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The map label for this gene is murB [H]

Identifier: 238892447

GI number: 238892447

Start: 217887

End: 218915

Strand: Direct

Name: murB [H]

Synonym: KP1_0209

Alternate gene names: 238892447

Gene position: 217887-218915 (Clockwise)

Preceding gene: 238892446

Following gene: 238892448

Centisome position: 4.15

GC content: 55.1

Gene sequence:

>1029_bases
ATGAACCACTCCCTCAAACCCTGGAATACCTTTGGCATTGAACGCTTCGCCAAGACGATAGTACGCGCCGAAACTGAGCA
ACAGTTGCTAAGCGCCTGGCAAACCGCTGCCGCGGCAGGCGAACCCACGCTGATCCTTGGGGAAGGCAGTAATGTCCTGT
TTCTGAACGACTATGCCGGTACGGTGATCCTCAACCGGATTATGGGGATCGAGGTGAGCGAAACGCCGGACGCCTGGCGC
TTGCACGTCGGCGCCGGCGAAAACTGGCATCAGTTGGTGCAGTTCACGCTACAGCATGCGATGCCAGGTCTGGAAAATCT
GGCGTTAATCCCTGGCTGCGCAGGATCTTCGCCGATCCAGAATATTGGCGCCTACGGCGTTGAGCTACAGCGGGTTTGCG
AATATGTTGACTGCATTGAGCTGGAAACCGGGCGTAAGCAACGTCTTTCAGCCGCGGAATGCCGTTTTGGCTATCGCGAC
AGTATCTTCAAACATGAATATCAGGACCGCTATGCCATCGTTGCGATTGGCTTATCGTTAGCGAAAACATGGCAGCCTGT
ACTGAGTTACGGTGATTTAACGCGTCTCGATCCGCAGACCGTCACGCCGCAGCAGGTATTTGATGCGGTCTGTCATATGC
GAATGACTAAATTGCCGGATCCAAAGATTAACGGTAATGCCGGCAGCTTTTTTAAGAACCCGATCGTCAGCGCTCAGGTT
GCGAAAGCGCTGCTGGCGCAGTTCCCTCATGCACCGCACTATCCGCAGGCAAATGGCAGCGTCAAGCTGGCCGCTGGCTG
GCTAATCGATCAATGTGAGCTCAAAGGACAACGCATCGGCGGCGCGGCCGTCCATCGACAGCAGGCGCTGGTACTGATTA
ATGAAGATCGAGCGACCAGCGAGGATGTGGTAAAACTTGCTCATTATGTTCGCCAGCGGGTGGGTGCGAAATTCGATGTA
TGGCTTCAGCCCGAGGTGCGCTTCATTGGCACGCATGGTGAAGTCAACGCAGAGGAGAGCATTGCGTGA

Upstream 100 bases:

>100_bases
CCACCGGTAACGCCCCGCAATATCATTGCCCCTGTAATCAGACAAGCCTTCCCCCGCCAGATACGATAAACTAACGCCGA
TTTTGCATCAGGAAGCTACT

Downstream 100 bases:

>100_bases
AAGACCATACTATCCCTTTAACGCTAATTTCTATCCTTGCTGATGGCGAGTTTCACTCTGGCGAACAGCTTGGTGAGCAG
TTAGGCATGAGCCGGGCGGC

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase [H]

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MNHSLKPWNTFGIERFAKTIVRAETEQQLLSAWQTAAAAGEPTLILGEGSNVLFLNDYAGTVILNRIMGIEVSETPDAWR
LHVGAGENWHQLVQFTLQHAMPGLENLALIPGCAGSSPIQNIGAYGVELQRVCEYVDCIELETGRKQRLSAAECRFGYRD
SIFKHEYQDRYAIVAIGLSLAKTWQPVLSYGDLTRLDPQTVTPQQVFDAVCHMRMTKLPDPKINGNAGSFFKNPIVSAQV
AKALLAQFPHAPHYPQANGSVKLAAGWLIDQCELKGQRIGGAAVHRQQALVLINEDRATSEDVVKLAHYVRQRVGAKFDV
WLQPEVRFIGTHGEVNAEESIA

Sequences:

>Translated_342_residues
MNHSLKPWNTFGIERFAKTIVRAETEQQLLSAWQTAAAAGEPTLILGEGSNVLFLNDYAGTVILNRIMGIEVSETPDAWR
LHVGAGENWHQLVQFTLQHAMPGLENLALIPGCAGSSPIQNIGAYGVELQRVCEYVDCIELETGRKQRLSAAECRFGYRD
SIFKHEYQDRYAIVAIGLSLAKTWQPVLSYGDLTRLDPQTVTPQQVFDAVCHMRMTKLPDPKINGNAGSFFKNPIVSAQV
AKALLAQFPHAPHYPQANGSVKLAAGWLIDQCELKGQRIGGAAVHRQQALVLINEDRATSEDVVKLAHYVRQRVGAKFDV
WLQPEVRFIGTHGEVNAEESIA
>Mature_342_residues
MNHSLKPWNTFGIERFAKTIVRAETEQQLLSAWQTAAAAGEPTLILGEGSNVLFLNDYAGTVILNRIMGIEVSETPDAWR
LHVGAGENWHQLVQFTLQHAMPGLENLALIPGCAGSSPIQNIGAYGVELQRVCEYVDCIELETGRKQRLSAAECRFGYRD
SIFKHEYQDRYAIVAIGLSLAKTWQPVLSYGDLTRLDPQTVTPQQVFDAVCHMRMTKLPDPKINGNAGSFFKNPIVSAQV
AKALLAQFPHAPHYPQANGSVKLAAGWLIDQCELKGQRIGGAAVHRQQALVLINEDRATSEDVVKLAHYVRQRVGAKFDV
WLQPEVRFIGTHGEVNAEESIA

Specific function: Cell wall formation [H]

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Escherichia coli, GI1790407, Length=342, Percent_Identity=79.2397660818713, Blast_Score=578, Evalue=1e-166,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094 [H]

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C [H]

EC number: =1.1.1.158 [H]

Molecular weight: Translated: 37809; Mature: 37809

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHSLKPWNTFGIERFAKTIVRAETEQQLLSAWQTAAAAGEPTLILGEGSNVLFLNDYAG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEECCCH
TVILNRIMGIEVSETPDAWRLHVGAGENWHQLVQFTLQHAMPGLENLALIPGCAGSSPIQ
HHHHHHHHCCEECCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHH
NIGAYGVELQRVCEYVDCIELETGRKQRLSAAECRFGYRDSIFKHEYQDRYAIVAIGLSL
HHHHCCHHHHHHHHHHHHHHCCCCHHHHCCHHHHCCCCHHHHHHHHHCCCEEEEEEHHHH
AKTWQPVLSYGDLTRLDPQTVTPQQVFDAVCHMRMTKLPDPKINGNAGSFFKNPIVSAQV
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCHHHHH
AKALLAQFPHAPHYPQANGSVKLAAGWLIDQCELKGQRIGGAAVHRQQALVLINEDRATS
HHHHHHHCCCCCCCCCCCCCEEEEECCEEHHHHHCCCCCCCHHHHCCCEEEEEECCCCCH
EDVVKLAHYVRQRVGAKFDVWLQPEVRFIGTHGEVNAEESIA
HHHHHHHHHHHHHHCCEEEEEECCCEEEEECCCCCCCHHCCC
>Mature Secondary Structure
MNHSLKPWNTFGIERFAKTIVRAETEQQLLSAWQTAAAAGEPTLILGEGSNVLFLNDYAG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEECCCH
TVILNRIMGIEVSETPDAWRLHVGAGENWHQLVQFTLQHAMPGLENLALIPGCAGSSPIQ
HHHHHHHHCCEECCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHH
NIGAYGVELQRVCEYVDCIELETGRKQRLSAAECRFGYRDSIFKHEYQDRYAIVAIGLSL
HHHHCCHHHHHHHHHHHHHHCCCCHHHHCCHHHHCCCCHHHHHHHHHCCCEEEEEEHHHH
AKTWQPVLSYGDLTRLDPQTVTPQQVFDAVCHMRMTKLPDPKINGNAGSFFKNPIVSAQV
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCHHHHH
AKALLAQFPHAPHYPQANGSVKLAAGWLIDQCELKGQRIGGAAVHRQQALVLINEDRATS
HHHHHHHCCCCCCCCCCCCCEEEEECCEEHHHHHCCCCCCCHHHHCCCEEEEEECCCCCH
EDVVKLAHYVRQRVGAKFDVWLQPEVRFIGTHGEVNAEESIA
HHHHHHHHHHHHHHCCEEEEEECCCEEEEECCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]