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The map label for this gene is citW [H]

Identifier: 238893031

GI number: 238893031

Start: 846556

End: 847947

Strand: Direct

Name: citW [H]

Synonym: KP1_0868

Alternate gene names: 238893031

Gene position: 846556-847947 (Clockwise)

Preceding gene: 238893028

Following gene: 238893032

Centisome position: 16.13

GC content: 59.05

Gene sequence:

>1392_bases
ATGAATAATAACGACAGGGCTGAATTTATGAGCACCACAGACAATGCATTCTCTGCAACCCTTGAACCGATCGATACGCC
GAAAACCACGCTCAAGCAGCGCTGGTGGCATATCATGGATAACTGGAAGGTGGGGATCGTCCCGCTGCCGCTGTTTCTGC
TGGCCGGAGGACTGATTGCCCTCGACTGCCTTGGCGGCAAACTGCCGAGCGATATCGTGGTGATGGTGGCCACCCTGGCT
TTCTTTGGCTTCGCTTGCGGCGAGTTTGGTAAACGCCTCCCGGTGCTGGGGAAACTCGGTGCGGCGGCGATCTGCGCCAC
CTTTATTCCTTCCGCGCTGGTCCACTATGGTCTGCTGCCTGACGTGGTTATTGAATCCACGACCAAATTCTATAAATCCA
CTAACATTCTCTATCTCTATATCTGCTGCATCATTGTCGGCAGCATCATGAGTATGAACCGCACCACGCTGATTCAGGGC
TTTCTGAAGATCTTCTTCCCGATGCTGTGCGGCGAAGTGGTCGGCATGCTGGTGGGCATCGGCGTCGGCACGCTGCTGGG
CATGGAGCCGTTCCAGGTGTTCTTCTTTATCGTGCTGCCGATTATGGCCGGCGGTGTGGGAGAGGGGGCGATCCCGCTGT
CAATGGGTTATGCCGCGCTGATGCATATGGAGCAGGGCGTGGCCCTGGGCCGGGTATTGCCGATGGTGATGCTTGGCAGC
CTGACGGCGATCGTCATCTCCGGCTGCCTCAACCAGCTCGGCAAGCGCTTCCCGCATCTGACCGGCGAAGGGCAACTGAT
GCCGAACCGCAGCCATGAAACCCGCAGCCTCAGCGAGAGCGAAGGCGTGAGCGGTAAGACCGACGTTGGGACCCTCGCCT
CCGGCGCGCTGCTGGCGGTACTGCTGTATATGATGGGGATGCTCGGCCACAAACTGATTGGTCTGCCGGCGCCGGTAGGC
ATGCTGTTCCTCGCGGTACTGTTAAAGCTGGCTAACGTGGTGTCTCCGCGTCTGCAGGAGGGGTCGCAGATGGTGTATAA
ATTCTTCCGCACCGCGGTCACCTACCCGATCCTCTTTGCCGTCGGCGTGGCGATCACTCCGTGGCAGGAACTGGTAAACG
CCTTCACTTTAACCAACCTGCTGGTGATCGTCAGTACCGTCTCCGCGCTGGTGGCGACCGGTTTCCTGGTTGGTAAAAAG
ATAGGGATGCACCCGATCGATGTGGCGATTGTTTCCTGTTGCCAGAGCGGGCAGGGCGGCACCGGCGATGTGGCGATCCT
GACCGCCGGCAACCGCATGAGCCTGATGCCGTTCGCGCAGATCGCTACCCGCATCGGCGGGGCGATAAATGTCTCGCTGG
GGTTGCTGTTCCTCAGCCACTATCTGGCGTGA

Upstream 100 bases:

>100_bases
TCAGCGAATAGAAACCATAAAAACCATAGTGACCATTAAAACTTCTTTTTTAATCTGGGAAGCTTCACATTAACGACGCC
GCTGTCCCTTTACGCTGAAA

Downstream 100 bases:

>100_bases
TATAACGCTACGCTCAGCGATAAATCTGCTATTTTCCGCTACAGAACGCCGAAAATATCTGCGTTCTGTATCCTAAATGC
TCCGCATTTAGCGTTACAAT

Product: citrate/acetate antiporter

Products: NA

Alternate protein names: Citrate/malate-proton symporter [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MNNNDRAEFMSTTDNAFSATLEPIDTPKTTLKQRWWHIMDNWKVGIVPLPLFLLAGGLIALDCLGGKLPSDIVVMVATLA
FFGFACGEFGKRLPVLGKLGAAAICATFIPSALVHYGLLPDVVIESTTKFYKSTNILYLYICCIIVGSIMSMNRTTLIQG
FLKIFFPMLCGEVVGMLVGIGVGTLLGMEPFQVFFFIVLPIMAGGVGEGAIPLSMGYAALMHMEQGVALGRVLPMVMLGS
LTAIVISGCLNQLGKRFPHLTGEGQLMPNRSHETRSLSESEGVSGKTDVGTLASGALLAVLLYMMGMLGHKLIGLPAPVG
MLFLAVLLKLANVVSPRLQEGSQMVYKFFRTAVTYPILFAVGVAITPWQELVNAFTLTNLLVIVSTVSALVATGFLVGKK
IGMHPIDVAIVSCCQSGQGGTGDVAILTAGNRMSLMPFAQIATRIGGAINVSLGLLFLSHYLA

Sequences:

>Translated_463_residues
MNNNDRAEFMSTTDNAFSATLEPIDTPKTTLKQRWWHIMDNWKVGIVPLPLFLLAGGLIALDCLGGKLPSDIVVMVATLA
FFGFACGEFGKRLPVLGKLGAAAICATFIPSALVHYGLLPDVVIESTTKFYKSTNILYLYICCIIVGSIMSMNRTTLIQG
FLKIFFPMLCGEVVGMLVGIGVGTLLGMEPFQVFFFIVLPIMAGGVGEGAIPLSMGYAALMHMEQGVALGRVLPMVMLGS
LTAIVISGCLNQLGKRFPHLTGEGQLMPNRSHETRSLSESEGVSGKTDVGTLASGALLAVLLYMMGMLGHKLIGLPAPVG
MLFLAVLLKLANVVSPRLQEGSQMVYKFFRTAVTYPILFAVGVAITPWQELVNAFTLTNLLVIVSTVSALVATGFLVGKK
IGMHPIDVAIVSCCQSGQGGTGDVAILTAGNRMSLMPFAQIATRIGGAINVSLGLLFLSHYLA
>Mature_463_residues
MNNNDRAEFMSTTDNAFSATLEPIDTPKTTLKQRWWHIMDNWKVGIVPLPLFLLAGGLIALDCLGGKLPSDIVVMVATLA
FFGFACGEFGKRLPVLGKLGAAAICATFIPSALVHYGLLPDVVIESTTKFYKSTNILYLYICCIIVGSIMSMNRTTLIQG
FLKIFFPMLCGEVVGMLVGIGVGTLLGMEPFQVFFFIVLPIMAGGVGEGAIPLSMGYAALMHMEQGVALGRVLPMVMLGS
LTAIVISGCLNQLGKRFPHLTGEGQLMPNRSHETRSLSESEGVSGKTDVGTLASGALLAVLLYMMGMLGHKLIGLPAPVG
MLFLAVLLKLANVVSPRLQEGSQMVYKFFRTAVTYPILFAVGVAITPWQELVNAFTLTNLLVIVSTVSALVATGFLVGKK
IGMHPIDVAIVSCCQSGQGGTGDVAILTAGNRMSLMPFAQIATRIGGAINVSLGLLFLSHYLA

Specific function: Proton motive force-driven secondary transporter that catalyzes the uptake of both citrate and malate. Appears to be an electroneutral proton-solute symporter; the number of protons transported is equal to the valence of the transported anions. Is strictl

COG id: COG3493

COG function: function code C; Na+/citrate symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:citrate (SCF) symporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004679
- InterPro:   IPR018025 [H]

Pfam domain/function: PF03390 2HCT [H]

EC number: NA

Molecular weight: Translated: 49245; Mature: 49245

Theoretical pI: Translated: 8.32; Mature: 8.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNNDRAEFMSTTDNAFSATLEPIDTPKTTLKQRWWHIMDNWKVGIVPLPLFLLAGGLIA
CCCCCHHHHHHCCCCHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCHHHH
LDCLGGKLPSDIVVMVATLAFFGFACGEFGKRLPVLGKLGAAAICATFIPSALVHYGLLP
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCH
DVVIESTTKFYKSTNILYLYICCIIVGSIMSMNRTTLIQGFLKIFFPMLCGEVVGMLVGI
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVGTLLGMEPFQVFFFIVLPIMAGGVGEGAIPLSMGYAALMHMEQGVALGRVLPMVMLGS
HHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
LTAIVISGCLNQLGKRFPHLTGEGQLMPNRSHETRSLSESEGVSGKTDVGTLASGALLAV
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCHHCCCCCCCCHHHHHHHHHHHH
LLYMMGMLGHKLIGLPAPVGMLFLAVLLKLANVVSPRLQEGSQMVYKFFRTAVTYPILFA
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
VGVAITPWQELVNAFTLTNLLVIVSTVSALVATGFLVGKKIGMHPIDVAIVSCCQSGQGG
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCC
TGDVAILTAGNRMSLMPFAQIATRIGGAINVSLGLLFLSHYLA
CCCEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNNNDRAEFMSTTDNAFSATLEPIDTPKTTLKQRWWHIMDNWKVGIVPLPLFLLAGGLIA
CCCCCHHHHHHCCCCHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCHHHH
LDCLGGKLPSDIVVMVATLAFFGFACGEFGKRLPVLGKLGAAAICATFIPSALVHYGLLP
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCH
DVVIESTTKFYKSTNILYLYICCIIVGSIMSMNRTTLIQGFLKIFFPMLCGEVVGMLVGI
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVGTLLGMEPFQVFFFIVLPIMAGGVGEGAIPLSMGYAALMHMEQGVALGRVLPMVMLGS
HHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
LTAIVISGCLNQLGKRFPHLTGEGQLMPNRSHETRSLSESEGVSGKTDVGTLASGALLAV
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCHHCCCCCCCCHHHHHHHHHHHH
LLYMMGMLGHKLIGLPAPVGMLFLAVLLKLANVVSPRLQEGSQMVYKFFRTAVTYPILFA
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
VGVAITPWQELVNAFTLTNLLVIVSTVSALVATGFLVGKKIGMHPIDVAIVSCCQSGQGG
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCC
TGDVAILTAGNRMSLMPFAQIATRIGGAINVSLGLLFLSHYLA
CCCEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969509; 9384377; 11566984 [H]