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The map label for this gene is lexA [H]

Identifier: 238027471

GI number: 238027471

Start: 2057527

End: 2058234

Strand: Direct

Name: lexA [H]

Synonym: bglu_1g18740

Alternate gene names: 238027471

Gene position: 2057527-2058234 (Clockwise)

Preceding gene: 238027456

Following gene: 238027472

Centisome position: 52.67

GC content: 65.25

Gene sequence:

>708_bases
TTGAATTTCCCCGACTACTGTATAAAAATACAGATCACTGTCTATCCATACAGTCCGACCATGACCAAACTCACCGCACG
CCAGCAGCAAGTGTTCGACCTGGTTCGCCGCGCGATCGAGCGCTCCGGCTTCCCGCCGACCCGCGCCGAGATTGCGGCCG
AACTCGGCTTCAGTTCGCCGAACGCGGCCGAGGAGCACTTGCGCGCCCTTGCCCGCAAGGGCGTGATCGAGCTGGCCGCC
GGCGCCTCGCGCGGCATTCGCCTGCTCGGTCTCGACGAGGCGCCGCACCAGCTCACGCTGCCGCATGCGGCGCTGATGCA
ACTGTCGCTGCCGCTCGTCGGGCGTGTCGCGGCAGGTAGCCCGATCCTCGCGCAGGAACACATCTCGCAGCACTACGCTT
GCGACCCGGCCCTCTTCACGAGCAAACCCGACTACCTGCTGAAGGTACGCGGGCTGTCGATGCGCGACGCCGGCATCCTC
GACGGCGATCTGCTCGCCGTGCAGAAGCGCAGCGAAGCCAAGGACGGCCAGATCATCGTCGCGCGGCTCGGCGACGACGT
CACCGTCAAGCGCCTGAAGCGCCATTCCACCGGCATCGAGCTGATCGCCGAAAACCCCGACTACGAAAACATCTTCGTGA
AGGCCGGCAGCGCGGAATTCGCGCTCGAAGGCATCGCCGTCGGGCTGATCCGCTCCGGGGAACTGTAA

Upstream 100 bases:

>100_bases
TAAGGACCGTCCGACGGACGGTTGCGGCATCGAAACCGCCGTTTCGACGTCGCTCGATCGCGGCAGAATCGACGCGATAG
CGCCGAACCTGAAGTAACGC

Downstream 100 bases:

>100_bases
TACCGGGGCCGGCTGCCGGTCGCTTCGTCCGCTGCCGGCTTGAATCTGCTCAGCACGTTCGTCCCTCCATCCGATCTGGA
GAACACATGGAACGCTTCAC

Product: LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MNFPDYCIKIQITVYPYSPTMTKLTARQQQVFDLVRRAIERSGFPPTRAEIAAELGFSSPNAAEEHLRALARKGVIELAA
GASRGIRLLGLDEAPHQLTLPHAALMQLSLPLVGRVAAGSPILAQEHISQHYACDPALFTSKPDYLLKVRGLSMRDAGIL
DGDLLAVQKRSEAKDGQIIVARLGDDVTVKRLKRHSTGIELIAENPDYENIFVKAGSAEFALEGIAVGLIRSGEL

Sequences:

>Translated_235_residues
MNFPDYCIKIQITVYPYSPTMTKLTARQQQVFDLVRRAIERSGFPPTRAEIAAELGFSSPNAAEEHLRALARKGVIELAA
GASRGIRLLGLDEAPHQLTLPHAALMQLSLPLVGRVAAGSPILAQEHISQHYACDPALFTSKPDYLLKVRGLSMRDAGIL
DGDLLAVQKRSEAKDGQIIVARLGDDVTVKRLKRHSTGIELIAENPDYENIFVKAGSAEFALEGIAVGLIRSGEL
>Mature_235_residues
MNFPDYCIKIQITVYPYSPTMTKLTARQQQVFDLVRRAIERSGFPPTRAEIAAELGFSSPNAAEEHLRALARKGVIELAA
GASRGIRLLGLDEAPHQLTLPHAALMQLSLPLVGRVAAGSPILAQEHISQHYACDPALFTSKPDYLLKVRGLSMRDAGIL
DGDLLAVQKRSEAKDGQIIVARLGDDVTVKRLKRHSTGIELIAENPDYENIFVKAGSAEFALEGIAVGLIRSGEL

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1790476, Length=215, Percent_Identity=56.2790697674419, Blast_Score=246, Evalue=1e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 25548; Mature: 25548

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFPDYCIKIQITVYPYSPTMTKLTARQQQVFDLVRRAIERSGFPPTRAEIAAELGFSSP
CCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCC
NAAEEHLRALARKGVIELAAGASRGIRLLGLDEAPHQLTLPHAALMQLSLPLVGRVAAGS
CHHHHHHHHHHHCCCEEEECCCCCCEEEEECCCCCCEEECCHHHHHHHHCCHHHHHCCCC
PILAQEHISQHYACDPALFTSKPDYLLKVRGLSMRDAGILDGDLLAVQKRSEAKDGQIIV
CCHHHHHHHHHCCCCCHHCCCCCCEEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCEEE
ARLGDDVTVKRLKRHSTGIELIAENPDYENIFVKAGSAEFALEGIAVGLIRSGEL
EECCCCHHHHHHHHCCCCEEEEECCCCCCEEEEECCCCCEEHHHEEEEEEECCCC
>Mature Secondary Structure
MNFPDYCIKIQITVYPYSPTMTKLTARQQQVFDLVRRAIERSGFPPTRAEIAAELGFSSP
CCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCC
NAAEEHLRALARKGVIELAAGASRGIRLLGLDEAPHQLTLPHAALMQLSLPLVGRVAAGS
CHHHHHHHHHHHCCCEEEECCCCCCEEEEECCCCCCEEECCHHHHHHHHCCHHHHHCCCC
PILAQEHISQHYACDPALFTSKPDYLLKVRGLSMRDAGILDGDLLAVQKRSEAKDGQIIV
CCHHHHHHHHHCCCCCHHCCCCCCEEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCEEE
ARLGDDVTVKRLKRHSTGIELIAENPDYENIFVKAGSAEFALEGIAVGLIRSGEL
EECCCCHHHHHHHHCCCCEEEEECCCCCCEEEEECCCCCEEHHHEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA