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The map label for this gene is lon2 [H]

Identifier: 238028873

GI number: 238028873

Start: 3797334

End: 3798314

Strand: Reverse

Name: lon2 [H]

Synonym: bglu_1g33380

Alternate gene names: 238028873

Gene position: 3798314-3797334 (Counterclockwise)

Preceding gene: 238028880

Following gene: 238028872

Centisome position: 97.23

GC content: 69.32

Gene sequence:

>981_bases
ATGACGACGGCAATGGTGCGGCAGGAACTGGCGGTTGCGTCGTTCAGCCGCGTCTACGATCTGGAGCGGGTCGAGACGGC
GCTGGGCGATCTGAACGAGGGGGCGAGCGAGGCGCTGCGCTCGACCTACGAGAAGATGCTGAAGACGGGCAACCTGCGCT
TCTGCGTGAAGCCCACGCGCATGCCCGCGTTCGACGCGCTGGCCGAGTCGCTGCCGAACTTCTGCGGCCCGCTCGACGAC
CTGCGCAAGCAGGTGGCGCTGTGCCTCGAGACGGAGGACCGGCTGGAACTGATGCCGATCCTGCTGCTCGGCGCGCCCGG
CATCGGCAAGACGCACTTCGCGAAGGCGCTCGCGCAGATGCTCGGTACCGCCTACCACTACGTGCCGATGAGTTCGCTGA
CGGCGGGCTGGGTGCTCTCTGGGGCGTCCTCGCAATGGAAGAACGCGAAGCCGGGCAAGGTGTTCGACGCGCTCGTGAAC
GGCAGCTACGCGAACCCGGTGATCGTGATCGACGAGATCGACAAGGCCGGCAACGACGCGCAATACGATCCGCTCGGCGC
GCTCTACGCGCTGCTCGAGCACGACACCGCGAGCGCGTTCGTCGACGAGTTCGCCGAGGTGCCGATCGACGCCGGCAACG
TGATCTGGATCGCGACCGCGAACGACGCGAAGTCGATTCCCGAGCCGATCCTGAACCGCATGAACGTCTACGAGATTCCG
GCGCCCGACGAGGCCGGCGCGCGCCGCATCGCGCAGGCGATCTACACGCAGATCCGCGAGGCGCACGCATGGGGCCTGCG
CTTTCCCGAGCAGCTCGGCGAGGCGTCGCTCGCCGCGCTCGCGGCGGTGCCGCCGCGCACCATGCGGCGCGCGCTGCTGC
ACGCCTTCGGCGCCGCGCGGCTGGACGGCCGCAACGCGGTCGAGCCGCGCGACATCCGTGCCGACGAGGGCATGCCCAAG
CGGCGGCCGATCGGCTTCTGA

Upstream 100 bases:

>100_bases
TTTTGTCTGGCCAACACTGGCATCGAGGAGTTTGATGTCGCGCATCCGTATGAGGCGCGGCGGGGTTTCCACGAAGCGGC
AGGCGAGCAGGAGGTGTGTT

Downstream 100 bases:

>100_bases
CGCGCCGCCCGCGCCCCGCCCCGGCGCGCGGCGGGGCGCGGTGTTTTCTTATGCTCGGGATTCGGGGACGCAGGCTCGCG
CGGGCGGCGTTATGCTTGGC

Product: ATP-dependent Lon protease

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MTTAMVRQELAVASFSRVYDLERVETALGDLNEGASEALRSTYEKMLKTGNLRFCVKPTRMPAFDALAESLPNFCGPLDD
LRKQVALCLETEDRLELMPILLLGAPGIGKTHFAKALAQMLGTAYHYVPMSSLTAGWVLSGASSQWKNAKPGKVFDALVN
GSYANPVIVIDEIDKAGNDAQYDPLGALYALLEHDTASAFVDEFAEVPIDAGNVIWIATANDAKSIPEPILNRMNVYEIP
APDEAGARRIAQAIYTQIREAHAWGLRFPEQLGEASLAALAAVPPRTMRRALLHAFGAARLDGRNAVEPRDIRADEGMPK
RRPIGF

Sequences:

>Translated_326_residues
MTTAMVRQELAVASFSRVYDLERVETALGDLNEGASEALRSTYEKMLKTGNLRFCVKPTRMPAFDALAESLPNFCGPLDD
LRKQVALCLETEDRLELMPILLLGAPGIGKTHFAKALAQMLGTAYHYVPMSSLTAGWVLSGASSQWKNAKPGKVFDALVN
GSYANPVIVIDEIDKAGNDAQYDPLGALYALLEHDTASAFVDEFAEVPIDAGNVIWIATANDAKSIPEPILNRMNVYEIP
APDEAGARRIAQAIYTQIREAHAWGLRFPEQLGEASLAALAAVPPRTMRRALLHAFGAARLDGRNAVEPRDIRADEGMPK
RRPIGF
>Mature_325_residues
TTAMVRQELAVASFSRVYDLERVETALGDLNEGASEALRSTYEKMLKTGNLRFCVKPTRMPAFDALAESLPNFCGPLDDL
RKQVALCLETEDRLELMPILLLGAPGIGKTHFAKALAQMLGTAYHYVPMSSLTAGWVLSGASSQWKNAKPGKVFDALVNG
SYANPVIVIDEIDKAGNDAQYDPLGALYALLEHDTASAFVDEFAEVPIDAGNVIWIATANDAKSIPEPILNRMNVYEIPA
PDEAGARRIAQAIYTQIREAHAWGLRFPEQLGEASLAALAAVPPRTMRRALLHAFGAARLDGRNAVEPRDIRADEGMPKR
RPIGF

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=140, Percent_Identity=35, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI31377667, Length=144, Percent_Identity=32.6388888888889, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1786643, Length=155, Percent_Identity=32.258064516129, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17556486, Length=166, Percent_Identity=30.7228915662651, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17505831, Length=137, Percent_Identity=34.3065693430657, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319449, Length=141, Percent_Identity=35.4609929078014, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24666867, Length=136, Percent_Identity=36.7647058823529, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI221513036, Length=136, Percent_Identity=36.7647058823529, Blast_Score=102, Evalue=2e-22,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 35521; Mature: 35390

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAMVRQELAVASFSRVYDLERVETALGDLNEGASEALRSTYEKMLKTGNLRFCVKPTR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEECCCC
MPAFDALAESLPNFCGPLDDLRKQVALCLETEDRLELMPILLLGAPGIGKTHFAKALAQM
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHEECCCCCCHHHHHHHHHHH
LGTAYHYVPMSSLTAGWVLSGASSQWKNAKPGKVFDALVNGSYANPVIVIDEIDKAGNDA
HHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEECCCCCCCCC
QYDPLGALYALLEHDTASAFVDEFAEVPIDAGNVIWIATANDAKSIPEPILNRMNVYEIP
CCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEEECCCHHCCCHHHHHCCCEEECC
APDEAGARRIAQAIYTQIREAHAWGLRFPEQLGEASLAALAAVPPRTMRRALLHAFGAAR
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCHHHHHHHHCCCHHHHHHHHHHHHHHHH
LDGRNAVEPRDIRADEGMPKRRPIGF
CCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTAMVRQELAVASFSRVYDLERVETALGDLNEGASEALRSTYEKMLKTGNLRFCVKPTR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEECCCC
MPAFDALAESLPNFCGPLDDLRKQVALCLETEDRLELMPILLLGAPGIGKTHFAKALAQM
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHEECCCCCCHHHHHHHHHHH
LGTAYHYVPMSSLTAGWVLSGASSQWKNAKPGKVFDALVNGSYANPVIVIDEIDKAGNDA
HHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEECCCCCCCCC
QYDPLGALYALLEHDTASAFVDEFAEVPIDAGNVIWIATANDAKSIPEPILNRMNVYEIP
CCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEEECCCHHCCCHHHHHCCCEEECC
APDEAGARRIAQAIYTQIREAHAWGLRFPEQLGEASLAALAAVPPRTMRRALLHAFGAAR
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCHHHHHHHHCCCHHHHHHHHHHHHHHHH
LDGRNAVEPRDIRADEGMPKRRPIGF
CCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA