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The map label for this gene is aceB [H]

Identifier: 238892486

GI number: 238892486

Start: 264585

End: 266186

Strand: Direct

Name: aceB [H]

Synonym: KP1_0253

Alternate gene names: 238892486

Gene position: 264585-266186 (Clockwise)

Preceding gene: 238892484

Following gene: 238892487

Centisome position: 5.04

GC content: 57.68

Gene sequence:

>1602_bases
ATGACGCAGCAGGCGACAATCACCGATGAACTGGCCTTTAGTCAGCCCTATGGCGAGCAGGAGAAGCAGATCTTAACGCC
TGAGGCGGTAGAATTTCTGACGGAACTGGTGAGCCGCTTTACGCCGGCGCGCAATAAGCTGCTGGCCGCGCGTTTGCAGC
AACAGCAGGCTATTGACGACGGGCAGCTTCCGGATTTTATTTCGGAAACTGCTTCCATTAGAAATGGCGACTGGACTATT
CGCGGTATCCCGGCTGATTTGCAGGATCGCCGTGTTGAAATCACCGGCCCCGTCGAGCGCAAGATGGTCATTAACGCGCT
GAATGCCAACGTCAAAGTCTTTATGGCGGACTTTGAGGATTCGCTGGCGCCTGACTGGCGCAAAGTCATTGATGGTCAAA
TCAACCTGCGCGATGCCGTGAACGGGACCATCAGCTACACCAACGAGGCCGGCAAAATCTATCAGTTGCAGCCCAATCCC
GCTGTGCTGGTATGCCGTGTGCGCGGCCTGCATCTGCCGGAAAAGCATGTGACCTGGCGTAATGAGGCCATCCCCGGCAG
CCTGTTCGATTTTGCGCTCTATTTCTTTCATAACTACCAGGCGCTGCTGGCGAAAGGAAGTGGTCCCTACTTCTATCTGC
CAAAAACACAGGCCTGGCAGGAGGCGGCATGGTGGAACGATGTCTTCAGTTTTACGGAAGATCGCTTTGACCTGCCGCGG
GGCACCATCAAAGCCACGCTGCTGATTGAGACGCTGCCAGCGGTGTTCCAGATGGATGAGATCCTGCATGCGCTGCGCGA
CCATATTGTTGGCCTGAACTGCGGCCGCTGGGATTACATCTTCAGCTACATCAAGACGCTGAAAAACCATCCGGATCGCG
TACTGCCGGACCGGCAGGTGGTGACGATGGATAAACCCTTCCTCAGCGCCTACTCACGGTTGTTGATTAAGACCTGCCAT
AAACGCGGCGCGTTTGCGATGGGCGGTATGGCGGCGTTTATCCCGAGCAAAGATACCGAACGTAACCGCCAGGTGCTGAG
TAAAGTCACCGCCGATAAAGAGCTGGAGGCCAACAACGGTCACGATGGGACCTGGATCGCCCACCCGGGCCTGGCGGATA
CCGCCATGGCGGTGTTTGACCGCGTGCTGGGCGATAAGCCGAATCAGCTCTCGGTCACCCGGAGCGAGGATGCGCCAATT
ACCGCTGAACAACTGCTGGCTCCCTGCGAGGGCGAACGCACGGAAGCCGGAATGCGCGCCAACATTCGCGTGGCGGTGCA
GTACATCGAAGCGTGGATCTCCGGCAACGGCTGCGTACCGATTTATGGCCTGATGGAAGACGCCGCAACGGCCGAGATCT
CGCGCACCTCTATCTGGCAGTGGATCCATCATCAGAAAACCCTGAACGACGGTACCCCAGTCACTAAGGCGCTGTTCCGC
CAGTGGCTGGCGGAAGAGCTGATGGTGATTCAGGAGGAGCTGGGAGAGCACCGCTTCAGCCACGGCCGCTTTGACGATGC
GGCGCGACTGATGGAGCAGATCACCACCTCCGACGAGCTAATTGATTTTCTGACATTGCCGGGCTACCGCCTGCTGGCCT
AA

Upstream 100 bases:

>100_bases
TGATTTTGGAAATTAATTGAGTAGTCTTAATTGTGCTGAGCGAAAACTGCACAACGATCTTTCGCTCGCTTCCAGCGGAT
CAACCAAGAGGAGCAGCACA

Downstream 100 bases:

>100_bases
TCGCCAGATGGTGTGGTTCGCCATTTAGTCCTTCACCTATGAGCCTGGGGAGCCAGGAAATTATATGGAGCATCTGCACA
TGAAAACCCGTACCCAACAA

Product: malate synthase

Products: NA

Alternate protein names: MSA [H]

Number of amino acids: Translated: 533; Mature: 532

Protein sequence:

>533_residues
MTQQATITDELAFSQPYGEQEKQILTPEAVEFLTELVSRFTPARNKLLAARLQQQQAIDDGQLPDFISETASIRNGDWTI
RGIPADLQDRRVEITGPVERKMVINALNANVKVFMADFEDSLAPDWRKVIDGQINLRDAVNGTISYTNEAGKIYQLQPNP
AVLVCRVRGLHLPEKHVTWRNEAIPGSLFDFALYFFHNYQALLAKGSGPYFYLPKTQAWQEAAWWNDVFSFTEDRFDLPR
GTIKATLLIETLPAVFQMDEILHALRDHIVGLNCGRWDYIFSYIKTLKNHPDRVLPDRQVVTMDKPFLSAYSRLLIKTCH
KRGAFAMGGMAAFIPSKDTERNRQVLSKVTADKELEANNGHDGTWIAHPGLADTAMAVFDRVLGDKPNQLSVTRSEDAPI
TAEQLLAPCEGERTEAGMRANIRVAVQYIEAWISGNGCVPIYGLMEDAATAEISRTSIWQWIHHQKTLNDGTPVTKALFR
QWLAEELMVIQEELGEHRFSHGRFDDAARLMEQITTSDELIDFLTLPGYRLLA

Sequences:

>Translated_533_residues
MTQQATITDELAFSQPYGEQEKQILTPEAVEFLTELVSRFTPARNKLLAARLQQQQAIDDGQLPDFISETASIRNGDWTI
RGIPADLQDRRVEITGPVERKMVINALNANVKVFMADFEDSLAPDWRKVIDGQINLRDAVNGTISYTNEAGKIYQLQPNP
AVLVCRVRGLHLPEKHVTWRNEAIPGSLFDFALYFFHNYQALLAKGSGPYFYLPKTQAWQEAAWWNDVFSFTEDRFDLPR
GTIKATLLIETLPAVFQMDEILHALRDHIVGLNCGRWDYIFSYIKTLKNHPDRVLPDRQVVTMDKPFLSAYSRLLIKTCH
KRGAFAMGGMAAFIPSKDTERNRQVLSKVTADKELEANNGHDGTWIAHPGLADTAMAVFDRVLGDKPNQLSVTRSEDAPI
TAEQLLAPCEGERTEAGMRANIRVAVQYIEAWISGNGCVPIYGLMEDAATAEISRTSIWQWIHHQKTLNDGTPVTKALFR
QWLAEELMVIQEELGEHRFSHGRFDDAARLMEQITTSDELIDFLTLPGYRLLA
>Mature_532_residues
TQQATITDELAFSQPYGEQEKQILTPEAVEFLTELVSRFTPARNKLLAARLQQQQAIDDGQLPDFISETASIRNGDWTIR
GIPADLQDRRVEITGPVERKMVINALNANVKVFMADFEDSLAPDWRKVIDGQINLRDAVNGTISYTNEAGKIYQLQPNPA
VLVCRVRGLHLPEKHVTWRNEAIPGSLFDFALYFFHNYQALLAKGSGPYFYLPKTQAWQEAAWWNDVFSFTEDRFDLPRG
TIKATLLIETLPAVFQMDEILHALRDHIVGLNCGRWDYIFSYIKTLKNHPDRVLPDRQVVTMDKPFLSAYSRLLIKTCHK
RGAFAMGGMAAFIPSKDTERNRQVLSKVTADKELEANNGHDGTWIAHPGLADTAMAVFDRVLGDKPNQLSVTRSEDAPIT
AEQLLAPCEGERTEAGMRANIRVAVQYIEAWISGNGCVPIYGLMEDAATAEISRTSIWQWIHHQKTLNDGTPVTKALFRQ
WLAEELMVIQEELGEHRFSHGRFDDAARLMEQITTSDELIDFLTLPGYRLLA

Specific function: Glyoxylate bypass; second step. [C]

COG id: COG2225

COG function: function code C; Malate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malate synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790444, Length=533, Percent_Identity=88.9305816135084, Blast_Score=1000, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17561814, Length=516, Percent_Identity=53.1007751937985, Blast_Score=521, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI71982926, Length=410, Percent_Identity=55.8536585365854, Blast_Score=434, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6324212, Length=488, Percent_Identity=47.3360655737705, Blast_Score=428, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6322222, Length=523, Percent_Identity=45.8891013384321, Blast_Score=426, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011076
- InterPro:   IPR006252
- InterPro:   IPR001465
- InterPro:   IPR019830 [H]

Pfam domain/function: PF01274 Malate_synthase [H]

EC number: =2.3.3.9 [H]

Molecular weight: Translated: 60276; Mature: 60145

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00510 MALATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQATITDELAFSQPYGEQEKQILTPEAVEFLTELVSRFTPARNKLLAARLQQQQAIDD
CCCCCCCHHHHHCCCCCCCCHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCC
GQLPDFISETASIRNGDWTIRGIPADLQDRRVEITGPVERKMVINALNANVKVFMADFED
CCCCHHHHHHHCCCCCCEEEEECCCCCCCCEEEEECCHHHHHHHHHHCCCEEEEEECCCC
SLAPDWRKVIDGQINLRDAVNGTISYTNEAGKIYQLQPNPAVLVCRVRGLHLPEKHVTWR
CCCHHHHHHHCCCCEEHHHCCCEEEEECCCCEEEEECCCCEEEEEEECCCCCCHHHCCCC
NEAIPGSLFDFALYFFHNYQALLAKGSGPYFYLPKTQAWQEAAWWNDVFSFTEDRFDLPR
CCCCCCHHHHHHHHHHHCCHHEEECCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCC
GTIKATLLIETLPAVFQMDEILHALRDHIVGLNCGRWDYIFSYIKTLKNHPDRVLPDRQV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEE
VTMDKPFLSAYSRLLIKTCHKRGAFAMGGMAAFIPSKDTERNRQVLSKVTADKELEANNG
EEECCHHHHHHHHHHHHHHHHCCCEECCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCCC
HDGTWIAHPGLADTAMAVFDRVLGDKPNQLSVTRSEDAPITAEQLLAPCEGERTEAGMRA
CCCCEEECCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHCCCCCCCCCCCCCC
NIRVAVQYIEAWISGNGCVPIYGLMEDAATAEISRTSIWQWIHHQKTLNDGTPVTKALFR
HHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
QWLAEELMVIQEELGEHRFSHGRFDDAARLMEQITTSDELIDFLTLPGYRLLA
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHCCCHHHCC
>Mature Secondary Structure 
TQQATITDELAFSQPYGEQEKQILTPEAVEFLTELVSRFTPARNKLLAARLQQQQAIDD
CCCCCCHHHHHCCCCCCCCHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCC
GQLPDFISETASIRNGDWTIRGIPADLQDRRVEITGPVERKMVINALNANVKVFMADFED
CCCCHHHHHHHCCCCCCEEEEECCCCCCCCEEEEECCHHHHHHHHHHCCCEEEEEECCCC
SLAPDWRKVIDGQINLRDAVNGTISYTNEAGKIYQLQPNPAVLVCRVRGLHLPEKHVTWR
CCCHHHHHHHCCCCEEHHHCCCEEEEECCCCEEEEECCCCEEEEEEECCCCCCHHHCCCC
NEAIPGSLFDFALYFFHNYQALLAKGSGPYFYLPKTQAWQEAAWWNDVFSFTEDRFDLPR
CCCCCCHHHHHHHHHHHCCHHEEECCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCC
GTIKATLLIETLPAVFQMDEILHALRDHIVGLNCGRWDYIFSYIKTLKNHPDRVLPDRQV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEE
VTMDKPFLSAYSRLLIKTCHKRGAFAMGGMAAFIPSKDTERNRQVLSKVTADKELEANNG
EEECCHHHHHHHHHHHHHHHHCCCEECCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCCC
HDGTWIAHPGLADTAMAVFDRVLGDKPNQLSVTRSEDAPITAEQLLAPCEGERTEAGMRA
CCCCEEECCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHCCCCCCCCCCCCCC
NIRVAVQYIEAWISGNGCVPIYGLMEDAATAEISRTSIWQWIHHQKTLNDGTPVTKALFR
HHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
QWLAEELMVIQEELGEHRFSHGRFDDAARLMEQITTSDELIDFLTLPGYRLLA
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3050899; 3060852; 8265357; 9278503 [H]