Click here to switch to the map view.

The map label for this gene is emrA [H]

Identifier: 238028561

GI number: 238028561

Start: 3436785

End: 3437927

Strand: Direct

Name: emrA [H]

Synonym: bglu_1g30250

Alternate gene names: 238028561

Gene position: 3436785-3437927 (Clockwise)

Preceding gene: 238028558

Following gene: 238028562

Centisome position: 87.98

GC content: 72.7

Gene sequence:

>1143_bases
ATGTCGTCGACCCCTCAGGATGCACCGCAAGGCAATCGTCAGGAACCTGCCGCCACGCCGTCTGCGGGCAAGCCTTCCCC
CGACACCCCCGCACGCAAGCCGAACCGGCGCCGGATCCTGATCGCGCTGGCCGTGCTCGCGCTGCTCGGCGGCGCGATCT
GGCTGCTTCACTGGTGGACCGTGGGCCGCTTCATCGAAAGCACCGACGACGCCTACCTGCAGGCCGACAGCATGACCGCC
GCGCCGAAGGTGTCGGGCTACGTGACCGACGTCTACGTGGGCGACAACCAGCCGGTGAAGGCCGGCGCGCCGCTCGTGAG
GCTCGACGTGCGCCAGTATCAGGTCGCGCTGCAGCAGGCGCGAGCCACCGTGGACGCGCGCCGCGCCGACATCGCGCGCG
CCGAGGCCGACATCGCCCAGCAGCGCGCCAACCTCGAGCAGGCCCAGGCGCAGGCGCGCGTGTCGAGCATCAACCTGCAT
CACGCGAGCGACGAGTACGCGCGCTACGCGCCGCTCGCCGCGACCGGCGCCGAGACCCGCGAGCGCATCGCCGATCTCAG
GAACACGCGCGACCAGGCGCAGGCCACGCTGGCCGCCAACACGGCGTCGATCGCCGCGGCCCGCACCCAGATCGCCGCCA
GCACCGCGCAGCTGCAGCAGGCGCGGGCGCAGCTCGAGGCCGCGCAGGCGAGCGCCGCGCAGTCGCAGCTCGACCTCGAC
AACACCGTGGTGCGCAGCACGCTGGACGGCCGGGTCGGCGACCGCACCGTGCGCGTGGGCCAGTACGTGCAGCCCGGCAC
GCGGCTGCTGACCGTGGTGCCGGTGCAGAGCCTCTATCTGGTGGCGAACTTCAAGGAAACCCAGCTCGGCCGGATGCGCC
CGGGCCAGCCCGTCACGCTGCACGTGGACGCGCTGCCGGGCCGCGAACTGCACGGCCGGGTCGAGAGCTTCGCGCCCGGC
ACCGGCGCGCAGTTCGCGCTGCTGCCGCCCGAGAACGCCACCGGCAACTTCACGAAGATCGTGCAGCGCGTGCCGGTGCG
GATCCACGTCGACACCGACGACCAGGCGCGCCGCGTGCTGCTGCCGGGCCTGTCGGTGACCGTCGACGTCGATACGCGCG
ACGACGGGAACCAGCATGGCTGA

Upstream 100 bases:

>100_bases
TCCGTCATAGACCCCTCGCAATTCAAACAGACCACATTCTACTTGACACAAATTTACCAACTGGAATAATTATTCCGCTT
GGAATAATTTGGATACCCGA

Downstream 100 bases:

>100_bases
GTCCGCCACGCCGGCCGGCGCACCGGCCGCCCCCGCCCCGGCCGCCGAGCGCGCCACCGCCTCCGACTGGATCGCGGTGG
CAGCCGGCTCGCTCGGCGCG

Product: multidrug resistance efflux pump

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MSSTPQDAPQGNRQEPAATPSAGKPSPDTPARKPNRRRILIALAVLALLGGAIWLLHWWTVGRFIESTDDAYLQADSMTA
APKVSGYVTDVYVGDNQPVKAGAPLVRLDVRQYQVALQQARATVDARRADIARAEADIAQQRANLEQAQAQARVSSINLH
HASDEYARYAPLAATGAETRERIADLRNTRDQAQATLAANTASIAAARTQIAASTAQLQQARAQLEAAQASAAQSQLDLD
NTVVRSTLDGRVGDRTVRVGQYVQPGTRLLTVVPVQSLYLVANFKETQLGRMRPGQPVTLHVDALPGRELHGRVESFAPG
TGAQFALLPPENATGNFTKIVQRVPVRIHVDTDDQARRVLLPGLSVTVDVDTRDDGNQHG

Sequences:

>Translated_380_residues
MSSTPQDAPQGNRQEPAATPSAGKPSPDTPARKPNRRRILIALAVLALLGGAIWLLHWWTVGRFIESTDDAYLQADSMTA
APKVSGYVTDVYVGDNQPVKAGAPLVRLDVRQYQVALQQARATVDARRADIARAEADIAQQRANLEQAQAQARVSSINLH
HASDEYARYAPLAATGAETRERIADLRNTRDQAQATLAANTASIAAARTQIAASTAQLQQARAQLEAAQASAAQSQLDLD
NTVVRSTLDGRVGDRTVRVGQYVQPGTRLLTVVPVQSLYLVANFKETQLGRMRPGQPVTLHVDALPGRELHGRVESFAPG
TGAQFALLPPENATGNFTKIVQRVPVRIHVDTDDQARRVLLPGLSVTVDVDTRDDGNQHG
>Mature_379_residues
SSTPQDAPQGNRQEPAATPSAGKPSPDTPARKPNRRRILIALAVLALLGGAIWLLHWWTVGRFIESTDDAYLQADSMTAA
PKVSGYVTDVYVGDNQPVKAGAPLVRLDVRQYQVALQQARATVDARRADIARAEADIAQQRANLEQAQAQARVSSINLHH
ASDEYARYAPLAATGAETRERIADLRNTRDQAQATLAANTASIAAARTQIAASTAQLQQARAQLEAAQASAAQSQLDLDN
TVVRSTLDGRVGDRTVRVGQYVQPGTRLLTVVPVQSLYLVANFKETQLGRMRPGQPVTLHVDALPGRELHGRVESFAPGT
GAQFALLPPENATGNFTKIVQRVPVRIHVDTDDQARRVLLPGLSVTVDVDTRDDGNQHG

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788711, Length=353, Percent_Identity=34.5609065155807, Blast_Score=165, Evalue=4e-42,
Organism=Escherichia coli, GI1789041, Length=364, Percent_Identity=33.2417582417582, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1790519, Length=293, Percent_Identity=30.3754266211604, Blast_Score=128, Evalue=5e-31,
Organism=Escherichia coli, GI87081951, Length=320, Percent_Identity=25.9375, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1789637, Length=360, Percent_Identity=28.3333333333333, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790024, Length=242, Percent_Identity=28.5123966942149, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790012, Length=257, Percent_Identity=29.1828793774319, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789900, Length=311, Percent_Identity=25.08038585209, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787013, Length=318, Percent_Identity=27.9874213836478, Blast_Score=71, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 40935; Mature: 40804

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTPQDAPQGNRQEPAATPSAGKPSPDTPARKPNRRRILIALAVLALLGGAIWLLHWWT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VGRFIESTDDAYLQADSMTAAPKVSGYVTDVYVGDNQPVKAGAPLVRLDVRQYQVALQQA
HHHHHHCCCCCEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHH
RATVDARRADIARAEADIAQQRANLEQAQAQARVSSINLHHASDEYARYAPLAATGAETR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHCCCHHCCHHHH
ERIADLRNTRDQAQATLAANTASIAAARTQIAASTAQLQQARAQLEAAQASAAQSQLDLD
HHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
NTVVRSTLDGRVGDRTVRVGQYVQPGTRLLTVVPVQSLYLVANFKETQLGRMRPGQPVTL
HHHHHHHHCCCCCCCEEECCCCCCCCCEEEEEEECCEEEEEECCCHHHCCCCCCCCCEEE
HVDALPGRELHGRVESFAPGTGAQFALLPPENATGNFTKIVQRVPVRIHVDTDDQARRVL
EEECCCCHHHHCHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHCCEEEEECCCCCCCEEE
LPGLSVTVDVDTRDDGNQHG
ECCCEEEEEECCCCCCCCCC
>Mature Secondary Structure 
SSTPQDAPQGNRQEPAATPSAGKPSPDTPARKPNRRRILIALAVLALLGGAIWLLHWWT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VGRFIESTDDAYLQADSMTAAPKVSGYVTDVYVGDNQPVKAGAPLVRLDVRQYQVALQQA
HHHHHHCCCCCEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHH
RATVDARRADIARAEADIAQQRANLEQAQAQARVSSINLHHASDEYARYAPLAATGAETR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHCCCHHCCHHHH
ERIADLRNTRDQAQATLAANTASIAAARTQIAASTAQLQQARAQLEAAQASAAQSQLDLD
HHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
NTVVRSTLDGRVGDRTVRVGQYVQPGTRLLTVVPVQSLYLVANFKETQLGRMRPGQPVTL
HHHHHHHHCCCCCCCEEECCCCCCCCCEEEEEEECCEEEEEECCCHHHCCCCCCCCCEEE
HVDALPGRELHGRVESFAPGTGAQFALLPPENATGNFTKIVQRVPVRIHVDTDDQARRVL
EEECCCCHHHHCHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHCCEEEEECCCCCCCEEE
LPGLSVTVDVDTRDDGNQHG
ECCCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]