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The map label for this gene is cusR [H]

Identifier: 238028823

GI number: 238028823

Start: 3740530

End: 3741204

Strand: Direct

Name: cusR [H]

Synonym: bglu_1g32880

Alternate gene names: 238028823

Gene position: 3740530-3741204 (Clockwise)

Preceding gene: 238028822

Following gene: 238028824

Centisome position: 95.75

GC content: 70.96

Gene sequence:

>675_bases
ATGTCGAAGATCCTGACGATCGAGGACGATGTCCTGATCGCCGACAGCATCACGCGCCAGCTGCAGGCCGAGGGCCATAC
GGTGGACCTCGCGCGCACCGGCCGCGACGGCATCGCCAAGGTGATGGCGGGCGACTACGACGCGGTCACGCTCGACCGCA
TGCTGCCGGACCTCGACGGGCTCGCGATCCTCGCCACCATGCGCGGCGTCGGGCTCGACACGCCGGTGCTGGTGATGAGC
GCGATGTCGGAAGTGGACCAGCGCATCGCGGGCCTGCGCGCCGGCGGCGACGACTATCTGGTCAAGCCGTTCTCGCTGGC
CGAGATGGTGGCGCGGCTCGAGGTGCTGATGCGCCGCCGCCCGCGCAGCGCCCATGCCGACACGGTGCTGCGCGCTGGCG
GCATCGAGCTCGACCTCGTCCGGCGCCGCGCCTCGCTCGGCGCGCGCGAGCTGCAACTGCTGCCCACCGAGTTCCGCGTG
CTCGAATTCATGATGCGCCACGCGGGCCGCGTGCTCACGCGCACCATGATCTTCGAGGGGGTATGGGGCTGCCGGTTCGA
TCCCGGCACCAACCTGATCGACGTCCACGTCGGCCGCCTGCGCCGCAAGATCAACCGCCCCGGCGAAGCCCCGCTGATCC
GCACCATCCGCGGCGCGGGCTACCTGCTCGGCTGA

Upstream 100 bases:

>100_bases
CTCTCCATGAAGGTGCGCAGCTTCGTCGATTTCGCGGTGGGCCGCTATCGCGGCGCCGACCGCGCCGCGCCGCTGCGCGC
CGTCGCCTGACCCGCGGCCC

Downstream 100 bases:

>100_bases
CGCGCCGGGGCCGCGACTGCCGGCTCGCGCACCCGTTGCCCAGGCTGCCTGGACGAGCGCCGCGCGAACGCGGCCGCCTG
CCGGCGCGGGTCGCGCGCGC

Product: winged helix family two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 223

Protein sequence:

>224_residues
MSKILTIEDDVLIADSITRQLQAEGHTVDLARTGRDGIAKVMAGDYDAVTLDRMLPDLDGLAILATMRGVGLDTPVLVMS
AMSEVDQRIAGLRAGGDDYLVKPFSLAEMVARLEVLMRRRPRSAHADTVLRAGGIELDLVRRRASLGARELQLLPTEFRV
LEFMMRHAGRVLTRTMIFEGVWGCRFDPGTNLIDVHVGRLRRKINRPGEAPLIRTIRGAGYLLG

Sequences:

>Translated_224_residues
MSKILTIEDDVLIADSITRQLQAEGHTVDLARTGRDGIAKVMAGDYDAVTLDRMLPDLDGLAILATMRGVGLDTPVLVMS
AMSEVDQRIAGLRAGGDDYLVKPFSLAEMVARLEVLMRRRPRSAHADTVLRAGGIELDLVRRRASLGARELQLLPTEFRV
LEFMMRHAGRVLTRTMIFEGVWGCRFDPGTNLIDVHVGRLRRKINRPGEAPLIRTIRGAGYLLG
>Mature_223_residues
SKILTIEDDVLIADSITRQLQAEGHTVDLARTGRDGIAKVMAGDYDAVTLDRMLPDLDGLAILATMRGVGLDTPVLVMSA
MSEVDQRIAGLRAGGDDYLVKPFSLAEMVARLEVLMRRRPRSAHADTVLRAGGIELDLVRRRASLGARELQLLPTEFRVL
EFMMRHAGRVLTRTMIFEGVWGCRFDPGTNLIDVHVGRLRRKINRPGEAPLIRTIRGAGYLLG

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=40.7239819004525, Blast_Score=174, Evalue=4e-45,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=44.5945945945946, Blast_Score=168, Evalue=2e-43,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=39.5454545454545, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=37.5565610859729, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI1786599, Length=221, Percent_Identity=32.579185520362, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=33.7837837837838, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=31.6742081447964, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=33.3333333333333, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=32.9004329004329, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1788394, Length=220, Percent_Identity=30, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=28.6343612334802, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=28.82096069869, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=26.9565217391304, Blast_Score=77, Evalue=7e-16,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=25.9574468085106, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790437, Length=111, Percent_Identity=32.4324324324324, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788550, Length=109, Percent_Identity=30.2752293577982, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=33.8842975206612, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24742; Mature: 24611

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKILTIEDDVLIADSITRQLQAEGHTVDLARTGRDGIAKVMAGDYDAVTLDRMLPDLDG
CCCEEEECCCEEEHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCCCEEHHHHCCCCCC
LAILATMRGVGLDTPVLVMSAMSEVDQRIAGLRAGGDDYLVKPFSLAEMVARLEVLMRRR
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHCC
PRSAHADTVLRAGGIELDLVRRRASLGARELQLLPTEFRVLEFMMRHAGRVLTRTMIFEG
CCCCCHHHHHHCCCCHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHC
VWGCRFDPGTNLIDVHVGRLRRKINRPGEAPLIRTIRGAGYLLG
CCCCEECCCCCEEHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCC
>Mature Secondary Structure 
SKILTIEDDVLIADSITRQLQAEGHTVDLARTGRDGIAKVMAGDYDAVTLDRMLPDLDG
CCEEEECCCEEEHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCCCEEHHHHCCCCCC
LAILATMRGVGLDTPVLVMSAMSEVDQRIAGLRAGGDDYLVKPFSLAEMVARLEVLMRRR
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHCC
PRSAHADTVLRAGGIELDLVRRRASLGARELQLLPTEFRVLEFMMRHAGRVLTRTMIFEG
CCCCCHHHHHHCCCCHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHC
VWGCRFDPGTNLIDVHVGRLRRKINRPGEAPLIRTIRGAGYLLG
CCCCEECCCCCEEHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]