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The map label for this gene is uvrD [H]

Identifier: 238027765

GI number: 238027765

Start: 2379563

End: 2381932

Strand: Reverse

Name: uvrD [H]

Synonym: bglu_1g21890

Alternate gene names: 238027765

Gene position: 2381932-2379563 (Counterclockwise)

Preceding gene: 238027768

Following gene: 238027764

Centisome position: 60.97

GC content: 68.82

Gene sequence:

>2370_bases
ATGCCCGATCTGTTAGCGAACCTGAATCCCGAACAATACGCCGCCGTCACGCTGCCGAACGAGCCCGCGCTGATTCTCGC
CGGTGCGGGCAGCGGCAAGACGCGCGTGCTGATCACGCGGATCGCGTGGCTGATCCAGCACGGCTACGCGTCGCCGCCCA
CCGTGCTGGCCGTCACCTTCACGAACAAGGCCGCGCGCGAGATGCTCTCGCGCCTGTCGGCGATGATGCCGATCGACACG
CGCGGGATGTGGATCGGCACCTTCCACGGCCTCTGCAACCGCATGCTGCGCGCCCACTATCGCGACGCCGGGCTGCCGCA
GACGTTCCAGATCCTCGACACGGCCGACCAGCTCTCCGCCATCAAGCGGCTGATGAAGGCCTCGAACATCGACGACGAGA
AGTACCCGCCGAAGAACGTCCAGTACTTCATCAACAACGCCAAGGAGCAGGGGCTGCGCCCGGACAAGGTCGAGGCCAAC
GACAGCTTCAACCGGATGTTCGTGCAGCTCTACCAGGCCTACGACCAGCAGTGCCAGCGCGAGGGCGTGGTCGATTTCCC
CGAGCTGCTGCTGCGCTGCTTCGAGCTGCTGAGCTACAACCCGGCGCTGCGCGCGCACTATCAGGCGCGCTTCCGGCATA
TCCTCGTCGACGAGTTCCAGGACACCAACAAGCTGCAGTACGCGTGGCTCAAGCTGCTCGCGGGCGAGCAGAACGCGATC
TTCGCGGTCGGCGACGACGACCAGTCGATCTATGCGTTTCGCGGCGCGAACGTCGGCAACATGCGCGACTTCGAGGACGA
GTTCCGGGTCCGCAACCTGATCAAGCTTGAGCAGAACTACCGCTCGCACGGCAACATCCTCGACGCGGCCAACCACCTGA
TCGCCCACAACTCGCGCCGGCTCGGCAAGAACCTGCGCACCGACGCGGGCCACGGCGAGCCGGTGCGCGTCTACGAGGCG
GCCACCGATTCGCAGGAGGCCGGCTGGATCGTCGAGGAGATCCGCTCGCTGATCAACGGCGGCATGGCGCGCAGCGAGGT
GGCCGTGCTCTATCGCAGCAATGCGCAGTCGCGCGCGATCGAGCACACGCTGATGACGGCCGGCATCGCCTATCGCGTCT
ACGGCGGCCTGCGCTTCTTCGAGCGCCAGGAAATCAAGCACGCGCTCGCCTACCTGCGCCTGATCGACAACCCCAGCGAC
GACACGGCATTCGCACGCGTGGTCAACTTCCCCACGCGCGGCATCGGCGCGCGCTCGATCGAGCAGCTGGCCGACGCCGC
GCGCCTGCACAATTGCGCGATGGCGGCGGCGATTCCCTACGTGACGGGCAAGGCCGGCACGAGCCTGGGCGCGTTCGCGA
ACCTGATCGCGAAGCTGCGCGCCGAAACCAGGCAGATGAGCCTGCCGGAGATGGTCGAGTACGTGGTGCGCGCGAGCGGC
CTGGCCGATTTCTACCAAGGCGAGCGCGAAGGGCAGGACCGCCTCGAGAACCTGCAGGAACTCGTCAACGCGGCCGCCGC
GTTCGTCAGCGAGGAGGGCTACGGGCTCGACACGCCGGCGCGCTCGATTCCGCTGCGCCCGGGCGCGAGCGCCGCGCCCG
AACTGGCGGCGGGCGGCGACGCGGCCGGCGCCGTGCTCGCGCCGGCCGCTCCCGACGATCCGGCCCAGAACCCCGACACC
ATGACGCCGCTCGCGGGCTTTCTCTCGCATGCGTCGCTGGAGGCCGGCGACAATCAGGCCCAGGCCGGCCAGGACGCGGT
GCAGCTGATGACGGTGCATGCGGCCAAGGGGCTCGAATTCTCGGCGGTGTTCATCACCGGGCTCGAGGAAGGCCTGTTCC
CGCACGAGAACAGCGCGCTCGAAACCGACGGGCTCGAGGAGGAGCGCCGGCTGATGTACGTGGCGATCACGCGTGCCAAG
GAGCGGCTCTACCTGTCGTTCGCGCAGAGCCGGCTGCTGCACGGCCAGACCCGCTACAACATCCGTTCGCGCTTCTTCGA
CGAGCTGCCGCAGCAGGTGCTGAAGTGGCTCACCCCGCAGGTCGAGGCCGGCAGCCGCTGGGGCGGCCGCGCCGACAACG
CCGGCTGGGGCCGCAACTGGTTCGCCCGGCCGGGCGGCGCCGCAGGCGGCACGCGCGACGCGGTGGTGGACGCGGCCGTG
ACGGCGCCGCTGCCCGCGTTCGCGAACGCGCAGCGCGCGGCCGGCAACGGCTTCAAGGTCGGCCAGCCGGTGTTCCATAC
CAAGTTCGGCGAGGGCACGGTGACGGCCCTCGAGGGCGAGGGCGCCGATGCGAAGGCGCAGGTCCGCTTCAAGCGCCACG
GCGAGAAATGGCTCGCGCTCGCGGTGGCGAAACTTCAGGCAGTGGAATGA

Upstream 100 bases:

>100_bases
CTGCCCGGGGCGCGCCGCCGTTCTATAATGGCGAGCCATCGCGCCGCCCGGCCGTGCCCGGCCCCGCGCGCCTCACGCCT
CCTCGTCCGTCTTGCGCTTT

Downstream 100 bases:

>100_bases
CGAGGATGCAGATGCCCTACGACAGGAAACGGCCGCTCGGCATCCTCGCCGCGCTGCCGCAGGAACTCGGCGACCTGGTC
GCCCGGATGGAGACCGAAGG

Product: DNA helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 789; Mature: 788

Protein sequence:

>789_residues
MPDLLANLNPEQYAAVTLPNEPALILAGAGSGKTRVLITRIAWLIQHGYASPPTVLAVTFTNKAAREMLSRLSAMMPIDT
RGMWIGTFHGLCNRMLRAHYRDAGLPQTFQILDTADQLSAIKRLMKASNIDDEKYPPKNVQYFINNAKEQGLRPDKVEAN
DSFNRMFVQLYQAYDQQCQREGVVDFPELLLRCFELLSYNPALRAHYQARFRHILVDEFQDTNKLQYAWLKLLAGEQNAI
FAVGDDDQSIYAFRGANVGNMRDFEDEFRVRNLIKLEQNYRSHGNILDAANHLIAHNSRRLGKNLRTDAGHGEPVRVYEA
ATDSQEAGWIVEEIRSLINGGMARSEVAVLYRSNAQSRAIEHTLMTAGIAYRVYGGLRFFERQEIKHALAYLRLIDNPSD
DTAFARVVNFPTRGIGARSIEQLADAARLHNCAMAAAIPYVTGKAGTSLGAFANLIAKLRAETRQMSLPEMVEYVVRASG
LADFYQGEREGQDRLENLQELVNAAAAFVSEEGYGLDTPARSIPLRPGASAAPELAAGGDAAGAVLAPAAPDDPAQNPDT
MTPLAGFLSHASLEAGDNQAQAGQDAVQLMTVHAAKGLEFSAVFITGLEEGLFPHENSALETDGLEEERRLMYVAITRAK
ERLYLSFAQSRLLHGQTRYNIRSRFFDELPQQVLKWLTPQVEAGSRWGGRADNAGWGRNWFARPGGAAGGTRDAVVDAAV
TAPLPAFANAQRAAGNGFKVGQPVFHTKFGEGTVTALEGEGADAKAQVRFKRHGEKWLALAVAKLQAVE

Sequences:

>Translated_789_residues
MPDLLANLNPEQYAAVTLPNEPALILAGAGSGKTRVLITRIAWLIQHGYASPPTVLAVTFTNKAAREMLSRLSAMMPIDT
RGMWIGTFHGLCNRMLRAHYRDAGLPQTFQILDTADQLSAIKRLMKASNIDDEKYPPKNVQYFINNAKEQGLRPDKVEAN
DSFNRMFVQLYQAYDQQCQREGVVDFPELLLRCFELLSYNPALRAHYQARFRHILVDEFQDTNKLQYAWLKLLAGEQNAI
FAVGDDDQSIYAFRGANVGNMRDFEDEFRVRNLIKLEQNYRSHGNILDAANHLIAHNSRRLGKNLRTDAGHGEPVRVYEA
ATDSQEAGWIVEEIRSLINGGMARSEVAVLYRSNAQSRAIEHTLMTAGIAYRVYGGLRFFERQEIKHALAYLRLIDNPSD
DTAFARVVNFPTRGIGARSIEQLADAARLHNCAMAAAIPYVTGKAGTSLGAFANLIAKLRAETRQMSLPEMVEYVVRASG
LADFYQGEREGQDRLENLQELVNAAAAFVSEEGYGLDTPARSIPLRPGASAAPELAAGGDAAGAVLAPAAPDDPAQNPDT
MTPLAGFLSHASLEAGDNQAQAGQDAVQLMTVHAAKGLEFSAVFITGLEEGLFPHENSALETDGLEEERRLMYVAITRAK
ERLYLSFAQSRLLHGQTRYNIRSRFFDELPQQVLKWLTPQVEAGSRWGGRADNAGWGRNWFARPGGAAGGTRDAVVDAAV
TAPLPAFANAQRAAGNGFKVGQPVFHTKFGEGTVTALEGEGADAKAQVRFKRHGEKWLALAVAKLQAVE
>Mature_788_residues
PDLLANLNPEQYAAVTLPNEPALILAGAGSGKTRVLITRIAWLIQHGYASPPTVLAVTFTNKAAREMLSRLSAMMPIDTR
GMWIGTFHGLCNRMLRAHYRDAGLPQTFQILDTADQLSAIKRLMKASNIDDEKYPPKNVQYFINNAKEQGLRPDKVEAND
SFNRMFVQLYQAYDQQCQREGVVDFPELLLRCFELLSYNPALRAHYQARFRHILVDEFQDTNKLQYAWLKLLAGEQNAIF
AVGDDDQSIYAFRGANVGNMRDFEDEFRVRNLIKLEQNYRSHGNILDAANHLIAHNSRRLGKNLRTDAGHGEPVRVYEAA
TDSQEAGWIVEEIRSLINGGMARSEVAVLYRSNAQSRAIEHTLMTAGIAYRVYGGLRFFERQEIKHALAYLRLIDNPSDD
TAFARVVNFPTRGIGARSIEQLADAARLHNCAMAAAIPYVTGKAGTSLGAFANLIAKLRAETRQMSLPEMVEYVVRASGL
ADFYQGEREGQDRLENLQELVNAAAAFVSEEGYGLDTPARSIPLRPGASAAPELAAGGDAAGAVLAPAAPDDPAQNPDTM
TPLAGFLSHASLEAGDNQAQAGQDAVQLMTVHAAKGLEFSAVFITGLEEGLFPHENSALETDGLEEERRLMYVAITRAKE
RLYLSFAQSRLLHGQTRYNIRSRFFDELPQQVLKWLTPQVEAGSRWGGRADNAGWGRNWFARPGGAAGGTRDAVVDAAVT
APLPAFANAQRAAGNGFKVGQPVFHTKFGEGTVTALEGEGADAKAQVRFKRHGEKWLALAVAKLQAVE

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=801, Percent_Identity=44.1947565543071, Blast_Score=641, Evalue=0.0,
Organism=Escherichia coli, GI48994965, Length=684, Percent_Identity=35.5263157894737, Blast_Score=358, Evalue=1e-99,
Organism=Escherichia coli, GI1787196, Length=340, Percent_Identity=28.5294117647059, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6322369, Length=760, Percent_Identity=27.3684210526316, Blast_Score=208, Evalue=3e-54,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 86757; Mature: 86626

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDLLANLNPEQYAAVTLPNEPALILAGAGSGKTRVLITRIAWLIQHGYASPPTVLAVTF
CCCCCCCCCHHHEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEE
TNKAAREMLSRLSAMMPIDTRGMWIGTFHGLCNRMLRAHYRDAGLPQTFQILDTADQLSA
CCHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
IKRLMKASNIDDEKYPPKNVQYFINNAKEQGLRPDKVEANDSFNRMFVQLYQAYDQQCQR
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
EGVVDFPELLLRCFELLSYNPALRAHYQARFRHILVDEFQDTNKLQYAWLKLLAGEQNAI
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEE
FAVGDDDQSIYAFRGANVGNMRDFEDEFRVRNLIKLEQNYRSHGNILDAANHLIAHNSRR
EEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHH
LGKNLRTDAGHGEPVRVYEAATDSQEAGWIVEEIRSLINGGMARSEVAVLYRSNAQSRAI
HCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCHHHEEEEECCCCHHHHH
EHTLMTAGIAYRVYGGLRFFERQEIKHALAYLRLIDNPSDDTAFARVVNFPTRGIGARSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHH
EQLADAARLHNCAMAAAIPYVTGKAGTSLGAFANLIAKLRAETRQMSLPEMVEYVVRASG
HHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC
LADFYQGEREGQDRLENLQELVNAAAAFVSEEGYGLDTPARSIPLRPGASAAPELAAGGD
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AAGAVLAPAAPDDPAQNPDTMTPLAGFLSHASLEAGDNQAQAGQDAVQLMTVHAAKGLEF
CCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHCHHHHHHHHHHHHHCCCEE
SAVFITGLEEGLFPHENSALETDGLEEERRLMYVAITRAKERLYLSFAQSRLLHGQTRYN
EEEEEECHHHCCCCCCCCCCCCCCCCHHHHEEEEEEHHHHHHHHHHHHHHHHHCCCHHHH
IRSRFFDELPQQVLKWLTPQVEAGSRWGGRADNAGWGRNWFARPGGAAGGTRDAVVDAAV
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
TAPLPAFANAQRAAGNGFKVGQPVFHTKFGEGTVTALEGEGADAKAQVRFKRHGEKWLAL
HCCCCHHCCCHHCCCCCCCCCCCHHEEECCCCCEEEEECCCCCCHHHHHHHHCCHHHHHH
AVAKLQAVE
HHHHHHHCC
>Mature Secondary Structure 
PDLLANLNPEQYAAVTLPNEPALILAGAGSGKTRVLITRIAWLIQHGYASPPTVLAVTF
CCCCCCCCHHHEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEE
TNKAAREMLSRLSAMMPIDTRGMWIGTFHGLCNRMLRAHYRDAGLPQTFQILDTADQLSA
CCHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
IKRLMKASNIDDEKYPPKNVQYFINNAKEQGLRPDKVEANDSFNRMFVQLYQAYDQQCQR
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
EGVVDFPELLLRCFELLSYNPALRAHYQARFRHILVDEFQDTNKLQYAWLKLLAGEQNAI
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEE
FAVGDDDQSIYAFRGANVGNMRDFEDEFRVRNLIKLEQNYRSHGNILDAANHLIAHNSRR
EEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHH
LGKNLRTDAGHGEPVRVYEAATDSQEAGWIVEEIRSLINGGMARSEVAVLYRSNAQSRAI
HCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCHHHEEEEECCCCHHHHH
EHTLMTAGIAYRVYGGLRFFERQEIKHALAYLRLIDNPSDDTAFARVVNFPTRGIGARSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHH
EQLADAARLHNCAMAAAIPYVTGKAGTSLGAFANLIAKLRAETRQMSLPEMVEYVVRASG
HHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC
LADFYQGEREGQDRLENLQELVNAAAAFVSEEGYGLDTPARSIPLRPGASAAPELAAGGD
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AAGAVLAPAAPDDPAQNPDTMTPLAGFLSHASLEAGDNQAQAGQDAVQLMTVHAAKGLEF
CCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHCHHHHHHHHHHHHHCCCEE
SAVFITGLEEGLFPHENSALETDGLEEERRLMYVAITRAKERLYLSFAQSRLLHGQTRYN
EEEEEECHHHCCCCCCCCCCCCCCCCHHHHEEEEEEHHHHHHHHHHHHHHHHHCCCHHHH
IRSRFFDELPQQVLKWLTPQVEAGSRWGGRADNAGWGRNWFARPGGAAGGTRDAVVDAAV
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
TAPLPAFANAQRAAGNGFKVGQPVFHTKFGEGTVTALEGEGADAKAQVRFKRHGEKWLAL
HCCCCHHCCCHHCCCCCCCCCCCHHEEECCCCCEEEEECCCCCCHHHHHHHHCCHHHHHH
AVAKLQAVE
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]