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The map label for this gene is fbaA [H]

Identifier: 238892303

GI number: 238892303

Start: 53459

End: 54301

Strand: Direct

Name: fbaA [H]

Synonym: KP1_0053

Alternate gene names: 238892303

Gene position: 53459-54301 (Clockwise)

Preceding gene: 238892302

Following gene: 238892304

Centisome position: 1.02

GC content: 50.06

Gene sequence:

>843_bases
ATGAGTCTGTATAATTTTAATGAGATTTTAAAAATCGCTCAGGAAAGAGATTTTAAAGCGATTGGCTCGTTTAACTTGCA
CTGTATTGAGATGTTACCGGCTTTTTTCAAAGCCGCGCAAAACAGCCGCAGCCCATTAATGATCCAAATATCAACCGGTA
CCGCAGAGTATCTGGGGTATCGGTTACTGGTCGATGCCGTGCGTTCATTAGCAGACAGTGAAAATATCCCGACCTGCCTG
CATCTCGATCACTGCTCCGATATTAAAGCCATCGAGACGGCAATGAATGCGGGCTTTTCTTCGGTGATGTACGACGGGTC
TCACTTAAGCCTCGAGGAAAATATCGGTAACACGCGGATTGTGGTGGAAATGGCACGGCCGCGGAATATTACGGTAGAAG
GTGAGCTGGGGGCGATCGGCGGGTCAGAGGATGGAAAAGCGGTGGCTGCCGAAGATATCTGTTTTACTACCGTCGAAGAC
GCGACGCGTTTTGTGAAGGAGACACAGGTCGATATGCTGGCCGTCTCGGTGGGCACTGTGCATGGCCTGTACACCGGTAA
AGCGCAGATACAGCATGCGCGGCTGAAGGCGATAAGCGAAGCGACGGGCGTGCCGCTGGTGCTGCATGGCGGCACAGGTG
TCAGCGATGAGGATATGCGGCTGGCCGTCACCGAAGGGATTAATAAAGTGAACGTCGGAACGGAAATGAACGTGCAGTGG
GTCGATCGCTGTAAATCAACGTTTGAGAAAGGAAAAGTAAATGACAGCGTACGGAAATTTTTAATTCCCGCCAACCAGGC
AGTGACTGCCGTATTAATGGAAAAAATGGCGCTATTTAAATAG

Upstream 100 bases:

>100_bases
CAGAATAACTGGCTCTTTGTCGCCTTATTTATTGTGTTTGTCGCCGCACTGGCATGGTTTGTCAACGGGAAATCCGCTAA
GCCGAAAGGGGAAAGTGTTC

Downstream 100 bases:

>100_bases
CGTTGTTACCGACACATATCTTTTGTTGCCCTGTCTTCCGCCAGGGAGGGAGCTTGCTATGTTTGAATCATTGAAAACGC
TGTGGAAAAAAGAGCAAAAC

Product: putative class-II ketose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MSLYNFNEILKIAQERDFKAIGSFNLHCIEMLPAFFKAAQNSRSPLMIQISTGTAEYLGYRLLVDAVRSLADSENIPTCL
HLDHCSDIKAIETAMNAGFSSVMYDGSHLSLEENIGNTRIVVEMARPRNITVEGELGAIGGSEDGKAVAAEDICFTTVED
ATRFVKETQVDMLAVSVGTVHGLYTGKAQIQHARLKAISEATGVPLVLHGGTGVSDEDMRLAVTEGINKVNVGTEMNVQW
VDRCKSTFEKGKVNDSVRKFLIPANQAVTAVLMEKMALFK

Sequences:

>Translated_280_residues
MSLYNFNEILKIAQERDFKAIGSFNLHCIEMLPAFFKAAQNSRSPLMIQISTGTAEYLGYRLLVDAVRSLADSENIPTCL
HLDHCSDIKAIETAMNAGFSSVMYDGSHLSLEENIGNTRIVVEMARPRNITVEGELGAIGGSEDGKAVAAEDICFTTVED
ATRFVKETQVDMLAVSVGTVHGLYTGKAQIQHARLKAISEATGVPLVLHGGTGVSDEDMRLAVTEGINKVNVGTEMNVQW
VDRCKSTFEKGKVNDSVRKFLIPANQAVTAVLMEKMALFK
>Mature_279_residues
SLYNFNEILKIAQERDFKAIGSFNLHCIEMLPAFFKAAQNSRSPLMIQISTGTAEYLGYRLLVDAVRSLADSENIPTCLH
LDHCSDIKAIETAMNAGFSSVMYDGSHLSLEENIGNTRIVVEMARPRNITVEGELGAIGGSEDGKAVAAEDICFTTVEDA
TRFVKETQVDMLAVSVGTVHGLYTGKAQIQHARLKAISEATGVPLVLHGGTGVSDEDMRLAVTEGINKVNVGTEMNVQWV
DRCKSTFEKGKVNDSVRKFLIPANQAVTAVLMEKMALFK

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=276, Percent_Identity=34.0579710144928, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI87082041, Length=277, Percent_Identity=31.7689530685921, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1788072, Length=263, Percent_Identity=33.8403041825095, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1789293, Length=281, Percent_Identity=27.0462633451957, Blast_Score=83, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 30505; Mature: 30374

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLYNFNEILKIAQERDFKAIGSFNLHCIEMLPAFFKAAQNSRSPLMIQISTGTAEYLGY
CCCCCHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHH
RLLVDAVRSLADSENIPTCLHLDHCSDIKAIETAMNAGFSSVMYDGSHLSLEENIGNTRI
HHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCHHHEECCCCEEEHHCCCCEEE
VVEMARPRNITVEGELGAIGGSEDGKAVAAEDICFTTVEDATRFVKETQVDMLAVSVGTV
EEEECCCCEEEEECCCCCCCCCCCCCEEEECCCEEEEHHHHHHHHHHHHHHHEEEEHHHE
HGLYTGKAQIQHARLKAISEATGVPLVLHGGTGVSDEDMRLAVTEGINKVNVGTEMNVQW
HEEECCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEECCCCCEEECCCCCCHHH
VDRCKSTFEKGKVNDSVRKFLIPANQAVTAVLMEKMALFK
HHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLYNFNEILKIAQERDFKAIGSFNLHCIEMLPAFFKAAQNSRSPLMIQISTGTAEYLGY
CCCCHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHH
RLLVDAVRSLADSENIPTCLHLDHCSDIKAIETAMNAGFSSVMYDGSHLSLEENIGNTRI
HHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCHHHEECCCCEEEHHCCCCEEE
VVEMARPRNITVEGELGAIGGSEDGKAVAAEDICFTTVEDATRFVKETQVDMLAVSVGTV
EEEECCCCEEEEECCCCCCCCCCCCCEEEECCCEEEEHHHHHHHHHHHHHHHEEEEHHHE
HGLYTGKAQIQHARLKAISEATGVPLVLHGGTGVSDEDMRLAVTEGINKVNVGTEMNVQW
HEEECCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEECCCCCEEECCCCCCHHH
VDRCKSTFEKGKVNDSVRKFLIPANQAVTAVLMEKMALFK
HHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2457578; 1640835; 9353933; 9384377; 1556067 [H]