Click here to switch to the map view.

The map label for this gene is hemC [H]

Identifier: 238892405

GI number: 238892405

Start: 167845

End: 168801

Strand: Reverse

Name: hemC [H]

Synonym: KP1_0163

Alternate gene names: 238892405

Gene position: 168801-167845 (Counterclockwise)

Preceding gene: 238892407

Following gene: 238892404

Centisome position: 3.22

GC content: 63.22

Gene sequence:

>957_bases
ATGACGGTAACAAGCATGTTAGACAAAGTTTTGAAAATTGCCACACGGCAAAGCCCGCTTGCGCTATGGCAGGCGCAGTA
TGTTAAAGCGCGCCTGGAACAAGCGCATCCCGGACTGAAGGTCGAGCTGGTGCCGATGGTCACGCGCGGGGATGTCATCC
TTGATACTCCGCTGGCAAAGGTGGGGGGCAAAGGCTTATTTGTGAAAGAGTTAGAGCTCGCCATGCTCGAAGGGCGCGCC
GATATCGCCGTCCATTCGATGAAAGATGTGCCGGTGGAATTCCCGGAGGGCCTGGGGCTGGTGACTATCTGCGAGCGCGA
CGATCCGCGCGACGCGTTTGTCTCCAATCGCTATGCCTCGATTGACGAACTGCCGGCCGGCAGCGTCGTTGGCACGTCAA
GTTTACGCCGTCAGTGCCAGCTGGCCGCCACCCGTCCGGACCTGGCGATCCGCTCTCTGCGCGGTAACGTCGGTACCCGG
CTGAGTAAGCTGGATAACGGCGAGTACGACGCCATCATCCTCGCCGCCGCCGGCCTGAAGCGCCTGCAGCTGGAAGCGCG
TATTCGCCAGCCGCTGTCGCCTGAGCAATCTCTGCCGGCGGTCGGCCAGGGCGCGGTCGGCATCGAATGCCGTCTTGATG
ATGCATGGACCCGGGGGCTGTTAGCGCCTCTCAACCATACGGAAACGGCGGTGCGCGTGCGCGCCGAGCGGGCGATGAAC
ACCCGCCTCGAAGGCGGCTGCCAGGTGCCGATCGGCAGCTATGCGGAACTGAAGGACGGGGAACTGTGGCTGCGGGCGCT
GGTTGGCGCTCCGGATGGTTCACAGCTGGTGCGCGGCGAACGACGCGGGCCAGCGGAACAAGCGGAAGCCCTCGGCATCT
CGCTGGCGGAAGAGCTTCTGGATAATGGCGCCCGCGAGATTCTCGCGGCGGTTTATGATGGAGAAGCCCCGCGATGA

Upstream 100 bases:

>100_bases
CATGAAAGGTTAAAAAAGAGTGGGCCGGAGCCACCTCCCACATAAACCGTGAAAACTAACATCCGTAAGACAACAATGTT
AGGATGGATAGTGGTCGATA

Downstream 100 bases:

>100_bases
GCATCCTGGTCACTCGTCCACTACCGCAAGGAGAAGCGCTGGTCAGCCGTCTGCGGGCCATGGGACGCGTGGCCTGGAGC
TTTCCGCTGATAGAATTTAC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MTVTSMLDKVLKIATRQSPLALWQAQYVKARLEQAHPGLKVELVPMVTRGDVILDTPLAKVGGKGLFVKELELAMLEGRA
DIAVHSMKDVPVEFPEGLGLVTICERDDPRDAFVSNRYASIDELPAGSVVGTSSLRRQCQLAATRPDLAIRSLRGNVGTR
LSKLDNGEYDAIILAAAGLKRLQLEARIRQPLSPEQSLPAVGQGAVGIECRLDDAWTRGLLAPLNHTETAVRVRAERAMN
TRLEGGCQVPIGSYAELKDGELWLRALVGAPDGSQLVRGERRGPAEQAEALGISLAEELLDNGAREILAAVYDGEAPR

Sequences:

>Translated_318_residues
MTVTSMLDKVLKIATRQSPLALWQAQYVKARLEQAHPGLKVELVPMVTRGDVILDTPLAKVGGKGLFVKELELAMLEGRA
DIAVHSMKDVPVEFPEGLGLVTICERDDPRDAFVSNRYASIDELPAGSVVGTSSLRRQCQLAATRPDLAIRSLRGNVGTR
LSKLDNGEYDAIILAAAGLKRLQLEARIRQPLSPEQSLPAVGQGAVGIECRLDDAWTRGLLAPLNHTETAVRVRAERAMN
TRLEGGCQVPIGSYAELKDGELWLRALVGAPDGSQLVRGERRGPAEQAEALGISLAEELLDNGAREILAAVYDGEAPR
>Mature_317_residues
TVTSMLDKVLKIATRQSPLALWQAQYVKARLEQAHPGLKVELVPMVTRGDVILDTPLAKVGGKGLFVKELELAMLEGRAD
IAVHSMKDVPVEFPEGLGLVTICERDDPRDAFVSNRYASIDELPAGSVVGTSSLRRQCQLAATRPDLAIRSLRGNVGTRL
SKLDNGEYDAIILAAAGLKRLQLEARIRQPLSPEQSLPAVGQGAVGIECRLDDAWTRGLLAPLNHTETAVRVRAERAMNT
RLEGGCQVPIGSYAELKDGELWLRALVGAPDGSQLVRGERRGPAEQAEALGISLAEELLDNGAREILAAVYDGEAPR

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=333, Percent_Identity=43.8438438438438, Blast_Score=242, Evalue=3e-64,
Organism=Homo sapiens, GI20149500, Length=333, Percent_Identity=43.8438438438438, Blast_Score=242, Evalue=3e-64,
Organism=Escherichia coli, GI48994974, Length=312, Percent_Identity=83.974358974359, Blast_Score=525, Evalue=1e-150,
Organism=Saccharomyces cerevisiae, GI6319996, Length=318, Percent_Identity=38.6792452830189, Blast_Score=195, Evalue=8e-51,
Organism=Drosophila melanogaster, GI20130425, Length=259, Percent_Identity=42.0849420849421, Blast_Score=199, Evalue=3e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 34321; Mature: 34190

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTSMLDKVLKIATRQSPLALWQAQYVKARLEQAHPGLKVELVPMVTRGDVILDTPLAK
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCEEEECCHHH
VGGKGLFVKELELAMLEGRADIAVHSMKDVPVEFPEGLGLVTICERDDPRDAFVSNRYAS
HCCCCEEHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCEEEEECCCCCHHHHHHCCCCC
IDELPAGSVVGTSSLRRQCQLAATRPDLAIRSLRGNVGTRLSKLDNGEYDAIILAAAGLK
HHCCCCCCEECCHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHCCCCCCCEEEEEECCHH
RLQLEARIRQPLSPEQSLPAVGQGAVGIECRLDDAWTRGLLAPLNHTETAVRVRAERAMN
HHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECHHHHCCCCCCCCCCHHHHHHHHHHHHH
TRLEGGCQVPIGSYAELKDGELWLRALVGAPDGSQLVRGERRGPAEQAEALGISLAEELL
HHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHH
DNGAREILAAVYDGEAPR
HCCHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TVTSMLDKVLKIATRQSPLALWQAQYVKARLEQAHPGLKVELVPMVTRGDVILDTPLAK
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCEEEECCHHH
VGGKGLFVKELELAMLEGRADIAVHSMKDVPVEFPEGLGLVTICERDDPRDAFVSNRYAS
HCCCCEEHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCEEEEECCCCCHHHHHHCCCCC
IDELPAGSVVGTSSLRRQCQLAATRPDLAIRSLRGNVGTRLSKLDNGEYDAIILAAAGLK
HHCCCCCCEECCHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHCCCCCCCEEEEEECCHH
RLQLEARIRQPLSPEQSLPAVGQGAVGIECRLDDAWTRGLLAPLNHTETAVRVRAERAMN
HHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECHHHHCCCCCCCCCCHHHHHHHHHHHHH
TRLEGGCQVPIGSYAELKDGELWLRALVGAPDGSQLVRGERRGPAEQAEALGISLAEELL
HHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHH
DNGAREILAAVYDGEAPR
HCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA