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The map label for this gene is fabG2 [H]

Identifier: 238028449

GI number: 238028449

Start: 3300777

End: 3301535

Strand: Direct

Name: fabG2 [H]

Synonym: bglu_1g29130

Alternate gene names: 238028449

Gene position: 3300777-3301535 (Clockwise)

Preceding gene: 238028448

Following gene: 238028452

Centisome position: 84.49

GC content: 70.62

Gene sequence:

>759_bases
ATGGAATTACGCGGCAACGTCTTTCTGATCACGGGAGGCGCATCGGGCCTCGGCGCCGGCACGGCGCGCATGCTCACCGG
CGCGGGCGCGAAGGTGGTGCTCGCGGACCTGAACCGCGAGGCGGGCGAAGCGCTCGCGGCCGAGCTCGGCGCACGCTTCG
TCAGCTGCGACGTCACACGCGAAGCCGACGCGCAGGCCGCCGTCGAGGCGGCCACCGGGCTCGGCACGCTGCGCGGCCTC
GTCAACTGCGCCGGCATCGCGCCGGCCGCGAAGACGGTCGGCAAGGACGGTCCGCATTCGCTCGAGCTGTTCGCGAAGGT
CGTGTCGATCAACCTCGTCGGCAGCTTCAACATGGCGCGCCTGGCCGCGGCCGCGATGGCCGCGAACGCGCCGATCGAAA
CCGGCGAGCGCGGCGTGATCGTCAATACCGCCTCGGTGGCCGCGTTCGACGGCCAGATCGGCCAGGCCGCCTATTCCGCC
TCGAAGGCCGGCGTGGCCGGCATGACGCTGCCGCTCGCACGCGACCTGTCGCGCAACGCGATCCGCGTGATGACGATCGC
GCCGGGCATCTTCGAGACGCCGATGCTGCTCGGCATGCCGCAGGAGGTGCAGGACGCGCTCGGCGCGATGGTGCCGTTCC
CGCCGCGCCTCGGCAAGCCCGACGAATACGCGATGCTGGTGCGCCAGATCATCGAGAATCCGATGTTGAACGGCGAGGTG
ATCCGCCTGGACGGCGCGATCCGCATGCAGCCGAAATGA

Upstream 100 bases:

>100_bases
TTCATTTTTTGCCGTCACCGCGCGCGGTTTCGTACAATCGTCCGGCAATGGATCGCGCCGGCCGATCACGGCGGCGGATC
GCGACAACCAAGGAGCGAAG

Downstream 100 bases:

>100_bases
GCGCCGGCGCGGCCTAGCGAGCCGCGCGCCGCGCCGCCCGCGGCGTGGGCGGCGCAGCGGGCGGGCGTCGTCGTACGGGA
CTGCGGAAGGCGGCCGGGGC

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MELRGNVFLITGGASGLGAGTARMLTGAGAKVVLADLNREAGEALAAELGARFVSCDVTREADAQAAVEAATGLGTLRGL
VNCAGIAPAAKTVGKDGPHSLELFAKVVSINLVGSFNMARLAAAAMAANAPIETGERGVIVNTASVAAFDGQIGQAAYSA
SKAGVAGMTLPLARDLSRNAIRVMTIAPGIFETPMLLGMPQEVQDALGAMVPFPPRLGKPDEYAMLVRQIIENPMLNGEV
IRLDGAIRMQPK

Sequences:

>Translated_252_residues
MELRGNVFLITGGASGLGAGTARMLTGAGAKVVLADLNREAGEALAAELGARFVSCDVTREADAQAAVEAATGLGTLRGL
VNCAGIAPAAKTVGKDGPHSLELFAKVVSINLVGSFNMARLAAAAMAANAPIETGERGVIVNTASVAAFDGQIGQAAYSA
SKAGVAGMTLPLARDLSRNAIRVMTIAPGIFETPMLLGMPQEVQDALGAMVPFPPRLGKPDEYAMLVRQIIENPMLNGEV
IRLDGAIRMQPK
>Mature_252_residues
MELRGNVFLITGGASGLGAGTARMLTGAGAKVVLADLNREAGEALAAELGARFVSCDVTREADAQAAVEAATGLGTLRGL
VNCAGIAPAAKTVGKDGPHSLELFAKVVSINLVGSFNMARLAAAAMAANAPIETGERGVIVNTASVAAFDGQIGQAAYSA
SKAGVAGMTLPLARDLSRNAIRVMTIAPGIFETPMLLGMPQEVQDALGAMVPFPPRLGKPDEYAMLVRQIIENPMLNGEV
IRLDGAIRMQPK

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=255, Percent_Identity=58.4313725490196, Blast_Score=273, Evalue=1e-73,
Organism=Homo sapiens, GI83715985, Length=255, Percent_Identity=56.078431372549, Blast_Score=251, Evalue=4e-67,
Organism=Homo sapiens, GI15277342, Length=240, Percent_Identity=33.75, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI40254992, Length=246, Percent_Identity=31.3008130081301, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI59889578, Length=194, Percent_Identity=32.4742268041237, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI31542939, Length=261, Percent_Identity=29.5019157088123, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI150247226, Length=202, Percent_Identity=32.6732673267327, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI224922801, Length=177, Percent_Identity=31.638418079096, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI5031737, Length=199, Percent_Identity=28.1407035175879, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI33667109, Length=197, Percent_Identity=28.4263959390863, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787335, Length=255, Percent_Identity=30.5882352941176, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87082160, Length=202, Percent_Identity=29.7029702970297, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87082100, Length=240, Percent_Identity=30.8333333333333, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787905, Length=235, Percent_Identity=30.2127659574468, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789208, Length=198, Percent_Identity=32.8282828282828, Blast_Score=68, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17538182, Length=249, Percent_Identity=48.995983935743, Blast_Score=230, Evalue=7e-61,
Organism=Caenorhabditis elegans, GI17555706, Length=227, Percent_Identity=34.3612334801762, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI25147288, Length=256, Percent_Identity=30.46875, Blast_Score=103, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17560676, Length=259, Percent_Identity=28.957528957529, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17561402, Length=259, Percent_Identity=28.1853281853282, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17567345, Length=203, Percent_Identity=30.5418719211823, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=241, Percent_Identity=28.6307053941909, Blast_Score=68, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322861, Length=204, Percent_Identity=30.8823529411765, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17737361, Length=254, Percent_Identity=58.2677165354331, Blast_Score=278, Evalue=3e-75,
Organism=Drosophila melanogaster, GI24639444, Length=260, Percent_Identity=32.6923076923077, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24644339, Length=229, Percent_Identity=31.8777292576419, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357041, Length=229, Percent_Identity=30.1310043668122, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28571526, Length=232, Percent_Identity=29.7413793103448, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21355319, Length=248, Percent_Identity=27.0161290322581, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 25809; Mature: 25809

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRGNVFLITGGASGLGAGTARMLTGAGAKVVLADLNREAGEALAAELGARFVSCDVTR
CCCCCCEEEEECCCCCCCCCHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCEEEEECCCC
EADAQAAVEAATGLGTLRGLVNCAGIAPAAKTVGKDGPHSLELFAKVVSINLVGSFNMAR
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHEEEECCCCHHH
LAAAAMAANAPIETGERGVIVNTASVAAFDGQIGQAAYSASKAGVAGMTLPLARDLSRNA
HHHHHHHCCCCCCCCCCEEEEEECEEEEECCCHHHHHHHHCCCCCCCEEHHHHHHCCCCC
IRVMTIAPGIFETPMLLGMPQEVQDALGAMVPFPPRLGKPDEYAMLVRQIIENPMLNGEV
EEEEEECCCHHHCCHHCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEE
IRLDGAIRMQPK
EEECCEEEECCC
>Mature Secondary Structure
MELRGNVFLITGGASGLGAGTARMLTGAGAKVVLADLNREAGEALAAELGARFVSCDVTR
CCCCCCEEEEECCCCCCCCCHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCEEEEECCCC
EADAQAAVEAATGLGTLRGLVNCAGIAPAAKTVGKDGPHSLELFAKVVSINLVGSFNMAR
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHEEEECCCCHHH
LAAAAMAANAPIETGERGVIVNTASVAAFDGQIGQAAYSASKAGVAGMTLPLARDLSRNA
HHHHHHHCCCCCCCCCCEEEEEECEEEEECCCHHHHHHHHCCCCCCCEEHHHHHHCCCCC
IRVMTIAPGIFETPMLLGMPQEVQDALGAMVPFPPRLGKPDEYAMLVRQIIENPMLNGEV
EEEEEECCCHHHCCHHCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEE
IRLDGAIRMQPK
EEECCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]