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The map label for this gene is phr [H]

Identifier: 238028072

GI number: 238028072

Start: 2870278

End: 2871747

Strand: Reverse

Name: phr [H]

Synonym: bglu_1g25230

Alternate gene names: 238028072

Gene position: 2871747-2870278 (Counterclockwise)

Preceding gene: 238028074

Following gene: 238028071

Centisome position: 73.51

GC content: 73.13

Gene sequence:

>1470_bases
TTGCCCTTGTCCGCCGATTCCCAAGCCCAGCCCGCGCTCGTCTGGTTCCGTGACGATCTGCGCGTGACCGACAACCCGGC
GCTCGCGCGCGCGGCCGAGTCGGGCCGCCCGCTCGTCTGCGTCTATGTGTTCGAGCGCGACGGCACGCGTCCGCTCGGCG
GCGCGGTGCGCTGGTGGCTCGACGGCGCGCTGCGTTCGCTCGATGCGAAGCTCGCCGCGCAGGGCGGCGGCCTCGTCGTG
CTCGAAGGCGACGAGCGTGAGACGATCGCCGCGCTCGCCGGCGAGCTGGGCGCCGGCGCGGTCTATTGGAACCGCCGCTA
CGACGGGCTCGCACGCGAAACCGACGCCGCGCTGAAGCGTTCGCTGAAGGAGGCCGGTATCGAGGTGGAGAGCTTCAACG
GCGCGCTGCTGCACGAGCCGTGGGAGATCCGCACCGGCAGCGGCGGCGCGTTCCAGGTGTTTACGGCCTACTGGCGTGCG
GCGCGCGCGGCGGGCGAGCTGCCTGCGCCGCTCGCGGAGCCGGCGAAATGGCGCTTTCACCGGCTGCCCGAGGCGCTCGC
GCGGCGCGCCACGCGCATCGACGCGCTCGGCCTGCTGCCGGTGCGCCCCGACTGGGCGGGCGGCCTGCGCGAGGCGTGGG
AGCCGTCCGAGGAGGGCGGGCTCGCGCGGCTCGAAGCATTCCTCGACAAGCAGATCCGCGGCTACGGCGACGCGCGCGAC
CGGCCCGACCGCCCGGCCACCAGCCGGCTCTCGCCGTACCTGCGCTTCGGCCAGCTGTCGGCGCGGCAGGTCTGGCACGC
GGCACAGGCCGCCGGGCGCGAGGGCGGCGCGGCGGTGGCGGCCGACATCGAGAAGTTTCTCAGCGAACTGGGCTGGCGCG
AGTTCAACACGAGCCTGCTCTATCATTTTCCCGAGCTGCCGATGCGCAACTATCGCGACCGCTTCGACGCGATGCCGTGG
CGCAGCGACGAGGCCGCGTTCGCTGCGTGGTGCCGCGGCCGCACCGGCTACCCGCTCGTCGATGCGGGCATGCGCGAGCT
GTGGGCCACGGGCTGGATGCACAACCGCGTGCGGATGGTGACGGCCTCGTTCCTGATCAAGCACCTGCTGATCGACTGGC
GCGCGGGCGAGCGCTGGTTCTGGGACACGCTGGTGGACGCCGACATTGCCAACAACTCGGCGAACTGGCAATGGGTGGCC
GGCAGCGGCGCCGACGCGGCGCCGTATTTCCGGATCTTCAATCCGGTCATGCAGGGCCGCAAGTTCGATCCGGACGGCGC
CTACGTGCGCCGCTGGGTGCCCGAGCTGGCGGGCCTGCCGGCCGACGCGATCCACGAGCCGTGGCGCGCCAAGCCGGTGG
TGCTGGAGGCGGCCGGCGTCGTGCTCGGCCGCACCTATCCGGCGCCCATCGTCGACCACGACGCCGCGCGCAAGCGCGCG
CTGGGCGCGCTCGAAGCGACCAAGCGCTAG

Upstream 100 bases:

>100_bases
CCGGCGCGGGTGCGCCGCGCGGCGGTCCGGGGCCGCCGCGCGTCGTCGTCGTGTCTCGCGCCGGCCTGCATCCTTGCGTC
AACCCGTTTCCACCGGAGCC

Downstream 100 bases:

>100_bases
GCGAGCCCGCCGCGGCGCGGCCGCATCGACGGGGGCGATGCAATGTGCCGGATGGCCGGTTCGGCACGGCGGGCATGGCG
CCGCTGCCGTGGGATGCGAT

Product: deoxyribodipyrimidine photolyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 489; Mature: 488

Protein sequence:

>489_residues
MPLSADSQAQPALVWFRDDLRVTDNPALARAAESGRPLVCVYVFERDGTRPLGGAVRWWLDGALRSLDAKLAAQGGGLVV
LEGDERETIAALAGELGAGAVYWNRRYDGLARETDAALKRSLKEAGIEVESFNGALLHEPWEIRTGSGGAFQVFTAYWRA
ARAAGELPAPLAEPAKWRFHRLPEALARRATRIDALGLLPVRPDWAGGLREAWEPSEEGGLARLEAFLDKQIRGYGDARD
RPDRPATSRLSPYLRFGQLSARQVWHAAQAAGREGGAAVAADIEKFLSELGWREFNTSLLYHFPELPMRNYRDRFDAMPW
RSDEAAFAAWCRGRTGYPLVDAGMRELWATGWMHNRVRMVTASFLIKHLLIDWRAGERWFWDTLVDADIANNSANWQWVA
GSGADAAPYFRIFNPVMQGRKFDPDGAYVRRWVPELAGLPADAIHEPWRAKPVVLEAAGVVLGRTYPAPIVDHDAARKRA
LGALEATKR

Sequences:

>Translated_489_residues
MPLSADSQAQPALVWFRDDLRVTDNPALARAAESGRPLVCVYVFERDGTRPLGGAVRWWLDGALRSLDAKLAAQGGGLVV
LEGDERETIAALAGELGAGAVYWNRRYDGLARETDAALKRSLKEAGIEVESFNGALLHEPWEIRTGSGGAFQVFTAYWRA
ARAAGELPAPLAEPAKWRFHRLPEALARRATRIDALGLLPVRPDWAGGLREAWEPSEEGGLARLEAFLDKQIRGYGDARD
RPDRPATSRLSPYLRFGQLSARQVWHAAQAAGREGGAAVAADIEKFLSELGWREFNTSLLYHFPELPMRNYRDRFDAMPW
RSDEAAFAAWCRGRTGYPLVDAGMRELWATGWMHNRVRMVTASFLIKHLLIDWRAGERWFWDTLVDADIANNSANWQWVA
GSGADAAPYFRIFNPVMQGRKFDPDGAYVRRWVPELAGLPADAIHEPWRAKPVVLEAAGVVLGRTYPAPIVDHDAARKRA
LGALEATKR
>Mature_488_residues
PLSADSQAQPALVWFRDDLRVTDNPALARAAESGRPLVCVYVFERDGTRPLGGAVRWWLDGALRSLDAKLAAQGGGLVVL
EGDERETIAALAGELGAGAVYWNRRYDGLARETDAALKRSLKEAGIEVESFNGALLHEPWEIRTGSGGAFQVFTAYWRAA
RAAGELPAPLAEPAKWRFHRLPEALARRATRIDALGLLPVRPDWAGGLREAWEPSEEGGLARLEAFLDKQIRGYGDARDR
PDRPATSRLSPYLRFGQLSARQVWHAAQAAGREGGAAVAADIEKFLSELGWREFNTSLLYHFPELPMRNYRDRFDAMPWR
SDEAAFAAWCRGRTGYPLVDAGMRELWATGWMHNRVRMVTASFLIKHLLIDWRAGERWFWDTLVDADIANNSANWQWVAG
SGADAAPYFRIFNPVMQGRKFDPDGAYVRRWVPELAGLPADAIHEPWRAKPVVLEAAGVVLGRTYPAPIVDHDAARKRAL
GALEATKR

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI188536100, Length=474, Percent_Identity=30.379746835443, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI4758072, Length=487, Percent_Identity=29.5687885010267, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI188536103, Length=436, Percent_Identity=29.5871559633028, Blast_Score=175, Evalue=9e-44,
Organism=Escherichia coli, GI1786926, Length=490, Percent_Identity=36.9387755102041, Blast_Score=282, Evalue=3e-77,
Organism=Saccharomyces cerevisiae, GI6324962, Length=520, Percent_Identity=29.2307692307692, Blast_Score=199, Evalue=1e-51,
Organism=Drosophila melanogaster, GI17137248, Length=504, Percent_Identity=29.5634920634921, Blast_Score=194, Evalue=8e-50,
Organism=Drosophila melanogaster, GI24585455, Length=504, Percent_Identity=29.5634920634921, Blast_Score=194, Evalue=8e-50,
Organism=Drosophila melanogaster, GI24648152, Length=518, Percent_Identity=27.4131274131274, Blast_Score=168, Evalue=7e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR019947
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 54385; Mature: 54254

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS00394 DNA_PHOTOLYASES_1_1 ; PS00691 DNA_PHOTOLYASES_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLSADSQAQPALVWFRDDLRVTDNPALARAAESGRPLVCVYVFERDGTRPLGGAVRWWL
CCCCCCCCCCCEEEEEECCCEECCCHHHHHHHCCCCCEEEEEEEECCCCCCCCHHHHHHH
DGALRSLDAKLAAQGGGLVVLEGDERETIAALAGELGAGAVYWNRRYDGLARETDAALKR
HHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHH
SLKEAGIEVESFNGALLHEPWEIRTGSGGAFQVFTAYWRAARAAGELPAPLAEPAKWRFH
HHHHHCCEEECCCCCEECCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
RLPEALARRATRIDALGLLPVRPDWAGGLREAWEPSEEGGLARLEAFLDKQIRGYGDARD
HHHHHHHHHHHHHHHEECEECCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCC
RPDRPATSRLSPYLRFGQLSARQVWHAAQAAGREGGAAVAADIEKFLSELGWREFNTSLL
CCCCCCHHHHCHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHCCHHE
YHFPELPMRNYRDRFDAMPWRSDEAAFAAWCRGRTGYPLVDAGMRELWATGWMHNRVRMV
EECCCCCHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TASFLIKHLLIDWRAGERWFWDTLVDADIANNSANWQWVAGSGADAAPYFRIFNPVMQGR
HHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHCCC
KFDPDGAYVRRWVPELAGLPADAIHEPWRAKPVVLEAAGVVLGRTYPAPIVDHDAARKRA
CCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCEEEEECCCCEECCCCCCCCCCHHHHHHH
LGALEATKR
HHHHHHCCC
>Mature Secondary Structure 
PLSADSQAQPALVWFRDDLRVTDNPALARAAESGRPLVCVYVFERDGTRPLGGAVRWWL
CCCCCCCCCCEEEEEECCCEECCCHHHHHHHCCCCCEEEEEEEECCCCCCCCHHHHHHH
DGALRSLDAKLAAQGGGLVVLEGDERETIAALAGELGAGAVYWNRRYDGLARETDAALKR
HHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHH
SLKEAGIEVESFNGALLHEPWEIRTGSGGAFQVFTAYWRAARAAGELPAPLAEPAKWRFH
HHHHHCCEEECCCCCEECCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
RLPEALARRATRIDALGLLPVRPDWAGGLREAWEPSEEGGLARLEAFLDKQIRGYGDARD
HHHHHHHHHHHHHHHEECEECCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCC
RPDRPATSRLSPYLRFGQLSARQVWHAAQAAGREGGAAVAADIEKFLSELGWREFNTSLL
CCCCCCHHHHCHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHCCHHE
YHFPELPMRNYRDRFDAMPWRSDEAAFAAWCRGRTGYPLVDAGMRELWATGWMHNRVRMV
EECCCCCHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TASFLIKHLLIDWRAGERWFWDTLVDADIANNSANWQWVAGSGADAAPYFRIFNPVMQGR
HHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHCCC
KFDPDGAYVRRWVPELAGLPADAIHEPWRAKPVVLEAAGVVLGRTYPAPIVDHDAARKRA
CCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCEEEEECCCCEECCCCCCCCCCHHHHHHH
LGALEATKR
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2837735; 2110564; 9360600 [H]