRHNALNAAAAVAVATEEGIDDRAILRALES
FQGTGRRFDFLGEFPLAEVNGKPGSAMLIDDYGHHPTEVDATIKAARAGWPDKNLVMVFQPHRYTRTRDLYDDFANVLTQ
VDALLMLDVYPAGEAPIPGADSRSLCRTIRGRGKVDPILVPDSAQAAEMLASVLTGNDLVLVQGAGNIGKIARHLAEIKL
IPQKTEEERHG
>Mature_491_residues
MNTQDLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLSQLGATIYFNHRPENVRDAS
VVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAG
VHARLGHSRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYHGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELL
PRVGRQITTYGFSDDADVRVEDYRQVGAQGHFRLVRQDKAILQVTLNAPGRHNALNAAAAVAVATEEGIDDRAILRALES
FQGTGRRFDFLGEFPLAEVNGKPGSAMLIDDYGHHPTEVDATIKAARAGWPDKNLVMVFQPHRYTRTRDLYDDFANVLTQ
VDALLMLDVYPAGEAPIPGADSRSLCRTIRGRGKVDPILVPDSAQAAEMLASVLTGNDLVLVQGAGNIGKIARHLAEIKL
IPQKTEEERHG

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=490, Percent_Identity=92.4489795918367, Blast_Score=857, Evalue=0.0,
Organism=Escherichia coli, GI1790680, Length=480, Percent_Identity=28.125, Blast_Score=146, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 53462; Mature: 53462

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTQDLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQL
CCHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHCCCCEECCCCCCCCHHHHHH
SQLGATIYFNHRPENVRDASVVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRH
HHCCCEEEECCCCCCCCCCEEEEEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHC
GIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGVHARLGHSRYLIAEADESDA
CEEEEECCCCHHHHHHHHHHHHHCCCCCEEECCCCEEECCCCEECCCCEEEEEECCCCCC
SFLHLQPMVAIVTNIEADHMDTYHGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELL
CEEEHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHH
PRVGRQITTYGFSDDADVRVEDYRQVGAQGHFRLVRQDKAILQVTLNAPGRHNALNAAAA
HHHCCEEEECCCCCCCCCCHHHHHHCCCCCCEEEEECCCEEEEEEECCCCCCCHHHHHHH
VAVATEEGIDDRAILRALESFQGTGRRFDFLGEFPLAEVNGKPGSAMLIDDYGHHPTEVD
EEEEHHCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCHH
ATIKAARAGWPDKNLVMVFQPHRYTRTRDLYDDFANVLTQVDALLMLDVYPAGEAPIPGA
HHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCC
DSRSLCRTIRGRGKVDPILVPDSAQAAEMLASVLTGNDLVLVQGAGNIGKIARHLAEIKL
CHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHEE
IPQKTEEERHG
CCCCCCCCCCC
>Mature Secondary Structure
MNTQDLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQL
CCHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHCCCCEECCCCCCCCHHHHHH
SQLGATIYFNHRPENVRDASVVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRH
HHCCCEEEECCCCCCCCCCEEEEEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHC
GIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGVHARLGHSRYLIAEADESDA
CEEEEECCCCHHHHHHHHHHHHHCCCCCEEECCCCEEECCCCEECCCCEEEEEECCCCCC
SFLHLQPMVAIVTNIEADHMDTYHGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELL
CEEEHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHH
PRVGRQITTYGFSDDADVRVEDYRQVGAQGHFRLVRQDKAILQVTLNAPGRHNALNAAAA
HHHCCEEEECCCCCCCCCCHHHHHHCCCCCCEEEEECCCEEEEEEECCCCCCCHHHHHHH
VAVATEEGIDDRAILRALESFQGTGRRFDFLGEFPLAEVNGKPGSAMLIDDYGHHPTEVD
EEEEHHCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCHH
ATIKAARAGWPDKNLVMVFQPHRYTRTRDLYDDFANVLTQVDALLMLDVYPAGEAPIPGA
HHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCC
DSRSLCRTIRGRGKVDPILVPDSAQAAEMLASVLTGNDLVLVQGAGNIGKIARHLAEIKL
CHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHEE
IPQKTEEERHG
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA