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The map label for this gene is corA [H]

Identifier: 238892414

GI number: 238892414

Start: 178161

End: 179126

Strand: Direct

Name: corA [H]

Synonym: KP1_0173

Alternate gene names: 238892414

Gene position: 178161-179126 (Clockwise)

Preceding gene: 238892413

Following gene: 238892417

Centisome position: 3.39

GC content: 56.94

Gene sequence:

>966_bases
TTGGGAGTCCCGGTCATGCTGAGCGCATTTCAACTGGAAAACAATCGTTTAACGCGCCTGGAAGCCGATGAGATCAAACA
CCTCGCCAGCTCGGTGTGGGTCGATCTGGTCGAGCCTGACGACGATGAGCGAAGCCGCGTGCAGACGGAACTGGGTCAAA
ACCTGGCGACGCGCCCGGAACTGGAAGATATCGAAGCCTCCGCGCGTTTCTTTGAAGATGAAGACGGGTTACACATCCAC
TCGTTCTTCTTTTTTGAAGATGCCGACGATCACGCCGGCAACTCTACCGTGGCGTTTACCATCCGCGAAGGCCGCCTGTT
CACGCTGCGCGAGCGCGAACTACCCGCTTTCCGCCTCTACCGTATGCGCGTGCGTAACCAGACGCTGGTCGACGGCAACG
CCTACGAACTGCTGCTCGACCTGTTCGAGACCAAAATCGAGCAGCTGGCGGATGAAATTGAAAACATCTACAGCGACCTG
GAAAAGCTGAGCCGCGTGATTATGGAAGGCCATCAGGGCGACGAGTACGACGAAGCGCTGTCGACGCTGGCGGAACTGGA
AGATATCGGCTGGAAGGTGCGCCTCTGTCTGATGGATACCCAGCGCGCACTGAACTTCCTCGTGCGCAAGGCGCGCCTGC
CGGCGGGCCAGCTGGAGCAGGCACGGGAGATCCTGCGCGATATCGAATCTCTGCTGCCGCACAACGAATCGCTGTTCCAG
AAGGTGAACTTCCTGATGCAGGCGGCGATGGGTTTTATCAATATCGAGCAGAACCGCATCATCAAGATCTTCTCGGTGGT
CTCGGTGGTATTCCTGCCGCCAACTCTGGTGGCCTCCAGTTACGGGATGAACTTTGAATTTATGCCCGAACTACACTGGA
GCTTTGGTTATCCGGGAGCCATCGTGTTTATGATGCTGGCCGGCCTGGCGCCGTATCTCTACTTCAAGCGCAAAAACTGG
CTGTAA

Upstream 100 bases:

>100_bases
CAGCGACCTGCCCCATTCCCGTCGCGCTGAGTCAGGCTTAATGGTCTGAAACCCAATTTGTTTCTGTGTGCCCACCGAAC
TGTCCGATAATTTTTTTGCA

Downstream 100 bases:

>100_bases
AAAAAGGGAGCGTCGGCTCCCTTCTTTACTGGCTGATGCAGGCTTAGCCTCTGCGCAACCGGCGCTGGGTATACAGCGCA
TCGACGATAAACACCGCCAG

Product: magnesium/nickel/cobalt transporter CorA

Products: Ni2; [Cytoplasm]; Co; 2 [Cytoplasm]; Mg (II) [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MGVPVMLSAFQLENNRLTRLEADEIKHLASSVWVDLVEPDDDERSRVQTELGQNLATRPELEDIEASARFFEDEDGLHIH
SFFFFEDADDHAGNSTVAFTIREGRLFTLRERELPAFRLYRMRVRNQTLVDGNAYELLLDLFETKIEQLADEIENIYSDL
EKLSRVIMEGHQGDEYDEALSTLAELEDIGWKVRLCLMDTQRALNFLVRKARLPAGQLEQAREILRDIESLLPHNESLFQ
KVNFLMQAAMGFINIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELHWSFGYPGAIVFMMLAGLAPYLYFKRKNW
L

Sequences:

>Translated_321_residues
MGVPVMLSAFQLENNRLTRLEADEIKHLASSVWVDLVEPDDDERSRVQTELGQNLATRPELEDIEASARFFEDEDGLHIH
SFFFFEDADDHAGNSTVAFTIREGRLFTLRERELPAFRLYRMRVRNQTLVDGNAYELLLDLFETKIEQLADEIENIYSDL
EKLSRVIMEGHQGDEYDEALSTLAELEDIGWKVRLCLMDTQRALNFLVRKARLPAGQLEQAREILRDIESLLPHNESLFQ
KVNFLMQAAMGFINIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELHWSFGYPGAIVFMMLAGLAPYLYFKRKNW
L
>Mature_320_residues
GVPVMLSAFQLENNRLTRLEADEIKHLASSVWVDLVEPDDDERSRVQTELGQNLATRPELEDIEASARFFEDEDGLHIHS
FFFFEDADDHAGNSTVAFTIREGRLFTLRERELPAFRLYRMRVRNQTLVDGNAYELLLDLFETKIEQLADEIENIYSDLE
KLSRVIMEGHQGDEYDEALSTLAELEDIGWKVRLCLMDTQRALNFLVRKARLPAGQLEQAREILRDIESLLPHNESLFQK
VNFLMQAAMGFINIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELHWSFGYPGAIVFMMLAGLAPYLYFKRKNWL

Specific function: Mediates influx of magnesium ions [H]

COG id: COG0598

COG function: function code P; Mg2+ and Co2+ transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family [H]

Homologues:

Organism=Escherichia coli, GI2367297, Length=316, Percent_Identity=92.4050632911392, Blast_Score=604, Evalue=1e-174,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004488
- InterPro:   IPR002523 [H]

Pfam domain/function: PF01544 CorA [H]

EC number: NA

Molecular weight: Translated: 37152; Mature: 37021

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVPVMLSAFQLENNRLTRLEADEIKHLASSVWVDLVEPDDDERSRVQTELGQNLATRPE
CCCCCEEHEEEECCCCEEEECHHHHHHHHHHHEEEEECCCCCHHHHHHHHHCCCCCCCCC
LEDIEASARFFEDEDGLHIHSFFFFEDADDHAGNSTVAFTIREGRLFTLRERELPAFRLY
HHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCCCCEEEEEEECCEEEEEECCCCCHHHHH
RMRVRNQTLVDGNAYELLLDLFETKIEQLADEIENIYSDLEKLSRVIMEGHQGDEYDEAL
HHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
STLAELEDIGWKVRLCLMDTQRALNFLVRKARLPAGQLEQAREILRDIESLLPHNESLFQ
HHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHH
KVNFLMQAAMGFINIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELHWSFGYPGA
HHHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCHHHHHHHCCCCEEECCCCCCCCCCHHH
IVFMMLAGLAPYLYFKRKNWL
HHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GVPVMLSAFQLENNRLTRLEADEIKHLASSVWVDLVEPDDDERSRVQTELGQNLATRPE
CCCCEEHEEEECCCCEEEECHHHHHHHHHHHEEEEECCCCCHHHHHHHHHCCCCCCCCC
LEDIEASARFFEDEDGLHIHSFFFFEDADDHAGNSTVAFTIREGRLFTLRERELPAFRLY
HHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCCCCEEEEEEECCEEEEEECCCCCHHHHH
RMRVRNQTLVDGNAYELLLDLFETKIEQLADEIENIYSDLEKLSRVIMEGHQGDEYDEAL
HHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
STLAELEDIGWKVRLCLMDTQRALNFLVRKARLPAGQLEQAREILRDIESLLPHNESLFQ
HHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHH
KVNFLMQAAMGFINIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELHWSFGYPGA
HHHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCHHHHHHHCCCCEEECCCCCCCCCCHHH
IVFMMLAGLAPYLYFKRKNWL
HHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Ni2; [Periplasm]; Co; 2 [Periplasm]; Mg (II) [Periplasm] [C]

Specific reaction: Ni2+ [Periplasm] = Ni2+ [Cytoplasm] Co+2 [Periplasm] = Co+2 [Cytoplasm] Mg (II) [Periplasm] = Mg (II) [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]