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The map label for this gene is ppiC [H]

Identifier: 238892379

GI number: 238892379

Start: 138658

End: 138939

Strand: Reverse

Name: ppiC [H]

Synonym: KP1_0137

Alternate gene names: 238892379

Gene position: 138939-138658 (Counterclockwise)

Preceding gene: 238892381

Following gene: 238892378

Centisome position: 2.65

GC content: 56.38

Gene sequence:

>282_bases
ATGGCAAAAAGCGCAGCGGCCCTGCATATCCTGGTCAAAGAAGAGAAACTGGCGCTGGAGATCCTCGCCAAACTGGAGCG
GGGCGTCAGCTTCGATCATCTGGCGAAACGCTATTCTAAATGTCCGTCTGGCCGCAACGGCGGCGACTTAGGCGAGTTTC
AGCAAGGCGCGATGGTCGGTCCGTTTGATCAAGCCGTCTTCAGCTGTCCGCTGCTCAAACCCTATGGCCCGGTGAAAACC
AAATTCGGCTACCACATCATCAAGGTGCTGTATCGCCGCTAG

Upstream 100 bases:

>100_bases
CAATCTTCGAACGGGGTGGGGATTGTAGCAGAAAGCGGAGCCGAGATTTACTGACTGATGGTAAAGTGTCAGCCACGCAA
ACCATCCTGAGAATGATGTC

Downstream 100 bases:

>100_bases
CGCGTGATACTATGGCGCCCTGATTTATCCCAACTCACTCAAGGCGCAATCATGGCTAAAACCGCGGCAGCACTGCATAT
CCTGGTAAAAGAAGAGAAAC

Product: peptidyl-prolyl cis-trans isomerase C

Products: NA

Alternate protein names: PPIase C; Parvulin; Rotamase C [H]

Number of amino acids: Translated: 93; Mature: 92

Protein sequence:

>93_residues
MAKSAAALHILVKEEKLALEILAKLERGVSFDHLAKRYSKCPSGRNGGDLGEFQQGAMVGPFDQAVFSCPLLKPYGPVKT
KFGYHIIKVLYRR

Sequences:

>Translated_93_residues
MAKSAAALHILVKEEKLALEILAKLERGVSFDHLAKRYSKCPSGRNGGDLGEFQQGAMVGPFDQAVFSCPLLKPYGPVKT
KFGYHIIKVLYRR
>Mature_92_residues
AKSAAALHILVKEEKLALEILAKLERGVSFDHLAKRYSKCPSGRNGGDLGEFQQGAMVGPFDQAVFSCPLLKPYGPVKTK
FGYHIIKVLYRR

Specific function: PPIases accelerate the folding of proteins. It prefers amino acid residues with hydrophobic side chains like leucine and phenylalanine in the P1 position of the peptides substrates [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Homo sapiens, GI38679892, Length=91, Percent_Identity=45.0549450549451, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1790211, Length=93, Percent_Identity=67.741935483871, Blast_Score=135, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17537235, Length=88, Percent_Identity=46.5909090909091, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356303, Length=87, Percent_Identity=44.8275862068966, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058 [H]

Pfam domain/function: PF00639 Rotamase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 10306; Mature: 10175

Theoretical pI: Translated: 10.17; Mature: 10.17

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKSAAALHILVKEEKLALEILAKLERGVSFDHLAKRYSKCPSGRNGGDLGEFQQGAMVG
CCCCCCEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHCCCCCCC
PFDQAVFSCPLLKPYGPVKTKFGYHIIKVLYRR
CHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKSAAALHILVKEEKLALEILAKLERGVSFDHLAKRYSKCPSGRNGGDLGEFQQGAMVG
CCCCCEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHCCCCCCC
PFDQAVFSCPLLKPYGPVKTKFGYHIIKVLYRR
CHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]