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The map label for this gene is uvrD [H]

Identifier: 238892413

GI number: 238892413

Start: 175652

End: 177820

Strand: Direct

Name: uvrD [H]

Synonym: KP1_0172

Alternate gene names: 238892413

Gene position: 175652-177820 (Clockwise)

Preceding gene: 238892412

Following gene: 238892414

Centisome position: 3.35

GC content: 61.0

Gene sequence:

>2169_bases
GTGCCAATGGACGTTTCTTACCTGCTCGACAGCCTTAATGACAAACAGCGTGAAGCCGTAGCGGCCTCGCGCACCAATAT
GCTGGTTCTGGCAGGGGCGGGCAGTGGTAAGACGCGCGTTCTGGTGCACCGTATCGCCTGGCTGCTGAGCGTGGAGAACT
GTTCCCCGTATTCCATTATGGCGGTGACCTTTACCAACAAAGCGGCGGCGGAGATGCGTCACCGTATCGGCCAGCTGATG
GGCACCACCCAGGGCGGCATGTGGGTGGGCACCTTCCACGGCCTGGCGCACCGTTTGCTGCGCGCGCACCATCTGGATGC
CAACCTGCCGCAGGACTTTCAAATCCTCGACAGCGAAGACCAGCTGCGTCTGCTGAAGCGTCTGATTAAGGCGATGAACC
TCGATGAGAAACAGTGGCCGCCGCGCCAGGCGATGTGGTACATCAACAGCCAGAAAGATGAAGGGCTGCGCCCGCATCAT
ATTCAGAGCTACGGCAACCCGGTCGAGCAGACCTGGCAGAAGGTCTATCAGGCCTATCAGGAAGCCTGCGACCGCGCCGG
GCTGGTGGATTTCGCCGAGCTGCTGCTGCGCGCCCACGAGCTGTGGCTGAACAAGCCGCATATCCTGCAGCACTATCGTG
AGCGTTTCACCAATATCCTTGTCGATGAATTTCAGGATACCAACAACATTCAGTACGCCTGGATCCGCCTGCTGGCGGGC
GATACCGGCAAAGTGATGATCGTTGGCGATGATGACCAGTCGATTTATGGCTGGCGCGGCGCGCAGGTCGAGAACATTCA
GCGCTTCCTCAACGACTTCCCCGGCGCGGAAACCATCCGCCTGGAGCAGAACTATCGCTCGACCAGCAATATTCTCAGCG
CTGCCAACGCCCTGATTGAAAACAACAACGGTCGGCTGGGCAAAAAGCTGTGGACCGACGGCGCCGACGGCGAGCCGATT
TCGCTGTACTGCGCCTTCAACGATCTCGACGAAGCGCGCTTTGTGGTGAACCGAATTAAAACCTGGCAGGAGAACGGCGG
CGCGCTGGAGCAATGCGCCATTCTCTATCGCAGTAACGCCCAGTCGCGTGTGCTGGAAGAGGCCCTCCTGCAGGCCAGTA
TGCCGTACCGTATCTACGGCGGCATGCGCTTCTTCGAGCGTCAGGAAATCAAAGACGCGCTCTCTTACCTGCGCCTTATC
GCCAACCGCAACGACGACGCGGCCTTTGAGCGCGTAGTCAATACGCCGACCCGCGGCATTGGCGACCGCACGCTGGACGT
GGTGCGCCAAACGTCGCGCGATCGCCAGCTGACGCTATGGCAGGCCAGTCGCGAGCTATTGAAAGAAAAAGCGCTGGCCG
GTCGCGCCGCCAGCGCCCTGCAGCGCTTTATGGAGCTGATTGACGCGCTGGCGCAGGAGACCACCGATATGCCGCTGCAC
GTTCAGACCGATCGGGTGATTAAAGACTCCGGCCTGCGCGCGATGTACGAGCAGGAGAAAGGTGAGAAGGGCCAGACCCG
TATTGAAAACTTAGAGGAGCTGGTGACGGCGACGCGCCAGTTCAGCTACAACGAAGAAGATGAAGATCTGATGCCGCTGC
AGGCGTTCCTCTCCCACGCCGCGCTGGAAGCGGGCGAGGGGCAGGCGGACACCTGGCAGGACGCGGTTCAGCTGATGACC
CTGCACTCGGCGAAAGGGCTGGAGTTCCCACAGGTGTTCATCGTCGGCGTCGAAGAAGGGATGTTCCCGAGCCAGATGGC
CCTTGATGAAGGCGGCCGCCTGGAGGAGGAGCGTCGCCTGGCCTACGTCGGCGTAACGCGCGCCATGCAGAAGCTGACGC
TGACCTATGCGGAAACCCGCCGTCTGTACGGGAAAGAGGTTTATCACCGCCCGTCGCGCTTTATTGGCGAGCTGCCGCAG
GAGTGCGTAGAAGAAGTGCGGCTGCGAGCCACGGTGAGCCGCCCGGTAAACCATCAGCGACTGGGCGCGCCGATTGCCGA
GAGCGATACCGGCTACAAGTTAGGCCAGCGCGTACGGCATCCGAAGTTTGGCGAAGGCACTATTGTCAACCTCGAAGGCA
GCGGCGAGCACAGCCGGCTGCAGGTGGCTTTTCAGGGCCAGGGAATCAAATGGCTGGTGGCGGCTTACGCCCGGCTGGAG
GCAGTGTAA

Upstream 100 bases:

>100_bases
TATTGAAATTTCACGGTTGGCATCTCTGACCTCGCTGATATAATCACCAGTCACTCTGTATATATTAACAGGGGTTCGTG
GAACCCCTTCTCTTCCGGCG

Downstream 100 bases:

>100_bases
CTTTAGGAAAAATATCATTATTTTGTAATATTCTGCTACCTTTATACGTTAAGGCGCCTGATTTGCGCTTTCGCGTTCCG
TTGCGTGTTGACGCCGATTT

Product: DNA-dependent helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 722; Mature: 721

Protein sequence:

>722_residues
MPMDVSYLLDSLNDKQREAVAASRTNMLVLAGAGSGKTRVLVHRIAWLLSVENCSPYSIMAVTFTNKAAAEMRHRIGQLM
GTTQGGMWVGTFHGLAHRLLRAHHLDANLPQDFQILDSEDQLRLLKRLIKAMNLDEKQWPPRQAMWYINSQKDEGLRPHH
IQSYGNPVEQTWQKVYQAYQEACDRAGLVDFAELLLRAHELWLNKPHILQHYRERFTNILVDEFQDTNNIQYAWIRLLAG
DTGKVMIVGDDDQSIYGWRGAQVENIQRFLNDFPGAETIRLEQNYRSTSNILSAANALIENNNGRLGKKLWTDGADGEPI
SLYCAFNDLDEARFVVNRIKTWQENGGALEQCAILYRSNAQSRVLEEALLQASMPYRIYGGMRFFERQEIKDALSYLRLI
ANRNDDAAFERVVNTPTRGIGDRTLDVVRQTSRDRQLTLWQASRELLKEKALAGRAASALQRFMELIDALAQETTDMPLH
VQTDRVIKDSGLRAMYEQEKGEKGQTRIENLEELVTATRQFSYNEEDEDLMPLQAFLSHAALEAGEGQADTWQDAVQLMT
LHSAKGLEFPQVFIVGVEEGMFPSQMALDEGGRLEEERRLAYVGVTRAMQKLTLTYAETRRLYGKEVYHRPSRFIGELPQ
ECVEEVRLRATVSRPVNHQRLGAPIAESDTGYKLGQRVRHPKFGEGTIVNLEGSGEHSRLQVAFQGQGIKWLVAAYARLE
AV

Sequences:

>Translated_722_residues
MPMDVSYLLDSLNDKQREAVAASRTNMLVLAGAGSGKTRVLVHRIAWLLSVENCSPYSIMAVTFTNKAAAEMRHRIGQLM
GTTQGGMWVGTFHGLAHRLLRAHHLDANLPQDFQILDSEDQLRLLKRLIKAMNLDEKQWPPRQAMWYINSQKDEGLRPHH
IQSYGNPVEQTWQKVYQAYQEACDRAGLVDFAELLLRAHELWLNKPHILQHYRERFTNILVDEFQDTNNIQYAWIRLLAG
DTGKVMIVGDDDQSIYGWRGAQVENIQRFLNDFPGAETIRLEQNYRSTSNILSAANALIENNNGRLGKKLWTDGADGEPI
SLYCAFNDLDEARFVVNRIKTWQENGGALEQCAILYRSNAQSRVLEEALLQASMPYRIYGGMRFFERQEIKDALSYLRLI
ANRNDDAAFERVVNTPTRGIGDRTLDVVRQTSRDRQLTLWQASRELLKEKALAGRAASALQRFMELIDALAQETTDMPLH
VQTDRVIKDSGLRAMYEQEKGEKGQTRIENLEELVTATRQFSYNEEDEDLMPLQAFLSHAALEAGEGQADTWQDAVQLMT
LHSAKGLEFPQVFIVGVEEGMFPSQMALDEGGRLEEERRLAYVGVTRAMQKLTLTYAETRRLYGKEVYHRPSRFIGELPQ
ECVEEVRLRATVSRPVNHQRLGAPIAESDTGYKLGQRVRHPKFGEGTIVNLEGSGEHSRLQVAFQGQGIKWLVAAYARLE
AV
>Mature_721_residues
PMDVSYLLDSLNDKQREAVAASRTNMLVLAGAGSGKTRVLVHRIAWLLSVENCSPYSIMAVTFTNKAAAEMRHRIGQLMG
TTQGGMWVGTFHGLAHRLLRAHHLDANLPQDFQILDSEDQLRLLKRLIKAMNLDEKQWPPRQAMWYINSQKDEGLRPHHI
QSYGNPVEQTWQKVYQAYQEACDRAGLVDFAELLLRAHELWLNKPHILQHYRERFTNILVDEFQDTNNIQYAWIRLLAGD
TGKVMIVGDDDQSIYGWRGAQVENIQRFLNDFPGAETIRLEQNYRSTSNILSAANALIENNNGRLGKKLWTDGADGEPIS
LYCAFNDLDEARFVVNRIKTWQENGGALEQCAILYRSNAQSRVLEEALLQASMPYRIYGGMRFFERQEIKDALSYLRLIA
NRNDDAAFERVVNTPTRGIGDRTLDVVRQTSRDRQLTLWQASRELLKEKALAGRAASALQRFMELIDALAQETTDMPLHV
QTDRVIKDSGLRAMYEQEKGEKGQTRIENLEELVTATRQFSYNEEDEDLMPLQAFLSHAALEAGEGQADTWQDAVQLMTL
HSAKGLEFPQVFIVGVEEGMFPSQMALDEGGRLEEERRLAYVGVTRAMQKLTLTYAETRRLYGKEVYHRPSRFIGELPQE
CVEEVRLRATVSRPVNHQRLGAPIAESDTGYKLGQRVRHPKFGEGTIVNLEGSGEHSRLQVAFQGQGIKWLVAAYARLEA
V

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=720, Percent_Identity=96.25, Blast_Score=1448, Evalue=0.0,
Organism=Escherichia coli, GI48994965, Length=641, Percent_Identity=38.2215288611544, Blast_Score=391, Evalue=1e-110,
Organism=Escherichia coli, GI1787196, Length=340, Percent_Identity=28.8235294117647, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6322369, Length=736, Percent_Identity=27.445652173913, Blast_Score=184, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6324477, Length=701, Percent_Identity=23.5378031383738, Blast_Score=128, Evalue=4e-30,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 82123; Mature: 81992

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMDVSYLLDSLNDKQREAVAASRTNMLVLAGAGSGKTRVLVHRIAWLLSVENCSPYSIM
CCCCHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEE
AVTFTNKAAAEMRHRIGQLMGTTQGGMWVGTFHGLAHRLLRAHHLDANLPQDFQILDSED
EEEECCHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCCCEECCCCH
QLRLLKRLIKAMNLDEKQWPPRQAMWYINSQKDEGLRPHHIQSYGNPVEQTWQKVYQAYQ
HHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHCCCHHHHHHHHHHHHHH
EACDRAGLVDFAELLLRAHELWLNKPHILQHYRERFTNILVDEFQDTNNIQYAWIRLLAG
HHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEC
DTGKVMIVGDDDQSIYGWRGAQVENIQRFLNDFPGAETIRLEQNYRSTSNILSAANALIE
CCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHC
NNNGRLGKKLWTDGADGEPISLYCAFNDLDEARFVVNRIKTWQENGGALEQCAILYRSNA
CCCCCCCHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
QSRVLEEALLQASMPYRIYGGMRFFERQEIKDALSYLRLIANRNDDAAFERVVNTPTRGI
HHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCC
GDRTLDVVRQTSRDRQLTLWQASRELLKEKALAGRAASALQRFMELIDALAQETTDMPLH
CHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
VQTDRVIKDSGLRAMYEQEKGEKGQTRIENLEELVTATRQFSYNEEDEDLMPLQAFLSHA
EECCCHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
ALEAGEGQADTWQDAVQLMTLHSAKGLEFPQVFIVGVEEGMFPSQMALDEGGRLEEERRL
HHCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHCCCCCCCHHHHH
AYVGVTRAMQKLTLTYAETRRLYGKEVYHRPSRFIGELPQECVEEVRLRATVSRPVNHQR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LGAPIAESDTGYKLGQRVRHPKFGEGTIVNLEGSGEHSRLQVAFQGQGIKWLVAAYARLE
CCCCCCCCCCCHHHHHHCCCCCCCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHH
AV
CC
>Mature Secondary Structure 
PMDVSYLLDSLNDKQREAVAASRTNMLVLAGAGSGKTRVLVHRIAWLLSVENCSPYSIM
CCCHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEE
AVTFTNKAAAEMRHRIGQLMGTTQGGMWVGTFHGLAHRLLRAHHLDANLPQDFQILDSED
EEEECCHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCCCEECCCCH
QLRLLKRLIKAMNLDEKQWPPRQAMWYINSQKDEGLRPHHIQSYGNPVEQTWQKVYQAYQ
HHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHCCCHHHHHHHHHHHHHH
EACDRAGLVDFAELLLRAHELWLNKPHILQHYRERFTNILVDEFQDTNNIQYAWIRLLAG
HHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEC
DTGKVMIVGDDDQSIYGWRGAQVENIQRFLNDFPGAETIRLEQNYRSTSNILSAANALIE
CCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHC
NNNGRLGKKLWTDGADGEPISLYCAFNDLDEARFVVNRIKTWQENGGALEQCAILYRSNA
CCCCCCCHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
QSRVLEEALLQASMPYRIYGGMRFFERQEIKDALSYLRLIANRNDDAAFERVVNTPTRGI
HHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCC
GDRTLDVVRQTSRDRQLTLWQASRELLKEKALAGRAASALQRFMELIDALAQETTDMPLH
CHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
VQTDRVIKDSGLRAMYEQEKGEKGQTRIENLEELVTATRQFSYNEEDEDLMPLQAFLSHA
EECCCHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
ALEAGEGQADTWQDAVQLMTLHSAKGLEFPQVFIVGVEEGMFPSQMALDEGGRLEEERRL
HHCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHCCCCCCCHHHHH
AYVGVTRAMQKLTLTYAETRRLYGKEVYHRPSRFIGELPQECVEEVRLRATVSRPVNHQR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LGAPIAESDTGYKLGQRVRHPKFGEGTIVNLEGSGEHSRLQVAFQGQGIKWLVAAYARLE
CCCCCCCCCCCHHHHHHCCCCCCCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHH
AV
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]