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The map label for this gene is gppA [H]

Identifier: 238892384

GI number: 238892384

Start: 143938

End: 145446

Strand: Reverse

Name: gppA [H]

Synonym: KP1_0142

Alternate gene names: 238892384

Gene position: 145446-143938 (Counterclockwise)

Preceding gene: 238892385

Following gene: 238892383

Centisome position: 2.77

GC content: 59.64

Gene sequence:

>1509_bases
ATGAAGAGTATGAGCTCCACCTCGCTATATGCCGCCATTGATTTGGGCTCCAATAGTTTCCATATGTTGGTGGTGCGCGA
GGTGGCGGGCAGCATCCAGACGCTGAGCCGCATTAAGCGTAAGGTTCGACTGGCCGCCGGCCTGAATAGCGACAACACCC
TCTCCGCAGAAGCGATGGAACGGGGCTGGCAGTGCTTACGCCTGTTTGCCGAGCGCCTGCAGGATATTCCGCCGACGCAA
ATCCGCGTCGTGGCCACCGCCACGCTGCGTCTTGCCGTCAATGCGGGGGAGTTTCTGGCGAAAGCGCAGGAGATCCTCGG
CACTCCAGTGCAAGTGATCAGCGGCGAAGAAGAAGCGCGCCTGATTTACCAGGGTGTCGCCCACACCACCGGCGGCGCCG
ATCAGCGCCTGGTGGTCGATATCGGCGGCGCCAGCACCGAGCTGGTGACCGGGACCGGCGCACAAACAACCTCGCTGTTT
AGCCTGTCGATGGGCTGTGTGACCTGGCTTGAACGCTATTTTGCCGACCGTAGTCTGACGAAAGAGAATTTCGATCTCGC
CGAAGCGGCTGCGCGCGAGGTGCTACTGCCCGTCGCCGATGTGCTGCGCTATCACGGATGGAAAGTGTGCGTTGGCGCCT
CCGGCACCGTTCAGGCTCTGCAGGAAATTATGATGGCGCAGGGGATGGATGAACGAATCACCCTCGCCAAACTCCAGCAG
CTTAAACAGCGCGCTATCCAGTGCGGACGTCTGGAAGAGCTGGAGATCGAAGGCTTAACCCTTGAGCGGGCGCTGGTGTT
TCCTAGCGGGCTGGCGATCCTGATCGCTATCTTCAGCGAACTGAATATTCAGTGTATGACCCTCGCGGGCGGCGCGTTAC
GCGAAGGCCTGGTGTACGGCATGCTGCATCTCTCCGTTGAGCAGGACATCCGCAGCCGCACGCTGCGTAATATTCAGCGT
CGTTTTATGATCGACACCGAACAGGCCCAGCGCGTCGGCGGCCTTGCCAGTCATCTGCTCAGTCAGTTGGATGGCAGCTG
GGAGCTGGATCCGCTAAGCCGTGATTTACTCCTTAGCGCCTGTGCGCTGCATGAGATTGGGCTGAGCGTGGATTTTAAGC
GCGCGCCGCAGCACGCCGCCTATCTGGTCAATAACCTCGACCTGCCGGGCTTTACCCCGGCGCAGAAGAAGCTGATTGCC
ACGCTGCTCCTTAACCAGACTAACGCTATCGACCTCTCTTCGCTTCATCAACAGAATGCCGTCCCACCGCGGGTGGCTGA
GCATCTGTGTCGTCTGCTGCGACTGGCAATCCTGTTTGCCAGCCGGCGGCGCGACGATCTGTTGCCCGCCATTCAGCTGA
CCGCTCAAGACGAACAACTGACGCTGATATTGCCGGGAAACTGGCTGGATGAACATCCGCTGGGTCGGGAGATGGTCGAT
CAGGAGTGTCAGTGGCAAAGCTACGTCCACTGGATACTTCGGGTCGCCAGCGGCGATACGCTGAAATAA

Upstream 100 bases:

>100_bases
TCAGTCATTCAGAATCTGCCAGGGCGACCTTCCTCTGGCGACCCGCTCAGTGATGTGGATCGGGCCTAAGCGCCCCGCCG
ACCAGGGAGCCTTCTGAACG

Downstream 100 bases:

>100_bases
TATCCAGCCAGGAGGGCGGATGCGGGAAGAACTGGATTTCAAATCGCTACGCTTTTTCTCTGCGCTCTACCGCTTGGGCA
ATGTTTCCCCAGCAGCGGAC

Product: guanosine pentaphosphate phosphohydrolase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MKSMSSTSLYAAIDLGSNSFHMLVVREVAGSIQTLSRIKRKVRLAAGLNSDNTLSAEAMERGWQCLRLFAERLQDIPPTQ
IRVVATATLRLAVNAGEFLAKAQEILGTPVQVISGEEEARLIYQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLF
SLSMGCVTWLERYFADRSLTKENFDLAEAAAREVLLPVADVLRYHGWKVCVGASGTVQALQEIMMAQGMDERITLAKLQQ
LKQRAIQCGRLEELEIEGLTLERALVFPSGLAILIAIFSELNIQCMTLAGGALREGLVYGMLHLSVEQDIRSRTLRNIQR
RFMIDTEQAQRVGGLASHLLSQLDGSWELDPLSRDLLLSACALHEIGLSVDFKRAPQHAAYLVNNLDLPGFTPAQKKLIA
TLLLNQTNAIDLSSLHQQNAVPPRVAEHLCRLLRLAILFASRRRDDLLPAIQLTAQDEQLTLILPGNWLDEHPLGREMVD
QECQWQSYVHWILRVASGDTLK

Sequences:

>Translated_502_residues
MKSMSSTSLYAAIDLGSNSFHMLVVREVAGSIQTLSRIKRKVRLAAGLNSDNTLSAEAMERGWQCLRLFAERLQDIPPTQ
IRVVATATLRLAVNAGEFLAKAQEILGTPVQVISGEEEARLIYQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLF
SLSMGCVTWLERYFADRSLTKENFDLAEAAAREVLLPVADVLRYHGWKVCVGASGTVQALQEIMMAQGMDERITLAKLQQ
LKQRAIQCGRLEELEIEGLTLERALVFPSGLAILIAIFSELNIQCMTLAGGALREGLVYGMLHLSVEQDIRSRTLRNIQR
RFMIDTEQAQRVGGLASHLLSQLDGSWELDPLSRDLLLSACALHEIGLSVDFKRAPQHAAYLVNNLDLPGFTPAQKKLIA
TLLLNQTNAIDLSSLHQQNAVPPRVAEHLCRLLRLAILFASRRRDDLLPAIQLTAQDEQLTLILPGNWLDEHPLGREMVD
QECQWQSYVHWILRVASGDTLK
>Mature_502_residues
MKSMSSTSLYAAIDLGSNSFHMLVVREVAGSIQTLSRIKRKVRLAAGLNSDNTLSAEAMERGWQCLRLFAERLQDIPPTQ
IRVVATATLRLAVNAGEFLAKAQEILGTPVQVISGEEEARLIYQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLF
SLSMGCVTWLERYFADRSLTKENFDLAEAAAREVLLPVADVLRYHGWKVCVGASGTVQALQEIMMAQGMDERITLAKLQQ
LKQRAIQCGRLEELEIEGLTLERALVFPSGLAILIAIFSELNIQCMTLAGGALREGLVYGMLHLSVEQDIRSRTLRNIQR
RFMIDTEQAQRVGGLASHLLSQLDGSWELDPLSRDLLLSACALHEIGLSVDFKRAPQHAAYLVNNLDLPGFTPAQKKLIA
TLLLNQTNAIDLSSLHQQNAVPPRVAEHLCRLLRLAILFASRRRDDLLPAIQLTAQDEQLTLILPGNWLDEHPLGREMVD
QECQWQSYVHWILRVASGDTLK

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=491, Percent_Identity=85.9470468431772, Blast_Score=866, Evalue=0.0,
Organism=Escherichia coli, GI1788848, Length=500, Percent_Identity=39, Blast_Score=332, Evalue=4e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 55358; Mature: 55358

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSMSSTSLYAAIDLGSNSFHMLVVREVAGSIQTLSRIKRKVRLAAGLNSDNTLSAEAME
CCCCCCCCEEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
RGWQCLRLFAERLQDIPPTQIRVVATATLRLAVNAGEFLAKAQEILGTPVQVISGEEEAR
HHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEEECHHHHHHHHHHHHCCCCEECCCCHHHH
LIYQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSLSMGCVTWLERYFADRSLT
HHHHHHHHCCCCCCCEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
KENFDLAEAAAREVLLPVADVLRYHGWKVCVGASGTVQALQEIMMAQGMDERITLAKLQQ
CCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHH
LKQRAIQCGRLEELEIEGLTLERALVFPSGLAILIAIFSELNIQCMTLAGGALREGLVYG
HHHHHHHCCCCCEEEECCEEEEHHHCCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHHH
MLHLSVEQDIRSRTLRNIQRRFMIDTEQAQRVGGLASHLLSQLDGSWELDPLSRDLLLSA
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
CALHEIGLSVDFKRAPQHAAYLVNNLDLPGFTPAQKKLIATLLLNQTNAIDLSSLHQQNA
HHHHHHCCCEEHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCC
VPPRVAEHLCRLLRLAILFASRRRDDLLPAIQLTAQDEQLTLILPGNWLDEHPLGREMVD
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCEEEEEECCCCCCCCCCCHHHHH
QECQWQSYVHWILRVASGDTLK
HHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKSMSSTSLYAAIDLGSNSFHMLVVREVAGSIQTLSRIKRKVRLAAGLNSDNTLSAEAME
CCCCCCCCEEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
RGWQCLRLFAERLQDIPPTQIRVVATATLRLAVNAGEFLAKAQEILGTPVQVISGEEEAR
HHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEEECHHHHHHHHHHHHCCCCEECCCCHHHH
LIYQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSLSMGCVTWLERYFADRSLT
HHHHHHHHCCCCCCCEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
KENFDLAEAAAREVLLPVADVLRYHGWKVCVGASGTVQALQEIMMAQGMDERITLAKLQQ
CCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHH
LKQRAIQCGRLEELEIEGLTLERALVFPSGLAILIAIFSELNIQCMTLAGGALREGLVYG
HHHHHHHCCCCCEEEECCEEEEHHHCCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHHH
MLHLSVEQDIRSRTLRNIQRRFMIDTEQAQRVGGLASHLLSQLDGSWELDPLSRDLLLSA
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
CALHEIGLSVDFKRAPQHAAYLVNNLDLPGFTPAQKKLIATLLLNQTNAIDLSSLHQQNA
HHHHHHCCCEEHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCC
VPPRVAEHLCRLLRLAILFASRRRDDLLPAIQLTAQDEQLTLILPGNWLDEHPLGREMVD
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCEEEEEECCCCCCCCCCCHHHHH
QECQWQSYVHWILRVASGDTLK
HHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA