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The map label for this gene is ilvG [H]

Identifier: 238892371

GI number: 238892371

Start: 129302

End: 130948

Strand: Direct

Name: ilvG [H]

Synonym: KP1_0129

Alternate gene names: 238892371

Gene position: 129302-130948 (Clockwise)

Preceding gene: 238892369

Following gene: 238892372

Centisome position: 2.46

GC content: 59.32

Gene sequence:

>1647_bases
ATGAATGGCGCGCAGTGGGTGGTACATGCTTTGCGGACACAGGGAGTCGACACAGTTTTTGGCTATCCGGGTGGCGCAAT
TATGCCGGTTTACGATGCACTGTATGACGGCGGCGTGGAGCACCTGCTGTGCCGGCATGAGCAAGGGGCAGCCATGGCGG
CCATTGGTTATGCGCGAGCAACCGGTAAAACCGGGGTGTGTATCGCGACGTCCGGCCCGGGCGCGACCAATCTGATCACC
GGCCTGGCGGACGCCCTGCTTGACTCTATTCCCATCGTAGCTATCACCGGCCAGGTGGCCGCACCCTTCATCGGCACGGA
TGCGTTCCAGGAAGTAGACGTTCTCGGTTTGTCACTGGCCTGTACTAAGCACAGTTTCCTTGTGCAGTCTCTGGACGAAC
TGCCGCGGGTTATTGCTGAGGCTTTCCAGGTGGCAAACTCAGGCCGTCCAGGTCCGGTGCTGGTTGATATCCCTAAGGAT
ATTCAGATGGCGCAGGGCGACCTCGATCCCCATTTCTCTACCGTCGCCGATGAGATGGCATTTCCGCAGGCGGAAGTGGC
GCAGGCTCTGCAGATGCTGGCCCAATCGCAGCAACCGATGCTGTATGTTGGCGGCGGGGTCGGCATGGCGCAGGCGGTAC
CGGCTTTGCGCGAATTCCTGGCGGTGACCAGGATGCCGGCAACCTGCACCCTGAAAGGGCTGGGCGTGGTGGATGCTGAT
TATCCCTATTATCTCGGCATGCTGGGAATGCACGGCACTAAGGCGGCCAACCTGGCAGTACAGGAGTGCGATCTGCTGAT
CGCCGTCGGCGCGCGCTTTGACGATCGCGTGACCGGTAAGCTCAATACCTTCGCACCGCATGCCAAAGTGATCCACATGG
ACATCGATCCGGCGGAGCTGAACAAGCTGCGTCAGGCGCATATCGGTCTGACAGGCGATCTGAACTGCCTGCTGCCGGCG
CTGCAGCAGCCGTTAGCTATCGATGGCTGGCGCGAGCGGAGTGCCGCACTGCGTGCCGAGCATGCCTGGCGTTACGATCA
TCCCGGTGAGGCAATCTACGCGCCGCTGCTGCTGAAGCAGCTTTCCGACCGCAAGCCGGCGGACAGTGTGGTGACCACCG
ACGTTGGCCAGCACCAGATGTGGTCGGCTCAGCATATGAGCTATACCCGCCCGGAAAACTTTATCACCTCCAGCGGCTTA
GGCACCATGGGCTTTGGCCTGCCGGCCGCCGTTGGCGCCCAGGTGGCGCGCCCTAACGATACGGTGATCTGTATCTCCGG
TGACGGCTCCTTCATGATGAATGTACAGGAGCTGGGCACCGTTAAACGCAAGCAGTTACCGCTGAAGATCGTGTTACTCG
ACAACCAGCGGTTAGGGATGGTTCGACAATGGCAGCAGCTGTTTTTCCAGGAACGTTATAGCGAAACCACTCTGACTGAT
AACCCTGATTTCCTCACGCTGGCCAGCGCCTTCGGTATTCCTGGCCAACACATCACCCGTAAAGACCAGGTTGAAGCGGC
ACTCGACACCATGCTTTCGAGCCAGGGGCCATACCTGCTTCATGTCTCAATCGACGAACTTGAGAATGTCTGGCCGTTGG
TGCCGCCCGGCGCCAGTAACTCTGAAATGCTGGAGAAATTATCATGA

Upstream 100 bases:

>100_bases
TCCGGGGGTTTTTTTATAACTGAAATAACCTAAGCGAGGAGCAGATGATGACTTTTAGCATAAAATTCTGTTTCTCCCGA
TTTATGACGGGGAACTAACT

Downstream 100 bases:

>100_bases
TGCAACATCAGGTCGCTTTACAGGCACGTTTCAACCCGGAAACCTTAGAGCGCGTGCTGCGCGTTGTCCGCCACCGGGGT
TTCCACATCTGCGCAATGAA

Product: acetolactate synthase 2 catalytic subunit

Products: NA

Alternate protein names: AHAS-II; ALS-II; Acetohydroxy-acid synthase II large subunit [H]

Number of amino acids: Translated: 548; Mature: 548

Protein sequence:

>548_residues
MNGAQWVVHALRTQGVDTVFGYPGGAIMPVYDALYDGGVEHLLCRHEQGAAMAAIGYARATGKTGVCIATSGPGATNLIT
GLADALLDSIPIVAITGQVAAPFIGTDAFQEVDVLGLSLACTKHSFLVQSLDELPRVIAEAFQVANSGRPGPVLVDIPKD
IQMAQGDLDPHFSTVADEMAFPQAEVAQALQMLAQSQQPMLYVGGGVGMAQAVPALREFLAVTRMPATCTLKGLGVVDAD
YPYYLGMLGMHGTKAANLAVQECDLLIAVGARFDDRVTGKLNTFAPHAKVIHMDIDPAELNKLRQAHIGLTGDLNCLLPA
LQQPLAIDGWRERSAALRAEHAWRYDHPGEAIYAPLLLKQLSDRKPADSVVTTDVGQHQMWSAQHMSYTRPENFITSSGL
GTMGFGLPAAVGAQVARPNDTVICISGDGSFMMNVQELGTVKRKQLPLKIVLLDNQRLGMVRQWQQLFFQERYSETTLTD
NPDFLTLASAFGIPGQHITRKDQVEAALDTMLSSQGPYLLHVSIDELENVWPLVPPGASNSEMLEKLS

Sequences:

>Translated_548_residues
MNGAQWVVHALRTQGVDTVFGYPGGAIMPVYDALYDGGVEHLLCRHEQGAAMAAIGYARATGKTGVCIATSGPGATNLIT
GLADALLDSIPIVAITGQVAAPFIGTDAFQEVDVLGLSLACTKHSFLVQSLDELPRVIAEAFQVANSGRPGPVLVDIPKD
IQMAQGDLDPHFSTVADEMAFPQAEVAQALQMLAQSQQPMLYVGGGVGMAQAVPALREFLAVTRMPATCTLKGLGVVDAD
YPYYLGMLGMHGTKAANLAVQECDLLIAVGARFDDRVTGKLNTFAPHAKVIHMDIDPAELNKLRQAHIGLTGDLNCLLPA
LQQPLAIDGWRERSAALRAEHAWRYDHPGEAIYAPLLLKQLSDRKPADSVVTTDVGQHQMWSAQHMSYTRPENFITSSGL
GTMGFGLPAAVGAQVARPNDTVICISGDGSFMMNVQELGTVKRKQLPLKIVLLDNQRLGMVRQWQQLFFQERYSETTLTD
NPDFLTLASAFGIPGQHITRKDQVEAALDTMLSSQGPYLLHVSIDELENVWPLVPPGASNSEMLEKLS
>Mature_548_residues
MNGAQWVVHALRTQGVDTVFGYPGGAIMPVYDALYDGGVEHLLCRHEQGAAMAAIGYARATGKTGVCIATSGPGATNLIT
GLADALLDSIPIVAITGQVAAPFIGTDAFQEVDVLGLSLACTKHSFLVQSLDELPRVIAEAFQVANSGRPGPVLVDIPKD
IQMAQGDLDPHFSTVADEMAFPQAEVAQALQMLAQSQQPMLYVGGGVGMAQAVPALREFLAVTRMPATCTLKGLGVVDAD
YPYYLGMLGMHGTKAANLAVQECDLLIAVGARFDDRVTGKLNTFAPHAKVIHMDIDPAELNKLRQAHIGLTGDLNCLLPA
LQQPLAIDGWRERSAALRAEHAWRYDHPGEAIYAPLLLKQLSDRKPADSVVTTDVGQHQMWSAQHMSYTRPENFITSSGL
GTMGFGLPAAVGAQVARPNDTVICISGDGSFMMNVQELGTVKRKQLPLKIVLLDNQRLGMVRQWQQLFFQERYSETTLTD
NPDFLTLASAFGIPGQHITRKDQVEAALDTMLSSQGPYLLHVSIDELENVWPLVPPGASNSEMLEKLS

Specific function: Catalyzes the first step in the biosynthesis of branched-chain amino acids [H]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=555, Percent_Identity=24.5045045045045, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI21361361, Length=498, Percent_Identity=24.6987951807229, Blast_Score=125, Evalue=9e-29,
Organism=Escherichia coli, GI1790104, Length=552, Percent_Identity=46.0144927536232, Blast_Score=495, Evalue=1e-141,
Organism=Escherichia coli, GI87081685, Length=564, Percent_Identity=42.9078014184397, Blast_Score=455, Evalue=1e-129,
Organism=Escherichia coli, GI1786717, Length=568, Percent_Identity=29.4014084507042, Blast_Score=264, Evalue=9e-72,
Organism=Escherichia coli, GI1787096, Length=543, Percent_Identity=29.2817679558011, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1788716, Length=552, Percent_Identity=26.4492753623188, Blast_Score=157, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17531299, Length=551, Percent_Identity=26.8602540834846, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17531301, Length=551, Percent_Identity=26.8602540834846, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17542570, Length=575, Percent_Identity=22.7826086956522, Blast_Score=115, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6323755, Length=581, Percent_Identity=44.4061962134251, Blast_Score=462, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6320816, Length=488, Percent_Identity=21.9262295081967, Blast_Score=98, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6323073, Length=482, Percent_Identity=22.8215767634855, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19922626, Length=571, Percent_Identity=25.9194395796848, Blast_Score=169, Evalue=5e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 58944; Mature: 58944

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGAQWVVHALRTQGVDTVFGYPGGAIMPVYDALYDGGVEHLLCRHEQGAAMAAIGYARA
CCHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHCCHHHHHHHCCCCCEEEEHHHHHC
TGKTGVCIATSGPGATNLITGLADALLDSIPIVAITGQVAAPFIGTDAFQEVDVLGLSLA
CCCCCEEEEECCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHEEEH
CTKHSFLVQSLDELPRVIAEAFQVANSGRPGPVLVDIPKDIQMAQGDLDPHFSTVADEMA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHCCCCCCHHHHHHHHHC
FPQAEVAQALQMLAQSQQPMLYVGGGVGMAQAVPALREFLAVTRMPATCTLKGLGVVDAD
CCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCEECCC
YPYYLGMLGMHGTKAANLAVQECDLLIAVGARFDDRVTGKLNTFAPHAKVIHMDIDPAEL
CCHHHHHHCCCCCCHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCHHHH
NKLRQAHIGLTGDLNCLLPALQQPLAIDGWRERSAALRAEHAWRYDHPGEAIYAPLLLKQ
HHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
LSDRKPADSVVTTDVGQHQMWSAQHMSYTRPENFITSSGLGTMGFGLPAAVGAQVARPND
HCCCCCCCCEEECCCCCHHHHHHHHCCCCCCCCCEECCCCCCCCCCCHHHHCCEECCCCC
TVICISGDGSFMMNVQELGTVKRKQLPLKIVLLDNQRLGMVRQWQQLFFQERYSETTLTD
EEEEEECCCCEEEEHHHHCCHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCC
NPDFLTLASAFGIPGQHITRKDQVEAALDTMLSSQGPYLLHVSIDELENVWPLVPPGASN
CCCEEEEHHHCCCCCHHCCCHHHHHHHHHHHHCCCCCEEEEEEHHHHHCCCCCCCCCCCC
SEMLEKLS
HHHHHHCC
>Mature Secondary Structure
MNGAQWVVHALRTQGVDTVFGYPGGAIMPVYDALYDGGVEHLLCRHEQGAAMAAIGYARA
CCHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHCCHHHHHHHCCCCCEEEEHHHHHC
TGKTGVCIATSGPGATNLITGLADALLDSIPIVAITGQVAAPFIGTDAFQEVDVLGLSLA
CCCCCEEEEECCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHEEEH
CTKHSFLVQSLDELPRVIAEAFQVANSGRPGPVLVDIPKDIQMAQGDLDPHFSTVADEMA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHCCCCCCHHHHHHHHHC
FPQAEVAQALQMLAQSQQPMLYVGGGVGMAQAVPALREFLAVTRMPATCTLKGLGVVDAD
CCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCEECCC
YPYYLGMLGMHGTKAANLAVQECDLLIAVGARFDDRVTGKLNTFAPHAKVIHMDIDPAEL
CCHHHHHHCCCCCCHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCEEEEEECCHHHH
NKLRQAHIGLTGDLNCLLPALQQPLAIDGWRERSAALRAEHAWRYDHPGEAIYAPLLLKQ
HHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
LSDRKPADSVVTTDVGQHQMWSAQHMSYTRPENFITSSGLGTMGFGLPAAVGAQVARPND
HCCCCCCCCEEECCCCCHHHHHHHHCCCCCCCCCEECCCCCCCCCCCHHHHCCEECCCCC
TVICISGDGSFMMNVQELGTVKRKQLPLKIVLLDNQRLGMVRQWQQLFFQERYSETTLTD
EEEEEECCCCEEEEHHHHCCHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCC
NPDFLTLASAFGIPGQHITRKDQVEAALDTMLSSQGPYLLHVSIDELENVWPLVPPGASN
CCCEEEEHHHCCCCCHHCCCHHHHHHHHHHHHCCCCCEEEEEEHHHHHCCCCCCCCCCCC
SEMLEKLS
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3550695; 1379743; 9278503; 1995430; 6154938; 7015336; 3897211 [H]